- Via biomimetic ultrafiltration, umbelliferone and scopoletin were screened as two anti-rheumatic candidates with the highest specific affinities towards the membrane proteomes of rheumatic fibroblast-like synoviocytes (FLS), the pivotal effector cells in RA. (frontiersin.org)
- Network pharmacology analysis and molecular docking analysis jointly revealed that umbelliferone and scopoletin act on multiple targets, mostly tyrosine kinases, in combating RA. (frontiersin.org)
- Taken together, our present study identified umbelliferone and scopoletin as two major anti-rheumatic components from SL that may bind and inhibit tyrosine kinases and subsequently inactivate NF-κB in RA-FLSs. (frontiersin.org)
- Noni contains the phytochemical, scopoletin, which has anti-bacterial activity, anti-inflammatory effects and regulates blood pressure. (hatcheryinternational.com)
- To extract scopoletin from the noni, Ponza used a method of fermenting it with molasses and water for 30 days. (hatcheryinternational.com)
- Found in the pulp of raw Noni fruit, Scopoletin is a potent anti-inflammatory that binds with serotonin to help regulate mood, sleep, hunger, and temperature. (realnoni.com)
- Noni ( Morinda citrifolia L.) contains phenolic compounds such as scopoletin, quercetin, and rutin, which have various biological activities including antioxidant, antiinflammatory, and hepatoprotective activities. (uns.ac.id)
- CONCLUSIONS: Despite differences in the enzymatic pool, both fungi caused a significant decrease in the amounts of phenolic compounds with the accumulation of the only scopoletin. (bvsalud.org)
- Gnonlonfin GJB, Sanni A, Brimer L. Review Scopoletin - A Coumarin Phytoalexin with Medicinal Properties. (japsonline.com)
- Like most phenylpropanoids, the biosynthetic precursor to scopoletin acid is 4-coumaroyl-CoA. (wikipedia.org)
- For scopoletin, most of biosynthetic investigations are based on Arabidopsis thaliana. (wikipedia.org)
- Scopoletin (7-hydroxy-6-methoxycoumarin) could be isolated from stem bark extract yielding 1.4 μmol/g by dry weight. (japsonline.com)
- The aim of this study was to investigate the ability of the ethanol extract, four fractions (F1-F4) and five compounds namely artemisinin (1), scopoletin (2), chrysosplenetin (3), eupatin (4) and 3- O -β- d -glucopyranoside of sitosterol (5) isolated from A. annua to modulate the activity of anticholinesterase (AchE) and the production of nitric oxide (NO) in LPS-activated RAW 264.7 macrophages. (springeropen.com)
- Scopolin is a glucoside of scopoletin formed by the action of the enzyme scopoletin glucosyltransferase. (wikipedia.org)
- Korsvedbarken er fylt med hydrokinoner (inkludert arbutin, metylarbutin og fri hydrokinon), garvestoffer (3 %), harpiks og kumariner (inkludert scopoletin og scopolin), de siste bare i sv rt sm mengder. (rolv.no)
- The lipophilic extracts and the purified scopoletin from L. lucidus have clear antibacterial activities, especially acting against P. aeruginosa strains. (japsonline.com)
- Hepatoprotective activity of scopoletin, a constituent ofSolanum lyratum. (uns.ac.id)
- Unlike the marginal impact of other compounds against low-density lipoprotein (LDL) oxidation and vascular endothelial inflammation, scopoletin showed remarkable activity on LDL oxidation (IC50 = 10.2 μM) and exerted vascular anti-inflammatory effects in EA.hy926 human endothelial cells activated by TNF-α. (gnu.ac.kr)
- Some compounds, such as scopoletin and damnacanthal, have been isolated and studied individually. (ayurvedicnaturally.com)
- Damnachanthal, nordamnacanthal, chitosan nanoparticles, scopoletin, and epicatechin are active compounds presented in noni plants that can act as anti-cancer. (uii.ac.id)
- proxeronine , vitamin C, carotene, potassium compounds and damnactal , which supports normal cell division, and scopoletin which has anti-inflammatory action by blocking cytokine production, and also antioxidant, hepatic and spasmolytic activity. (pharmavita.eu)
- Acetylcholinesterase inhibitory activity of scopolin and scopoletin discovered by virtual screening of natural products. (chemchart.com)
- These results demonstrate that owing to its anti-inflammatory activity in the vascular endothelium, scopoletin has the potential to inhibit atherosclerosis development. (gnu.ac.kr)
- Scopoletin is renowned for its anti-inflammatory and pain-relieving properties. (realnoni.com)
- Xeronine for cell regeneration and Scopoletin for anti-inflammatory effects. (spaonpenn.com)
- Scopolin is a glucoside of scopoletin formed by the action of the enzyme scopoletin glucosyltransferase. (wikipedia.org)
- For scopoletin, most of biosynthetic investigations are based on Arabidopsis thaliana. (wikipedia.org)
- Scopoletin is derived from 1,2-benzopyrones which is the core structure of coumarins formed through hydroxylation of cinnamates, trans/cis isomerization of the side chain, and lactonization. (wikipedia.org)
- First isolated by Eykman in 1884, scopoletin belongs to a class of phytochemicals (coumarins). (realnoni.com)
- De werkzaamheid van Voordeel Noni 1 L. is zo hoog omdat er géén enkele vorm van kunstmatige verbouwing aan te pas komt, maar ook omdat ze het een oorspronkelijke plantensoort betreft die niet door teling essentiële stoffen is kwijtgeraakt maar een buitengewone samenstelling heeft van bekende en onbekende werkzame inhoudsstoffen. (noni-sap.com)
- Noni werkt door de stimulans van endorfinen in de hersenen stemmingsverbeterend en kalmerend. (noni-sap.com)
- This study examined the inhibitory effect of scopoletin on TNF-α-induced vascular endothelial inflammation. (gnu.ac.kr)
- Scopoletin, a fluorescent compound was initially tested as an alternative PPD marker but was dismissed as it did not correlate well with PPD symptom development.Overexpression of anti-oxidant genes was observed in selected lines - between 4- to 5-fold increase of relative transcriptional level was achieved in fresh roots and up to 20-fold was achieved in transgenic roots that had been harvested after 24 hours. (bath.ac.uk)
- The NE Yuzu Fruit Cellular Extract delivers the natural molecules this botanical species can offer in a water-soluble format, including hesperidin, scopoletin, naringin, neohesperidin, obacunoic acid, limonoids and more. (nativeextracts.com)
- Scopoletin 140-280 N.D. - Chlorogenic Acid NLD. (nih.gov)
- Using the Jurkat T cell model of HIV-1 latency, we found that Scopoletin can reactivate latent HIV-1 replication with a similar potency to Prostratin and did so in a dose- and time-dependent manner. (nih.gov)
- Scopoletin can inhibit cancer cell proliferation by inducing cells in the G0 / G1 and S phases. (uii.ac.id)
- Scopoletin was isolated from this plant for the first time. (gnu.ac.kr)
- Scopoletin is a plant growth factor derived from the root of Scopolia carniolica, inhibits of acetylcholinesterase (AChE). (targetmol.com)
- This sensor is based on the electropolymerization of scopoletin or o-phenylenediamine in the presence of tyrosinase from mushrooms, which has a high homology to the human enzyme. (tubitak.gov.tr)
- Importantly, Scopoletin did not have a stimulatory effect on T lymphocyte receptors or HIV-1 receptors. (nih.gov)