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  • concentric
  • The T1 image (above right) shows pathognomonic findings of a subset of demyelination, Balo concentric sclerosis (BCS), which is characterized by concentric rings of alternating signal intensity which represent rings of demyelination (hypointensity) adjacent to rings of spared white matter (isointensity). (jaocr.org)
  • Gaffney S. At the Viewbox: Balo Concentric Sclerosis. (jaocr.org)
  • amyotrophic lateral s
  • Amyotrophic lateral sclerosis ( ALS ), also known as motor neurone disease ( MND ), or Lou Gehrig's disease , is a specific disease which causes the death of neurons controlling voluntary muscles . (wikipedia.org)
  • In 1869, the connection between the symptoms and the underlying neurological problems was first described by Jean-Martin Charcot , who in 1874 began using the term amyotrophic lateral sclerosis . (wikipedia.org)
  • Motor neuron diseases include amyotrophic lateral sclerosis (ALS), primary lateral sclerosis , progressive muscular atrophy , progressive bulbar palsy , pseudobulbar palsy , and spinal muscular atrophy . (wikipedia.org)
  • Amyotrophic lateral sclerosis (ALS) is a disease that breaks down tissues in the nervous system (a neurodegenerative disease) of unknown cause that affects the nerves responsible for movement. (encyclopedia.com)
  • Common medical conditions whose pathology involves sclerosis include: Amyotrophic lateral sclerosis, sometimes known as Lou Gehrig's disease, a progressive, incurable, usually fatal disease of motor neurons. (wikipedia.org)
  • ALS is a motor neuron disease, also spelled "motor neurone disease", which is a group of neurological disorders that selectively affect motor neurons, the cells that control voluntary muscles of the body, including amyotrophic lateral sclerosis (ALS), primary lateral sclerosis, progressive muscular atrophy, progressive bulbar palsy, pseudobulbar palsy, and spinal muscular atrophy. (wikipedia.org)
  • There is no evidence of the degeneration of spinal motor neurons or muscle wasting (amyotrophy) that occurs in amyotrophic lateral sclerosis (ALS). (wikipedia.org)

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  • primary
  • Primary lateral sclerosis (PLS) involves only upper motor neurons, and progressive muscular atrophy (PMA) involves only lower motor neurons. (wikipedia.org)
  • Primary lateral sclerosis, progressive muscle weakness in the voluntary muscles. (wikipedia.org)
  • Primary lateral sclerosis (PLS) is a rare neuromuscular disease characterized by progressive muscle weakness in the voluntary muscles. (wikipedia.org)
  • however, juvenile primary lateral sclerosis (JPLS) has been linked to a mutation in the ALS2 gene which encodes the cell-signalling protein alsin. (wikipedia.org)
  • Primary lateral sclerosis (PLS) usually presents with gradual-onset, progressive, lower-extremity stiffness and pain due to muscle spasticity. (wikipedia.org)
  • involves
  • The exact mechanism of action of hamartin and tuberin is not fully understood and an alternative explanation is seen in Knudon's 2-hit model of tumor genesis, which involves loss of heterozygosity that is found in many hamartomas around the bodies of people the tuberous sclerosis. (news-medical.net)
  • Gonadal mosaicism is a form of inherited tuberous sclerosis that involves the gene defects present in some of the reproductive cells of the parent, even though the parent themselves do not carry the mutated genes. (news-medical.net)
  • known
  • Although nuclear sclerosis may describe a type of early cataract in human medicine, in veterinary medicine the term is also known as lenticular sclerosis and describes a bluish-grey haziness at the nucleus that usually does not affect vision, except for unusually dense cases. (wikipedia.org)
  • Societies
  • Societies or individual institutions that fail to adapt and change at a sufficient pace are sometimes described as displaying institutional sclerosis. (wikipedia.org)
  • progressive
  • familial centrolobar sclerosis a progressive familial form of leukoencephalopathy marked by nystagmus, ataxia, tremor, parkinsonian facies , dysarthria, and mental deterioration. (thefreedictionary.com)