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  • parasites
  • Along with other helminth parasites Clonorchis sinensis and Opisthorchis viverrini, S. haematobium was declared as Group 1 (extensively proven) carcinogens by the WHO International Agency for Research on Cancer (IARC) Working Group on the Evaluation of Carcinogenic Risks to Humans in 2009. (wikipedia.org)
  • endemic area
  • Adult worm antigens separated by 2-dimensional gel electrophoresis were probed with pooled sera from Zimbabweans resident in a S. haematobium endemic area, followed by identification of individual antigenic parasite proteins using mass spectrometry. (gla.ac.uk)
  • urine
  • Egyptian school children infected with Schistosoma haematobium and treated with a single dose of metrifonate, 10 mg/kg body weight, had a marked reduction in urine egg counts reaching 90% during a 30-week follow-up. (ajtmh.org)
  • The involved cytokines may be excreted in urine and their presence in urine may therefore reflect S. haematobium -related urinary tract pathology. (biomedcentral.com)
  • Children aged 5-12 years from two primary schools in Tana Delta District of Kenya were examined for S. haematobium eggs using urine filtration technique, for haematuria using dipstix and for eosinophil cationic protein (ECP), IL-6, IFN- γ, TNF-α and IL-10 levels using ELISA, and for S. haematobium -related urinary tract pathology using ultrasonography. (biomedcentral.com)
  • larval stages
  • Methods were developed for the cost effective and rapid processing and microsatellite analysis of S. haematobium larval stages stored on Whatman-FTA cards and proved robust on miracidia and cercariae collected from Zanzibar and Niger. (biomedcentral.com)
  • The development of these novel and robust multiplex microsatellite assays, in combination with an improved protocol to elute gDNA from Whatman-FTA fixed schistosome larval stages, enables the high-throughput population genetic analysis of S. haematobium . (biomedcentral.com)
  • Here we present an enhanced method enabling the high-throughput and cost effective preparation of gDNA from individual schistosome larval stages facilitating multi-loci genetic analysis together with two novel S. haematobium multiplex microsatellite PCRs. (biomedcentral.com)
  • genetic
  • The molecular resources and protocols described here advance the way researchers can perform multi locus-based population genetic analyses of S. haematobium as part of the evaluation and monitoring of schistosomiasis control programmes. (biomedcentral.com)
  • The methods outlined here facilitate the high-throughput microsatellite-based population genetic analyses of S. haematobium . (biomedcentral.com)
  • simultaneous
  • Simultaneous consideration of the effects of different foci on transmission will allow for targeted application of control measures aimed at interrupting S. haematobium transmission at a local level. (ajtmh.org)
  • Here, 18 existing S. haematobium microsatellite loci were optimised to enable simultaneous amplification across two novel multiplex microsatellite PCR's, each containing nine loci. (biomedcentral.com)
  • reference
  • Initially the functionality and specificity of all the primer pairs were confirmed by amplifying all the loci in singleplex 12.5 μl reactions using 10 ng of S. haematobium reference gDNA obtained from the Schistosomiasis Collection at the Natural History Museum (SCAN [ 5 ]) and the Type-it Microsatellite PCR Kit (Qiagen) according to the manufacturer's protocol. (biomedcentral.com)
  • japonicum
  • Previously we developed partially protective, single Th- and B cell-epitope-based peptide-DNA dual vaccines (PDDV) (T3-PDDV and B3-PDDV, respectively) capable of eliciting immune responses against the Schistosoma japonicum 22.6 kDa tegument antigen (Sj22.6) and a 62 kDa fragment of myosin (Sj62), respectively. (biomedcentral.com)
  • citation needed] Estimated speciation dates for the japonicum group: ~3.8 million years ago for S. japonicum/South East Asian schistosoma and ~2.5 million years ago for S. malayensis/S. mekongi. (wikipedia.org)
  • hosts
  • Other hosts of Schistosoma spindale include: Bandicota indica Rattus argentiventer Rattus rattus diardii Rattus tiomanicus jalorensis Schistosoma spindale has been implicated of human cercarial dermatitis in India and in Malaysia. (wikipedia.org)
  • cattle
  • Surveys in Sri Lanka revealed prevalence of Schistosoma spindale of 31.2% (of 901 cattle), whilst in Bangladesh a similarly high prevalence of 36% has been reported. (wikipedia.org)
  • group
  • After decades of assessing the medical reports, it was finally declared by the WHO International Agency for Research on Cancer (IARC) Working Group on the Evaluation of Carcinogenic Risks to Humans in 2009 that S. haematobium is Group 1 carcinogen. (wikipedia.org)