Salivary proteins contain potential biomarkers for diagnosing and detecting various physiological and/or pathological conditions. (bvsalud.org)
Gel-based protein separation was performed on saliva, followed by identification of proteins using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS). Totally, 326 proteins were identified in the salivary samples, among which 101 were found to be specific for ruptured ectopic pregnancy (EPR). (bvsalud.org)
Reactome analysis revealed innate immune system, neutrophil degranulation, cell surface interactions at the vascular wall, and FCERI-mediated NF-kB activation as the major pathways to which the salivary proteins identified during EPR are associated. (bvsalud.org)
Intensive investigation on the salivary proteins specific to EP can potentially lead to setting up of a panel of candidate biomarkers and developing a non-invasive protein-based diagnostic kit. (bvsalud.org)
The results showed that low-molecular-weight mucin, alpha-amylase, secretory IgA, acidic proline-rich proteins, and cystatins adhered to all kinds of brackets, though the amino acid composition of pellicles differed between bracket types. (snu.ac.kr)
Due to the presence of histatins (proline-rich proteins including cystatins and statherin), calcium and phosphate are maintained in supersaturation and are available for remineralization of tooth structure. (dentistrytoday.com)
These findings confirm important quantitative differences between sexes in the O. erraticus saliva proteome, unveil novel salivary proteins and functions at the tick-host feeding interface and improve our understanding of the physiology of feeding in O. erraticus ticks. (biomedcentral.com)
Biomarkers9
Over the past two decades, using salivary biomarkers specifically for early cancer detection has attracted much research interest, especially for cancers occurring in the oral cavity and oropharynx, for which the five-year survival rate (62%) is still one of the lowest among all major human cancers. (springeropen.com)
Thus, much research effort has been dedicated to investigating potential salivary biomarkers for OSCC, and more than 100 such biomarkers have been reported in the literature. (springeropen.com)
However, some important issues and challenges have emerged that require solutions and further research in order to find reliable OSCC salivary biomarkers for clinical use. (springeropen.com)
This review article provides an up-to-date list of potential OSCC salivary biomarkers reported as of the fall of 2013, and discusses those emerging issues. (springeropen.com)
By raising the awareness of these issues on the part of both researchers and clinicians, it is hoped that reliable, specific and sensitive salivary biomarkers may be found soon-and not only biomarkers for early OSCC detection but also for detecting other types of cancers or even for monitoring non-cancerous disease activity. (springeropen.com)
The search for reliable salivary biomarkers for early detection of OSCC has developed rapidly, spurred on by the fact that collecting saliva is relatively easy and non-invasive, compared to the drawing of blood. (springeropen.com)
From the late 1990s until the present, more than 40 research studies have been published and more than 100 different salivary constituents have been suggested as potential OSCC salivary biomarkers (see Table 1 ). (springeropen.com)
This review article will provide an up-to-date list of potential OSCC salivary biomarkers, as of the fall of 2013, and will focus on some emerging issues/challenges that seem to be major roadblocks on the way to bringing reliable salivary biomarkers into actual clinical use. (springeropen.com)
Addressing these issues not only will serve to accelerate progress toward finding reliable salivary biomarkers for early OSCC detection, but also should have a positive effect on the search of reliable salivary biomarkers for other types of cancer detection or even for monitoring non-cancerous disease activity. (springeropen.com)
Protein2
The results obtained indicate that the β2-strand of salivary S cystatins has high helical propensity when isolated from native protein and acquire the final β structure by interaction with the rest of the polypeptide chain. (unicatt.it)
The aim was to evaluate differences of salivary protein expression in the CFS patient in respect to his healthy twin. (biomedcentral.com)
Proteome2
Therefore, the present investigation was designed to explore the salivary proteome with special reference to EP. (bvsalud.org)
The objective of the present work was to obtain and characterise the proteome of the saliva of O. erraticus adult ticks as a means to identify and select novel salivary antigen targets. (biomedcentral.com)
Saliva6
Identification of full-sized forms of salivary (S-type) cystatins (cystatin SN, cystatin SA, cystatin S, and two phosphorylated forms of cystatin S) in human whole saliva and determination of phosphorylation sites of cystatin S". J. Biochem. (wikipedia.org)
In humans, saliva is generated by 3 pairs of major and numerous minor salivary glands. (dentistrytoday.com)
The major salivary glands produce 93% of all saliva. (dentistrytoday.com)
Following ingestion of a dietary sugar, the stimulated production of saliva ceases after the sugar clears the mouth, and salivary output returns to a resting state within a short time.5,6 The tooth is most susceptible to demineralization and white spot production during the period of lowered pH. (dentistrytoday.com)
The importance of saliva is clearly observed after salivary flow is reduced. (dentistrytoday.com)
May involve the interaction of phosphate groups with calcium ions in saliva to form "bridges" Protective functions of early enamel pellicle: protection , lubrication by decreasing frictional forces, may selectively concentrate antimicrobial substances such as immunoglobulins, lysozyme, and cystatins at different oral surfaces. (medicpresents.com)
Glands3
For example, in 1869 a physician wrote that chewing gum would "exhaust the salivary glands and cause the intestines to stick together. (dentistrytoday.com)
4 The salivary glands are under the control of the autonomic nervous system and respond to hormonal influences. (dentistrytoday.com)
While only R. parkeri was detected in female salivary glands which suggest its ability to traffic from midgut to salivary glands via hemocoel. (usm.edu)
Cystatin3
The helical propensity of a peptide corresponding to β2-strand of salivary SA cystatin analyzed by CD display high helical propensity in aqueous solution, whereas peptides matching the β2-strand amino acid sequence of cystatins S and SN, display random coil conformation in aqueous solution but acquire α-helical conformation in the presence of trifluoroethanol (TFE). (unicatt.it)
Moreover molecular dynamics simulation performed on the homology modeling of cystatin SA constructed on the basis of recently determined three-dimensional structure of salivary cystatin D, suggests that cystatin SA does not significantly deviate from the starting structure over the course of the simulation. (unicatt.it)
This gene is located in the cystatin locus and encodes a type 2 salivary cysteine peptidase inhibitor. (wikipedia.org)
Constituents1
OBJECTIVES: Ovulation is such a critical physiological process that its noninvasive detection based on salivary constituents has several advantages in humans. (bvsalud.org)
Proteomic1
In the present study, we used a proteomic approach to evaluate the global changes in the salivary profile in a couple of monozygotic twins who were discordant for CFS. (biomedcentral.com)
Sequence1
Secondary structure prediction of salivary cystatins S, SA, and SN carried out by several methods label the 39-58 sequence (β2-strand) as predominantly α-helical. (unicatt.it)
Ticks1
Further, we saw R. parkeri differentially regulates gene expressions of cystatins in A. maculatum, suggesting a possible role of cystatins in R. parkeri infection in ticks. (usm.edu)
Components1
Definition Dental Plaque "is a specific but highly variable structural entity, resulting from sequential colonization of microorganisms on tooth surfaces, restorations & other parts of oral cavity, composed of salivary components like mucin, desquamated epithelial cells, debris & microorganisms, all embedded in extracellular gelatinous matrix. (medicpresents.com)
Oral1
Collectively, salivary pellicles were found to play a significant role in the initial adhesion of oral streptococci to orthodontic brackets. (snu.ac.kr)
Flow1
Natural cleansing mechanism: Gingival crevicular fluid & salivary flow Cleansing effect of mastication and tongue movement Rapid turnover rate of intraoral epithelial cells Host defence mechanisms like langerhans cells. (medicpresents.com)
Role1
This study encourages further study to assess the exact relationship of R. parkeri with bacterial diversity in A. maculatum and cystatins role during tick blood feeding and R. parkeri transmission. (usm.edu)
Modifications of the salivary proteome1
In the first part of this thesis, in order to highlight possible qualitative/quantitative modifications of the salivary proteome associated to the different forms of the disease, we investigated salivary samples collected from 6 CM, 35 SM patients, among which 8 with only systemic symptoms (SM-C) and 27 with both systemic and cutaneous symptoms (SM+C), and 48 healthy controls by a top-down proteomic approach. (unica.it)
Gland4
This immunosuppression makes patients vulnerable to several oral complications, including oral tumors, oral candidiasis, oral viral infections, HIV related salivary gland disorders, and oral ulcerations of diverse etiologies. (nih.gov)
Patients with HIV-related salivary gland disease present with signs and symptoms similar to those of patients with Sjögren's syndrome. (nih.gov)
The incidence of salivary gland disease among HIV infected patients appears to have increased following the introduction of HAART. (nih.gov)
We also analyzed PI repertoires of female 48, 96 and 120 h-fed midgut (MG) and salivary gland (SG) tissues. (biomedcentral.com)
Cystatin-SN1
Identification of full-sized forms of salivary (S-type) cystatins (cystatin SN, cystatin SA, cystatin S, and two phosphorylated forms of cystatin S) in human whole saliva and determination of phosphorylation sites of cystatin S". J. Biochem. (wikipedia.org)
Inhibitor1
This gene is located in the cystatin locus and encodes a type 2 salivary cysteine peptidase inhibitor. (wikipedia.org)
Characterization1
The preliminary pharmacological characterization of the recombinant I. ricinus cystatins suggests their immunomodulatory function as well as the potential of one I. ricinus cystatin to ameliorate the symptoms of experimental asthma in mice. (europa.eu)
Found1
A group of closely-related cystatins found in SALIVA . (nih.gov)
Function1
Salivary function is extremely sensitive to changes in our general well-being, ranging from subtle effects of over-the-counter cold medications to the devastation of life-threatening disease. (rcolldentist.com.sg)
Type1
There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. (wikipedia.org)
Complex1
Our work drastically improved our knowledge of I. ricinus salivary transcripts by considering the entire complex tick lifecycle and by performing massive Next Generation Sequencing (454 and Illumina pyrosequencing), a relatively novel, highly efficient and cost effective technology for the de novo sequencing and assembly of transcriptomes originating from organisms with an unknown genome (such as I. ricinus). (europa.eu)