EscherichiaMutagenesisInductionNalidixic AcidOxidative stressGenesLexAInducesConstitutiveMolecular biology2020MutantsRecA730IntracellularColiGenomicDinBAllelesProcessesCellular responseStressIrradiationProteinAbstractReplicationProteins involvedExpressionSynthesisSystemImmuneRegulationUnderstoodProliferationJournalVariationResultsClimateRegulatesEnvironmentalSubjectEarlyProduceDamage responsePeoplePlant
Escherichia4
- In the Escherichia coli Lac assay, stress-induced point mutagenesis requires induction of at least two stress responses: the RpoS-controlled general/starvation stress response and the SOS DNAdamage response, both of which upregulate DinB error-prone DNA polymerase, among other genes required for Lac mutagenesis. (elsevierpure.com)
- Differential requirements of two recA mutants for constitutive SOS expression in Escherichia coli K-12. (umass.edu)
- A qnr-plasmid allows aminoglycosides to induce SOS in Escherichia coli. (pasteur.fr)
- Rekombinacijski popravak i SOS odgovor u mutantu recA730 bakterije Escherichia coli (Doctoral thesis). (unizg.hr)
Mutagenesis9
- SOS functions (a concept reputedly derived from the SOS of the international distress signal) are involved in DNA repair and mutagenesis, in cell division inhibition, in recovery of normal physiological conditions after DNA repair, and possibly in cell death when DNA damage is extensive. (wakehealth.edu)
- Stress-induced mutagenesis is a collection of mechanisms observed in bacterial, yeast, and human cells in which adverse conditions provoke mutagenesis, often under the control of stress responses. (elsevierpure.com)
- Control of mutagenesis by stress responses may accelerate evolution specifically when cells are maladapted to their environments, i.e., are stressed. (elsevierpure.com)
- It is therefore important to understand how stress responses increase mutagenesis. (elsevierpure.com)
- We show that upregulation of DinB is the only aspect of the SOS response needed for stress-induced mutagenesis. (elsevierpure.com)
- We find that both dinB(o c ) alleles fully suppress the phenotype of constitutively SOS-"off" lexA(Ind - ) mutant cells, restoring normal levels of stress-induced mutagenesis. (elsevierpure.com)
- Thus, dinB is the only SOS gene required at induced levels for stress-induced point mutagenesis. (elsevierpure.com)
- Furthermore, although spontaneous SOS induction has been observed to occur in only a small fraction of cells, upregulation of dinB by the dinB(o c ) alleles in all cells does not promote a further increase in mutagenesis, implying that SOS induction of DinB, although necessary, is insufficient to differentiate cells into a hypermutable condition. (elsevierpure.com)
- The time course of induction of SOS-like stress responses such as enhanced reactivation (ER) and enhanced mutagenesis (EM) has been investigated in UV- C-irradiated skin fibroblasts from a xeroderma pigmentosum (XP) family, using herpes simplex virus type 1 as a probe. (johnshopkins.edu)
Induction4
- Because secretion systems for Stx are lacking, the release of Stx is mediated through bacterial cell lysis by Stx phages in response to the induction of the SOS response (a cellular response to DNA damage) ( 11 ). (cdc.gov)
- The findings suggest that the hypersusceptibility of the lon mutant to FQs could be due to abnormally high levels of SulA protein resulting from the depletion of Lon and the continuous induction of the SOS response in the presence of FQs. (biomedcentral.com)
- Protein induction by these responses is widely believed to be important for the organism's survival under hostile conditions. (biomedcentral.com)
- However, unlike eukaryotes and bacteria, there was no induction of DNA repair proteins in response to DNA damage, probably because these are expressed constitutively to deal with increased damage arising due to high growth temperatures. (biomedcentral.com)
Nalidixic Acid2
- In addition, a previous study from our laboratory identified dnaQ knockout mutants in a screen for mutants specifically defective in the SOS response after quinolone (nalidixic acid) treatment. (duke.edu)
- We report the identification of separation of function mutants from this screen, showing that proofreading function can be uncoupled from SOS phenotypes (partially constitutive SOS and the nalidixic acid SOS defect). (duke.edu)
Oxidative stress1
- Bacteria are known to respond to unfavorable conditions, e.g., exposure to toxic chemicals and physical agents, nutrient limitation, or sudden increase in growth temperature, by rapid expression of regulons related to the heat shock, SOS, and oxidative stress responses. (biomedcentral.com)
Genes6
- SOS box is the region in the promoter of various genes to which the LexA repressor binds to repress the transcription of SOS-induced proteins. (wikipedia.org)
- The identified SoS candidate regions harbored genes in several enriched annotation clusters and overlapped with previously found QTLs and associations for different traits in cattle. (sruc.ac.uk)
- DNA damage leads to cellular responses that include the increased expression of DNA repair genes, repression of DNA replication and alterations in cellular metabolism. (biomedcentral.com)
- Differential effects on the expression of the three transcription factor B ( tfb ) genes hint at a mechanism for the modulation of transcriptional patterns in response to DNA damage. (biomedcentral.com)
- The transcriptionally regulated genes have different roles under stress response. (intechopen.com)
- Thus, stress response studies during these growth stages reveal novel differentially regulated genes or proteins with important functions in plant stress adaptation. (intechopen.com)
LexA4
- SOS boxes differ in DNA sequences and binding affinity towards LexA from organism to organism. (wikipedia.org)
- SOS response SOS gene LexA RecA Walker, GC (October 1995). (wikipedia.org)
- LexA is the repressor of the SOS Response. (umass.edu)
- There are no clear archaeal homologues of either bacterial LexA or of eukaryal proteins involved in the transcriptional response to DNA damage, such as p53. (biomedcentral.com)
Induces3
- In E. coli, RecA polymerizes on ssDNA produced after DNA damage and induces the SOS Response. (umass.edu)
- and CdCl 2 strongly induces all three stress responses. (biomedcentral.com)
- Neonatal exposure to a Type-I pyrethroid (bioallethrin) induces dose-response changes in brain muscarinic receptors and behaviour in neonatal and adult mice. (cdc.gov)
Constitutive2
- Prior studies have shown that loss of ε leads to high mutation frequency, partially constitutive SOS, and poor growth. (duke.edu)
- METHODOLOGY/PRINCIPAL FINDINGS: Genetic analysis of two recA(C) mutants was used to determine the mechanism of constitutive SOS (SOS(C)) expression in a population of log phase cells using fluorescence of single cells carrying an SOS reporter system (sulAp-gfp). (umass.edu)
Molecular biology1
20201
- ont permis la publication de plus de 370 articles et monographies, dont une 44 en 2020. (u-paris.fr)
Mutants4
- Identification of these mutants, especially those with normal proofreading but SOS phenotype(s), also facilitates the study of the role of ε in SOS processes without the confounding results of high mutator activity associated with dnaQ knockout mutants. (duke.edu)
- Certain recA mutants express the SOS Response (recA(C)) in the absence of external DNA damage in log phase cells. (umass.edu)
- SOS(C) expression in recA4142 mutants was dependent on its initial level of transcription, recBCD, recFOR, recX, dinI, xthA and the type of medium in which the cells were grown. (umass.edu)
- SOS(C) expression in recA730 mutants was affected by none of the mutations or conditions tested above. (umass.edu)
RecA7304
- RecA730 causes SOS(C) expression by binding to ssDNA in a mechanism yet to be determined. (umass.edu)
- Dodatna mutacija recA730 u mutantu recA2201, koji ima fenotip mutanta recA nul jer ne hidrolizira ATP, dovodi do konformacijske promjene koja omogućuje dvostrukom mutantu recA730, 2201 da inducira SOS odgovor. (unizg.hr)
- Određivanjem razine SOS odgovora u bazalnim uvjetima i nakon uvedenog dvolančanog loma utvrdili smo kako je indukcija SOS odgovora u ovom dvostrukom mutantu ovisna o enzimu RecBCD te kako je za postizanje maksimalne razine SOS odgovora, koja je utvrđena u jednostrukom mutantu recA730, ipak potrebna i hidroliza vezanog ATP-a. (unizg.hr)
- Dodatna mutacija recA730 u mutantu recA4159, za koji se smatra da nema sposobnost vezanja ATP-a, nije omogućila indukciju SOS odgovora što upućuje da je jednostrukom mutantu recA730 za indukciju SOS odgovora potrebna konformacijska promjena do koje se dolazi vezanjem ATP-a. (unizg.hr)
Intracellular1
- Perilipin 5 (PLIN5) is a lipid-droplet-associated protein that coordinates intracellular lipolysis in highly oxidative tissues and is thought to regulate lipid metabolism in response to phosphorylation by protein kinase A (PKA). (uci.edu)
Coli3
- As a result of the impaired β159-Pol III interaction, E. coli strains bearing the dnaN159 allele display increased utilization of the three SOS-regulated DNA polymerases, Pol II ( polB ), Pol IV ( dinB ), and Pol V ( umuDC ) ( 29 , 38 - 40 ). (asm.org)
- Co-culture of E. coli O157:H7 and other E. coli isolated from cattle in the presence of sublethal concentrations of bAGPs significantly increased the emergence of non-O157, Stx-producing E. coli by triggering the SOS response system in E. coli O157:H7. (cdc.gov)
- An oligomeric switch controls the Mrr-induced SOS response in E. coli. (uci.edu)
Genomic2
- Here, we combine two complementary sets of analyses, genome-wide association (GWA) and signatures of selection (SoS), to identify genomic regions that contribute to variation in milk yield and/or contribute to adaptation in admixed dairy cattle of Kenya. (sruc.ac.uk)
- If validated, the GWA and SoS results indicate potential for SNP-based genomic selection for genetic improvement of smallholder crossbred cattle. (sruc.ac.uk)
DinB1
- Both produce SOS-induced levels of DinB constitutively. (elsevierpure.com)
Alleles1
- CONCLUSIONS/SIGNIFICANCE: It is concluded that not all recA(C) alleles cause SOS(C) expression by the same mechanism. (umass.edu)
Processes2
- A branch of genetics which deals with the genetic mechanisms and processes of microorganisms. (usda.gov)
- In addition to DNA repair proteins, bacteria and eukaryotes have damage response pathways whose function is to detect DNA damage and modulate cellular processes. (biomedcentral.com)
Cellular response1
- BACKGROUND: Repairing DNA damage begins with its detection and is often followed by elicitation of a cellular response. (umass.edu)
Stress7
- Stress-Inducible Cellular Responses. (wikipedia.org)
- The Stress Reaction or the Fight or Flight response was designed by nature to protect us from predators when mankind first walked the face of the earth. (hindustantimes.com)
- In an interview with HT Lifestyle, Dr Samir Dwivedi, Medical Director at India - International SOS, shared, "Stress reaction has been implicated in many pathologies, right from backaches, loss of memory, heart attacks, gastric ulcers, panic attacks and reproductive issues. (hindustantimes.com)
- Technically, stress is the body's response to a noxious stimulus. (hindustantimes.com)
- Meaning the response physiologically and psychologically that we produce to an event will be labeled as stress depending on whether we see the event as a threat, or we don't see the event. (hindustantimes.com)
- Therefore, stress itself is very much to be understood physiologically as the body's response to a threatening stimulus and the threatening stimulus depends on whether the person perceives something as a threat. (hindustantimes.com)
- FANCD2 modulates the mitochondrial stress response to prevent common fragile site instability. (u-paris.fr)
Irradiation1
- We analyzed the transcriptional response to UV irradiation in two related crenarchaea, Sulfolobus solfataricus and Sulfolobus acidocaldarius . (biomedcentral.com)
Protein1
- Z-ring inhibition occurred independently of SOS, SlmA-mediated nucleoid occlusion, and MinCDE proteins and did not result from a decreased FtsZ protein concentration. (nih.gov)
Abstract1
- Abstract This collection contains the administrative records of the directors of the Carnegie Institution of Washington Station for Experimental Evolution (1904-1921) and its successor, the Department of Genetics (1921-1962), and its final institution, The Genetics Research Unit (1962-1974), which was opened in Cold Spring Harbor, New York, in 1904. (cshl.edu)
Replication2
- There was, however, a clear transcriptional response, including repression of DNA replication and chromatin proteins. (biomedcentral.com)
- A clear response to DNA damage was observed, with down-regulation of the DNA replication machinery, changes in transcriptional regulatory proteins, and up-regulation of the biosynthetic enzymes for beta-carotene, which has UV protective properties, and proteins that detoxify reactive oxygen species. (biomedcentral.com)
Proteins involved1
- Guo R, Xu D, Wang W. Identification and analysis of new proteins involved in the DNA damage response network of Fanconi anemia and Bloom syndrome. (medscape.com)
Expression4
- UV-inducible sulAp expression, an indicator of the SOS response, is reduced by recF+ overexpression in vivo. (umass.edu)
- The Assay for Transposase-Accessible Chromatin using sequencing (ATAC-seq) is a powerful tool for studying regulatory DNA sequences that direct gene expression in response to specific developmental and environmental cues. (ucsd.edu)
- Beyond this protective role, Mrr can inflict chromosomal DNA damage that elicits the SOS response in the host cell upon heterologous expression of specific methyltransferases such as M.HhaII, or after exposure to high pressure (HP). (uci.edu)
- Rubins KH, Hensley LE, Wahl-Jensen V, Daddario Dicaprio KM, Young H, Reed DS, Jahrling PB, Brown PO, Relman DA, Geisbert TW "The temporal program of peripheral blood gene expression in the response of non-human primates to Ebola hemorrhagic fever. (openwetware.org)
Synthesis1
- Bloom syndrome patients also demonstrate impairment in lymphocytic proliferation, deficient immunoglobulin synthesis, and lowered response to mitogen stimulation, resulting in impairment of both cellular and humoral immune responses. (medscape.com)
System3
- We propose that the presence of a compact, incompletely replicated nucleoid or unsegregated chromosome masses at the normal mid-cell division site inhibits Z-ring formation and that the SOS system, SlmA, and MinC are not required for this inhibition. (nih.gov)
- Those of us who respond to any event as a threat, we produce the threat response to the autonomic nervous system. (hindustantimes.com)
- Priming of protective T cell responses against virus-induced tumors in mice with human immune system components. (starrcancer.org)
Immune1
- The team discovered that people who previously received AstraZeneca or Sinopharm COVID-19 vaccines had a "non-inferior" immune response when given a half dose of a Pfizer COVID-19 booster vaccine, comparable to those who received a full dose. (medicaldaily.com)
Regulation1
- Regulation of DNA damage response pathways by the cullin-RING ubiquitin ligases. (starrcancer.org)
Understood1
- Archaeal information processing pathways resemble those in eukaryotes, but archaeal damage response pathways remain poorly understood. (biomedcentral.com)
Proliferation1
- ZNF513 combined with KIF3C regulates gingival fibroblast proliferation, migration, and fibrosis response via the PI3K/AKT/mTOR and Ras/Raf/MEK/ERK pathways. (nature.com)
Journal3
- American Journal of Human Genetics 89, 15-27. (uni-koeln.de)
- American Journal of Human Genetics 89, 564-571. (uni-koeln.de)
- American Journal of Human Genetics 88, 127-137. (uni-koeln.de)
Variation2
- For SoS, we used two haplotype-based tests to compare haplotype length variation within admixed and between admixed and East African Shorthorn Zebu cattle populations. (sruc.ac.uk)
- These data have been extensively used to investigate how species are changing their phenology over time and in response to annual variation in temperature (Lee et al. (researchgate.net)
Results3
- The results indicate that the ER response can possibly be used as a prognostic marker to identify carriers in various hereditary cancer-prone syndromes at an early age. (johnshopkins.edu)
- We compare the results from GWA and SoS in an attempt to validate the most significant SoS results. (sruc.ac.uk)
- In the United States, defibrotide is the only FDA-approved drug showing significant results for treating veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) compared with historical controls. (medscape.com)
Climate2
- This population has been subject to natural selection in response to environmental stresses, such as harsh climate, low-quality feeds, poor management, and strong disease challenge. (sruc.ac.uk)
- Many researchers have studied the responses of plant phenology to climate change (e.g. (researchgate.net)
Regulates1
- WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity. (starrcancer.org)
Environmental1
Subject1
- SOS Response (Genetics)" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (wakehealth.edu)
Early1
- LOS tended to be shortened early and then prolonged late because the SOS tended to be delayed but then somewhat advanced, and EOS also exhibited a significant delay. (researchgate.net)
Produce1
- Also in 1952, Howe suggested that killed virus could produce good antibody responses in children. (technologyreview.com)
Damage response1
- Experimental studies of the archaeal DNA damage response have been very limited. (biomedcentral.com)
People2
- This graph shows the total number of publications written about "SOS Response (Genetics)" by people in this website by year, and whether "SOS Response (Genetics)" was a major or minor topic of these publications. (wakehealth.edu)
- Below are the most recent publications written about "SOS Response (Genetics)" by people in Profiles. (wakehealth.edu)