• In 1961, Rous sarcoma virus (RSV), which is closely related to ASLV, was shown to contain RNA, and oncogenic viruses, such as RSV and ASLV, were termed RNA tumor viruses. (wikipedia.org)
  • Rous continued to study the phenomenon he had begun to unravel for many years, but understanding the mechanistic bases for the complex natural history of Rous sarcoma virus and related viruses had to wait until modern molecular and cellular biologic technologies became available in the 1960s. (cdc.gov)
  • Multiple group specific antigen components of avian tumor viruses detected with chicken and hamster sera. (microbiologyresearch.org)
  • Complement-fixing antigens in tissue cultures of avian leukosis viruses. (microbiologyresearch.org)
  • Polypeptides of avian RNA tumor viruses. (microbiologyresearch.org)
  • Fluorescent antibody studies of viruses of the avian leukosis complex. (microbiologyresearch.org)
  • I. Avian leukemia-sarcoma viruses. (microbiologyresearch.org)
  • Immunofluorescent studies of group-specific antigen of the avian sarcoma-leukosis viruses. (microbiologyresearch.org)
  • These include the retroviruses avian leucosis/sarcoma viruses (ALSV) and reticuloendothesiosis viruses (REV), and the herpesvirus Marek's disease virus (MDV). (cdc.gov)
  • p47v-crk (v-Crk) is the product of a transforming gene, v-crk, that was isolated from avian sarcoma viruses. (bdbiosciences.com)
  • High levels of antibodies to avian leucosis, sarcoma viruses, and reticuloendotheliosis viruses recently found in poultry workers, provides evidence of infectious exposure to these cancer-causing poultry viruses. (nutritionfacts.org)
  • Poultry viruses, such as avian pox and Newcastle disease (ND), are known to have a negative impact on poultry reproductive performance 1 - 4 . (scialert.net)
  • For instance, avian pox viruses, DNA viruses, infect a wide range of domestic poultry causing a drop in egg production and impaired reproductive efficiency 3 , 4 . (scialert.net)
  • Studies conducted in the 1960s found that certain live poultry viruses, like fowl pox 17 , 18 , ND 8 , Rous sarcoma 19 and avian leukosis 20 , following either natural infection or vaccination, increased the occurrence of parthenogenesis in chickens 19 and turkeys 17 , 18 . (scialert.net)
  • Rohrschneider focused initially on cell-surface proteins in cells infected with avian oncorna viruses, identifying the envelope and group-specific antigens (gag proteins). (fredhutch.org)
  • The leukosis/sarcoma (L/S) group of diseases comprise of a variety of transmissible benign and malignant neoplasms, such as lymphoid, myeloid and erythroid leukosis, caused by avian leukosis viruses (ALV), belonging to the family Retroviridae . (caister.com)
  • The Epidemiology, Virology, and Pathogenicity of Human Infections with Avian Influenza Viruses. (cdc.gov)
  • We have examined the impact of methylprednisolone acetate (MPA) on survival of F344 rats that were bearing avian sarcoma virus (ASV)-induced gliomas and that were treated optimally with radiotherapy. (duke.edu)
  • The c-Jun proto-oncogene was first identified as the cellular homolog of the avian sarcoma virus v-Jun oncogene. (avivasysbio.com)
  • c-Src (cellular Src), encoded by Src gene, is a non-receptor tyrosine kinase first isolated as the normal cellular homolog to the potent avian sarcoma viral transforming oncogene v-Src [ 4 ]. (intechopen.com)
  • Localization of 9E3/CEF-4 in avian tissues: expression is absent in Rous sarcoma virus-induced tumors but is stimulated by injury. (silverchair.com)
  • The avian gene 9E3/CEF-4, a member of the superfamily of genes that includes KC and gro, is expressed abundantly in exponentially growing cultures of chick embryo fibroblasts (CEFs) and at high levels in CEFs transformed with Rous sarcoma virus (RSV). (silverchair.com)
  • The virus he discovered is now known as Rous sarcoma virus and has since been studied in many laboratories around the world. (cdc.gov)
  • Release of group-specific antigen into the extracellular medium was independent of subgroup or strain of avian leukosis or Rous sarcoma virus. (microbiologyresearch.org)
  • Isolation and characterization of proteins from Rous sarcoma virus. (microbiologyresearch.org)
  • The effects of reciprocal changes in temperature on the transformed state of cells infected with a Rous sarcoma virus mutant. (microbiologyresearch.org)
  • A virus in chick embryos which induces resistance in vitro to infection with Rous sarcoma virus. (microbiologyresearch.org)
  • The isolation of temperature-sensitive transformation-defective mutants of Rous sarcoma virus led to the hypothesis that the viral protein or proteins should be temperature-sensitive in its expression or function, and Dr. John Wyke and Rohrschneider found that expression of some of the cell-surface tumor antigens correlated with transformation, suggesting that they were under control of the transforming gene. (fredhutch.org)
  • The transforming protein of Rous sarcoma virus, Src, had just been identified by Dr. Ray Erikson's group using antibodies from tumor-bearing model organisms. (fredhutch.org)
  • Rohrschneider generated similar antisera and used them to good effect, performing some of the first immunoprecipitation and immunofluorescence experiments to identify the Src protein in Rous sarcoma virus-infected model organisms and to localize the protein to the cytoplasm. (fredhutch.org)
  • Avian Virology: Current Research and Future Trends (Edited by: Siba K. Samal). (caister.com)
  • Tyrosine-specific protein kinase activity associated with p105 of avian sarcoma virus PRCII. (wikidata.org)
  • Characterization of protein kinase activity associated with the transforming gene product of Fujinami sarcoma virus. (wikidata.org)
  • Detection of a protein of avian leukoviruses in uninfected chick cells by RIA. (microbiologyresearch.org)
  • Description: FES (Feline sarcoma oncogene) and Fer are the only two members of a unique family of cytoplasmic protein tyrosine kinases. (glucagon-receptor.com)
  • citation needed] Sarcoma in chickens has been studied since the early 1900s when Ellerman and Bang demonstrated that erythroleukemia can be transmitted between chickens by cell-free tissue filtrates, and in 1911 when (Francis) Peyton Rous proved that sarcoma can be transmitted through cell free extracts of solid chicken tumors. (wikipedia.org)
  • The major group-specific antigen (gs-a) of avian leukoviruses was detected by radioimmunoassay in extracellular medium of all embryonic cultures prepared from infected chickens. (microbiologyresearch.org)
  • Embryos of birds not carrying an avian leukosis virus infection and of chickens from a leukosis-free flock could thus clearly be distinguished from infected ones. (microbiologyresearch.org)
  • The phenomenon has been observed in a variety of avian species, including chickens 9 , turkeys 10 and quail 11 . (scialert.net)
  • The JUN gene is the putative transforming gene of avian sarcoma virus 17. (scientificlabs.co.uk)
  • RNA from an avian sarcoma virus was used to detect cellular sequences (sarc) homologous to the viral transforming gene (src). (princeton.edu)
  • He found that adhesion plaques also contained the oncoproteins of Abelson leukemia virus (Abl, now best known at the cause of chronic myelogenous leukemia) and the Susan McDonough and Gardner-Rasheed strains of feline sarcoma virus (Fms and Fgr), while, with colleague Dr. Bob Eisenman, the Myc oncoprotein was found in the nucleus. (fredhutch.org)
  • Identification and localization of avian leukosis group-specific antigen within 'leukosis-free' chick embryos. (microbiologyresearch.org)
  • Parthenogenesis is the spontaneous development of an embryo from an avian egg without going through the usual process of fertilization 7 , 8 . (scialert.net)
  • The subgroups evolved to utilize difference cellular receptors to gain entry into avian cells due to the host developing resistance to viral entry. (wikipedia.org)
  • Herpesvirus of turkeys (HVT), used originally as a vaccine against Marek's disease (MD), has recently been shown to be a highly effective viral vector for generation of recombinant vaccines that deliver protective antigens of other avian pathogens. (mdpi.com)
  • The N-terminal amino acid of an avian leukosis group-specific antigen from avian myeloblastosis virus. (microbiologyresearch.org)
  • 10521258 10.1021/bi991362q 1 'High Resolution Structure of the Catalytic Domain of Avian Sarcoma Virus Integrase' J.Mol.Biol. (rcsb.org)
  • This has been driven by fears arising from the rapid emergence, spread and public health impact of several recent outbreaks, such as the international spread of severe acute respiratory syndrome coronavirus (SARS-CoV) (2003), the potential of avian influenza H5N1 to emerge as a highly lethal pandemic as increasing numbers of human cases are reported (2003 and continuing), and the very rapid global spread of pandemic H1N1 influenza in 2009-2010. (who.int)
  • Scholars@Duke publication: Effect of methylprednisolone on radiotherapy of F344 rats with avian sarcoma virus induced gliomas. (duke.edu)
  • Avian sarcoma leukosis virus is characterized by a wide range of tumors, the most common of which are lymphomas. (wikipedia.org)
  • The role of two members of the ETS (E26 avian leukemia oncogene) family of transcription factors, ETS-1 and ETS-2, has been investigated in many cancers but has not yet been studied in ocular tumors. (molvis.org)
  • Endogenous retrovirus sequences were detected by using a 32 P-labeled avian leukosis viral RNA probe. (princeton.edu)
  • Genetic structure, transforming sequence, and gene product of avian sarcoma virus UR1. (wikidata.org)
  • The radioimmunoassay of the group-specific antigen seems to be well suited to complement the COFAL (complement fixation avian leukosis) and RIF (resistance inducing factor) tests in the detection of leukosis virus in infected material. (microbiologyresearch.org)
  • This was one of the initial discoveries that mutations in a cell surface receptor could initiate oncogenesis, just one year after the avian erythroblastosis virus oncogene was found to be a mutant EGF receptor. (fredhutch.org)
  • We have studied the structures of the unintegrated forms of avian sarcoma virus (ASV) DNA using agarose gel electrophoresis in conjunction with restriction endonucleases and molecular hybridization techniques. (tmu.edu.tw)