• You need info about Pig Protein S100-A6 (S100A6) ELISA Kit or any other Gentaur produtct? (gentaurshop.com)
  • The aim of this study was to investigate the expression and silencing of the S100A8 gene, which encodes the S100 calcium-binding protein A8 (S100A8), and apoptosis and phosphorylation of protein kinase B (Akt) in tissue samples of endometrial carcinoma and HEC-1A endometrial adenocarcinoma cells in vitro . (medscimonit.com)
  • Immunohistochemistry (IHC) was used to detect expression of the S100A8 protein in 74 tissue samples of endometrial cancer and 22 normal endometrial tissue samples. (medscimonit.com)
  • S100A8 mRNA and S100A8 protein levels were detected by quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and Western blotting. (medscimonit.com)
  • Objectives Systemic lupus erythematosus (SLE) is associated with elevated levels of S100A8/A9, pro-inflammatory proteins mainly secreted by activated polymorphonuclear neutrophils (PMNs). (lu.se)
  • S100A8/A9 belongs to the Ca 2+ binding S100 protein family and has recently gained a lot of interest as a critical alarmin modulating the inflammatory response after its release (extracellular S100A8/A9) from neutrophils and monocytes. (sandysboardlife.com)
  • Enzyme-linked immunosorbent assays (ELISAs) were used to determine the serum concentrations of the S100A8, S100A9, and IL-6 proteins. (scielo.br)
  • The aim of this study was to explore the relationship between the proteins S100B and S100A1B and symptoms and signs of cognitive impairment for 3 months after mild traumatic brain injury (MTBI). (nih.gov)
  • The S100B interaction with calcium/calmodulin-dependent protein kinase (CaMK)-type domain of Ribosomal S6 Kinase 1 (RSK1) can facilitate therapeutic targeting of melanomas, because S100B inhibits the first phosphorylation event on RSK1 in the MAPK pathway responsible for cell growth in malignant melanomas. (elte.hu)
  • We showed that the activation of the entire C-terminal random coil of the homodimer S100A4 protein can play a role in mediating interaction with selected partner proteins. (elte.hu)
  • This Human S100A1 ELISA Kit was designed for the quantitative measurement of Human S100A1 protein in serum, plasma, tissue homogenates. (cusabio.com)
  • Description: A sandwich ELISA kit for detection of S100 Calcium Binding Protein A10 from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (novosides.eu)
  • The S100 proteins are a family of low molecular-weight proteins found in vertebrates characterized by two calcium-binding sites that have helix-loop-helix ("EF-hand-type") conformation. (wikipedia.org)
  • The S100 proteins comprise a family of 21 low molecular weight (9-13 kDa) proteins that are characterized by the presence of two calcium-binding EF-hand motifs. (nih.gov)
  • S100 proteins exist in cells as anti-parallel hetero- and homodimers and upon calcium binding interact with target proteins to regulate cell function. (nih.gov)
  • S100 proteins are of interest as mediators of calcium-associated signal transduction and undergo changes in subcellular distribution in response to extracellular stimuli. (nih.gov)
  • Small calcium binding protein that plays important roles in several biological processes such as Ca(2+) homeostasis, chondrocyte biology and cardiomyocyte regulation. (cusabio.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse S100 Calcium Binding Protein A10 (S100A10) in serum, plasma, tissue homogenates, cell lysates and other biological fluids. (novosides.eu)
  • The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. (cancerindex.org)
  • We can assist you in finding the right ELISA kits, PCR kits, recombinant proteins, antibodies, provide you with datasheets, manuals, kit protocols and other information about the products. (gentaurshop.com)
  • They are encoded by a family of genes whose symbols use the S100 prefix, for example, S100A1, S100A2, S100A3. (wikipedia.org)
  • The authors present results from the development of a serum-based, 4-protein (biglycan, myeloperoxidase, annexin-A6, and protein S100-A9) biomarker panel for EAC.METHODS: A vertically integrated, proteomics-based biomarker discovery approach was used to identify candidate serum biomarkers for the detection of EAC. (usuhs.edu)
  • 4. Kessel C, Holzinger D, Foell D. Phagocyte-derived S100 proteins in autoinflammation: putative role in pathogenesis and usefulness as biomarkers. (scielo.br)
  • Abnormal S100 serum concentrations and symptoms or signs of cognitive impairment were not significantly associated in patients with MTBI and a Glasgow Coma Scale score of 14 or 15. (nih.gov)
  • The authors present results from the development of a serum-based, 4-protein (biglycan, myeloperoxidase, annexin-A6, and protein S100-A9) biomarker panel for EAC. (usuhs.edu)
  • 05). Eleven proteins from this data set were then tested using enzyme-linked immunosorbent assays in serum samples, of which 5 proteins were significantly elevated in abundance among patients who had EAC compared with normal controls, which mirrored trends across the disease spectrum present in the tissue data. (usuhs.edu)
  • In the blood vascular system, human serum albumin (HSA) is a vital globular transport protein with potential multiple ligand binding sites. (researchgate.net)
  • 15]. In addition, S100 in serum is an early that the pathogenesis and pathophysiology marker of BBB openings that may precede of the syndrome are still obscure [3]. (who.int)
  • S100 proteins have been implicated in a variety of intracellular and extracellular functions, such as regulation of protein phosphorylation, transcription factors, Ca2+ homeostasis, the dynamics of cytoskeleton constituents, enzyme activities, cell growth and differentiation, and the inflammatory response. (wikipedia.org)
  • Several members of the S100 protein family are useful as markers for certain tumors and epidermal differentiation. (wikipedia.org)
  • In vitro, S100β/Sca1 cells isolated from atheroprone regions of the mouse aorta expressed hedgehog signalling components, acquired the di-methylation of histone 3 lysine 4 (H3K4me2) stable SMC epigenetic mark at the Myh11 locus and underwent myogenic differentiation in response to recombinant sonic hedgehog (SHh). (dcu.ie)
  • Recombinant SHh promoted myogenic differentiation of human induced pluripotent stem cell-derived S100β neuroectoderm progenitors in vitro. (dcu.ie)
  • Within cells, S100 proteins are involved in aspects of regulation of proliferation, differentiation, apoptosis, Ca 2+ homeostasis, energy metabolism, inflammation and migration/invasion through interactions with a variety of target proteins including enzymes, cytoskeletal subunits, receptors, transcription factors and nucleic acids. (sandysboardlife.com)
  • S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. (cancerindex.org)
  • Exhibiting high consistence in sequence and structure, S100 family members are interchangeable in function and they show a wide spectrum of biological processes, including proliferation, apoptosis, migration, inflammation and differentiation and the like. (cancerindex.org)
  • Estrogens are important regulators of growth and differentiation in (range, 0 -9 fmol/mg protein, median 0.7). (lu.se)
  • Another protein, calgranulin A (Cal A), is involved in the regulation of several cell processes, including the cell cycle and cell differentiation. (bvsalud.org)
  • Cystatin A (Cys A), a cysteine protease inhibitor, is a precursor of proteins involves in keratinocyte keratinization, and is expressed during the late phase of differentiation of these cells. (bvsalud.org)
  • S100 proteins are small, acidic proteins that are mostly in the form of homo-, or hetero-dimers but can also form tetramers and hexamers [46, 47]. (sandysboardlife.com)
  • SCOPe: Structural Classification of Proteins - extended. (berkeley.edu)
  • SCOP: Structural Classification of Proteins and ASTRAL. (berkeley.edu)
  • The S100 protein monomer consists of two helix-loop-helix structural motifs, and is also known as EF-hands. (sandysboardlife.com)
  • These changes allow interactions with specific target proteins and modulate their activity. (cusabio.com)
  • S100 proteins family and their complexes with many interactions partners are mostly involved in tumors and metastasis. (elte.hu)
  • We evidenced that the equilibrium between filaments and single molecules can be controlled via S100 protein interactions and phosphorylation at the C-terminal end of the heavy chains. (elte.hu)
  • The primary focus of Rajnarayanan's research team is to design and develop molecules that target functionally relevant protein interactions and molecular solutions to understand protein circuitry in the endocrine and the neuroendocrine system. (nyit.edu)
  • Lee, D.H., Asare, B.K. and Rajnarayanan, R.V. (2016) "Discovery at the Interface: Towards Novel Anti-Proliferative Agents Targeting Human Estrogen Receptor\S100 Interactions. (nyit.edu)
  • The biological effects of FGF1 are mediated through the activation of the four transmembrane phosphotyrosine kinase fibroblast growth factor receptors in the presence of heparin sulfate proteoglycans and, therefore, require the release of the protein into the extracellular space. (rcsb.org)
  • S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. (cancerindex.org)
  • Sections of lymph node and skin were embedded using the acetone, methyl benzoate and xylene (AMeX) method and dendritic cells were immunostained with anti S-100 protein antibody (S-100, and OKT-6 (CD1a) using the restaining method. (fujita-hu.ac.jp)
  • In immunohistochemical study, these eosinophilic cells expressed CD1a and S100 protein. (scirp.org)
  • They are also considered as damage-associated molecular pattern molecules (DAMPs), and knockdown of aryl hydrocarbon receptor downregulates the expression of S100 proteins in THP-1 cells. (wikipedia.org)
  • The protein constituents of this complex include FGF1, S100A13, and the p40 form of synaptotagmin 1 (Syt1). (rcsb.org)
  • S100 is an acidic acute liver failure may in part be correlated to protein with a molecular weight of 21 kDA impaired astrocytic functions [16]. (who.int)
  • The symbol has often been hyphenated, but current gene and protein nomenclature, such as HUGO Gene Nomenclature Committee nomenclature, does not use hyphens in symbols. (wikipedia.org)
  • What does this gene/protein do? (cancerindex.org)
  • Lately, in 1993, gene IT15 (interesting transcript 15), which codes unstable protein huntingtin (htt) comprising variable number of CAG repeats, was identified [ 5 ]. (hindawi.com)
  • The different mobility in the Ca2+-coordinating EF-hand sites indicate that they "communicate" by an allosteric mechanism operating through changes in protein dynamics that must be responsible for the elevated Ca2+-affinity. (elte.hu)
  • this is explained by the proteins that was termed "S100" because it fact that astrocytes form part of the BBB and was soluble in 100% saturated ammonium the increase in its permeability in HE due to sulfate solution [4]. (who.int)
  • Mechanistically, CAV2 directly interacts with S100s in HNSCC cells , and CAV2 reduces S100A14 protein expression by promoting its ubiquitylation and subsequent degradation via the proteasome . (bvsalud.org)
  • Prognostic values of S100 family members in ovarian cancer patients. (cancerindex.org)
  • While the prognostic value of each individual S100 in ovarian cancer is still elusive. (cancerindex.org)
  • In current study, we investigated the prognostic value of S100 family members in the ovarian cancer. (cancerindex.org)
  • Specifically, S100 binding preferentially disassemble NM2A, while tail phosphorylation disassemble NM2B. (elte.hu)
  • The various markers that enable assessment of the progression of preneoplastic lesions to spindle cell carcinoma include the p16 protein, which halts the cell cycle and induces apoptosis by pRb-mediated phosphorylation of cyclin-dependent kinase 4 (CDK4). (bvsalud.org)
  • Most S100 proteins consist of two identical polypeptides (homodimeric), which are held together by noncovalent bonds. (wikipedia.org)
  • Through virtual models, his 2004 study centered on the potential for old drugs to target the coronavirus's main enzyme catalyzing the breakdown of proteins into smaller polypeptides or single amino acids, an essential process for the propagation of the coronaviral life cycle. (nyit.edu)
  • Further, S100 proteins are markers for inflammatory diseases and can mediate inflammation and act as antimicrobials. (wikipedia.org)
  • Deletion of the inflammatory S100-A9/MRP14 protein does not influence survival in hSOD1G93A ALS mice. (umassmed.edu)
  • They also function as chemotactic agents and may play a role in the pathogenesis of epidermal disease, as selected S100 proteins are markedly overexpressed in psoriasis, wound healing, skin cancer, inflammation, cellular stress, and other epidermal states. (nih.gov)
  • and identifying EF hand protein S100 as a non-classical interactor of estrogen receptors. (nyit.edu)
  • Ezrin, a member of the ERM (Ezrin/Radixin/Moesin) protein family shows similar pathological properties as the S100 proteins. (elte.hu)
  • Using transgenic eGFP mice and genetic lineage tracing of S100β vSCs in vivo, we identified S100β/ Sca1 cells derived from a S100β non-SMC parent population within lesions that co-localise with smooth muscle α-actin (SMA) cells following iatrogenic flow restriction, an effect attenuated following hedgehog inhibition with the smoothened inhibitor, cyclopamine. (dcu.ie)
  • Large-scale inference of protein tissue origin in gram-positive sepsis plasma using quantitative targeted proteomics. (lu.se)
  • The p63 protein, a homologue of p53, may be associated with tumor formation in the epithelial tissue, acting as an oncogene 11,12 . (bvsalud.org)
  • Immunohistochemical studies were positive for immunological markers HMB45 and S-100 protein, confirming a diagnosis of melanoma. (bmj.com)
  • Strongly positive S-100 protein immunohistochemical stain. (bmj.com)
  • Taken together, our findings indicate that CAV2 promotes HNSCC invasion and metastasis by regulating the expression of S100 proteins , presenting a novel potential target for anticancer therapy in HNSCC . (bvsalud.org)
  • Tumors detected and diagnosed early have a favorable prognosis if treated with a complete or en-bloc excision. (medscape.com)
  • Conclusion: p63, p16, MIB, Cal A, Cys A are markedly expressed and p16 is strongly suppressed in oral cavity tumors, which suggests that the latter protein may play a role in negative regulation of cell cycle progression. (bvsalud.org)
  • Both S100β and PTCH1 cells were present in human vessels while S100β cells were enriched in arteriosclerotic lesions. (dcu.ie)
  • Nakamura Y, Becker LE, Marks A. S100 protein in human chordoma and human and rabbit notochord. (medscape.com)
  • Rajnarayanan's team has developed human computer interface (HCI) devices using 3-D printed protein models to generate functionally relevant clusters of simulated structural interactomics data to accelerate compound discovery. (nyit.edu)
  • S100 proteins have been used in the lab as cell markers for anatomic pathology. (wikipedia.org)
  • The work of my small laboratory in the national program for prevention of mental retardation by early diagnosis of congenital hypothyroidism, and finally screening of early markers of initial stages of dementia en elderly people. (bvsalud.org)