Retinol binding proteins. Medical search. Frequent questions

Cellular: RBP1, RBP2, RBP5, RBP7 Interstitial: RBP3 Plasma: RBP4 Retinol plays a crucial role in the growth and differentiation of various body tissues, and it has been previously characterized that embryos are extremely sensitive to alterations in retinol concentration that can lead to spontaneous abortion and malformations occurring during development. (wikipedia.org)
Retinol-binding protein 4 (RBP4) is closely associated with a variety of abnormal glycolipid metabolism diseases such as insulin resistance, obesity, diabetes mellitus, and metabolic syndrome. (nih.gov)
More specifically, retinol-binding protein 4 (RBP4), which is a retinol carrier protein in the serum, is well known for its effects in the adipose tissues. (snu.ac.kr)
However, RBP4 expression in BAT is significantly increased along with uncoupling protein 1 when thermogenesis is activated. (snu.ac.kr)
Retinoid의 대사, 더 구체적으로 retinol-binding protein 4(RBP4)는, 에너지 대사에 중요한 영향을 끼친다. (snu.ac.kr)
RBP4는 비타민 A로 알려진 retinol을 혈액속에서 운반하는 단백질이다. (snu.ac.kr)
ELISA na kvantitatívne stanovenie retinol viažuceho proteínu 4 (RBP4) v ľudskom sére a plazme. (promedeuslab.cz)

CRABPs, cellular retinoic acid-binding proteins capable of binding retinol and retinoic acid with high affinity. (wikipedia.org)

The kinetics of estrogen (E) modulation of retinol-binding protein (RBP) production in the liver of immature chicks were compared with those governing de novo induction of riboflavin carrier protein (RCP) in the same tissue. (iisc.ac.in)

Retinol and retinoic acid play crucial roles in the modulation of gene expression and overall development of an embryo. (wikipedia.org)
CRBP I/II, cellular-binding proteins involved in transport of retinol and metabolites into retinyl esters for storage or into retinoic acid. (wikipedia.org)
As previously mentioned, retinol and retinoic acid are modulators of gene expression and are necessary for the proper development and growth of a conceptus. (wikipedia.org)
Vitamin A is any of several retinoid derivatives of beta-carotene, primarily retinol, retinal, or retinoic acid. (mcw.edu)
We have shown that fine-tuning of retinoic acid activity depends on its spatiotemporal patterns of synthesis (by retinol and retinaldehyde dehydrogenases) and catabolism (by CYP26 enzymes). (igbmc.fr)

RBP is also bound to a carrier protein, transthyretin. (wikipedia.org)
In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. (nih.gov)
In addition, other factors associated with low retinol concentrations (eg, low plasma transthyretin or zinc concentrations or mutations in the transthyretin gene) were not present. (huji.ac.il)
1. Transthyretin, aka prealbumin, is made in the liver and transports what proteins? (jotform.com)
The TTR gene provides instructions for making a protein called transthyretin. (medlineplus.gov)
To transport thyroxine, four transthyretin proteins must attach (bind) to each other to form a four-protein unit (tetramer). (medlineplus.gov)
To transport retinol, transthyretin must form a tetramer and bind to another protein called retinol-binding protein. (medlineplus.gov)
Transthyretin is produced primarily in the liver, and a small amount of this protein is produced in an area of the brain called the choroid plexus and in the light-sensitive tissue that lines the back of the eye (the retina). (medlineplus.gov)
Nearly all of these variants change one protein building block (amino acid) in the transthyretin protein. (medlineplus.gov)
The most common variant found in people with transthyretin amyloidosis replaces the amino acid valine with the amino acid methionine at position 50 in the transthyretin protein (written as Val50Met or V50M). (medlineplus.gov)
Another common variant replaces the amino acid valine with the amino acid isoleucine at position 142 in the transthyretin protein (written as Val142Ile or V142I). (medlineplus.gov)
As a result, the tetramers break down into individual transthyretin proteins, which attach to each other to form strands called fibrils. (medlineplus.gov)
In some older adults, deposits of normal transthyretin proteins cause a condition called senile systemic amyloidosis. (medlineplus.gov)
for reasons that are unclear, the transthyretin protein begins to form protein deposits. (medlineplus.gov)
Transthyretin (TTR) is a homotetrameric serum and cerebrospinal fluid protein that transports thyroxine (T4) and retinol by binding to retinol binding protein. (rcsb.org)

This protein transports vitamin A (retinol) and a hormone called thyroxine throughout the body. (medlineplus.gov)

It delivers retinol from the liver stores to the peripheral tissues. (nih.gov)
We now report that pure CRBP delivers retinol to the specific nuclear binding sites without itself remaining bound. (rupress.org)
Thus, CRBP delivers retinol to the interior of the nucleus, to specific binding sites which are primarily, if not solely, on the chromatin. (rupress.org)

0.6 μmol/L) and plasma retinol concentrations were extremely low (0.19 μmol/L). Interestingly, intestinal absorption of retinyl esters was normal. (huji.ac.il)
There are two different types: provitamin A (carotenoids) and preformed vitamin A (retinol or retinyl ester). (greatist.com)

Traditionally, RBP is synthesized within the liver with secretion being dependent upon retinol concentrations. (wikipedia.org)
A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells. (nih.gov)
Bioinformatics analysis indicated the up-regulated proteins were significantly enriched in "GnRH secretion" and "Circadian rhythm" signaling pathway. (frontiersin.org)

also called orosomucoid) is synthesized in the liver and structurally belongs to the lipocalin superfamily of secretory proteins, such as retinol-binding protein and α1-microglobulin. (cdc.gov)

This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. (nih.gov)

Plasma retinol-binding protein, the retinol transport vehicle in serum. (wikipedia.org)
Bovine/Ovine RBP, identical to that found in plasma has been identified in the placental tissues of both the ovine and the bovine, suggesting that RBP may be highly involved in retinol transport and metabolism during pregnancy. (wikipedia.org)
After an antigen binds to a BCR, the B cell activates to proliferate and differentiate into either plasma cells , which secrete soluble antibodies with the same paratope, or memory B cells , which survive in the body to enable long-lasting immunity to the antigen. (wikipedia.org)
Progesterone (P) could neither modulate nor substitute for E in enhancing plasma levels of either of the 2 proteins while the anti-estrogens, en- and zuclomifene citrate severely suppressed the production of both the proteins. (iisc.ac.in)
To correlate inflammatory cytokines and vascular endothelial growth factor (VEGF) in vitreous and plasma with vitreous Retinol Binding Protein 3 (RBP3), diabetic retinopathy (DR) severity, and DR worsening in population with type 1 and type 2 diabetes. (figshare.com)
The plasma retinol and a-tocopherol were extracted with n-hexane. (who.int)

Beta carotene, also known as provitamin A, is the plant source of retinol from which mammals make two-thirds of their vitamin A. Carotenoids, the largest group of the 3, contain multiple conjugated double bonds and exist in a free alcohol or in a fatty acyl-ester form. (medscape.com)
Serum concentrations of alpha-tocopherol, beta-carotene, and retinol preceding the diagnosis of rheumatoid arthritis and systemic lupus erythematosus. (vitalraadet.dk)

This data analysis calculates concentrations using a Four Parameter Logistic (4PL) curve fit in accordance with Arbor Assays' Retinol Binding Protein EIA Kit (K062-H1, K062-H5). (myassays.com)
TRIMERO Diagnostics offers IVD CE marked Retinol Binding Protein assays, for serum and urine samples, available for nephelometers and the most popular Clinical Chemistry analyzers present on the market. (clinlabint.com)
11 proteins were up-regulated and 17 proteins were down-regulated, while consistent presence/absence expression profile group contains one elevated protein and nine reduced proteins, among which seven proteins were identified as potential biomarkers for IVR treatment through PRM assays. (frontiersin.org)
Esmaeili R, Zhang M, Sternberg MR, Mapango C, Pfeiffer CM . A new multiplex immunoassay for serum ferritin, soluble transferrin receptor, C-reactive protein, α-1-glycoprotein, and retinol-binding protein showed variable comparability with traditional reference assays external icon . (cdc.gov)

Within a mature animal, retinol is transported from the liver via the circulatory system while bound to RBP to the desired target tissue. (wikipedia.org)
We have previously reported that purified cellular retinol-binding (CRBP) will mediate specific binding of retinol to nuclei isolated from rat liver. (rupress.org)
The body cannot make vitamin A and must rely on dietary sources of vitamin A. Meat sources provide vitamin A (as retinol), while vegetable and fruit sources provide carotene (a substance that can be converted into vitamin A by the liver). (labtestsonline.org.uk)

Porcine All three previously mentioned types of retinol-binding proteins (RBP, CRBP, CRABP) have been identified within the porcine placenta during pregnancy via immunohistochemistry. (wikipedia.org)
RBP and CRBP have been identified in the endometrial glands and areolar trophoblasts, suggesting that RBP is crucial in transport of retinol from the gland to the trophectoderm of the conceptus. (wikipedia.org)
CRBP is also capable of delivering retinol specifically to isolated chromatin with no apparent loss of binding sites, as compared to whole nuclei. (rupress.org)
CRBP again does not remain bound after transferring retinol to the chromatin binding sites. (rupress.org)
When isolated nuclei are incubated with [3H]retinol-CRBP, sectioned, and autoradiographed, specifically bound retinol is found distributed throughout the nuclei. (rupress.org)

In addition to this, they estimated that another 190 million preschool age children and 19 million pregnant women were at risk of vitamin A deficiency, with low retinol concentrations that reflected an inadequate supply of vitamin A. In these countries, a low vitamin A is most strongly associated with health consequences during periods of high nutritional demands such as pregnancy, illnesses and lactation. (labtestsonline.org.uk)

Retinol (vitamin A alcohol) is involved in the proper differentiation of epithelia. (rupress.org)

To compare the differences of vitreous protein profiles in PDR patients before and after a complete anti-vascular endothelial growth factor (VEGF) loading dose with ranibizumab treatment. (frontiersin.org)
A total of 2680 vitreous proteins were identified. (frontiersin.org)
We previously reported that preoperative IVR treatment in patients with severe PDR contributes to a decreased risk of postoperative neovascular glaucoma ( 11 ), and found further changes in vitreous protein profiles of PDR patients treated with and without IVR ( 12 ). (frontiersin.org)
While there have been no reports on the changes in vitreous humor (VH) protein profile before and after IVR treatment in the same patient. (frontiersin.org)

The presence of low molecular weight retinol binding protein (RBP) in urine reflects tubular damage. (avmi.net)

The relationship between NAFLD and retinol-binding protein 4 - an updated systematic review and meta-analysis. (nih.gov)

Validation of a rapid enzyme immunoassay for the quantitation of retinol-binding protein to assess vitamin A status within populations. (who.int)

The process by which RBP releases retinol for cellular availability is still unknown and not concisely determined. (wikipedia.org)
Interaction of the retinol/cellular retinol-binding protein complex with isolated nuclei and nuclear components. (rupress.org)

Likewise, cycloheximide inhibition of RBP accumulation followed a pattern similar to that of hepatic general protein synthesis. (iisc.ac.in)

This infant presented with symptoms indicative of Kwashiorkor, a dietary protein deficiency. (medscape.com)
Objective: Our aim was to investigate the cause of the retinol deficiency in these 2 siblings. (huji.ac.il)

Regulation of transport and metabolism of retinol necessary for a successful pregnancy is accomplished via RBP. (wikipedia.org)
Expression of RBP in developing conceptuses, extraembryonic membranes, and at the fetal-maternal interface indicate that there may be some regulation of retinol transport and metabolism that occurs due to RBP by the extraembryonic membranes. (wikipedia.org)
Retinol-binding protein (RBP) binds vitamin A and regulates its absorption and metabolism. (medscape.com)

The retinoid designation resulted from finding that vitamin A had the biologic activity of retinol, which was originally isolated from the retina. (medscape.com)

Retinol-binding proteins have been identified within the uterus, embryo, and extraembryonic tissue of the bovine, ovine, and porcine, clearly indicating that RBP plays a role in proper retinol exposure to the embryo and successful transport at the maternal-fetal interface. (wikipedia.org)

Kada transferinski protein napunjen gvožđem naiđe na transferinski receptor na površini ćelije , npr. (wikipedia.org)

Positive Expression of Retinol-Binding Protein 4 Is Related to the Malignant Clinical Features Leading to Poor Prognosis of Glioblastoma. (nih.gov)
The binding of retinol to these sites may affect gene expression. (rupress.org)

Title : Accounting for the influence of inflammation on retinol-binding protein in a population survey of Liberian preschool-age children Personal Author(s) : Larson, Leila Margaret;Addo, O. Yaw;Sandalinas, Fanny;Faigao, Katherine;Kupka, Roland;Flores-Ayala, Rafael;Suchdev, Parminder S. (cdc.gov)

Interplay of retinol binding protein 4 with obesity and associated chronic alterations (Review). (nih.gov)

Retinol is taken up by the peripheral tissue from the complex. (labtestsonline.org.uk)

C?reactive protein [hsCRP], urinary albumin excretion [UAE]), as well as blood pressure were obtained. (ac.ir)
No consistent evidence was found for intergroup differences in proximal renal tubule function as measured by urinary beta2-microglobulin or retinol binding protein. (cdc.gov)

[2] [3] Each tip of the "Y" of an antibody contains a paratope (analogous to a lock) that is specific for one particular epitope (analogous to a key) on an antigen, allowing these two structures to bind together with precision. (wikipedia.org)
To allow the immune system to recognize millions of different antigens, the antigen-binding sites at both tips of the antibody come in an equally wide variety. (wikipedia.org)
The class hence determines the function triggered by an antibody after binding to an antigen, in addition to some structural features. (wikipedia.org)
The antigen binding site is circled. (wikipedia.org)
Structurally an antibody is also partitioned into two antigen-binding fragments (Fab), containing one V L , V H , C L , and C H 1 domain each, as well as the crystallisable fragment (Fc), forming the trunk of the Y shape. (wikipedia.org)

Assessment of retinol-binding protein is used to determine visceral protein mass in health-related nutritional studies. (wikipedia.org)

In the human body, retinol is the predominant form, and 11- cis -retinol is the active form. (medscape.com)
Chaudhary-Webb M, Schleicher RL, Erhardt JG, Pendergrast EC, Pfeiffer CM. An HPLC ultraviolet method using low sample volume and protein precipitation for the measurement of retinol in human serum suitable for laboratories in low- and middle-income countries external icon . (cdc.gov)

Proteins were validated with targeted proteomics using parallel reaction monitoring (PRM) in a validation set consisting of samples from the above patients. (frontiersin.org)
La présente analyse récapitule les facteurs pathologiques majeurs liant l'obésité au diabète, en se concentrant sur les données épidémiologiques actuelles relatives aux patients diabétiques obèses dans le monde arabe, l'étiologie de la maladie et les déterminants génétiques du diabète et de l'obésité. (who.int)

Recommended Dietary Allowances (RDAs) are listed as retinol activity equivalents (RAE). (greatist.com)

Anatomy1

Diseases2

Chemicals and Drugs14

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes6

Information Science3

Health Care1

RBP47

Capable of binding1

Riboflavin carrier1

Retinoic acid5

Transthyretin15

Thyroxine1

Delivers retinol3

Retinyl2

Secretion3

Secretory proteins1

Belongs to the lipocalin1

Plasma6

Beta-carotene2

Assays4

Liver3

CRBP5

Concentrations1

Vitamin A alcohol1

Vitreous4

Tubular damage1

NAFLD1

Immunoassay1

Cellular2

Synthesis1

Deficiency2

Metabolism3

Retinoid1

Uterus1

Receptor1

Expression2

Inflammation1

Alterations1

Peripheral1

Urinary2

Antigen5

Nutritional1

Human2

Patients2

Activity1