Kaposi'sEndometrial stromal sarcomaManaging Kaposi sarcomaSynovialEwing SarcomaMetastaticOncologyLeiomyosarcomaDevelopment and progressionRecurrentVitroEwing'sTherapeuticsCliniciansBoneMoloneyConnective tissueImmunotherapyIrradiationMesenchymalMurineOutcomesPatientsAbstractHerpesvirusChemotherapyHeterogeneousHistologicallyCharacteristicMutationsSoftNeoplasmsInhibitorGenePathologicalTherapeuticMorphologyChromosomeCarcinogenesisHeterogeneityScientificTumor suppressorCanineCommonlyVariantsTherapyIncidenceInfectionCommon geneticVascularProteins
Kaposi's7
- Using the dimeric protease (Pr) from Kaposi's sarcoma-associated herpesvirus (KSHV) as a model system, we sought to dissect a putative allosteric network linking a cryptic site at the dimerization interface to enzyme function. (rcsb.org)
- For clinical aspects of the disease, see Kaposi's sarcoma . (wikidoc.org)
- This virus causes Kaposi's sarcoma , a cancer commonly occurring in AIDS patients, as well as primary effusion lymphoma and some types of multicentric Castleman's disease . (wikidoc.org)
- In 1872, Moritz Kaposi described a blood vessel tumor (originally called "idiopathic multiple pigmented sarcoma of the skin") that has since been eponymously named Kaposi's sarcoma (KS). (wikidoc.org)
- It was first found by Yuan Chang and Patrick S. Moore , a wife and husband team at Columbia University in 1994, by isolating DNA fragments of a herpesvirus from a Kaposi's sarcoma (KS) tumor in an AIDS patient. (wikidoc.org)
- Scientists by then had been searching for the agent causing Kaposi's sarcoma and over 20 agents had been described as the possible cause of KS, including cytomegalovirus and HIV itself. (wikidoc.org)
- The discovery of this herpesvirus sparked considerable controversy and scientific in-fighting until sufficient data had been collected to show that indeed KSHV was the causative agent of Kaposi's sarcoma. (wikidoc.org)
Endometrial stromal sarcoma2
- Morphologic distinction between uterine leiomyosarcoma (ULMS) and endometrial stromal sarcoma (ESS) alone is not straightforward and has been shown to be challenging especially with poor differentiation, so immunohistochemistry (IHC) is often employed as an adjunct to morphology in uterine sarcoma. (biomedcentral.com)
- Uterine leiomyosarcoma (ULMS) and endometrial stromal sarcoma (ESS) are among the most frequent uterine sarcomas, which, in adults, lead to fatal lung metastases and patients have an extremely poor prognosis (Tsuyoshi and Yoshida 2018 ). (biomedcentral.com)
Managing Kaposi sarcoma1
Synovial11
- Synovial sarcoma is a high-grade soft tissue malignancy, for which current cytotoxic chemotherapies provide limited benefit. (nature.com)
- Although histone deacetylase (HDAC) inhibitors are known to suppress synovial sarcoma in vitro and in vivo , the exact mechanism is not clear. (nature.com)
- In this study, we report a central role of the transcription factor, early growth response-1 (EGR1), in the regulation of HDAC inhibitor-induced apoptotic cell death in synovial sarcoma. (nature.com)
- The SS18-SSX oncoprotein, characteristic of synovial sarcoma, maintains EGR1 expression at low levels, whereas it is significantly increased after HDAC inhibitor treatment. (nature.com)
- Using a combination of gain- and loss-of-function approaches, we show that EGR1 modulation of PTEN contributes to HDAC inhibitor-induced apoptosis in synovial sarcoma. (nature.com)
- Finally, restoration of EGR1 or PTEN expression is sufficient to induce synovial sarcoma cell death. (nature.com)
- Taken together, our findings indicate that SS18-SSX-mediated attenuation of an EGR1-PTEN network regulates synovial sarcoma cell survival, and that HDAC inhibitor-mediated apoptosis operates at least in part through reactivation of this pathway. (nature.com)
- 2008). Molecular characterization of synovial sarcoma in children and adolescents: evidence of akt activation. (nature.com)
- The SYT protein involved in the t(X;18) synovial sarcoma translocation is a transcriptional activator localised in nuclear bodies. (nature.com)
- According to the Chinese government's press agency Xinhua , the student Wei Zexi died with synovial sarcoma, a form of cancer which affects the soft tissue, after being diagnosed in 2014. (neowin.net)
- 56 synovial sarcoma cases were selected for this study. (biomedcentral.com)
Ewing Sarcoma4
- In contrast, other reports have shown larger numbers of patients who have received RT for malignancies such as breast cancer , lymphoma, and Ewing sarcoma . (medscape.com)
- While the tenets of this strategy can be applied to any cancer, for both pragmatic and scientific reasons I focus my efforts on Ewing Sarcoma (ES), a cancer which I actively treat in adults and adolescent and young adult (AYA) patients alike. (curesarcoma.org)
- Ewing sarcoma (ES) is a rare primary neoplasm in the lumbar adult spine and may mimic a benign tumor. (revistaneurocirugia.com)
- Spinal Ewing Sarcoma Debuting with Cord Compression: Have We Discovered the Thread of Ariadne? (iiarjournals.org)
Metastatic3
- In one case study, a patient with advanced metastatic vulvar epithelioid sarcoma showed a partial resolution of both lung and pleural metastases when pazopanib was administered, whereas all other therapies had failed MET (mesenchymal to epithelial transition) is another biological pathway that is likely involved in the development and progression of epithelioid sarcoma. (wikipedia.org)
- ULMS accounts for 60-70% of all uterine sarcoma and 1% of all uterine malignancies, but it is most dangerous due to their characteristic chemo-resistance and metastatic potential (Juhasz-Böss et al. (biomedcentral.com)
- The recently published EORTC 62012 trial which involved 455 patients with locally advanced, unresectable or metastatic high-grade soft tissue sarcomas concluded that an intensified therapy with doxorubicin and ifosfamide is not suitable for palliation of advanced soft tissue sarcomas because of the severe side-effects and should only be used when the specific goal is tumour shrinkage ( 13 ). (spandidos-publications.com)
Oncology2
- Experimental Cancer Therapeutics Unit (ECRU) We are continuously upgrading and expanding our clinical services to keep up with the rapid developments in Oncology worldwide. (nccs.com.sg)
- His clinical and research interests also include Sarcoma Medical Oncology, Thoracic Oncology and Health Economics. (liferaftgroup.org)
Leiomyosarcoma1
- Within cohorts of soft tissue diagnoses assembled by tissue type (liposarcoma, leiomyosarcoma, undifferentiated sarcoma, and other), endosialin expression was significantly correlated with a better outcome. (hindawi.com)
Development and progression1
- Dr. Myklebost's research has concentrated on gene aberrations frequently found in samples from sarcoma patients and what these can tell us about the mechanisms involved in sarcoma development and progression. (sarcomahelp.org)
Recurrent1
- Patients with late staged and/or recurrent sarcoma have poor prognosis despite complex multimodal therapy. (clinicaltrials.gov)
Vitro5
- Further, I have experience in my laboratory with experimental evolution using ES lines in vitro, in analyzing their resultant RNAseq and miRseq, and have begun applying mathematical models to chart the course of tumor progression. (curesarcoma.org)
- To approach these aims I will pursue the following objectives: (i) map evolutionary trajectories to convergent phenotypic states uncovered by experimental evolution (ii) identify classes of convergent phenotypes considering approved chemo- and radiotherapy and finally (iii) utilize seed-based and interactome-focused data-science methods to derive actionable molecular signatures and validate in vitro. (curesarcoma.org)
- During serial passage of mouse embryo fibroblasts in vitro it was found that an established line of cells was more susceptible to murine sarcoma virus transformation than early passages of the cells from which it was derived. (microbiologyresearch.org)
- Characteristics of the in vitro assay of murine sarcoma virus (moloney) and virus-infected cells. (microbiologyresearch.org)
- Morphological transformation of mouse embryo cells in vitro by murine sarcoma virus (harvey). (microbiologyresearch.org)
Ewing's1
- The emergence of genetic alterations as prognostic factors, as illustrated by Ewing's family of tumors, osteosarcoma, and p53 expression in soft tissue sarcomas in general, is discussed. (johnshopkins.edu)
Therapeutics2
- He has completed a Fellowship in Drug Development at Princess Margaret Cancer Centre in Toronto, Canada with a special focus on Experimental Therapeutics. (liferaftgroup.org)
- Tibotec Therapeutics has expanded access to its experimental protease inhibitor TMC114 after early tests showed the drug is effective against HIV that is resistant to other protease drugs. (hivplusmag.com)
Clinicians5
- We believe that advancing the scientific understanding of any sarcoma may help researchers and clinicians better understand 'similar' sarcomas. (sarcomahelp.org)
- Rather, the report, which is directed at sarcoma researchers and clinicians, should present the important results of the research without giving all of the detail that is required in a scientific journal article - for example, it would leave out most of the specific detailed graphs, charts and tables and the details of the biostatistical analysis. (sarcomahelp.org)
- Our Grant Review Panel is made up of sarcoma experts, academics, clinicians and people affected by sarcoma. (sarcoma.org.uk)
- Sarcoma-related research, covering anything from experimental biology to clinical trials, has been performed by clinicians and scientists affiliated with Lund University (LU) and/or SUS Lund for many years. (lu.se)
- With the ultimate goal of improving outcome for sarcoma patients, the purpose of LUCC Sarcoma network is to facilitate an exchange of ideas between clinicians and scientists from different backgrounds of sarcoma research. (lu.se)
Bone16
- Is new bone formation in osteogenic sarcoma the result of a local supersaturation of tissue fluids with calcium? (nih.gov)
- An experimental and pathological study of the role of the periosteum in the formation of bone in various primary bone tumors. (nih.gov)
- Experimental sarcoma of bone. (nih.gov)
- bone involvement by sarcoma of the neighboring soft parts. (nih.gov)
- Bone sarcomas such as osteosarcoma and chondrosarcoma are frequently refractory to conventional chemotherapy and radiotherapy that exhibit poor prognosis. (oncotarget.com)
- However, the potential role of the Wnt signaling in bone sarcomas is still unclear. (oncotarget.com)
- Here we demonstrate aberrant activation of Wnt/β-catenin signaling in bone sarcoma cells, involving an autocrine Wnt signaling loop with upregulation of specific Wnt ligands and receptors. (oncotarget.com)
- Activation of Wnt/β-catenin signaling with Wnt3a or GSK-3β inhibitor drives the proliferation of bone sarcoma cells, whereas downregulation of activated Wnt signaling with dnTCF4 or siLEF1 suppresses bone sarcoma proliferation and induces cell cycle arrest. (oncotarget.com)
- Taken together, our findings establish the evidence that aberrant activation of Wnt/β-catenin pathway involving an autocrine Wnt singaling drives the proliferation of bone sarcoma cells, and identify the autocrine activation of the Wnt/β-catenin signaling as a potential novel therapeutic target for bone sarcomas. (oncotarget.com)
- Osteosarcomas and chondrosarcomas are recognized as the most common primary bone sarcomas [ 1 ], which involve mesenchymal tissues and exhibit highly heterogeneous histologic and molecular profiles [ 2 ]. (oncotarget.com)
- Accumulated evidence suggests that bone sarcomas are highly resistant to chemotherapy and radiotherapy, and thus surgical resection is considered as the crucial treatment strategy [ 3 ]. (oncotarget.com)
- Despite an increase in knowledge with regard to identification of critical signaling pathways in bone sarcomas, they are characterized by a relatively high morbidity and mortality [ 4 ]. (oncotarget.com)
- Accordingly, novel therapeutic strategies have emerged into the bone sarcoma field by exploring the biology of bone sarcomas and targeting several crucial pathways governing sarcomagenesis and aggressive clinical features [ 5 ]. (oncotarget.com)
- Bone sarcomas represent about half of sarcomas. (ascopost.com)
- The face of this young man mirrors the suffering typical in bone sarcoma patients of the 19th century. (ascopost.com)
- Treatment of bone and soft-tissue sarcomas requires specific pathologic diagnosis, but it wasn't until the 1970s that histologic analysis became reliable enough to make differential diagnosis accurate. (ascopost.com)
Moloney3
- Requirements for RNA and DNA synthesis in the transformation of mouse embryo cells by murine sarcoma virus (moloney). (microbiologyresearch.org)
- Production of altered cell foci in tissue culture by defective moloney sarcoma virus particles. (microbiologyresearch.org)
- Effect of cytosine arabinoside on the replication of the Moloney sarcoma virus in 3T3 cell cultures. (microbiologyresearch.org)
Connective tissue1
- During the 20th century, numerous other connective tissue cell types were identified as sources of sarcoma. (ascopost.com)
Immunotherapy2
- The aim of this clinical trial is to assess the feasibility, safety and efficacy of CAR T cells immunotherapy in patients who have sarcoma that is relapsed or late staged. (clinicaltrials.gov)
- Thus, in this study, the 4SCAR-IgT cells targeting sarcoma surface antigens will be infused in dose escalation cohorts.This study will assess the feasibility, safety, efficacy and side effects of CAR T cells immunotherapy in patients who have sarcoma that is relapsed or late staged. (clinicaltrials.gov)
Irradiation2
- A late effect of ionizing radiation is the development of sarcoma within the field of irradiation, referred to as postradiation sarcoma (PRS) or radiation-induced sarcoma (RIS). (medscape.com)
- A 78-year-old man presented with high-grade myofibroblastic sarcoma 13 years after curatively intended pion irradiation of the prostate with 30 Gy. (curehunter.com)
Mesenchymal1
- Epithelioid sarcoma is a rare soft tissue sarcoma arising from mesenchymal tissue and characterized by epithelioid-like features. (wikipedia.org)
Murine9
- Experimental studies revealed p53 gene alterations or increased p53 messenger ribonucleic acid (mRNA) levels in murine PRS. (medscape.com)
- An explanation can be made in terms of the growth rates of the cells involved, although primary cells were more susceptible to murine sarcoma virus than would be expected from their rate of growth. (microbiologyresearch.org)
- Non-dividing (amitotic) cells were not susceptible to murine sarcoma virus transformation. (microbiologyresearch.org)
- Replication of murine sarcoma virus-HARVEY in tissue cultures of virus-induced sarcomas. (microbiologyresearch.org)
- Murine sarcoma and leukemia viruses: assay using clonal lines of contact-inhibiting mouse cells. (microbiologyresearch.org)
- Infection of stationary cultures with murine sarcoma virus (harvey). (microbiologyresearch.org)
- Transformation by murine sarcoma virus: fixation (deoxyribonucleic acid synthesis) and development. (microbiologyresearch.org)
- Pathologic and virologic studies of tumors induced in mice by two strains of murine sarcoma vims. (microbiologyresearch.org)
- Different cell culture characteristics of two strains of murine sarcoma virus. (microbiologyresearch.org)
Outcomes1
- Soft tissue sarcomas (STS) are rare malignant tumors often associated with poor outcomes and high local recurrence rates. (bvsalud.org)
Patients14
- [ 10 ] Although the implication for individual patients is significant, there is little doubt that overall, the benefits of ionizing RT far outweigh the potential risks of developing sarcomas. (medscape.com)
- Peripheral blood mononuclear cells (PBMCs) of patients who have CD133, GD2, Muc1, CD117 or other marker positive sarcoma will be obtained through apheresis, and T cells will be activated and modified to sarcoma-specific CAR-T cells. (clinicaltrials.gov)
- Determine the impact on survival and the antitumor effects of thalidomide in patients with sarcomas or carcinosarcoma (mixed mesodermal tumors) of gynecologic origin. (knowcancer.com)
- From the start he joined up with the clinical sarcoma group, maintaining a National Competence Centre for Sarcoma , where most Norwegian patients are treated. (sarcomahelp.org)
- We aimed to assess the diagnostic utility of Transgelin, Stathmin, BCOR and Cyclin-D1 separately and in-combinations in distinguishing ULMS from ESS, and to evaluate their prognostic value in patients with such sarcoma subtypes. (biomedcentral.com)
- We included 44 patients with uterine sarcoma. (biomedcentral.com)
- Goldberg said, "Preliminary studies have shown responses in sarcoma patients with P53 mutations. (medscape.com)
- Order high quality, up-to-date information for sarcoma patients. (sarcoma.org.uk)
- We only fund research which will be most beneficial to sarcoma patients. (sarcoma.org.uk)
- That's why we only fund research which is the best quality sarcoma science and will be most relevant and beneficial to sarcoma patients. (sarcoma.org.uk)
- Patients in the standard arm (surgery alone) will undergo large en- bloc curative intent surgery will be performed within 4 weeks following randomization. (who.int)
- The morphological heterogeneity among sarcomas, combined with the facts that they may affect any age group and that they could develop at all anatomical sites, calls for centralized management of the patients. (lu.se)
- Lund University Hospital (SUS Lund) is for many years one of the national sarcoma centers, where sarcoma patients are diagnosed and treated. (lu.se)
- Furthermore, there is considerable expertise in Lund on aspects ranging from the diagnostics, imaging, and treatment of sarcoma patients to mechanistic models of sarcoma development. (lu.se)
Abstract1
- abstract = "The use of cytogenetics has led to significant improvement in the diagnoses and classification of sarcomas. (johnshopkins.edu)
Herpesvirus3
- A common genetic variant in FCGR3A-V158F and risk of Kaposi sarcoma herpesvirus infection and classic Kaposi sarcoma. (cdc.gov)
- Influence of HLA alleles on shedding of Kaposi sarcoma-associated herpesvirus in saliva in an African population. (cdc.gov)
- HLA polymorphisms and detection of kaposi sarcoma-associated herpesvirus DNA in saliva and peripheral blood among children and their mothers in the uganda sickle cell anemia KSHV Study. (cdc.gov)
Chemotherapy1
- People in the experimental group will receive domvanalimab plus zimberelimab every 4 weeks and chemotherapy every 2 weeks or the domvanalimab-zimberelimab-chemo combination once every 3 weeks. (medscape.com)
Heterogeneous2
- The term "sarcoma" identifies a heterogeneous group of rare tumors comprising over 60 different histologic variants ( 1 ). (frontiersin.org)
- Soft tissue sarcomas are a heterogeneous group of solid malignant tumours which represent ~1% of all new cancer cases in Europe and the United States ( 1 ). (spandidos-publications.com)
Histologically1
- Histologically, epithelioid sarcoma forms nodules with central necrosis surrounded by bland, polygonal cells with eosinophilic cytoplasm and peripheral spindling. (wikipedia.org)
Characteristic2
- Several research teams are currently developing techniques to reverse this loss of genetic function characteristic of epithelioid sarcoma. (wikipedia.org)
- Many of the major sarcomas have been found to have characteristic tumor-specific chromosomal translocations that are currently used in the diagnosis of these tumors. (johnshopkins.edu)
Mutations1
- Epithelioid sarcoma typically contains chromosome 22q11.2 mutations or deletions and 8q gains, particularly i(8) (>q10). (wikipedia.org)
Soft13
- It accounts for less than 1% of all soft tissue sarcomas. (wikipedia.org)
- Anti-VEGF agents such as pazopanib have shown promise across several different carcinomas and in soft tissue sarcomas. (wikipedia.org)
- Monoclonal antibodies targeting endosialin have entered clinical trials, including soft tissue sarcomas. (hindawi.com)
- We evaluated a cohort of 94 soft tissue sarcoma samples to assess the correlation between gene expression and protein expression by immunohistochemistry for endosialin and PDGFR- β , a reported interacting protein, across available diagnoses. (hindawi.com)
- Since expression does vary across histologic groups, endosialin may represent a selective target in soft tissue sarcomas. (hindawi.com)
- Valluru MK, Mukherjee D, Fisher M, Madrigal-Esquivel C, Bradford J, Kanthou C, Tozer GM & English WR (2019) VEGFA isoform switching in soft tissue sarcoma is associated with decreased survival. (sheffield.ac.uk)
- Fibrosarcomas are rare soft tissue sarcomas originating from the intra- and intermuscular fibrous tissues, fascia and tendons and account for ~3% of all soft tissue sarcomas. (spandidos-publications.com)
- Few agents such as doxorubicin, ifosfamide and dacarbazine have proven to be effective in the therapy of soft tissue sarcomas ( 2 ). (spandidos-publications.com)
- Doxorubicin, which has been the most frequently used chemotherapeutic agent in the treatment of soft tissue sarcomas, demonstrates response rates of 20-30% in disseminated disease ( 9 , 10 ). (spandidos-publications.com)
- In 1829, John Lobstein, MD (1777-1835), described soft-tissue sarcomas that arise in the retroperitoneal space. (ascopost.com)
- Results Ninety-six individual fragments were derived from soft tissue sarcomas (STS) and 120 fragments were derived from osteosarcoma. (bmj.com)
- Acknowledgements This work was supported by the Northwestern University - Flow Cytometry Core Facility supported by Cancer Center Support Grant (NCI CA060553), the Analytical bioNano Technology Core supported by the Soft and Hybrid Nanotechnology Experimental (SHyNE) Resource (NSF ECCS-2025633). (bmj.com)
- Orphan designation of the medicine had been granted in the United States for soft tissue sarcoma, solid tumors with NTRK-fusion proteins and infantile fibrosarcoma. (europa.eu)
Neoplasms1
- Sarcomas are rare, malignant tumors, consisting of only 1% of all neoplasms. (ascopost.com)
Inhibitor2
- Pharmaceutical maker GlaxoSmithKline ended Phase III trials of its experimental CCR5 inhibitor aplaviroc after three study subjects developed severe liver toxicity. (hivplusmag.com)
- Domvanalimab (from Gilead Sciences) is an experimental immune checkpoint inhibitor, and zimberelimab (from Arcus Biosciences) is an investigational angiogenesis inhibitor. (medscape.com)
Gene2
- The most common genetic mutation (found in 80-90% of epithelioid sarcomas) is the inactivation of the SMARCB1 gene, or the loss of INI-1 function, which is thought to be a major contributor to disease progression. (wikipedia.org)
- Indeed, the identification of histotype-specific (pathognomonic) gene alterations is of paramount importance in the differential diagnosis among sarcoma variants, between malignant and benign mimics, as well as between sarcoma and other tumor types ( 1 - 3 ). (frontiersin.org)
Pathological1
- In the diagnosis of sarcomas, tumor cell morphology (shape, pattern of growth, microenvironment contexture) and the expression of differentiation markers represent the most important factors, but molecular investigations are increasingly employed to complement these pathological assessments. (frontiersin.org)
Therapeutic1
- Several of these have been copied into relevant experimental cell models to understand the mechanisms better, and to try to develop this understanding into new therapeutic options. (sarcomahelp.org)
Morphology1
- Immunohistochemistry (IHC) is often employed as an adjunct to morphology in uterine sarcoma as morphologic distinction alone is not straightforward and has been shown to be challenging especially with poor differentiation or in cases with equivocal features (Hwang et al. (biomedcentral.com)
Chromosome1
- In particular, about one third of all sarcomas presents pathognomonic chromosome rearrangements (translocations, deletions, insertions) that result in fusion genes and corresponding expression of fusion transcripts ( 4 ). (frontiersin.org)
Carcinogenesis2
- The finding that the addition of equimolar amounts of manganese dust to nickel-subsulfide dust significantly depresses nickel-subsulfide induced tumorigenesis provides an experimental system for investigations of metal interactions in carcinogenesis. (cdc.gov)
- Carcinogenesis by RNA sarcoma viruses. (microbiologyresearch.org)
Heterogeneity1
- Due to their rarity and heterogeneity, the accuracy of sarcoma diagnosis remains challenging. (frontiersin.org)
Scientific3
- Open Science implies, in part, the timely and public dissemination, availability and use of scientific data as well as the sharing of experimental methodology and observations. (sarcomahelp.org)
- Neurocirugía will consider for publication, original clinical and experimental scientific works associated with neurosurgery and other related neurological sciences. (revistaneurocirugia.com)
- Proposals will be assessed on scientific quality and relevance to people affected by sarcoma. (sarcoma.org.uk)
Tumor suppressor1
- As this tumor suppressor is commonly inactivated in epithelioid sarcoma, cell division can fail to appropriately halt, resulting in unregulated cellular growth and the formation of cancer tumors. (wikipedia.org)
Canine3
- Here we report reproducible culture of highly potent TINKs from naturally occurring canine sarcomas for use in modeling the human TME. (bmj.com)
- Methods Canine sarcoma tumor specimens were cut into fragments and cultured individually in 24-well plates with medium supplemented with 6000 IU/ml of rhIL-2. (bmj.com)
- Conclusions Our results demonstrated that functional TINKs can be efficiently expanded from canine sarcoma tumor tissue with little NK cell infiltration seen by immunohistochemistry. (bmj.com)
Commonly1
- Epithelioid sarcoma most commonly strikes young adults, yet no age group is immune. (wikipedia.org)
Variants2
Therapy3
- Another goal of the study is to assess the safety and efficacy of the therapy that combines CAR T cells and IgT cells to treat sarcoma. (clinicaltrials.gov)
- English WR, Lunt SJ, Fisher M, Lefley DV, Dhingra M, Lee Y-C, Bingham K, Hurrell JE, Lyons SK, Kanthou C & Tozer GM (2017) Differential Expression of VEGFA Isoforms Regulates Metastasis and Response to Anti-VEGFA Therapy in Sarcoma . (sheffield.ac.uk)
- Treatment is with surgery for early disease and targeted therapy, an experimental protocol, or palliative therapy for advanced disease. (msdmanuals.com)
Incidence1
- After 24 months, the incidence of sarcomas at the injection site was 63 percent in the group that received the combination of nickel-subsulfide and manganese dusts, compared with incidences of 96 to 100 percent in the groups that received nickel-subsulfide alone or in combination with aluminum, copper, or chromimum dusts. (cdc.gov)
Infection1
- Results of experimental studies with rodents, monkeys, and pigs ( 17 - 21 ) suggest that heterologous Flavivirus antibodies protect against or modify subsequent infection with WNV. (cdc.gov)
Common genetic1
- Loss of SMARCB1 function is the most common genetic mutation observed in epithelioid sarcoma, and this dysfunction is likely a major driver of disease progression. (wikipedia.org)
Vascular2
- VEGF (vascular endothelial growth factor) is often over-expressed in epithelioid sarcoma. (wikipedia.org)
- Astley -Paston Cooper, MD (1768-1841), the most important surgeon in London in the first quarter of the 19th century, was a pioneer in vascular, ear, and experimental surgery. (ascopost.com)
Proteins1
- Endosialin likely interacts with a network of extracellular and hypoxia activated proteins in sarcomas and other tumor types. (hindawi.com)