Sox transcription factors. Medical search. Frequent questions

The expression patterns of Sox genes in the embryonic pancreas suggest that they could have important and possibly redundant functions in pancreas development. (mdc-berlin.de)
This group of SOX genes regulate neural progenitor identity. (wikipedia.org)
It is involved in chondrogenesis and regulates the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes. (thermofisher.com)
Representative activated (red) or repressed (blue) genes by each transcription factor are shown in the box. (medicalxpress.com)
At 48 hours, after differentiation into vascular endothelium was determined, a system of transcription was established in which genes unique to vascular endothelial differentiation were induced. (medicalxpress.com)
Transcription factors are proteins that regulate the transcription of genes, or the production of mRNA from DNA. (biolegend.com)
The underphosphorylated, active form of Rb interacts directly with E2F1 , leading to cell cycle arrest, while the hyperphosphorylated form decouples from E2F1, thus promoting the transcription of genes promoting entry into the S phase. (biolegend.com)
A major obstacle to the development of compounds that could overcome cellular resistance to treatment has been the fact that SOX 11 - a transcription factor that binds to DNA and acts as a master switch to turn genes off and on - is generally considered "undruggable. (scitechdaily.com)
This increase suggests Sox11 expression is trophic factor sensitive and that it may contribute to the transcriptional control of genes involved in the increased survival and axonal projections that has been documented in these transgenic animals (Albers et al. (pitt.edu)
These data suggest that the developmentally regulated transcription factor Sox11 is induced in adult neurons after injury to promote neurite growth and axon regeneration and inhibit apoptosis by regulating genes associated with each of these distinct biological pathways. (pitt.edu)
[ 4 ] The Hox genes, well described as the master regulators of development, encode a set of transcription factors that specify the identity of particular segments during embryogenesis. (medscape.com)
SOX11 (SOX = SRY-related HMG box) is a nuclear transcription factor belonging to subgroup C of SRY (sex determining region on Y-chromosome) related HMG (high mobility group) box genes. (nordiqc.org)
The SOX genes are co-expressed in embryonic neuronal progenitor cells and the mesenchymal cells in many developing organs. (nordiqc.org)
The mouse and human Fli1 genes are similarly regulated by Ets factors in T cells. (musc.edu)
Using single-cell RNA-sequencing data, we examined the expression profiles of Sox genes in the mouse incisor dental pulp. (ehu.eus)
We found that in several MSCs, Sox genes co-expressed with regulatory genes such as Sp7 , Satb2 , Msx1 , Snai2 , Dlx1 , Twist2 , and Tfap2a . (ehu.eus)
In addition, Sox family genes colocalized with Runx2 and Lef1 , which are highly enriched in MSCs undergoing osteoblast differentiation. (ehu.eus)

In sentinel node, SOX-10 is positive in metastatic melanomas and nodal capsular nevus but not in dendritic cells, which usually express S100 protein. (thermofisher.com)
During the creation of new blood vessels, the vascular endothelial growth factor (VEGF) protein differentiates stem cells into vascular endothelial cells and stimulates them to create new blood vessels. (medicalxpress.com)
Transcription factor SOX-10 is a protein that in humans is encoded by the SOX10 gene. (standardofcare.com)
SOX10 can influence the generation of Myelin Protein Zero (MPZ) transcription through its interactions with proteins that are important for the functionality of neurons. (standardofcare.com)
The encoded protein contains two different binding sites that are known to bind DNA and function as a regulator of gene transcription. (biolegend.com)
STAT3 protein belongs to a group of intracellular transcription factors that mediate a variety of functions such as cellular differentiation, proliferation, and apoptosis. (biolegend.com)
The SOX 11 protein, which is expressed in up to 90 percent of mantle cell lymphoma patients, is an attractive target for therapy," said senior author Samir Parekh, MD, Professor of Medicine (Hematology and Medical Oncology), Icahn School of Medicine at Mount Sinai. (scitechdaily.com)
Protein expression was investigated by ELISA and immunofluorescence, transcription factor-DNA binding by ELISA, gene expression by real-time PCR, prostaglandin E 2 (PGE 2 ) by radioimmunoassay, and matrix metalloproteinase (MMP) activity and nitric oxide (NO) production by fluorometry. (karger.com)
A large family of structurally-related transcription factors that were originally discovered based upon their close sequence homology to an HMG-box domain found in SEX-DETERMINING REGION Y PROTEIN. (bvsalud.org)
On the basis of this action, the SOX2 protein is called a transcription factor. (medlineplus.gov)

Essential FA, mainly polyunsaturated fatty acids (PUFA), may modulate gene expression in diverse biological processes thought regulating transcription factors (TF), including peroxisome proliferator receptors (PPAR) , liver X receptors (LXR) , and sterol regulatory element-binding proteins ( SREBP ) 3 . (nature.com)
HMG-box domains are found in one or more copies in HMG-box proteins, which form a large, diverse family involved in the regulation of DNA-dependent processes such as transcription, replication, and strand repair, all of which require the bending and unwinding of chromatin. (embl.de)
We focus our attention on three families of transcription factors that are known to have roles in vertebrate chondrogenesis: Sox and the Ant- and Prd- class families of the homeodomain proteins. (europa.eu)
A newly recognized family of transcription factors that appear to have important roles in sensory neuron biology is the Sox family of high-mobility group (HMG) domain proteins. (pitt.edu)
Alatzoglou KS, Kelberman D, Dattani MT. The role of SOX proteins in normal pituitary development. (medlineplus.gov)
In the CYTOPLASM, I-kappa B proteins bind to the transcription factor NF-KAPPA B. Cell stimulation causes its dissociation and translocation of active NF-kappa B to the nucleus. (bvsalud.org)

The high-mobility group (HMG) domain is a DNA-binding motif that is shared abundant non-histone components of chromatin and by specific regulators of transcription and cell differentiation. (embl.de)
Dynamically and epigenetically coordinated gata/ets/sox transcription factor expression is indispensable for endothelial cell differentiation. (medicalxpress.com)
Many SOX transcription factors play important roles in regulating CELL DIFFERENTIATION. (bvsalud.org)
SOX transcription factors play key roles in cell differentiation and cell fate determination during development. (ehu.eus)

SOX1, SOX2 and SOX3, members of the SOX gene family (specifically the SOXB1 group), contain transcription factors related to SRY, the testis-determining factor. (wikipedia.org)
SOX1 is a member of the SOX gene family, in particular the SOXB1 group, which includes SOX1, SOX2, and SOX3. (wikipedia.org)
Overexpression of either SOX1, SOX2, or SOX 3 increases neural progenitors and prevents neural differentiation. (wikipedia.org)

Unique and selective effects of five Ets family members, Elf3, Ets1, Ets2, PEA3, and PU.1, on the promoter of the type II transforming growth factor-beta receptor gene. (musc.edu)
Activation of the murine type II transforming growth factor-beta receptor gene: up-regulation and function of the transcription factor Elf-3/Ert/Esx/Ese-1. (musc.edu)

Description Mus musculus transcription factor SOX-2 gene. (vectorbuilder.com)

In a screen of transcriptional activity in transgenic animals that overexpress either NGF or GDNF in the skin (NGF-OE and GDNF-OE mice), the transcription factor Sox11 was significantly increased in developing neurons of the trigeminal ganglia. (pitt.edu)
The rise in Sox11 in response to enhanced trophic factor level and axotomy has led us to hypothesize that Sox11 is an essential transcriptional regulator in both embryonic and adult systems that is trophic factor responsive. (pitt.edu)
Strong lymphoid nuclear expression of SOX11 transcription factor defines lymphoblastic neoplasms, mantle cell lymphoma and Burkitt's lymphoma. (nordiqc.org)
Ek S, Dictor M, Jerkeman M, Jirström K, Borrebaeck C a K. Nuclear expression of the non B-cell lineage Sox11 transcription factor identifies mantle cell lymphoma. (nordiqc.org)

Our findings establish Sox17 as a tissue -specific modifier of Wnt responses and point to a novel paradigm where genomic specificity of Wnt/β-catenin transcription is determined through functional interactions between lineage-specific Sox TFs and β-catenin/Tcf transcriptional complexes. (xenbase.org)

Sry-related HMG-BOX gene 10, (SOX-10), a nuclear transcription factor that participates in neural crest development and in the specification and differentiation of cells of melanocytic lineage, has been recently shown to be a sensitive marker of melanoma. (thermofisher.com)
Furthermore, they found that a transcription factor group essential for blood vessel differentiation (ETS/GATA/SOX) has a previously unknown role. (medicalxpress.com)
Schematic representation of the genetic regulatory network linking four transcription factors and EC differentiation. (medicalxpress.com)
Transcription factors SOX and FLI1, both important for endothelial differentiation, were induced between 12 and 24 hours. (medicalxpress.com)
Previously, in the region that controls the function of the transcription factor that promotes differentiation from ES cells to a specific cell type, bivalent modifications of histones such as the accelerator and brake histone marks for transcription were thought to have coexisted. (medicalxpress.com)
SoxE factors are a key family of regulatory factors that mediate multiple cell fate decisions within the neural crest including the formation of the precursor population and differentiation of the melanocyte, cartilage and glial cell lineages. (northwestern.edu)

Mesenchymal stem cells (MSCs) can differentiate into chondrocytes, while mechanical loading has been proposed as alternative strategy to induce chondrogenesis excluding the use of exogenous factors. (nature.com)

SOX1 is a gene that encodes a transcription factor with a HMG-box (high mobility group) DNA-binding domain and functions primarily in neurogenesis. (wikipedia.org)
In ectodermal cells committed to a certain cell fate, SOX1 has shown to be one of the earliest transcription factors expressed. (wikipedia.org)
SOX1 is a 39 kDa transcription factor that belongs to the SOXB1 subgroup. (novusbio.com)

The SOX gene family encodes transcription factors. (wikipedia.org)
The SOX10 gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and determination of cell fate. (standardofcare.com)

SOX10 is a transcription factor active during embryonic development and it is essential for the generation of glial lineages from trunk crest cells. (standardofcare.com)
Pax6 is a transcription factor present during embryonic development. (biolegend.com)
DESCRIPTION (provided by applicant): The reiterative use of transcriptional regulatory factors is a hallmark of embryonic development. (northwestern.edu)

Here, we describe the identification of HMG-box transcription factors of the Sox gene family in the mouse pancreas. (mdc-berlin.de)
SRY-related high-mobility-group box 9 (SOX9) is a member of the SOX family of transcription factors. (cancerindex.org)
Sox6, a member of the Sox (Sry-related HMG box) family of transcription factors, plays an important role in embryonic muscle development and adult fast myofiber maintenance. (tubitak.gov.tr)
RUNX1 belongs to the runt domain family of transcription factors and regulates target gene expression through forming a heterodimeric DNA-binding complex with CBFB. (biolegend.com)
The role of SOX 11 in lymphopoiesis remains to be elucidated and hitherto, SOX 4 is the only gene in the SOX family that is found to have an important role in early B- and T-cell development. (nordiqc.org)
We have built on these studies by demonstrating that SoxE factors are context dependent transcriptional regulators, and that SUMO modification converts them to repressors by facilitating the recruitment of groucho family co-repressors. (northwestern.edu)

Ets factors and a newly identified polymorphism regulate Fli1 promoter activity in lymphocytes. (musc.edu)

Furthermore, an examination of the histone code revealed that the regulatory genomic region of the transcription factors (ETS/GATA/SOX) was found to have gradually switched from a "brake histone mark," which suppresses transcription, to an "accelerator histone mark," which activates transcription, while in the process of differentiating into the vascular endothelium. (medicalxpress.com)
Silva IAL, Varela D, M. Cancela L, Conceição N . Zebrafish optineurin: genomic organization and transcription regulation . (ualg.pt)

About half the motifs have a typical ACAAT Sox core. (utoronto.ca)
Effects of three Sp1 motifs on the transcription of the FGF-4 gene. (musc.edu)

The Mount Sinai research showed the efficacy of the molecules as single agents, as well as the synergy of ibrutinib in combination with a SOX 11 inhibitor - either of which could potentially represent a therapeutic strategy for treating MCL. (scitechdaily.com)
E2F1 (E2F transcription factor 1) inhibitor HLM006474 was used in EC-specific Sox17 mice. (bvsalud.org)

Varela D, Conceição N, M. Cancela L . Transcriptional regulation of human T-box 5 gene (TBX5) by bone- and cardiac-related transcription factors . (ualg.pt)
Varela T, Conceição N, Laizé V, Cancela ML . Transcriptional regulation of human DUSP4 gene by cancer‐related transcription factors . (ualg.pt)
The capability of these cells to differentiate depends on the stem cell type, the regulation of gene expression by various transcription factors and interaction with the stem cell niche 1,4 . (biolegend.com)
This valuable data study presents convincing data that expression of the C. elegans transcription factor NHR-67 is sufficient to drive an invasive fate, and that the alternative proliferative fate is associated with NHR-67 transcriptional down-regulation. (elifesciences.org)
PUBLIC HEALTH RELEVANCE: The goal of this research project is to elucidate the molecular mechanisms via which Group E Sox factors are regulated, and to understand how this regulation contributes to their ability to control numerous distinct developmental decisions in the neural crest and other tissues. (northwestern.edu)

A network of super enhancer(SE) driven transcription factors(TFs) underlies lineage identity and their dysregulation leads to cancer. (nih.gov)
Once the transcription factor binds to an enhancer region, this can cause stimulation or repression of gene transcription. (biolegend.com)
BACKGROUND: Rare genetic variants and genetic variation at loci in an enhancer in SOX17 (SRY-box transcription factor 17) are identified in patients with idiopathic pulmonary arterial hypertension (PAH) and PAH with congenital heart disease. (bvsalud.org)

Previous work has identified members of the homeodomain and basic helix-loop-helix families of transcription factors as critical determinants of mammalian pancreatic development. (mdc-berlin.de)

Collectively, the distinct expression patterns of the SOX transcription factors suggest that they play essential regulatory roles in directing. (ehu.eus)

SOX-10 reaction is not identified in any other mesenchymal and epithelial tumors except for myoepitheliomas and diffuse astrocytomas. (thermofisher.com)
These small molecule inhibitors could also be useful tools for understanding the pathogenesis of other malignancies that can be traced to SOX 11, including epithelial ovarian tumors, medulloblastoma, gliomas, and basal-like breast cancer," says Dr. Parekh. (scitechdaily.com)
Many transcription factors exist in a variety of tumors that could be targeted by scientists, and what we've demonstrated through our work is that there is indeed an effective way to make them druggable. (scitechdaily.com)

Expression of seven of these Sox factors was studied in more detail by in situ hybridization from the stage of early pancreatic outgrowth to birth. (mdc-berlin.de)
In some cases, Sox17 and β-catenin synergistically activate transcription apparently independent of Tcfs, whereas on other enhancers, Sox17 represses β-catenin/Tcf-mediated transcription to spatially restrict gene expression domains. (xenbase.org)
Role of the transcription factor Sox-2 in the expression of the FGF-4 gene in embryonal carcinoma cells. (musc.edu)
The Fli-1 transcription factor regulates the expression of CCL5/RANTES. (musc.edu)

Given the ubiquitous nature of Sox TFs and Wnt signaling, this mechanism has important implications across a diverse range of developmental and disease contexts. (xenbase.org)
The foundation for this investigation has been laid by our studies demonstrating that SUMO modification of SoxE factors has a dramatic effect on their developmental function, switching them from promoters of neural crest formation to promoters of inner ear formation. (northwestern.edu)
The proposed research is designed to reveal the molecular mechanisms that govern SoxE function and that may serve as paradigms for how other reiteratively utilized transcription factors can carry out such a diverse developmental of tasks. (northwestern.edu)

Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. (nih.gov)

SOXC Transcription Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)

Lineage specification is governed by gene regulatory networks (GRNs) that integrate the activity of signaling effectors and transcription factors (TFs) on enhancers. (xenbase.org)
B) Histone marking on the regulatory region of EC master transcription factors was switched following the order, (1) release the brake mark and then (2) enter the acceleration mark. (medicalxpress.com)

Mutations in the transcription factor-coding gene SOX18, the growth factor-coding gene VEGFC and its receptor-coding gene VEGFR3/FLT4 cause primary lymphedema in humans. (bvsalud.org)

Characterization of the human nasal embryonic LHRH factor gene, NELF, and a mutation screening among 65 patients with idiopathic hypogonadotropic hypogonadism (IHH). (medscape.com)

RUNX1 regulates CD4 gene transcription during multiple stages of T cell development and represses the CD4 gene in CD4-CD8- (double negative) T cells. (biolegend.com)

Fli-1 controls transcription from the MCP-1 gene promoter, which may provide a novel mechanism for chemokine and cytokine activation. (musc.edu)

Transcription factors have an important role in the ability of a cell to self-renew and also differentiate into most cell types, also known as pluripotency 1 . (biolegend.com)

Transcription of nhr-67 is downregulated following post-translational degradation of its direct upstream regulator, HLH-2 (E/Daughterless) in VU cells. (elifesciences.org)

In a study in Clinical Cancer Research published in June, the team reported that the drugs, known as small-molecule inhibitors of the SOX 11 oncogene, are toxic to MCL tumor development in human cells studied outside the body. (scitechdaily.com)

To better understand the role of dietary FA on metabolic diseases, for the first time, a study to identify key transcription factors (TF) involved in lipid metabolism and inflammatory response by transcriptome analysis from liver samples of animal models was performed. (nature.com)

Effects of B-Myb on gene transcription: phosphorylation-dependent activity ans acetylation by p300. (musc.edu)

View our full list of available antibodies for transcription factors . (biolegend.com)

As a transcription factor, Pax6 acts at the molecular level in the signaling and formation of the central nervous system 11 . (biolegend.com)

Because SoxE factors specifically, and the neural crest more generally, underlie a large group of diseases and congenital defects, this work will also directly impact issues related to human health. (northwestern.edu)

Discussion at the Vancouver meeting spanned several areas of research, including signaling pathway activation of EMT and the transcription factors and gene targets involved. (rupress.org)
The anchor cell induces nearby epidermal precursor cells to generate vulval cells via an epidermal growth factor (EGF) signaling pathway. (wormbook.org)

We will use a combination of in vivo and in vitro approaches to further investigate the mechanisms via which SUMO modification alters SoxE function, as well as investigate how Wnt signals, SoxD factors, and specific SoxE functional domains contribute to the diverse functions of these factors. (northwestern.edu)

a hostile microenvironment and deficiency of growth factors in the injured spinal cord limited the therapeutic effects of grafted NSCs that are largely determined by their survival, neurogenic potency, integration capacity, and axial identity," the researchers continued. (genengnews.com)

Orthologous to human HBP1 (HMG-box transcription factor 1). (nih.gov)
Human malignant melanoma stained with anti-SOX-10 antibody using peroxidase-conjugate and DAB chromogen. (thermofisher.com)

and the YABBY plant-specific transcription factors. (embl.de)

Anatomy5

Chemicals and Drugs48

Analytical, Diagnostic and Therapeutic Techniques and Equipment6

Phenomena and Processes22

Information Science3

Genes17

Protein10

Proteins6

Cell differentiation4

SOX23

Transforming growth factor2

Musculus1

Sox114

Lineage-specific1

Differentiation6

Chondrogenesis1

SOX13

Encodes2

Embryonic development3

Family6

FLI11

Genomic2

Motifs2

Inhibitor2

Regulation5

Enhancer3

Families of transcription factors1

Roles1

Tumors3

Expression4

Developmental3

Polymerase1

Descriptor1

Regulatory2

Mutations1

Patients with idiopathic1

Regulates1

Mechanism1

Important1

REGULATOR1

Development1

Role1

Gene transcription1

Antibodies1

Molecular1

Group1

Signaling pathway2

Functional1

Spinal Cord1

Human2

Specific1