• myelin
  • In this system neurons but not other cell types, repress the expression of Schwann cell p75NGFR while inducing the expression of the POU domain transcription factor, suppressed cAMP inducible POU, and myelin P0. (rupress.org)
  • I found that BMP2/4 acts to maintain the immature Schwann cell type by promoting its differentiation from the Schwann cell precursor and inhibiting the upregulation of myelin proteins. (bl.uk)
  • Regulation of the myelin gene periaxin provides evidence for Krox-20-independent myelin-related signalling in Schwann cells. (semanticscholar.org)
  • The myelin sheath is created by a synthesis and wrapping of Schwann cell plasma membrane around the axon. (medscape.com)
  • Demyelination and axon loss are pathological hallmarks of the neuroinflammatory disorder multiple sclerosis (MS). Although we have an increasingly detailed understanding of how immune cells can damage axons and myelin individually, we lack a unified view of how the axon-myelin unit as a whole is affected by immune-mediated attack. (rupress.org)
  • In this review, we propose that as a result of the tight cell biological interconnection of axons and myelin, damage to either can spread, which might convert a local inflammatory disease process early in MS into the global progressive disorder seen during later stages. (rupress.org)
  • peripheral nervou
  • Immune cells enter the peripheral nervous system (PNS) and central nervous system (CNS) in several neurological conditions of infectious or autoimmune origin. (rupress.org)
  • present
  • In general, plasma membrane interactions are prevented by repulsive forces generated by steric and electrostatic repulsion of large and negatively charged oligosaccharide polymers present at the cell surface. (rupress.org)
  • surface
  • In contrast, neurites expressed G4, an L1-related molecule in chicken, on their entire cell surface independently of whether they were in contact with other cells or not. (semanticscholar.org)
  • In most cases, membranes are, therefore, only closely connected to each other within tiny regions by anchoring junctions that are strong enough to overcome the repellent forces of the cell surface. (rupress.org)