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  • tyrosine
  • As a core component of mTORC2, mTOR also functions as a tyrosine protein kinase that promotes the activation of insulin receptors and insulin-like growth factor 1 receptors. (wikipedia.org)
  • Receptor-linked tyrosine kinases such as the epidermal growth factor receptor (EGFR) are activated by extracellular ligands. (wikipedia.org)
  • Binding of epidermal growth factor (EGF) to the EGFR activates the tyrosine kinase activity of the cytoplasmic domain of the receptor. (wikipedia.org)
  • In a simplified model, the presence of mitogens and growth factors trigger the activation of canonical receptor tyrosine kinases such as EGFR leading to their dimerization and subsequent activation of the small GTPase Ras. (wikipedia.org)
  • regulation
  • Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression. (nih.gov)
  • We detected a robust down-regulation of S6 kinase 1 (S6K1) mRNA that was accompanied by a sharp decrease in protein levels and activity. (curehunter.com)
  • It also may be involved in the regulation of protein turn-over. (wikipedia.org)
  • Such series of kinases provide opportunities for feedback regulation and signal amplification. (wikipedia.org)
  • signaling cascade
  • Liu, Mao, LaFortune, Alonso, Gallick, Fueyo, Yung: Cell cycle-dependent nuclear export of phosphatase and tensin homologue tumor suppressor is regulated by the phosphoinositide-3-kinase signaling cascade. (antikoerper-online.de)
  • interacts
  • This gene encodes an evolutionarily conserved protein that interacts with cullins. (wikipedia.org)
  • In 1994, Stuart L. Schreiber, David M. Sabatini and Robert T. Abraham independently discovered a protein that directly interacts with FKBP12-rapamycin, which became known as mTOR due to its homology to the yeast TOR/DRR genes. (wikipedia.org)
  • When RPTOR is phosphorylated by AMPK, it interacts with 14-3-3 protein and inhibits its activity. (wikipedia.org)
  • p70S6K
  • Due to the role of p70S6K in protein synthesis and also its involvement in a variety of human diseases ranging from diabetes and obesity to cancer, p70S6K is now being considered as a new therapeutic target for drug development. (bmj.com)
  • Ribosomal protein S6 kinase beta-1 (S6K1), also known as p70S6 kinase (p70S6K, p70-S6K), is an enzyme (specifically, a protein kinase) that in humans is encoded by the RPS6KB1 gene. (wikipedia.org)
  • Physical exercise activates protein synthesis via phosphorylation (activation) of p70S6K in a pathway that is dependent on mTOR, specifically mTORC1. (wikipedia.org)
  • Exercise has been shown to increase levels of IGF-1 in muscle, thus inducing the IGF-1/PI3K/Akt/p70S6K signaling pathway, and thereby increasing the protein synthesis required to build muscle. (wikipedia.org)
  • histone
  • In basic research, peptide microarrays are often used to profile an enzyme (like kinase, phosphatase, protease, acetyltransferase, histone deacetylase etc.), to map an antibody epitope or to find key residues for protein binding. (wikipedia.org)
  • inhibition
  • Inhibition of the S6K1 protein, or a lack of it, slows the production of adipose (fat) cells by disrupting and retarding the initial "commitment stage" of their formation. (wikipedia.org)
  • residues
  • Docking proteins such as GRB2 contain an SH2 domain that binds to the phosphotyrosine residues of the activated receptor. (wikipedia.org)
  • regulates
  • Previous studies in our laboratory have shown the neuron-specific specificity protein 4 (Sp4) transcriptionally regulates many excitatory neurotransmitter receptor subunit genes such as those for of N-methyl-D-aspartate (NMDA) receptors and of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. (cura-cancer.com)
  • This region interacts with phospholipase C-δ1 (PLCδ1) and activates its ability to hydrolyze the membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP2) into diacylglycerol (DAG) and inositol 1,4,5-triphosphate (IP3), which in turn activates protein kinase C (PKC) and increases intracellular calcium ion concentration, which regulates the actin cytoskeleton. (wikipedia.org)
  • In the case of stress (DNA damage, hypoxia) or low energy availability, it is activated and regulates protein synthesis down. (wikipedia.org)
  • Tumor
  • Interferons (IFNs) are a group of signaling proteins made and released by host cells in response to the presence of several pathogens, such as viruses, bacteria, parasites, and also tumor cells. (wikipedia.org)
  • A tumor suppressor gene is a gene whose protein product acts to prevent cells from proliferating at inappropriate times, or to induce apoptosis of cells which are damaged beyond repair. (wikipedia.org)
  • Inhibition
  • Inhibition of the S6K1 protein, or a lack of it, slows the production of adipose (fat) cells by disrupting and retarding the initial "commitment stage" of their formation. (wikipedia.org)
  • genes
  • The aims of the study were to compile a catalog of human genes involved in response to TBEV infection and to rank genes from the catalog based on the number of neighbors in the network of pairwise interactions involving these genes and TBEV RNA or proteins. (biomedcentral.com)
  • We reconstructed a network formed by pairwise interactions between TBEV virion itself, viral RNA and viral proteins and 140 genes/proteins from TBEVHostDB. (biomedcentral.com)
  • Two genes/proteins ( CCR5 and IFNAR1 ) that had maximal number of interactions were revealed. (biomedcentral.com)
  • Among nine genes associated with severe forms of TBEV infection, three genes/proteins ( CCR5 , IL10 , ARID1B) were found to have protein-protein interactions within the network, and two genes/proteins ( IFNL3 and the IL10, that was just mentioned) were up- or down-regulated in response to TBEV infection. (biomedcentral.com)
  • The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. (cancer-genetics.org)
  • More than twenty distinct IFN genes and proteins have been identified in animals, including humans. (wikipedia.org)
  • In addition, interferons induce production of hundreds of other proteins-known collectively as interferon-stimulated genes (ISGs)-that have roles in combating viruses and other actions produced by interferon. (wikipedia.org)
  • Researchers believe that this protein helps control the activity of other genes and plays an important role in the brain. (wikipedia.org)
  • highly conserved
  • The highly conserved Rho-GAP domain (amino acids 639-847) functions to enhance the GTPase activity of the Rho-GTPase proteins RhoA and Cdc42, promoting the hydrolysis of their bound GTP to GDP and thus "shutting off" these proteins. (wikipedia.org)
  • This highly conserved protein family is found in both plants and mammals. (wikipedia.org)
  • Activation
  • This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of cap-dependent mRNA translation. (wikipedia.org)
  • cells
  • The dig protein product (DlgA) is localized at septate junctions between epithelial cells, and cDNA sequencing indicates that the gene product includes a domain with homology to guanylate kinase (GUK). (biologists.org)
  • this protein therefore resembles the DlgA protein in being located in a specialized cell junction that functions in information transfer between cells. (biologists.org)
  • IFNs belong to the large class of proteins known as cytokines, molecules used for communication between cells to trigger the protective defenses of the immune system that help eradicate pathogens. (wikipedia.org)
  • In response to interferon, cells produce large amounts of an enzyme known as protein kinase R (PKR). (wikipedia.org)
  • The RPS6KA3 gene makes a protein that is involved with signaling within cells. (wikipedia.org)
  • The protein is involved in cell signaling pathways that are required for learning, the formation of long-term memories, and the survival of nerve cells. (wikipedia.org)
  • actin
  • In addition, hydrolysis of PIP2 releases actin regulatory proteins assembled at PIP2 molecules on the membrane and allows them to promote the disassembly of actin filaments. (wikipedia.org)
  • In its dephosphorylated state, cMyBP-C binds predominantly to myosin S2 and brakes crossbridge formation, however, when phosphorylated in response to β-adrenergic stimulation through activating cAMP-dependent protein kinase (PKA), it favours binding to actin, then accelerating crossbridge formation, enhancing force development and promoting relaxation. (wikipedia.org)
  • distinct
  • The encoded protein may be distinct from other members of this family, however, as studies suggest it is not growth factor dependent and may not participate in the same signaling pathways. (wikipedia.org)
  • activity
  • Molecular mechanisms underlying cardiac arrhythmias remain poorly understood, particularly in regard to posttranslational modulation of channel ( I to,f ) activity through kinase-mediated phosphorylation. (ahajournals.org)
  • This protein complex has NADH dehydrogenase activity and oxidoreductase activity. (wikipedia.org)
  • lipids
  • It deals with the structure and function of cellular components such as proteins, carbohydrates, lipids, nucleic acids and other biomolecules. (wikipedia.org)
  • binds
  • cMyBP-C is a myosin-associated protein that binds at 43 nm intervals along the myosin thick filament backbone, stretching for 200 nm on either side of the M-line within the crossbridge-bearing zone (C-region) of the A band in striated muscle. (wikipedia.org)
  • Cloning
  • Sometimes researchers opt to empirically determine which host is most suitable for their model studies by cloning the cDNA sequence into different expression vectors and expressing small amounts of proteins in different hosts for evaluation. (mybiosource.com)