Granin (chromogranin and secretogranin) is a protein family of regulated secretory proteins ubiquitously found in the cores of amine and peptide hormone and neurotransmitter dense-core secretory vesicles. (wikipedia.org)
chromogranin A (CgA) chromogranin B (CgB) secretogranin II (SgII) (see also secretoneurin) secretogranin III (SgIII) secretogranin V (SgV) Some other proteins are also proposed to belong to the granins based on their physico-chemical properties. (wikipedia.org)
It belongs to the family of granins that includes chromogranin B, chromogranin C, and secretogranin II. (medscape.com)
Chromogranin A contains multiple cleavage sites, which undergo a tissue-specific proteolytic process, leading to the production of many biologically active peptides including vasostatin I, vasostatin II, pancreastatin, catestatin, parastatin, and serpinin. (medscape.com)
From NCBI Gene: The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. (nih.gov)
Interestingly, immunoreactivity for secretogranin II, triggerbot script rainbow six III and chromogranin B was identified in myoepithelial cells. (novomerc34.com)
Among them, differences in pro-neuropeptide Y, proenkephalin-A, neuroendocrine convertase-2, neurosecretory protein VGF, chromogranin-A, and secretogranin-1 and -3 concentrations relative to parturition highlight propeptides and prohormone processings involved in the control of feed intake and energy homeostasis. (uhi.ac.uk)
Protein8
Secretogranin II is an acidic protein of 559 to 586 amino acid residues that can stimulate DOPAMINE release from neurons and release of pituitary GONADOTROPINS . (nih.gov)
Secretogranin-2 is a neuroendocrine secretory granule protein, which is the precursor for biologically active peptides. (nih.gov)
Studies in rodents suggest that the full-length protein, secretogranin II, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles. (nih.gov)
The activity and function of GBA is regulated by several accessory proteins including lysosomal integral membrane protein 2 (LIMP2) and progranulin (PGRN). (biomedcentral.com)
Expression of the desmosomal protein Desmoglein-2 was reduced in pediatric dilated cardiomyopathy pediatric patients. (cusabio.cn)
The deduced amino acid sequence of NK-2 protein consists of 723 amino acid residues. (nih.gov)
Since homeobox proteins are known to be regulators of gene expression, we predict that NK-2 protein activates the gene program that commits cells to the neuroectodermal pathway of development and thereby initiates the developmental program for the formation of the nervous system. (nih.gov)
also known as ASH1), neurogenic differentiation factor 1 (NeuroD1), yes-associated protein 1 (YAP1) and POU class 2 homeobox 3 (POU2F3). (cancerindex.org)
SgII1
Secretoneurin (SN) is a neuropeptide derived from specific proteolytic processing of the precursor secretogranin II (SgII). (jmcb.info)
SCG32
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Secretogranin III (SCG3) in serum, plasma, tissue homogenates and other biological fluids. (noveoninc.com)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Secretogranin III (SCG3) in samples from Serum, plasma, tissue homogenates and other biological fluids with no significant corss-reactivity with analogues from other species. (noveoninc.com)
Acidic1
Granins (chromogranins or secretogranins) are acidic proteins and are present in the secretory granules of a wide variety of endocrine and neuro-endocrine cells. (wikipedia.org)
Species1
Northern analysis revealed one species of NK-2 poly At RNA, 3.2 kb in length, which is most abundant in 3-6 hr embryos. (nih.gov)
Peptides1
Cumulative evidences suggest that CgA's derived peptides are involved in a wide range of activities, like regulation of blood pressure (catestatin), glucose metabolism (pancreastatin, catestatin), neuroprotection (serpinin), and tumor angiogenesis (vasostatin I, vasostatin II). (medscape.com)
Antigen3
Lou H, Kodama T, Wang YN, Katz NM, Ramwell PW, Foegh ML. Major histocompatibility complex class II antigen expression is suppressed by estradiol in cardiac allografts. (nih.gov)
Lou H, Kodama T, Zhao Y, Maurice P, Wang YN, Katz NM, Foegh ML. Inhibition of transplant coronary arteriosclerosis in rabbits by chronic estradiol treatment is associated with abolishing MHC class II antigen expression. (nih.gov)
Description: A sandwich ELISA kit for detection of Secretogranin III from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (noveoninc.com)
Neuroectodermal2
37. Secretogranin II expression in Ewing's sarcomas and primitive neuroectodermal tumors. (nih.gov)
Both the initial time of expression of the NK-2 gene at the cellular blastoderm stage of development and the initial pattern of expression of NK-2 coincide exactly with the appearance of the neuroectodermal anlage. (nih.gov)
MRNA1
NK-2 mRNA was detected at all later stages of embryonic development and in adult flies, but less NK-2 mRNA was detected in larvae and pupae. (nih.gov)
Desmoglein1
The homozygous desmoglein 2 variant c.1003A;G co-segregated with Arrhythmogenic right ventricular cardiomyopathy, indicating autosomal recessive inheritance and complete penetrance. (cusabio.cn)
Gene6
Two transcript variants encoding different isoforms have been found for this gene. (nih.gov)
At least two mutations in the GNAS gene have been identified in people with primary macronodular adrenal hyperplasia (PMAH), a disorder that causes multiple lumps (nodules) to form in the adrenal glands, which are small hormone-producing glands located on top of each kidney. (medlineplus.gov)
For a small subset of genes, however, only one of the two gene copies is active. (medlineplus.gov)
Dad 12 rH ANNUAL REPORT OF THE LABORATORY OF BIOCHEMICAL GENETICS NATIONAL HEART, LUNG, AND BLOOD INSTITUTE October 1, 1989 through September 30, 1990 Previously, we cloned three neighboring Drosophila homeobox genes designated NK-1, NK-3, and NK-4 that reside in the right arm of the third chromosome at bands 93E1-5, and a fourth homeobox gene, NK-2 that resides in the X chromosome at bands 1C1-5. (nih.gov)
In situ hybridization analysis showed that expression of the NK-2 gene is initiated at the cellular blastoderm stage in the ventrolateral portion of the embryo, which later in development, gives rise to the nervous system. (nih.gov)
In 12 hr and older embryos expression of the NK-2 gene was found both the central nervous system and in cells associated with the midgut. (nih.gov)
The nucleotide sequences of approximately 3.5 kb of NK-2 cDNA and genomic DNA were determined. (nih.gov)
Human1
In the United States alone, there are at least 15 human diseases for which the associated pathogens are transmitted by ticks [ 2 ]. (biomedcentral.com)
Perspectives1
In parasites including ticks, protease inhibitor function is viewed from two perspectives: one being their significance in regulating the homeostasis of the tick itself, and the other being their significance in regulating the parasite-host interaction. (biomedcentral.com)
Studies2
Results Twenty-two studies (7106 patients) were eligible. (medscape.com)
Bedside teaching is a vital component of medical education and one of the most effective ways to learn clinical and communication skills.1,2 Evidence-based studies show that interpersonal and communication skills of doctors have a significant impact on patient care.3-6 Bedside teaching is defined as teaching in the presence of a patient. (c-kitinhibitors.com)
Role1
The basolateral amygdala (BLA) is a center of salience networks that underlie emotional experience and thus plays a key role in long-term fear memory formation 1 , 2 . (biorxiv.org)
Journal1
Journal of Proteome Research , 14 (2), 823-828. (uhi.ac.uk)
[ 1 ] The condition has an estimated prevalence of up to 20% in Western populations, [ 2 ] and the impact of IBS socially and economically is significant, with up to 12% of IBS patients having to stop work completely. (medscape.com)
University1
2 Interventional Institute of Zhengzhou University, Zhengzhou, China. (nih.gov)
Months2
Maintain refrigerated at 2°C to 8°C for up to 6 months. (lsbio.com)
Being in a boot for 2 months brought my foot alot of problems. (novomerc34.com)