• Retinoids regulate gene expression through binding to the nuclear retinoic acid receptors (RARs) and retinoid X receptors (RXRs). (nih.gov)
  • Our goal is to decipher the highly diverse functions of vitamin A, its active derivatives (retinoic acids), and the corresponding nuclear receptors (RARs/RXRs), in neural development, aging, and in stem cell control. (igbmc.fr)
  • Retinoids are classified by their common biological pathway, where the molecules themselves or their metabolites bind to a retinoid receptor: either retinoic acid receptors (RARs) or retinoid X receptors (RXRs), both of which have three subtypes: alpha, beta, and gamma. (skintherapyletter.com)
  • 2005). The Retinoid X Receptors (RXRs) family (RXR alpha, beta, and gamma), preferentially bind 9-cis -RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. (thermofisher.com)
  • 2000). PPARs form heterodimers with the Retinoid-X Receptors (RXRs). (bodybuilding.com)
  • Our results demonstrate the presence of PPARs alpha, beta/delta and gamma and of RXRs beta and gamma. (unich.it)
  • and retinoid-X receptors, RXRs). (minclinic.ru)
  • These findings suggest a convergence of the signaling pathways of some members of the nuclear receptor superfamily. (nih.gov)
  • Peroxisome Profilerator-Activated Receptors (PPARs) are nuclear hormone receptors that belong to the steroid/ thyroid /retinoid superfamily of receptors (Keller et al. (bodybuilding.com)
  • PPARs are ligand-activated transcription factors belonging to the steroid, thyroid and retinoid nuclear receptor superfamily. (unich.it)
  • Bone-growth regulatory factors that are members of the transforming growth factor-beta superfamily of proteins. (childrensmercy.org)
  • Transforming growth factor-beta superfamily in mouse embryonic stem cell self-renewal. (childrensmercy.org)
  • Retinoic acid induction of major histocompatibility complex class I genes in NTera-2 embryonal carcinoma cells involves induction of NF-kappa B (p50-p65) and retinoic acid receptor beta-retinoid X receptor beta heterodimers. (uchicago.edu)
  • We have purified and cloned a HeLa cell nuclear protein that strongly stimulates binding of retinoic acid and thyroid hormone receptors (RARs and TRs) to response elements. (nih.gov)
  • Three murine members of the RXR family (mRXR alpha, beta, and gamma) have also been cloned, and their interactions with RARs and TRs have been investigated. (nih.gov)
  • Comparative full transcriptome profile analysis of the hair bulb region of normal and miniaturized hair follicles from vertex and occipital region in males with and without androgenetic alopecia revealed that next to the androgen receptor as well the retinoid receptor and particularly the PPAR pathway is involved in progressive hair miniaturization. (nature.com)
  • Our results identify ROR beta as a retinoid-regulated nuclear receptor, providing a novel pathway for retinoid action. (nih.gov)
  • As an agonist of the retinoic-X receptor (RXR) pathway, Bxt notably increased the nuclear expression of the RXRα throughout transcriptionally active euchromatin domains. (frontiersin.org)
  • This receptor forms heterodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. (wikipedia.org)
  • We show also that unstable RAR-RXR heterodimers were formed in solution, and that C-terminal sequences and the DNA-binding domains of both receptors were required for efficient formation of stable heterodimers on response elements. (nih.gov)
  • Retinoid X receptor beta (RXR-beta), also known as NR2B2 (nuclear receptor subfamily 2, group B, member 2) is a nuclear receptor that in humans is encoded by the RXRB gene. (wikipedia.org)
  • Recombinant full length protein corresponding to Human Retinoid X Receptor beta/RXRB. (abcam.com)
  • In addition, miRNA profiling shows enrichment of miRNA-targeted genes in retinoid receptors and PPARGC1α / PPARγ signaling, and antigen presentation pathways. (nature.com)
  • Biochemical analyses have also identified some pathways potentially involved in ALS pathogenesis, including retinoid pathways. (frontiersin.org)
  • Cross-referencing of these motifs with pathways showing transcriptional changes revealed known regulatory pathways of distal alveolar differentiation, such as the WNT and transforming growth factor beta (TGFB) pathways, and putative novel regulators of adult AEC differentiation including hepatocyte nuclear factor 4 alpha (HNF4A), and the retinoid X receptor (RXR) signaling pathways. (huji.ac.il)
  • Leptin and adiponectin can augment the oxidation of fatty acid in liver by activating the nuclear receptor super-family of transcription factors, namely peroxisome proliferator-activated receptor (PPAR)-α. (wjgnet.com)
  • Bexarotene acts by stimulating retinoid X receptors (RXR), which control how much ApoE is produced. (case.edu)
  • Bexarotene (Bxt) is a retinoid-X receptor agonist used in the treatment of cutaneous lymphoma with a favorable safety profile whose effects have been recently investigated in other neurodegenerative diseases. (frontiersin.org)
  • [ 11 ] Loss of 2 of the retinoid receptors (RXR-beta and RXR-gamma) seems apparent in sebaceous carcinoma. (medscape.com)
  • In contrast, no ligands for the retinoic acid receptor-related orphan receptors beta and gamma (ROR beta and gamma) have been identified, yet structural data and structure-function analyses indicate that ROR beta is a ligand-regulated nuclear receptor. (nih.gov)
  • Trifarotene 50 μg/g cream is a fourth generation topical retinoid with retinoic acid receptor gamma selectivity. (skintherapyletter.com)
  • C29H33NO4) is a fourth generation retinoid with higher selectivity and agonist activity for RAR gamma (RARγ), the most abundant subtype in skin. (skintherapyletter.com)
  • Different isotypes of PPARs (alpha, beta/delta and gamma) have distinct physiological functions depending on their different ligand activation profiles and tissue distribution. (unich.it)
  • PPARalpha, beta/delta and gamma are differentially modulated during culture time suggesting that they may be involved in neuronal maturation. (unich.it)
  • We also investigate the therapeutic potential of specific retinoids in neurological and psychiatric diseases. (igbmc.fr)
  • To investigate the therapeutic potential of retinoids on hepatocellular carcinoma (HCC), the present study evaluates the apoptotic effect of a panel of natural and synthetic retinoids in three human HCC cell lines as well as explores the underlying mechanisms. (escholarship.org)
  • Many fatty acid cell signaling activities are mediated by peroxisome proliferator-activated receptors (PPARs). (unich.it)
  • We demonstrate the concurrent up-regulation of PPARGC1a in the epithelial compartment and androgen receptor in the dermal papilla of miniaturized hair. (nature.com)
  • 1986. Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor. . (cornell.edu)
  • Although PPARs have been described in neurons by in situ studies, the presence and possible modulation of these receptors during neuronal differentiation has not been explored yet. (unich.it)
  • Retinoid-induced suppression of squamous cell differentiation in human oral squamous cell carcinoma xenografts (line 1483) in athymic nude mice. (tamu.edu)
  • In vitro, retinoids decrease expression of differentiation markers in head and neck squamous carcinoma cells. (tamu.edu)
  • Retinoid treatment produced a marked suppression of the squamous cell differentiation of tumor cells manifest by decreased keratinization, loss of stratification, and accumulation of basal cells. (tamu.edu)
  • These studies demonstrate that retinoids do not universally decrease tumor growth but profoundly suppress squamous cell differentiation in vivo in this xenograft model. (tamu.edu)
  • When there is not enough Nio-A-Let to bind these receptors, natural cell differentiation and growth are interrupted. (minclinic.ru)
  • Retinoids exert this effect by their ability to diffuse through dermal cell membranes, then be converted to retinoic acid, which binds to specific nuclear receptors and modulates expression of the genes involved in cellular proliferation and differentiation. (skinsciencesoul.com)
  • The cancer chemopreventive retinoid N -(4 hydroxyphenyl)retinamide (4HPR) has already been shown to restrain prostate cancer growth in vitro and in vivo, though its mechanisms of action are only partially explained. (biomedcentral.com)
  • Vitamin A is made up of a family of compounds called the retinoids. (medscape.com)
  • The retinoid designation resulted from finding that vitamin A had the biologic activity of retinol, which was originally isolated from the retina. (medscape.com)
  • There are essentially 3 forms of vitamin A: retinols, beta carotenes, and carotenoids. (medscape.com)
  • Beta carotene, also known as provitamin A, is the plant source of retinol from which mammals make two-thirds of their vitamin A. Carotenoids, the largest group of the 3, contain multiple conjugated double bonds and exist in a free alcohol or in a fatty acyl-ester form. (medscape.com)
  • If you're not already using a retinoid vitamin A, know that it's revered for its anti-aging, glow-inducing, and acne-fighting prowess-and that's due to its profound ability to speed up your skin cell turnover processes, magically boost collagen production, and so much more holy grail-ishness within skin. (skinsciencesoul.com)
  • Retinoids are the umbrella term for any vitamin A derivative product. (skinsciencesoul.com)
  • Retinoid vitamin A derivatives can be classified in five core categories: retinyl esters, retinol, retinaldehyde, retinoic acid esters, and retinoic acid. (skinsciencesoul.com)
  • 1 Since tretinoin, subsequent generations of topical retinoids, determined by structural modifications, have sought to either increase efficacy, improve tolerability, or both. (skintherapyletter.com)
  • Screen drug effects on a specific receptor or full panels in agonist or antagonist mode. (indigobiosciences.com)
  • Using nondenaturing mass spectrometry and scintillation proximity assays we found that all-trans retinoic acid (ATRA) and several retinoids bind to the ROR beta ligand-binding domain (LBD). (nih.gov)
  • The serum and decidual IL-17, IL-23 and retinoid orphan receptor C (RORC) levels were also significantly higher in RPL patients. (biomedcentral.com)
  • The purified protein is a human retinoid X receptor beta (hRXR beta). (nih.gov)
  • Her Endocrinology research is multidisciplinary, incorporating elements of Beta, Beta protein, Wild type, Homeotic gene and In vivo. (research.com)
  • TREM2 deficiency has a restraining effect on amyloid pathology in a region-specific manner, lowering macrophage and neuroinflammatory activity (both of which are associated with formation of amyloid plaques and tangles ) in the hippocampus , olfactory bulb, and thalamus, but having no significant effect on the brainstem and cortex, nor on levels of amyloid precursor protein (the building block of amyloid beta). (brightfocus.org)
  • Gene expression of nuclear receptors was assessed by real-time PCR. (escholarship.org)
  • Gene expression analysis of nuclear receptors revealed that the basal and inducibility of retinoic acid receptor beta (RARbeta) expression positively correlate with the susceptibility of HCC cells to fenretinide treatment. (escholarship.org)
  • Our findings reveal that endogenous expression of retinoids receptor RARbeta gene determines the susceptibility of HCC cells to fenretinide-induced apoptosis. (escholarship.org)
  • The expression pattern of further relevant genes involved in retinoid metabolism was also evaluated. (mdpi.com)
  • It functions as an activator of gene expression by retinoid alpha-receptor transcription factor and ligand-dependent transcription factor. (medscape.com)
  • 2004. A liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein E expression, secretion and cholesterol homeostasis in astrocytes. . (cornell.edu)
  • REtinoic acid receptor-beta expression was also increased by 2.9-9.7-fold after chronic retinoid treatment. (tamu.edu)
  • The exact mechanism of fen-retinide-induced cell death is not fully understood, although it is reported to induce apoptosis indepen-dently of retinoic acid receptor expression [6-9], lacking the carboxyl group required for binding to these receptors [10]. (lsd1receptor.com)
  • Retinoic acid receptor beta expression and growth inhibition of gynecologic cancer cells by the synthetic retinoid N-(4-hydroxyphenyl) retinamide. (cellosaurus.org)
  • Our studies of specific retinoid receptors and bioactive metabolites in control of diverse biological processes should contribute to a better understanding of the mechanisms underlying development and function of specific cell types and relevant neural circuits. (igbmc.fr)
  • These retinoids did not decrease the rate of exponential tumor growth but increased the latent period until exponential growth began. (tamu.edu)
  • This process starts with the gentlest retinoid molecules known as retinol esters (or, alternatively, retinyl esters). (skinsciencesoul.com)
  • Arguably the most visible retinoid on the market, retinol is also naturally occurring in the body and is the most well-studied topical option. (skinsciencesoul.com)
  • However, higher concentrations of retinol can sometimes lead to increased irritation, the same problem encountered with, for example, prescription-strength Retin-A. The upside here is that if you experience irritation when using a high-concentration retinol product without known irritating preservatives (parabens or sodium benzoate), you are very likely reaping the benefits of retinoic acid being absorbed into the skin's cell receptors. (skinsciencesoul.com)
  • 2005). RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors (Lane and Bailey, 2005). (thermofisher.com)
  • 2008. Plasmin potentiates synaptic N-methyl-D-aspartate receptor function in hippocampal neurons through activation of protease-activated receptor-1. . (cornell.edu)
  • In 2008 Case Western Reserve researcher Gary Landreth, PhD, professor of neurosciences, discovered that the main cholesterol carrier in the brain, Apolipoprotein E (ApoE), facilitated the clearance of the amyloid beta proteins. (case.edu)
  • In recent years, there's been only limited headway with the "amyloid hypothesis," ie, the idea that increased levels of amyloid beta and tau amyloid proteins, on their own, are sufficient to tip the scales and cause otherwise benign plaques and tangles to turn lethal. (brightfocus.org)
  • The present view of the scientific community is that small soluble forms of amyloid beta cause the memory impairments seen in animal models and humans with the disease. (case.edu)
  • ATRA and related retinoids inhibit ROR beta but not ROR alpha transcriptional activity suggesting that high-affinity, subtype-specific ligands could be designed for the identification of ROR beta target genes. (nih.gov)
  • Her primary areas of investigation include Internal medicine, Endocrinology, Cell biology, Receptor and Immunology. (research.com)
  • Little information is available on effects of retinoids on head and neck squamous carcinoma cell xenograft growth in vivo. (tamu.edu)
  • Topical retinoids serve as cornerstone therapy for acne with efficacy demonstrated across the spectrum of acne severity. (skintherapyletter.com)
  • Retinoids are commonly used in skincare products due to their effectiveness in anti-aging and acne treatment. (skinsciencesoul.com)
  • Alzheimer's disease arises in large part from the body's inability to clear naturally-occurring amyloid beta from the brain. (case.edu)
  • The elevation of brain ApoE levels, in turn, speeds the clearance of amyloid beta from the brain. (case.edu)
  • This observation demonstrated that the drug addresses the amount of both soluble and deposited forms of amyloid beta within the brain and reverses the pathological features of the disease in mice. (case.edu)
  • Amyloid beta-Peptides" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rush.edu)
  • This graph shows the total number of publications written about "Amyloid beta-Peptides" by people in this website by year, and whether "Amyloid beta-Peptides" was a major or minor topic of these publications. (rush.edu)
  • Below are the most recent publications written about "Amyloid beta-Peptides" by people in Profiles. (rush.edu)
  • TREM2 is selectively increased by myeloid cells surrounding amyloid-beta deposits. (brightfocus.org)
  • Tregs secrete interleukin-10 (IL-10), transforming growth factor beta (TGF-β) and IL-35 as anti-inflammatory cytokines. (biomedcentral.com)
  • Lamb's lab, and others, have investigated a genetic variant of an inflammatory factor known as triggering receptor expressed on myeloid cells 2, or TREM2. (brightfocus.org)
  • Toll-like diseases and causes severe and long-lasting health problems in the case of chronifi- receptor. (cdc.gov)
  • We are also testing known and newly characterized retinoids for treatment of such brain disorders in relevant animal models. (igbmc.fr)
  • Fenretinide-induced apoptosis of Huh-7 hepatocellular carcinoma is retinoic acid receptor beta dependent. (escholarship.org)
  • Heyman, RA Synthesis of high specific activity [3H]-9-cis-retinoic acid and its application for identifying retinoids with unusual binding properties. (bindingdb.org)
  • Her studies deal with areas such as Retinoid, Nuclear receptor, Retinoid X receptor, Adipocyte and Signal transduction as well as Receptor. (research.com)