• S-Nitroso-N-acetylpenicillamine (SNAP) is the organosulfur compound with the formula ONSC(CH3)2CH(NHAc)CO2H. (wikipedia.org)
  • SNAP is an S-nitrosothiol and is used as a model for the general class of S-nitrosothiols which have received much attention in biochemistry because nitric oxide and some organic nitroso derivatives serve as signaling molecules in living systems, especially related to vasodilation. (wikipedia.org)
  • In this study, Tygon® PVC tubing was impregnated with a NO donor molecule, S-nitroso-N-acetylpenicillamine (SNAP), via a simple solvent-swelling-impregnation method, where polymer samples were submerged in a SNAP impregnation-solvent (methanol, acetone, plasticizer). (ucf.edu)
  • Cell viability in simulated ischemia/reperfusion (SI/R)-induced injury and a known cardiocytoprotective NO-donor, S-nitroso-n-acetylpenicillamine (SNAP) was tested. (nih.gov)
  • They treated the cells with a chemical called SNAP (S-nitroso-N-acetylpenicillamine), which generates nitric oxide. (medicalnewstoday.com)
  • S -Nitroso- N -acetylpenicillamine (SNAP), sodium nitroprusside (SNP), and S -nitrosoglutathione (GSNO). (kennesaw.edu)
  • LTD is also induced by the NO donors S-nitroso-N-acetylpenicillamine (SNAP) and hydroxylamine. (torvergata.it)
  • We examined the effect of an NO producer, S-nitroso-acetyl-penicillamine (SNAP), on the growth and survival in vitro of P. chabaudi AS, P. berghei and P. falciparum. (ncl.ac.uk)
  • In this paper, we, for the first time, demonstrate that the concentration of buffer remarkably affects the stability of RSNOs including naturally occurring S-nitrosoglutathione (GSNO) and synthetic S-nitroso-N-acetylpenicillamine (SNAP). (allergy-link.com)
  • To establish if NO leads to biochemical and cellular ASD-like phenotypes, C57BL/6J wild-type (WT) male mice were treated with an NO donor, S-nitroso-N-acetyl penicillamine (SNAP). (beyondair.net)
  • Treatment of cells with S-nitroso-N-acetylpenicillamine (SNAP), an NO donor, was shown to induce cell death, and treatment with melatonin (100 μm) significantly attenuated the occurrence of NO-induced cell death. (elsevierpure.com)
  • Conversely, bolus injections of authentic NO or S-nitroso-N-acetyl penicillamine accelerate repriming in intact vessels and restore photorelaxation in endothelium-deficient preparations. (uhi.ac.uk)
  • 17. Nitric oxide donor, (+/-)-S-nitroso-N-acetylpenicillamine, stabilizes transactive hypoxia-inducible factor-1alpha by inhibiting von Hippel-Lindau recruitment and asparagine hydroxylation. (nih.gov)
  • An organic NO donor, S-nitroso-N-acetylpenicillamine, significantly inhibited the replication cycle of SARS CoV in a concentration-dependent manner. (nitricoxideinnovations.com)
  • An NO-independent IL-1 signalling pathway facilitates CYP2B proteins down-regulation by an NO donor We shown previously the 4-Demethylepipodophyllotoxin manufacture NO donor substances NOC-18, em S /em -nitroso- em N /em -acetylpenicillamine and em S /em -nitrosoglutath-ione could all down-regulate CYP2B protein in rat hepatocytes [26], which NOC-18 may possibly also down-regulate CYP2B6?in human being hepatocytes [27]. (gasyblog.com)
  • In scramble MIN6 cells or wild-type islets, acute exposure to oxidative stressors, including hydrogen peroxide (H 2 O 2 ) and S-nitroso-N-acetylpenicillamine, resulted in cell damage as determined by decrease in cell viability, reduced ATP content, morphology changes of islets, and/or alterations of apoptotic biomarkers in a concentration- and/or time-dependent manner. (hindawi.com)
  • This effect was NO-dependent, and treatment of cells with the NO donors (Z)-1-[2-(2-aminoethyl)-N-(2-ammonioethyl) aminodiazen-1-ium-1,2-diolate (NOC-18), S-nitrosoglutathione, and S-nitroso-N-acetylpenicillamine also suppressed CYP2B proteins. (nih.gov)
  • With real-time confocal microscopy, the effect of three nitric oxide (NO) donors, S-nitroso-N-acetylpenicillamine, S-nitrosoglutathione, and diethylamine NO adduct, on the dynamic intracellular Ca 2+ concentration ([Ca 2+ ](i)) response of porcine tracheal smooth muscle (TSM) cells to acetylcholine (ACh) was examined. (elsevierpure.com)
  • The nitric oxide-releasing agent S-nitro-N-acetylpenicillamine and 2,2-diethyl-1-nitroxyhydraxine also elevated [Ca2+]i. (nih.gov)