Retinol binding proteins plasma. Medical search. Frequent questions

It is mainly, though not exclusively, synthesized in the liver and circulates in the bloodstream as a hepatokine bound to retinol in a complex with transthyretin. (wikipedia.org)
In plasma, the RBP-retinol complex interacts with transthyretin, which prevents its loss by filtration through the kidney glomeruli. (wikipedia.org)
The RBP4-retinol complex then binds transthyretin in circulation to prevent renal filtration of RBP4. (wikipedia.org)
The underlying monoclonal plasma cell dyscrasia is often of low-grade origin and usually lacks the malignant sheets of immature plasma cells in the bone marrow as seen in multiple myeloma (MM). ATTR amyloidosis is an autosomal-dominant hereditary disease caused by various point mutations of transthyretin (TTR), or is a disease of the very old (senile type). (medscape.com)
Transthyretin is almost entirely produced in the liver and is a transport protein of thyroid hormone and retinol-binding protein. (medscape.com)
Transthyretin (TTR), previously called thyroxin-binding Prealbumin, is a 55 kDa homotetramer of 14-15 kDa monomers that is found in plasma. (biogenex.com)
The proteins are usually found in association with TRANSTHYRETIN. (bvsalud.org)
Retinol and retinol-binding protein stabilize transthyretin via formation of retinol transport complex. (ox.ac.uk)
Transthyretin (TTR) is a plasma hormone carrier protein associated with hereditary and senile forms of systemic amyloid disease, wherein slow tetramer disassembly is thought to be an obligatory step. (ox.ac.uk)
Plasma transport of retinol is carried out exclusively by the retinol-binding protein (RBP), through complexation with transthyretin. (ox.ac.uk)
Using mass spectrometry to examine the subunit exchange dynamics, we find that retinol stabilizes the quaternary structure of transthyretin, through its interactions with RBP, reducing the rate of transthyretin disassembly ∼17-fold compared to apoTTR. (ox.ac.uk)
In the absence of retinol but in the presence of RBP, transthyretin is only marginally stabilized with the rate of disassembly reduced ∼two-fold with respect to apoTTR. (ox.ac.uk)
Surprisingly, we found two retinoids that stabilize transthyretin directly, in the absence of RBP, whereas retinol itself requires RBP in order to stabilize transthyretin. (ox.ac.uk)
It is also interesting to note that because of its anti inflammatory role Foretinib manufacture this protein and its mimics are being evaluated for its therapeutic potential in clinical trials with encouraging results in severe inflammatory conditions [21 22 Transthyretin is usually a transporter of thyroid hormones in plasma and is a negative acute phase protein. (health-ground.com)
In plasma retinol binding proteins interacts and is available as a complicated with transthyretin. (health-ground.com)
Like transthyretin retinol binding proteins is also a poor acute phase proteins and its creation is certainly inhibited by proinflammatory cytokines [23]. (health-ground.com)
Transthyretin is a tetrameric binding protein involved in the transport of thyroid hormones and in the cotransport of retinol by forming a complex in plasma with retinol-binding protein. (unifesp.br)
Mutation in the transthyretin (prealbumin) protein located on 18q11.2-q12.1. (mhmedical.com)
Two main types of amyloidosis affecting the heart are (1) light chain amyloidosis-a clonal plasma cell disorder due to the overproduction and misfolding of antibody light chain fragments and (2) transthyretin amyloidosis (ATTR). (mhmedical.com)
Transthyretin is a tetrameric serum protein that is synthesized primarily by the liver. (mhmedical.com)

Retinol binding protein 4, also known as RBP4, is a transporter protein for retinol (vitamin A alcohol). (wikipedia.org)
RBP4 is a single polypeptide chain with a hydrophobic pocket where retinol binds. (wikipedia.org)
In serum, TTR and RBP4 bind in a 1 to 1 stoichiometry (two molecules of TTR combine with two molecules of RBP4 to form a complex with a total molecular weight of approximately 80,000 Daltons). (wikipedia.org)
Retinol-binding protein 4 has been a drug target for eye diseases as RBP4 is the sole carrier for retinol, which is an essential nutrient for the visual cycle. (wikipedia.org)
In addition to the liver, RBP4 is also secreted by adipocytes of the fat tissue in a smaller portion and acts as a signal to surrounding cells, when there is a decrease in plasma glucose concentration. (wikipedia.org)
Maternal retinol-binding protein 4 (RBP4) and lipids may relate to preeclampsia and preterm birth risk but longitudinal data are lacking. (nih.gov)
This study aimed to investigate the changes in serum levels of retinol-binding protein 4 (RBP4) with cerebral infarction, relationship of RBP4 with oxidative stress and carotid atherosclerosis, and its possible role in cerebral infarction. (degruyter.com)
Background: Retinol?binding protein 4 (RBP4) is known to regulate lipid and glucose metabolism and insulin resistance. (ac.ir)
Weight, height, waist and hip circumferences, blood pressure (BP) of participants, fasting plasma glucose, hemoglobin A1c, total cholesterol, high?density lipoprotein cholesterol, triglyceride (TG), and serum RBP4 were measured from fasting blood sample taken from each participant after an overnight fast (12-14 h). (ac.ir)
BACKGROUND Retinol binding protein 4 (RBP4) expressed in adipocytes and liver, is an adipokine belonging to the lipocalin family and is involved in the transport of vitamin A/retinol. (sputnic-group.ru)
Apart from its role as a retinol transporter, RBP4 has also been implicated in causing insulin resistance in muscle and liver. (sputnic-group.ru)

It delivers retinol from the liver stores to the peripheral tissues. (wikipedia.org)
The physiologic basis lies in pregnancy whereby the mutated gene product, retinol binding protein (RBP), has negative effects in transferring vitamin A from maternal liver storage sites to the placenta, and then again on the fetal circulation side when delivering vitamin A from the placenta to developing fetal tissues, most notably the developing eye. (wikipedia.org)
In Immunohistochemistry of normal tissue, TTR has secretory positivity in plasma and is also found in the liver, the brain, in pancreatic islets and in renal tubules. (biogenex.com)
They are members of the lipocalin family of proteins and play a role in the transport of RETINOL from the LIVER to the peripheral tissues. (bvsalud.org)
Retinol binding proteins transports retinol in the liver towards the peripheral tissue. (health-ground.com)
After absorption, retinol is transported via chylomicrons to the liver, where it is either stored as retinol ester or reexported into the plasma in combination with retinol-binding protein for delivery to tissue sites. (medscape.com)
After 16 weeks, both BEE groups had significantly lower liver weights, serum TAG, homoeostasis model assessment and serum monocyte chemoattractant protein-1 compared with HFD. (cambridge.org)
the liver maintains plasma copper concentrations. (northamericanpharmacal.com)

STRA6 is a multi transmembrane domain protein that mediates the cellular uptake of vitamin A. In accordance with its role as the transmembrane transporter of vitamin A, STRA6 plays a major role in embryonic development. (sputnic-group.ru)

13. Human class 1 heparin-binding growth factor: structure and homology to bovine acidic brain fibroblast growth factor. (nih.gov)
Although sequence homology is limited, crystallographic studies suggest conserved 3D structures across the group of binding proteins. (guidetopharmacology.org)
It has a high degree of homology to plasma retinol-binding protein, also known as lipocalins. (bioradiations.com)
Limited N-terminal sequence analysis of these two isoforms showed that the protein had complete homology with bovine placental and plasma retinol-binding protein (RBP) over the first 20 amino acids. (animbiosci.org)

Once within tissues, retinol is bound by cellular retinoid-binding proteins, cellular retinoid-binding protein I (CRBPI) and cellular retinoid-binding protein II (CRBPII). (medscape.com)
Intracellular retinol in peripheral tissues can also combine with plasma retinol-binding protein within that tissue, or it can be incorporated into retinyl esters in lipoproteins. (medscape.com)
2) We will demonstrate the relevance of apocarotenoids in humans using analytical chemistry to characterize the presence and quantify the amounts of apo-carotenals and apocarotenoic acids in human plasma and tissues and in foods. (nih.gov)
The uterine endometrium is the only source of retinol for embryonic tissues. (animbiosci.org)
The uterine RBP appears to transport retinol locally toward embryonic tissues. (animbiosci.org)
Amyloidosis is a heterogeneous disease that results from the deposition of toxic insoluble beta-sheet fibrillar protein aggregates in different tissues. (mhmedical.com)

In these complexes, retinol may be either esterified or further oxidized via retinol to retinoic acid, which ultimately binds to a set of transcription factors in the nucleus. (medscape.com)
Background: Recent reports indicate the potential role of the stimulated by retinoic acid 6 (STRA6) protein in developing insulin resistance. (mdpi.com)

These studies will also establish the relationship of cellular retinol-binding proteins and carotenoid cleavage enzymes in the metabolic function of these enzymes. (nih.gov)
In the process of exocytosis, during the fusion of a vesicle with the plasma membrane cellular content is transferred into the extracellular space. (biologyonline.com)

Along with other proteins, apolipoproteins bind lipids to form lipoproteins such as high-density lipoprotein (HDL), low-density lipoprotein (LDL), and very low-density lipoprotein (VLDL). (bioradiations.com)
The plasma concentrations of lipids, apolipoproteins and lipid-soluble antioxidants (α-tocopherol, γ-tocopherol, lycopene, α-carotene, β-carotene and retinol) were determined using standardized methods. (uam.es)

It is essentially a lipophilic protein mainly synthesized by hepatocytes and adipose tissue. (degruyter.com)
Currently, no data exists on the relative expression and regulation of omentin-1 in adipose tissue (AT) of PCOS women.Objectives: To assess mRNA and protein levels of omentin-1 in omental (om) AT of PCOS women and matched controls, including circulating omentin-1. (endocrine-abstracts.org)

This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A) in the blood. (wikipedia.org)

When vitamin A intake is low, the absorption efficiency remains high, carotenoid cleavage is enhanced, the plasma transport remains at essentially normal levels, recycling and utilization mechanisms become more efficient, and the excretion of metabolites markedly decreases. (medscape.com)

This will be accomplished by quantitation of the immediate post- prandial plasma concentrations of parent carotenoids and metabolites after subjects consume a single serving of tomato juice containing nutritionally relevant amounts of beta-carotene or lycopene as well as by quantitation of steady state concentrations in plasma after 4 weeks of daily consumption. (nih.gov)
Thus, we examined the cross-sectional association of high-sensitivity CRP (hs-CRP) levels with fat-soluble plasma antioxidant concentrations in a cohort of healthy prepubertal children. (uam.es)
Pearson correlation analysis showed significant correlations between plasma hs-CRP and α-carotene and retinol concentrations. (uam.es)
These severe phase proteins concentrations were considerably raised in sufferers who had been slower to very clear parasites after treatment. (health-ground.com)

Zinc interacts with taurine and vitamin A in the retina, modifies plasma membranes in the photoreceptors, regulates the light-rhodopsin reaction within the photoreceptor, modulates synaptic transmission, and serves as an antioxidant in both the RPE and retina. (northamericanpharmacal.com)

Changes in serum protein profiles were studied using proteomics techniques involving Sodium Dodecyl Sulphate- Polyacrylamide Gel Electrophoresis (SDS-PAGE), two-dimensional gel electrophoresis (2-DE), Matrix-assisted Laser Desorption / Ionization-Time of Flight / Time of Flight mass spectrometry (MALDI-TOF/TOF) and Surface-Enhanced Laser Desorption / Ionization-Time of Flight mass spectrometry (SELDI-TOF). (um.edu.my)

Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane (PubMed:22665496). (nih.gov)

6. Partial amino acid sequence of human plasma retinol-binding protein. (nih.gov)
10. Amino acid sequence of bovine brain derived class 1 heparin-binding growth factor. (nih.gov)
Vitamin B6 functions in protein and amino acid metabolism. (medscape.com)
The antigen corresponds to amino acid range 18-201 of the target protein. (thermofisher.com)

Historically, it was thought that the most important role of some carotenoids was their metabolic conversion via cleavage at the central double bond to the essential micronutrient, vitamin A (retinol). (nih.gov)

Transcriptional intermediary factor 1alpha mediates physical interaction and functional synergy between the coactivator-associated arginine methyltransferase 1 and glucocorticoid receptor-interacting protein 1 nuclear receptor coactivators. (igbmc.fr)
Retinol-binding protein that mediates retinol transport in blood plasma (PubMed:5541771). (nih.gov)

Seven serum proteins were confidently identified by MALDI-TOF/TOF which includes plasma retinol binding protein, serum albumin fragment, complement c3 precursor, haptoglobin, Apolipoprotein H, alpha 1 macroglobulin (A1M) and alpha 1 antiproteinase. (um.edu.my)
SELDI-TOF univariate analysis revealed the alterations towards low molecular weight (LMW) serum proteins (2,500-40,000 kDa). (um.edu.my)

An important fat-soluble vitamin, vitamin A's basic molecule is a retinol, or vitamin A alcohol. (medscape.com)

Description of the protein which includes the UniProt Function and the NCBI Gene Summary. (nih.gov)
A large number of proteins that play a role in the regulation of gene expression are thought to contain zinc. (northamericanpharmacal.com)

Catalog Number: B2010765 (1 mL) SSA Antibody Positive Plasma is human plasma positive for the Sjogren Syndrome Antigen A antibody. (moleculardepot.com)
Carcinoembryonic antigen (CEA) is a glycosylated protein that plays important roles in the adhesion between cells. (moleculardepot.com)
Significance of correlation between levels of carcinoembryonic antigen and carbohydrate antigen 19-9, carcinoembryonic antigen and C-reactive protein, carcinoembryonic antigen and alpha-1 antitrypsin in gastric and colon cancer patients. (moleculardepot.com)

Catalog Number: B2010856 (1 mL) SARS-CoV-2 Antibody Positive Plasma is a human plasma tested positive for SARS-CoV-2 antibodies. (moleculardepot.com)
Catalog Number: B2010808 (1 mL) Antinuclear Antibody Speckled Positive Plasma is human plasma positive for antinuclear antibody speckled ANA. (moleculardepot.com)
Catalog Number: B2010776 (1 mL) Anti-Mitochondrial Antibody Positive Plasma is human plasma positive for AMA. (moleculardepot.com)
Catalog Number: B2010766 (1 mL) Smith/Ribonucleoprotein (SM/RNP) Antibody Positive Plasma is human plasma positive for the Smith/Ribonucleoprotein (SM/RNP) antibodies. (moleculardepot.com)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Jumping Translocation Breakpoint Protein (JTB) in Tissue homogenates, cell lysates and other biological fluids. (2sars.com)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Jumping Translocation Breakpoint Protein (JTB) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (2sars.com)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Cystatin A (CSTA) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. (resourcerecovery.be)

While the role of apolipoproteins and low-density lipoproteins (LDL) in cardiovascular disease (CVD) has been understood for some time, emerging research is revealing that these proteins may prove to be valuable biomarkers beyond CVD. (bioradiations.com)

Fatty acid-binding proteins are low molecular weight (100-130 aa) chaperones for long chain fatty acids, fatty acyl CoA esters, eicosanoids, retinols, retinoic acids and related metabolites and are usually regarded as being responsible for allowing the otherwise hydrophobic ligands to be mobile in aqueous media. (guidetopharmacology.org)

The specific amyloidosis type is based on the genetic demonstration of a mutation in the prealbumin protein (substitution of serine for isoleucine at position 84). (mhmedical.com)

This protein may also be involved in other intracellular processes including proteolysis, nerve regeneration, autophagy and glucose homeostasis. (biogenex.com)

In humans, it is a molecular chaperone responsible for aiding protein folding of secreted proteins. (bioradiations.com)
Retinol-binding protein-4 (RBP-4) may increase IR in mice, with elevated levels in insulin resistant mice and humans with obesity and type 2 diabetes. (endocrine-abstracts.org)

It is a homo-tetrameric carrier protein, which transports thyroid hormones in the plasma and cerebrospinal fluid. (biogenex.com)

Description: A sandwich ELISA kit for detection of Jumping Translocation Breakpoint Protein from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (2sars.com)
Description: A competitive ELISA for quantitative measurement of Human Translocation protein SEC62(SEC62) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (2sars.com)
Description: A competitive ELISA for quantitative measurement of Porcine Translocation protein SEC62(SEC62) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (2sars.com)
Description: A competitive ELISA for quantitative measurement of Human Cytochrome P450 2A13(CYP2A13) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (scalegen.com)
Description: A sandwich ELISA kit for detection of Cystatin A from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (resourcerecovery.be)
Description: A sandwich quantitative ELISA assay kit for detection of Human Cystatin A (CSTA) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. (resourcerecovery.be)

When vitamin A intakes are high, the absorption efficiency is reduced, the plasma transport of vitamin A remains the same, recycling becomes less efficient, the oxidation of vitamin A is enhanced, biliary excretion markedly increases, and urinary and fecal excretion is augmented. (medscape.com)

A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells. (wikipedia.org)
Secretion of RBP by caprine endometrium of days 13, 15 and 21 of pregnancy suggested that retinol played an important role in conceptus development during periattachment period of early pregnancy. (animbiosci.org)

Retinoids and spermatogenesis: lessons from mutant mice lacking the plasma retinol binding protein. (igbmc.fr)

A vitamin A-transport protein, RBP, was identified in cultures conditioned by endometrium of days 13-21 of pregnancy. (animbiosci.org)
4) Zinc is also required in hepatic synthesis of retinol binding protein, the transport protein of vitamin A. (5) Without adequate zinc, symptoms of vitamin A deficiency can appear, despite vitamin A supplementation. (northamericanpharmacal.com)

1) It is a cofactor in many biological processes including DNA, RNA, and protein synthesis. (northamericanpharmacal.com)

A major low molecular weight protein consisted of two major isoforms (pI 5.3-6.0) of similar molecular mass (21 kDa). (animbiosci.org)

The analyses of retinol (vitamin A) and a-tocopherol (vitamin E) were performed according to Shearer [4] and Bieri et al. (who.int)

In this study as expected we found many acute phase proteins being differentially expressed. (health-ground.com)

Some of the identified proteins also are important transport proteins in blood. (health-ground.com)
These features indicated a potential for interaction with host proteins present in the plasma and cells from ingested blood. (unifesp.br)

After adjusting by sex, body mass index (BMI) and lipid levels, only the association with retinol remains significant, with children in the highest hs-CRP tertile group (hs-CRP ≥ 0.60 mg/dL) showing significantly lower levels of retinol than those from the tertiles 1 and 2. (uam.es)
The aim of the present study was to determine the effects of CoQ 10 and vitamin E on lipid peroxidation and antioxidant profile in rats treated with the chemotherapeutic agent doxorubicin, along with the biochemical parameters of albumin, globulin, total protein, alanine aminotransferase (ALT) and glucose levels. (fusabil.org)

In AA amyloidosis, the precursor protein is serum amyloid A protein (SAA), an acute-phase reactant. (medscape.com)
These studies reported the differential expression of many acute phase proteins in the plasma in these conditions. (health-ground.com)
Beta-carotene [ie, provitamin A] is converted to retinol but not rapidly enough for acute toxicity. (medscape.com)

Unless otherwise stated all data on this page refer to the human proteins. (guidetopharmacology.org)

Primary organizing protein component of the shell enclosing fat molecules, and is absolutely required for the formation of LDL, VLDL, and intermediate-density lipoprotein (IDL). (bioradiations.com)

Recent studies have shown that plasma omentin-1 levels decrease with obesity. (endocrine-abstracts.org)

This protein maintains normal levels of thyroid hormone, retinol, alpha-1-Antitrypsin, and retinol-binding protein in the circulation. (mhmedical.com)

Interestingly, ATRA treatment induces the translocation of RARα to the plasma membrane, where it colocalizes with Akt. (biomedcentral.com)
is a process in which a cell takes in materials from the outside by engulfing and fusing them with its plasma membrane . (biologyonline.com)

Different types of systemic amyloidosis are recognized depending on the type of precursor protein of the amyloid fibril. (medscape.com)
In AL amyloidosis, the precursor protein is a κ or λ immunoglobulin light chain. (medscape.com)

The relationship between C-reactive protein (CRP) levels and plasma antioxidants has been established in adults. (uam.es)
A stepwise linear regression selected retinol, BMI, apo A-I and sex as predictors of hs-CRP levels, in a model explaining 19.2% of the variability of hs-CRP. (uam.es)
Because the body can make use of both preformed vitamin A and provitamin A carotenoids that it converts into vitamin A (retinol), and these substances have different bioactivity levels, the recommended dietary allowances (RDAs) for vitamin A are given as mcg of retinol activity equivalents (RAE). (medscape.com)
Clinical value of monitoring plasma octreotide levels during chronic octreotide long-acting repeatable therapy in carcinoid patients. (interscienceinstitute.com)
Validation of serum versus plasma measurements of chromogranin a levels in patients with carcinoid tumors: lack of correlation between absolute chromogranin a levels and symptom frequency. (interscienceinstitute.com)

A very recently described adipokine, retinol-binding protein 4 (RBP-4), has been shown to modulate insulin signalling and possibly lead to IR. (endocrine-abstracts.org)

When bound the structure of cardiolipin and Apo H both undergo large changes in structure that allow for involvement in phospholipid binding. (bioradiations.com)

Previous studies showed that the soluble portion of the MEG-14 protein displays features of an intrinsically disordered protein and is expressed exclusively in the parasite esophageal gland. (unifesp.br)

25-OHD (25-hydroxyvitamin D), the major circulating metabolite of vitamin D, was measured in serum by competitive protein-binding (CPB) assay and radioimmunoassay kit (Nichols, San Juan Capistrano, California). (who.int)

All of these proteins showed possible association with hypertension in which A1M being the most related. (um.edu.my)

It is also involved in the transport of retinol (vitamin A) in the plasma by associating with retinolbinding protein. (biogenex.com)

Anatomy2

Diseases2

Chemicals and Drugs15

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes7

Information Science3

Health Care1

Transthyretin20

RBP411

Liver8

Transporter1

Homology4

Tissues6

Retinoic acid2

Cellular2

Lipids2

Adipose tissue2

Lipocalin family1

Carotenoid cleavage1

Concentrations4

Interacts1

Proteomics1

STRA61

Amino4

Metabolic1

Mediates2

Serum Proteins2

Vitamin A alcohol1

Gene2

Antigen3

Antibody7

Biomarkers1

Hydrophobic1

Prealbumin1

Intracellular1

Humans2

Thyroid hormones1

ELISA6

Absorption1

Secretion2

Mice1

Transport protein2

Synthesis1

Isoforms1

Analyses1

Differentially1

Blood2

Lipid2

Acute3

Human1

Molecules1

Obesity1

Circulation1

Membrane2

Precursor2

Levels5

Insulin1

Phospholipid1

Exclusively1

Assay1

Association1

Involved in the transport1