• proteins
  • CD40L induces binding of nuclear factor (NF)-kappaB/Rel proteins to two tandem kappaB sites located immediately 3' to the IL-4-responsive region of the mouse germline epsilon promoter. (umassmed.edu)
  • In addition to the NF-kappaB/Rel complexes induced by CD40L, two nuclear complexes, each which contain both STAT6 and NF-kappaB/Rel proteins, are induced in splenic B cells by a combination of CD40L and IL-4, and bind to the CD40L/IL-4-responsive region of the germline epsilon promoter. (umassmed.edu)
  • Comparative analysis of the proteome and transcriptome revealed that expression of these proteins was mainly regulated at the transcriptional level, which argues against a major role for posttranscriptional mechanisms that modulate the STAT6-dependent proteome. (jimmunol.org)
  • Histone acetyltransferases can also acetylate non-histone proteins, such as nuclear receptors and other transcription factors to facilitate gene expression. (wikipedia.org)
  • mice
  • Purified B cells from Stat6−/− and wild-type control mice were either untreated or activated with IL-4, anti-IgM F(ab′)2 and IL-4, or PMA and ionomycin. (nih.gov)
  • In this study, we compared the transcriptomes and proteomes of primary mouse B cells from wild-type and STAT6-deficient mice cultured for 4 d in the presence or absence of IL-4. (jimmunol.org)
  • Basic helix-loop-helix family, member e41", or BHLHE41, is a gene that encodes a basic helix-loop-helix transcription factor repressor protein in various tissues of both humans and mice. (wikipedia.org)
  • induce
  • In addition to the above results, Zhang in 2006 reported that STAT6 silencing prevents growth and induce apoptosis in digestive tract cancer tumor HT-29 cells . (exposed-skin-care.net)
  • deregulation
  • Though STAT6 is definitely primarily known to become connected with allergic swelling and asthma, STAT6 deregulation offers also been implicated in numerous additional diseases. (exposed-skin-care.net)
  • Deregulation of BHLHE41 transcription levels has been characterized as a marker in the progression of several cancers. (wikipedia.org)
  • coactivator
  • Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. (uniprot.org)
  • molecule
  • IL-4 is the major factor driving Th2 differentiation, IgE class switching, and alternative macrophage activation, whereas IL-13 functions as an effector molecule that mediates eosinophilic inflammation, airway hyperresponsiveness, and mucus hypersecretion. (jimmunol.org)
  • genome
  • In watch of this, we searched for to research the impact of STAT6 silencing on genome wide gene reflection patterns in NCI-H460 cells (lung cancers epithelial). (exposed-skin-care.net)
  • receptor
  • Although signaling through both B cell receptor (BCR) and IL-4 receptor (R) converge on the extinction of B7h mRNA levels, BCR down-regulation occurs through Ca2+ mobilization, whereas IL-4R down-regulation occurs through a distinct Stat6-dependent pathway. (nih.gov)
  • STAT6 is activated by signaling through IL-4 receptor. (wikipedia.org)
  • Numbers of molecules enhance or dampen IL-9 production and contribute to TH9 development such as: Activin A that can fully substitute the role of TGF-β in TH9 cells, then Jagged2, programmed cell death ligand (PD-L2), cyclooxy- genase (COX)-2, 1,25-dihydroxyvitamin D3, calcitonin gene-related peptide (CGRP), tumor necrosis factor receptor superfamily member 4 (TNFRSF4 or OX40), and thymic stromal lymphopoietin (TSLP). (wikipedia.org)
  • dependent
  • BCR-mediated B7h down-regulation occurs through Ca2+ signaling, whereas IL-4-mediated down-regulation occurs through a distinct Stat6-dependent signaling pathway. (nih.gov)
  • 3-fold by IL-4 in a STAT6-dependent manner. (jimmunol.org)
  • mechanisms
  • Although, a few focus on genetics and some communicating companions of STAT6 possess been known till time, the precise mechanisms of STAT6 mediated signaling is unknown generally. (exposed-skin-care.net)
  • Irf4
  • STAT6, IRF4, GATA3 are absolutely required for TH9 cell development and other such as PU.1, BATF, NF-κB, NFAT1, STAT5, AP-1 contribute to TH9 sub-population commitment and to IL-9 production. (wikipedia.org)
  • IRF4 is a transcription factor that has been implicated in acute leukemia. (wikipedia.org)
  • induces
  • STAT6 takes on a important part in Capital t cell hepatitis via enhancing appearance of eotaxins in hepatocytes and endothelial cells, and induces IL-5 appearance, infiltration of eosinophils and neutrophils into the liver and leading to hepatitis . (exposed-skin-care.net)
  • Among other factors, IL-13 induces these MMPs as part of a mechanism that protects against excessive allergic inflammation that predisposes to asphyxiation. (wikipedia.org)
  • epsilon
  • Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon, also known as NFKBIE, is a protein which in humans is encoded by the NFKBIE gene. (wikipedia.org)
  • recruitment
  • There are also evidences that IL-4-caused service of 1536200-31-3 STAT6 is definitely connected with reduced hepatic appearance of TNF as well as attenuation of liver neutrophil recruitment and may protect against hepatic ischemia/reperfusion injury . (exposed-skin-care.net)