• cells
  • To characterize the molecular sequelae induced in retinoblastoma (Rb) cells by histone deacetylase inhibitors (HDACIs). (arvojournals.org)
  • Pigment epithelium-derived factor (PEDF) has binding affinity for cell-surface receptors in retinoblastoma cells and for glycosaminoglycans. (biomedcentral.com)
  • 125 I-PEDF formed complexes with protease-resistant components of medium conditioned by human retinoblastoma Y-79 cells. (biomedcentral.com)
  • These data indicate that retinoblastoma cells secrete heparin/heparan sulfate with binding affinity for PEDF, which may be important in efficient cell-surface receptor binding. (biomedcentral.com)
  • Given that binding to cell-surface receptors is the first step in the biological activity of PEDF, we used human retinoblastoma Y-79 cells and their conditioned media (CM) as sources of functional PEDF receptors and extracellular matrix components, respectively, to examine the GAG content in CM and their effects on PEDF ligand-receptor interactions. (biomedcentral.com)