• histone deacetylase
  • The Rb-E2F/DP complex also attracts a histone deacetylase (HDAC) protein to the chromatin, reducing transcription of S phase promoting factors, further suppressing DNA synthesis. (wikipedia.org)
  • Histone deacetylase inhibitors exert their anti-tumour effects via the induction of expression changes of oncogenes or tumour suppressor, through modulating that the acetylation/deactylation of histones and/or non-histone proteins such as transcription factors. (wikipedia.org)
  • The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. (wikipedia.org)
  • genes
  • The proteins encoded by two groups of conserved genes, the Polycomb and trithorax groups, have been proposed to maintain, at the level of chromatin structure, the expression pattern of homeotic genes during Drosophila development. (genetics.org)
  • The proteins encoded by the Polycomb group are postulated to prevent transcription of homeotic genes outside of their normal expression domain and the proteins encoded by the trithorax group are postulated to allow transcription of homeotic genes within their normal expression domain. (genetics.org)
  • complexes
  • Working as a post-doctoral fellow in the laboratory of Dr. Ed Harlow, Dyson demonstrated that the retinoblastoma protein can form complexes in vitro with the E7 oncoprotein of Human papilloma virus type-16. (wikipedia.org)
  • It is present in protein complexes involved in histone acetylation and chromatin assembly. (wikipedia.org)
  • This encoded protein is also part of corepressor complexes, which is an integral component of transcriptional silencing. (wikipedia.org)
  • Molecular
  • In this study we investigated the direct consequences of Rb protein knockout in the Arabidopsis male germline using cytological and molecular markers. (le.ac.uk)
  • cyclin-depend
  • A cyclin-dependent kinase complex (CDKC, cyclin-CDK) is a protein complex formed by the association of an inactive catalytic subunit of a protein kinase, cyclin-dependent kinase (CDK), with a regulatory subunit, cyclin. (wikipedia.org)
  • The Cyclin D/Cdk4 complex is a multi-protein structure consisting of the proteins Cyclin D and cyclin-dependent kinase 4, or Cdk4, a serine-threonine kinase. (wikipedia.org)
  • Retinal
  • PURPOSE: This study was designed to determine whether the Y79 retinoblastoma cell line, a prototype for retinoblastoma cells, exhibits differential adhesive properties toward extracellular matrix (ECM)/basement membrane (BM) proteins compared to normal human retinal (NHR) cells. (arvojournals.org)
  • phosphorylate
  • CDKCs Associated with Cell Cycle Phases in Mammalian Cells During late G1 phase, CDKCs bind and phosphorylate members of the retinoblastoma (Rb) protein family. (wikipedia.org)
  • These receptor tyrosine kinases in turn phosphorylate and activate many other proteins, including Fos/Jun/Myc and phosphatidylinositol 3 kinase (PI-3-K). Fos/Jun/Myc helps to activate the Cyclin D/Cdk4 complex. (wikipedia.org)
  • cell
  • The retinoblastoma protein (pRb) phosphoprotein is a key player in the regulation of cell growth and proliferation. (aacrjournals.org)
  • Retinoblastoma (RB) protein expression was examined in paraffin and frozen tissue sections of 36 primary non-small cell lung carcinomas (NSCLC) using immunohistochemistry with confirmation by direct Western blotting. (aacrjournals.org)
  • The Retinoblastoma (Rb) protein is a conserved repressor of cell proliferation. (le.ac.uk)
  • We observed that the loss of Rb protein does not have a major impact on microspore division but causes limited hyperproliferation of the vegetative cell and, to a lesser degree, of the sperm cells. (le.ac.uk)
  • Our results indicate that hyperproliferation caused by the loss of Rb protein prevents or delays cell determination during plant male gametogenesis, providing further evidence for a direct link between fate determination and cell proliferation. (le.ac.uk)
  • Retinoblastoma protein function and p16(INK4a) expression in actinic keratosis, squamous cell carcinoma in situ and invasive squamous cell carcinoma of the skin and links between p16(INK4a) expression and infiltrative behavior. (lu.se)
  • The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. (wikipedia.org)
  • It s found in all cells of the body and acts as a brake on the cell division cycle by preventing certain regulatory proteins from triggering DNA replication. (webclearinghouse.net)
  • Members of the Rb protein family are tumor suppressors, which prevent uncontrolled cell proliferation that would occur during tumor formation. (wikipedia.org)
  • The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. (wikipedia.org)
  • Cyclin D1 is a protein required for progression through the G1 phase of the cell cycle. (wikipedia.org)
  • histones
  • Histones are highly alkaline proteins that package and order DNA into structural units called nucleosomes, which comprise the major protein component of chromatin. (wikipedia.org)