• S6K1
  • Inhibition of the S6K1 protein, or a lack of it, slows the production of adipose (fat) cells by disrupting and retarding the initial "commitment stage" of their formation. (wikipedia.org)
  • Crystal structures of the S6K1 kinase domain in complexes with inhibitors. (nih.gov)
  • The crystal structures of the S6K1 kinase domain in complexes with staurosporine and the S6K1-specific inhibitor PF-4708671 have been reported. (nih.gov)
  • The crystal structures of the five inhibitors in complexes with the S6K1 kinase domain were determined at resolutions between 1.85 and 2.10 Å. (nih.gov)
  • p90RSK
  • The main distinguishing feature between p90rsk and p70rsk is that the 90 kDa family contain two non-identical kinase domains, while the 70 kDa family contain only one kinase domain. (wikipedia.org)
  • Gene
  • Amplification of the region of DNA encoding this gene and overexpression of this kinase are seen in some breast cancer cell lines. (wikipedia.org)
  • This gene encodes a member of the tob/btg1 family of anti-proliferative proteins that have the potential to regulate cell growth. (wikipedia.org)
  • Interactions of this protein with the v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 gene product p185 interferes with growth suppression. (wikipedia.org)
  • Two mRNAs from the gene have been identified that encode proteins of 1335 (isoform 1) and 1177 (isoform 2) amino acids long. (wikipedia.org)
  • inhibitors
  • Compound F179, with a carbonyl group in the middle of the molecule, altered the αC helix conformation by interacting with the invariant Lys123.Compounds F176 and F177 bound slightly distant from the hinge region, and their sulfoamide groups formed polar interactions with the protein.The structural features required for the specific binding of inhibitors are discussed. (nih.gov)
  • RSK1
  • Expect a predominant band approximately 88 kDa in size corresponding to RSK1. (vwr.com)
  • This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a C-terminal region of human RSK1 Protein. (vwr.com)
  • tyrosine
  • As a core component of mTORC2, mTOR also functions as a tyrosine protein kinase that promotes the activation of insulin receptors and insulin-like growth factor 1 receptors. (wikipedia.org)
  • inhibits
  • IκBα inhibits NF-κB by masking the nuclear localization signals (NLS) of NF-κB proteins and keeping them sequestered in an inactive state in the cytoplasm. (wikipedia.org)
  • When RPTOR is phosphorylated by AMPK, it interacts with 14-3-3 protein and inhibits its activity. (wikipedia.org)
  • Because mTORC1 inhibits autophagy and stimulates cell growth, it can cause damaged proteins and cell structures to accumulate. (wikipedia.org)
  • interactions
  • Compounds F176 and F177 bound slightly distant from the hinge region, and their sulfoamide groups formed polar interactions with the protein. (nih.gov)
  • Sequence
  • Sequence analysis of mTOR revealed it to be the direct ortholog of proteins encoded by the yeast target of rapamycin 1 and 2 (TOR1 and TOR2) genes, which Joseph Heitman, Rao Movva, and Michael N. Hall had identified in August 1991 and May 1993. (wikipedia.org)
  • encode
  • The 70-kb pYV is critical to Yersinia's pathogenicity, since it contains many genes known to encode virulence factors and its loss gives avirulence of all Yersinia species. (wikipedia.org)
  • signaling cascade
  • Liu, Mao, LaFortune, Alonso, Gallick, Fueyo, Yung: Cell cycle-dependent nuclear export of phosphatase and tensin homologue tumor suppressor is regulated by the phosphoinositide-3-kinase signaling cascade. (antikoerper-online.de)
  • amino acids
  • Contrary to common practice, the provision of protein/amino acids as a continuous infusion significantly limits protein synthesis whereas intermittent feeding maximally stimulates skeletal muscle synthesis. (springeropen.com)
  • regulates
  • Intracellular IL-6 and TNF-α protein levels were also significantly decreased in HDAC4 KD cells, indicating that synthesis of cytokines is reduced (Figure 1, C and D). The induction of IL-6 and TNF-α mRNA by LPS, however, was not affected by HDAC4 KD (Figure 1, E and F). These results indicate that HDAC4 regulates inflammatory cytokine production posttranscriptionally, possibly at the translation level. (nih.gov)
  • tumor
  • such mutations inactivate the IκBα protein, thus causing NF-κB to be chronically active in the lymphoma tumor cells and this activity contributes to the malignant state of these tumor cells. (wikipedia.org)
  • genes
  • It represents about 800 protein-coding genes compared to the Y chromosome containing about 70 genes, out of 20,000 - 25,000 total genes in the human genome. (wikipedia.org)
  • In 1994, Stuart L. Schreiber, David M. Sabatini and Robert T. Abraham independently discovered a protein that directly interacts with FKBP12-rapamycin, which became known as mTOR due to its homology to the yeast TOR/DRR genes. (wikipedia.org)
  • interacts
  • The protein interacts with both mothers against decapentaplegic Drosophila homolog 2 and 4 to enhance their DNA binding activity. (wikipedia.org)
  • cellular
  • Protein phosphorylation in particular plays a significant role in a wide range of cellular processes and is a very important posttranslational modification. (wikipedia.org)
  • mTOR links with other proteins and serves as a core component of two distinct protein complexes, mTOR complex 1 and mTOR complex 2, which regulate different cellular processes. (wikipedia.org)
  • The two natural products were used to discover the FK506- and rapamycin-binding proteins, including FKBP12, and to provide evidence that FKBP12-FK506 and FKBP12-rapamycin might act through gain-of-function mechanisms that target distinct cellular functions. (wikipedia.org)
  • It deals with the structure and function of cellular components such as proteins, carbohydrates, lipids, nucleic acids and other biomolecules. (wikipedia.org)
  • variants
  • Fibrous papule (FP) variants and their expression of phosphorylated ribosomal protein S6 (p-S6).A and B, Hypercellular FP with closely compacted dermal stromal cells which are immunoreactive for pS6. (nih.gov)
  • The insets in B, D, F, H, and J highlight positive p-S6 staining in the dermal stromal cells of FP variants. (nih.gov)
  • CREB
  • However, it remains unknown whether plasticity molecules, such as brain-derived neurotrophic factor (BDNF) and cyclic AMP response element-binding protein (CREB), are expressed in the hippocampus following resistance exercise. (biomedsearch.com)