• regulation
  • Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression. (nih.gov)
  • We detected a robust down-regulation of S6 kinase 1 (S6K1) mRNA that was accompanied by a sharp decrease in protein levels and activity. (curehunter.com)
  • This, in addition to the recent interest in the cell cycle regulation pathway cyclin D1/cyclin-dependent kinases [ 20 ], has resulted in the appearance of several therapies targeting these pathways in order to circumvent or delay the development of endocrine resistance. (biomedcentral.com)
  • It also may be involved in the regulation of protein turn-over. (wikipedia.org)
  • Such series of kinases provide opportunities for feedback regulation and signal amplification. (wikipedia.org)
  • Target of Rapamycin
  • The p70S6 kinase functions as part of a signaling pathway that includes mTOR (the mechanistic target of rapamycin). (wikipedia.org)
  • That of FKBP12-rapamycin remained mysterious until genetic and molecular studies in yeast established FKBP12 as the target of rapamycin, and implicated TOR1 and TOR2 as the targets of FKBP12-rapamycin in 1991 and 1993, followed by studies in 1994 when several groups, working independently, discovered the mTOR kinase as its direct target in mammalian tissues. (wikipedia.org)
  • Sequence analysis of mTOR revealed it to be the direct ortholog of proteins encoded by the yeast target of rapamycin 1 and 2 (TOR1 and TOR2) genes, which Joseph Heitman, Rao Movva, and Michael N. Hall had identified in August 1991 and May 1993. (wikipedia.org)
  • Because of these different names, mTOR, which had been first used by Robert T. Abraham, was increasingly adopted by the community of scientists working on the mTOR pathway to refer to the protein and in homage to the original discovery of the TOR protein in yeast that was named TOR, the Target of Rapamycin, by Joe Heitman, Rao Movva, and Mike Hall. (wikipedia.org)
  • signaling cascade
  • Liu, Mao, LaFortune, Alonso, Gallick, Fueyo, Yung: Cell cycle-dependent nuclear export of phosphatase and tensin homologue tumor suppressor is regulated by the phosphoinositide-3-kinase signaling cascade. (antikoerper-online.de)
  • interacts
  • This gene encodes an evolutionarily conserved protein that interacts with cullins. (wikipedia.org)
  • In 1994, Stuart L. Schreiber, David M. Sabatini and Robert T. Abraham independently discovered a protein that directly interacts with FKBP12-rapamycin, which became known as mTOR due to its homology to the yeast TOR/DRR genes. (wikipedia.org)
  • When RPTOR is phosphorylated by AMPK, it interacts with 14-3-3 protein and inhibits its activity. (wikipedia.org)
  • histone
  • Classical ER signaling needs to bind to estrogens and HSP90 chaperone protein before binding to transcription start site of target genes such as cyclin D. This transcription activity is partly mediated by histone deacetylation by HDAC6. (biomedcentral.com)
  • In basic research, peptide microarrays are often used to profile an enzyme (like kinase, phosphatase, protease, acetyltransferase, histone deacetylase etc.), to map an antibody epitope or to find key residues for protein binding. (wikipedia.org)
  • inhibition
  • Inhibition of the S6K1 protein, or a lack of it, slows the production of adipose (fat) cells by disrupting and retarding the initial "commitment stage" of their formation. (wikipedia.org)
  • residues
  • Docking proteins such as GRB2 contain an SH2 domain that binds to the phosphotyrosine residues of the activated receptor. (wikipedia.org)
  • receptor
  • The signal starts when a signaling molecule binds to the receptor on the cell surface and ends when the DNA in the nucleus expresses a protein and produces some change in the cell, such as cell division. (wikipedia.org)
  • Receptor-linked tyrosine kinases such as the epidermal growth factor receptor (EGFR) are activated by extracellular ligands. (wikipedia.org)
  • In a simplified model, the presence of mitogens and growth factors trigger the activation of canonical receptor tyrosine kinases such as EGFR leading to their dimerization and subsequent activation of the small GTPase Ras. (wikipedia.org)
  • synthesis
  • Due to the role of p70S6K in protein synthesis and also its involvement in a variety of human diseases ranging from diabetes and obesity to cancer, p70S6K is now being considered as a new therapeutic target for drug development. (bmj.com)
  • Animal studies have shown that the administration of interleukin (IL)-6 or tumor necrosis factor (TNF)- α increases skeletal muscle breakdown, decreases the rate of protein synthesis, and reduces plasma concentrations of insulin-like growth factor [ 12 , 13 ]. (hindawi.com)
  • The proton gradient can be dissipated by re-entry of protons to the mitochondrial matrix through uncoupling proteins (UCPs), which leads to uncoupling of respiration and ATP synthesis. (jci.org)
  • Phosphorylation of S6 induces protein synthesis at the ribosome. (wikipedia.org)
  • The kinase activity of this protein leads to an increase in protein synthesis and cell proliferation. (wikipedia.org)
  • Physical exercise activates protein synthesis via phosphorylation (activation) of p70S6K in a pathway that is dependent on mTOR, specifically mTORC1. (wikipedia.org)
  • Exercise has been shown to increase levels of IGF-1 in muscle, thus inducing the IGF-1/PI3K/Akt/p70S6K signaling pathway, and thereby increasing the protein synthesis required to build muscle. (wikipedia.org)
  • In turn, active PDK1, along with mTORC1, phosphorylates S6K in the part of the mTOR pathway which promotes protein synthesis and cell growth. (wikipedia.org)