• myelin
  • I found that BMP2/4 acts to maintain the immature Schwann cell type by promoting its differentiation from the Schwann cell precursor and inhibiting the upregulation of myelin proteins. (bl.uk)
  • Regulation of the myelin gene periaxin provides evidence for Krox-20-independent myelin-related signalling in Schwann cells. (semanticscholar.org)
  • The myelin sheath is created by a synthesis and wrapping of Schwann cell plasma membrane around the axon. (medscape.com)
  • Demyelination and axon loss are pathological hallmarks of the neuroinflammatory disorder multiple sclerosis (MS). Although we have an increasingly detailed understanding of how immune cells can damage axons and myelin individually, we lack a unified view of how the axon-myelin unit as a whole is affected by immune-mediated attack. (rupress.org)
  • In this review, we propose that as a result of the tight cell biological interconnection of axons and myelin, damage to either can spread, which might convert a local inflammatory disease process early in MS into the global progressive disorder seen during later stages. (rupress.org)
  • peripheral nervou
  • An understanding of the relationship of the Schwann cell to other neuronal elements in the peripheral nervous system is helpful in conceptualizing the pathophysiology of a neurilemmoma. (medscape.com)
  • Immune cells enter the peripheral nervous system (PNS) and central nervous system (CNS) in several neurological conditions of infectious or autoimmune origin. (rupress.org)