• mice
  • Research in mice suggests that rolipram has the ability to ramp up the activity of proteasomes and reduce the burden of these aggregates. (wikipedia.org)
  • Since children with NF1-associated optic gliomas often develop visual loss and Nf1 genetically engineered mice with optic glioma exhibit RGC neuronal apoptosis in vivo , we further demonstrate that RGC apoptosis resulting from optic glioma in Nf1 genetically engineered mice is attenuated by rolipram treatment in vivo . (jneurosci.org)
  • Similar to optic glioma-induced RGC apoptosis, the increased RGC neuronal death in Nf1 +/− mice after optic nerve crush injury is also attenuated by rolipram treatment in vivo . (jneurosci.org)