Scavenger receptors are pattern recognition receptors (PRRs) found most commonly on immune cells. (wikipedia.org)
The multi-functional class A macrophage scavenger receptor (SRA)/CD204 has emerged as an important class of pattern recognition receptors with broad ligand binding ability. (cdc.gov)
These professional antigen-presenting cells are able to discriminate unmodified self from non-self thanks to pattern recognition receptors such as the Toll like Receptors (TLR) and Scavenger Receptors (SR). SR were originally identified by their ability to bind and internalize modified lipoproteins and microorganisms but also particles and TLR agonists. (biomedcentral.com)
Cysteine-rich2
The scavenger receptor cysteine-rich (SRCR) domain at the end of the extracellular side of MARCO binds ligands to activate the subsequent immune responses. (wikipedia.org)
In contrast, the intestinal SALSA was more enriched with the scavenger receptor cysteine-rich domains. (researchgate.net)
SCARB12
The Hopkins group has also developed a simple blood test for this variation of the scavenger receptor class B type 1 gene (SCARB1) but emphasized there is no approved therapy yet to address the problem in infertile women. (bwfund.org)
APOE associated to the LVP allows the initial virus attachment to cell surface receptors such as the heparan sulfate proteoglycans (HSPGs), syndecan-1 (SDC1), syndecan-1 (SDC2), the low-density lipoprotein receptor (LDLR) and scavenger receptor class B type I (SCARB1) (PubMed:12970454, PubMed:12356718, PubMed:12913001, PubMed:28404852, PubMed:22767607). (proteopedia.org)
Uptake3
In this study, HepG2 cells, an in vitro model system for human hepatocytes, were used to evaluate the interaction of lipoprotein receptors with liposomes carrying fluorescently labeled cholesterol and their subsequent intracellular uptake. (researcher-app.com)
In these experiments, two lipoprotein receptors, scavenger receptor class B type 1 (SR-B1) and low-density lipoprotein receptor (LDLR), accounted for approximately 20% and 10%, respectively, of the intracellular uptake of the labeled liposomes. (researcher-app.com)
The inventors' work established that CXCL16, a membranebound scavenger receptor, influences the uptake, subcellular localization, and cytokine profile induced by D oligonucleotides. (fda.gov)
Antigen1
Finally, mononuclear cells isolated from lung (L-MCs), which are used as precursors for L-DCs, expressed more antigen-presenting cell-associated markers such as MHC class II and CD172α compared to their counterparts from blood. (biomedcentral.com)
Macrophages3
MARCO is a class A scavenger receptor that is found on particular subsets of macrophages. (wikipedia.org)
The macrophage class A scavenger receptor (SRA) facilitates the clearance of noxious particles, oxidants, and infectious organisms by alveolar macrophages. (psu.edu)
CD36, also known as scavenger receptor class B member 3, is a protein that is expressed on the surface of various cell types, including macrophages, platelets, and adipocytes. (thermofisher.com)
Lipoprotein1
Lectin-like Oxidized Low-density Lipoprotein Receptor 1 (LOX-1), also known as Oxidized Low-density Lipoprotein Receptor 1 (OLR1), is a type II transmembrane receptor belonging to the class E scavenger receptor (SR-E) subfamily of the C-type lectin family. (rndsystems.com)
Thrombospondin receptor1
Alessio M, Roggero S, Bussolino F, Saitta M, Malavasi F: Characterization of the murine monoclonal antibody NL07 specific for the human thrombospondin receptor (CD36 molecule). (exbio.cz)
CD1632
CD163, a scavenger receptor that serves as an M2 macrophage phenotype marker, is also expressed on monocytes, and binds to haptoglobin-hemoglobin complexes, mediating their endocytosis [ 11 ]. (biomedcentral.com)
Overall, B-DCs demonstrated higher expression of CD86 and CD172α than L-DCs, but both cell types expressed high levels of MHC class II and CD44, as well as moderate amounts of CD163, CD204, and Bla36. (biomedcentral.com)
Protein5
Macrophage receptor with collagenous structure (MARCO) is a protein that in humans is encoded by the MARCO gene. (wikipedia.org)
For more information see the shaul PW, Mineo C: The scavenger receptor class B type I adaptor protein PDZK1 maintains endothelial monolayer integrity. (thedollpalace.com)
The protein encoded by this gene serves as a receptor for thrombospondin in platelets and various cell lines, and is the fourth major glycoprotein of the platelet surface. (thermofisher.com)
CD36 (fatty acid translocase, FAT) is an 88 kDa ditopic glycosylated protein that belongs to the class B family of scavenger receptors. (exbio.cz)
In a cross-sectional study of 48 AD patients without diabetes, 20 cognitively normal diabetic patients, 16 patients with frontotemporal dementia, and 84 cognitively normal controls, researchers found that dysfunctionally phosphorylated insulin receptor substrate-1 (IRS-1), a neuronal protein, is detectable in blood using exosome-based technology and may be able to predict AD up to 10 years before the appearance of symptoms. (medscape.com)
Phagocytosis3
The primary function of scavenger receptors is to regulate phagocytosis of pathogens, but they also participate in cell-cell recognition and initiation of inflammatory responses. (wikipedia.org)
Through phagocytosis, MARCO also brings pathogens into the cell, which are processed by intracellular compartments that contain other signaling receptors such as TLR3, NOD2, and NALP3. (wikipedia.org)
Phagocytosis is a term coined from the Greek to describe the receptor-mediated engulfment and degradation of dead cells and microbes. (frontiersin.org)
SCARA54
Scavenger receptor class A member 5 (SCARA5) was proved to be the downstream driving gene of THSD7A . (hindawi.com)
We found that scavenger receptor class A member 5( SCARA5 ), located on chromosome 8p21.1, is the downstream driving gene of THSD7A in ESCC [ 5 ]. (hindawi.com)
SCARA5 has significant class A scavenger receptor characteristics [ 6 ]. (hindawi.com)
Previous research showed that scavenger receptor class A member 5 (SCARA5) was one of the potential biomarkers of OSCC, and its expression is significantly low in OSCC. (degruyter.com)
Ligand1
The C-terminal SRCR domain of MARCO affects the ability of the receptor to bind and take up ligand, activate inflammatory signaling, and adhere to surfaces. (wikipedia.org)
Ligands3
Binding of these ligands to RAGE does not accelerate clearance or degradation but rather begins a sustained period of cellular activation mediated by receptor-dependent signaling. (jci.org)
Other unusual features of the receptor include its ability to engage classes of molecules, rather than individual ligands, and its enhanced surface expression in environments rich in RAGE ligands. (jci.org)
Taken together, these features of RAGE allow the receptor to propagate cellular dysfunction in a number of pathophysiologically relevant situations, most often dictated by the formation and persistence of ligands in the tissues. (jci.org)
Intestinal1
Intestinal scavenger receptor class B type I as a novel regulator of chylomicron production in healthy and diet-induced obese states. (harvard.edu)
Type2
The aim of this thesis was to examine the changes in gene expression during foam cell formation and to study the HDL-receptor scavenger receptor class B type I (SR-BI), which may be of importance for reverse cholesterol transport.To search for genes that may be of importance for foam cell formation, expression profiling of human macrophages exposed to oxLDL was performed. (gu.se)
A class of oxidized LDL receptors that contain C-type lectin-like extracellular domains. (bvsalud.org)
Adaptive immunity2
The multiligand receptors that form the focus of this Perspective series have expectedly diverse functions, often conforming to potential gaps in the host response to invading pathogens that are not effectively manned by adaptive immunity. (jci.org)
SCFAs reduced viral burdens in the airways and intestines by downregulating the SARS-CoV-2 entry receptor, angiotensin-converting enzyme 2 (ACE2), and enhancing adaptive immunity via GPR41 and 43 in male animals. (rockefeller.edu)
Binds2
Initially, the microglia clear the Aβ, which binds to receptors such as MARCO. (wikipedia.org)
Kapinsky M, Torzewski M, Büchler C, Duong CQ, Rothe G, Schmitz G: Enzymatically degraded LDL preferentially binds to CD14(high) CD16(+) monocytes and induces foam cell formation mediated only in part by the class B scavenger-receptor CD36. (exbio.cz)
Molecule1
The salivary scavenger and agglutinin (SALSA), also known as gp340 and dmbt1, is an antimicrobial and inflammation-regulating molecule located at the mucosal surfaces. (researchgate.net)
Genes1
One way MARCO does this is by tethering a pathogen to other receptors on the cell, including PRRs such as TLR2, which then lead to the activation of the transcription factor NF-κB, which regulates expression of genes that encode cytokines. (wikipedia.org)
Gene1
The swabs of all birds were positive for HPAI (H5N1) virus, as evidenced by generic influenza A M-gene reverse transcription-PCR ( 1 ) and specific H5 PCR, as recommended by the European Union ( http://eur-lex.europa.eu/LexUriServ/site/en/oj/2006/l_237/l_23720060831en00010027.pdf , 04/08/2006). (cdc.gov)
Overall, the data demonstrate that SRA/CD204 plays an important role in the normative inflammatory lung response to ODE, as evidenced by the enhanced dust-mediated injury viewed in the absence of this receptor. (cdc.gov)
The adiponectin receptors, AdipoR1 and AdipoR2, are thought to transmit the insulin-sensitizing, anti-inflammatory, and atheroprotective effects of adiponectin. (diabetesjournals.org)
Immune1
MARCO, being a PRR, is able to bind to a wide variety of bacteria, making it an important receptor for activating an immune response against bacteria. (wikipedia.org)
Acute1
Identification of phenotypes in paediatric patients with acute respiratory distress syndrome: a latent class analysis. (cdc.gov)
Binding1
E1/E2 heterodimer binding on CD81 activates the epithelial growth factor receptor (EGFR) signaling pathway (PubMed:22855500). (proteopedia.org)
Endothelial1
P-selectin (marker for endothelial cell func- instructions. (who.int)
Contribute1
This last point is crucial, since it explains how upregulation of this receptor can contribute to an ascending spiral of RAGE-dependent cellular perturbation. (jci.org)
Cell2
Although the recognition of CpG DNA by B cells and plasmacytoid dendritic cells is mediated by TLR 9, these cell types differ in their ability to bind and respond to structurally distinct classes of CpG oligonucleotides. (fda.gov)
Fusion with the host cell is most likely mediated by both E1 and E2, through conformational rearrangements of the heterodimer required for fusion rather than a classical class II fusion mechanism (PubMed:16533059, PubMed:29505618, PubMed:24698129). (proteopedia.org)
Cholesterol3
Tissue distribution and regulation of SR-BI indicate that it may function both as a scavenger receptor and as a receptor for HDL-cholesterol. (gu.se)
Following up studies in female mice that first linked a deficiency in these receptors for HDL - the so-called "good" or "healthy" cholesterol - and infertility, researchers report finding the same link in studies of women with a history of infertility. (bwfund.org)
Human1
Synthetic peptide within Human Scavenging Receptor SR-BI aa 50-150 (N terminal). (abcam.com)
Studies1
For expert guidance, we've invited Dr James (Chip) Howard, professor at the University of North Carolina in the Department of Neurology and principal investigator on multiple studies involving new drug classes for treating MG. Welcome, Chip. (medscape.com)
Results2
These results suggest that SR-BI may have both scavenger receptor and HDL-receptor function in the ovary. (gu.se)
We also found that SRC-3 depletion in cultured HESCs results in a significant attenuation in the induction of a wide-range of established biomarkers of decidualization, despite exposure of these cells to a deciduogenic stimulus and normal progesterone receptor expression. (frontiersin.org)
Domains1
Other members of the class A scavenger receptors tend to have alpha helical coiled coil domains, but MARCO does not. (wikipedia.org)