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  • nucleic acid
  • Isolated nucleic acid molecules are disclosed, comprising an alphavirus nonstructural protein gene which, when operably incorporated into a recombinant alphavirus.Thomas Simonson's Research Group. (1004682.gq)
  • The maintenance of the Mg(2+) balance of the body is essential for neuromuscular excitability, protein synthesis, nucleic acid stability, and numerous enzymatic systems. (ru.nl)
  • kinase
  • Moreover, activation of protein kinase C by phorbol 12-myristate 13-acetate-PMA potentiated the inhibitory effect of REA on TRPM6 channel activity. (ru.nl)
  • Phosphorylation of Thr at position 148 is detected in response to various stress conditions such as UV irradiation, oxidative stress, and anisomycin treatment or JDP2 is also regulated by other kinases such as p38 MAPK and doublecortin like protein kinase. (wikipedia.org)
  • promoter
  • 4 Membrane Protein Production in Escherichia coli: Overview and Protocols 91 promoter, which is weakly sensitive to cAMP regulation, associated with a lacO-.La tétracycline se fixe sur la petite sous-unité du ribosome au niveau d'un site proche de la localisation de l'ARNm.Recombinant protein production in eukaryotic systems. (1004682.gq)
  • Mouse p53 protein negatively regulates the JDP2 promoter in F9 cells as part of the JDP2˗p53 autoregulatory circuit. (wikipedia.org)
  • The core promoter marks the start site for transcription by binding RNA polymerase and other proteins necessary for copying DNA to RNA. (wikipedia.org)
  • For example, some repressor proteins can bind to the core promoter to prevent polymerase binding. (wikipedia.org)
  • The core promoter of prokaryotic genes, conversely, is sufficient for strong expression and is regulated by repressors. (wikipedia.org)
  • Amino Acids
  • The protein JDP2 has 163 amino acids, belongs to the family of basic leucine zipper (bZIP), and shows high homology with the ATF3 bZIP domain. (wikipedia.org)
  • Δ324 found at low levels in human and mouse cells - an alternative splice variant encoding an 88kDa protein lacking zinc fingers 6 and 7 Δ105 variant is unique to mice, and results in a protein truncated by 105 amino acids at the acidic C-terminus. (wikipedia.org)
  • isoforms
  • Two transcript variants encoding different isoforms have been found for this gene, and a brefeldin A-sensitive association of RII-alpha protein with one of the isoforms has been demonstrated in the Golgi apparatus. (wikipedia.org)
  • A large number of transcript variations exist, encoding different isoforms or chimeric proteins. (wikipedia.org)
  • KorB
  • Cooperativity between KorB and either KorA or TrbA repressor proteins is a key element of these circuits and deletion analysis has implicated the conserved C-terminal domain of KorAand TrbAin this interaction. (bham.ac.uk)
  • Studies on mutants showed that tyrosine 84 (or phenylalanine, in some alleles) is dispensable for repressor activity but critical for the specific interaction with KorB in both in vivo reporter gene assays and in vitro electrophoretic mobility shift and co-purification assays. (bham.ac.uk)
  • Regulation
  • Regulation of the epithelial Mg2+ channel TRPM6 by estrogen and the associated repressor protein of estrogen receptor activity (REA). (ru.nl)
  • SAP30 proteins provide the first example in which the DNA and PIs seem to stand in a mutually antagonizing interrelationship in regard to their interaction with zinc finger proteins and thus exemplifies the molecular mechanism how these lipids can contribute for gene regulation. (wikipedia.org)
  • An additional layer of regulation occurs for protein coding genes after the mRNA has been processed to prepare it for translation to protein. (wikipedia.org)
  • interaction
  • The esc protein consists primarily of multiple copies of the WD repeat, a motif that has been implicated in protein-protein interaction. (semanticscholar.org)
  • Finally, we showed that the interaction between REA and TRPM6 is a dynamic process, as short-term 17beta-estradiol treatment disassociates the binding between these proteins. (ru.nl)
  • This study aims to study the significance of the FIR-SAP155 interaction for the coordination of c-myc transcription, pre-mRNA splicing, and c-Myc protein modification, as well as to interrogate FIRΔexon2 for other functions relating to altered FIR pre-mRNA splicing. (aacrjournals.org)
  • family
  • The Jun dimerization protein is a member of the AP-1 family of transcription factors. (wikipedia.org)
  • TGF-β, along with other TGF-β family ligands such as bone morphogenic protein (BMP) and activin are involved in regulating important cellular functions such as proliferation, differentiation, apoptosis, and matrix production. (wikipedia.org)
  • SAP30 and SAP30L together constitute a well-conserved SAP30 protein family. (wikipedia.org)
  • Proteins of the SAP30 family (SAP30 proteins) have a functional nucleolar localization signal and they are able to target Sin3A to the nucleolus. (wikipedia.org)
  • As of December 2004, this family of proteins has about 2,353 members that are transcriptional regulators. (wikipedia.org)
  • In the majority of the family members, this motif is on the N-terminal end of the protein and is highly conserved. (wikipedia.org)
  • UniProt
  • p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later. (uniprot.org)
  • Genes
  • miRNAs are an abundant class of tiny RNAs that are often found to be conserved evolutionarily across species boundaries and are capable of regulating the expression of protein-coding genes in multicellular eukaryotes ( Bartel, 2004 ). (plantcell.org)
  • At this point, β-catenin becomes a coactivator for TCF and LEF to activate Wnt genes by displacing Groucho and HDAC transcription repressors. (wikipedia.org)
  • More than twenty distinct IFN genes and proteins have been identified in animals, including humans. (wikipedia.org)
  • Another cellular enzyme, RNAse L-also induced by interferon action-destroys RNA within the cells to further reduce protein synthesis of both viral and host genes. (wikipedia.org)
  • In addition, interferons induce production of hundreds of other proteins-known collectively as interferon-stimulated genes (ISGs)-that have roles in combating viruses and other actions produced by interferon. (wikipedia.org)
  • In response, these receptors work with other proteins to regulate the expression of specific genes, thereby controlling the development, homeostasis, and metabolism of the organism. (wikipedia.org)
  • Cux1 DNA binding is stimulated by activation of the PAR2/F2RL1 cell-surface G-protein-coupled receptor in fibroblasts and breast-cancer epithelial cells to regulate Matrix metalloproteinase 10, Interleukin1-alpha, and Cyclo-oxygenase 2 (COX2) genes. (wikipedia.org)
  • Human genes encoded teneurin domain proteins (TENM1-4) are list in the infoboxes. (wikipedia.org)
  • kinase
  • After Fas stimulation, Daxx is activated and plays its role of pro-apoptotic protein in activating the c-JUN-N-Terminal Kinase (JNK) pathway. (wikipedia.org)
  • In response to interferon, cells produce large amounts of an enzyme known as protein kinase R (PKR). (wikipedia.org)
  • p16 (also known as cyclin-dependent kinase inhibitor 2A, multiple tumor suppressor 1 and as several other synonyms), is a tumor suppressor protein, that in humans is encoded by the CDKN2A gene. (wikipedia.org)
  • Researchers from the Wellcome Trust Sanger Institute reported that the mutation of CUX1 reduces the inhibitory effects of a biological inhibitor, PIK3IP1 (phosphoinositide-3-kinase interacting protein 1), resulted in higher activity of the growth promoting enzyme, phosphoinositide 3-kinase (PI3K) which leads to tumor progression. (wikipedia.org)
  • Mitogen-activated protein kinase kinase kinase 7-interacting protein 2 is an enzyme that in humans is encoded by the MAP3K7IP2 gene. (wikipedia.org)
  • This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. (wikipedia.org)
  • class of proteins
  • IFNs belong to the large class of proteins known as cytokines, molecules used for communication between cells to trigger the protective defenses of the immune system that help eradicate pathogens. (wikipedia.org)
  • In the field of molecular biology, nuclear receptors are a class of proteins found within cells that are responsible for sensing steroid and thyroid hormones and certain other molecules. (wikipedia.org)
  • regulate
  • This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKL through the activation of the receptor activator of NF-kappB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. (wikipedia.org)
  • highly conserved
  • Their distinct protein domain architecture is highly conserved between invertebrate and vertebrate teneurins, particularly in the extracellular part. (wikipedia.org)
  • receptor
  • Engineering Deceit with the Clouds: The H3 receptor site is an inducible metabolic promoter for orthogonal drug delivery and prokariotic gene regulation using Lactose derived repressors: An hypothesis. (openwetware.org)
  • First of all, by binding to cadherin receptor intracellular cytoplasmic tail domains, it can act as an integral component of a protein complex in adherens junctions that helps cells maintain epithelial layers. (wikipedia.org)
  • Daxx, a Death domain-associated protein, was first discovered through its cytoplasmic interaction with the classical death receptor Fas. (wikipedia.org)
  • nucleus
  • This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. (wikipedia.org)
  • The activated GR complex up-regulates the expression of anti-inflammatory proteins in the nucleus or represses the expression of pro-inflammatory proteins in the cytosol (by preventing the translocation of other transcription factors from the cytosol into the nucleus). (wikipedia.org)
  • specificity
  • These results indicate that SNARE proteins contribute to the overall specificity of membrane trafficking in vivo, and that the polarity of syntaxin 3 is essential for epithelial cell polarization. (rupress.org)
  • distinct
  • At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4. (wikipedia.org)
  • Receptors
  • The four histamine receptors that have been discovered in humans are designated H1 through H4, and are all '''G Protein-Coupled Receptors''' (GPCR). (openwetware.org)
  • encode
  • Some exons of this gene overlap with some exons from the C21orf41 gene, which is transcribed in an opposite orientation to this gene but does not seem to encode a protein. (wikipedia.org)
  • Recombinant
  • An increase in copy number is useful for genetic engineering applications to increase the production yield of recombinant protein. (wikipedia.org)
  • cell
  • Short coding motifs, which appear to lack secondary structure, include those that label proteins for delivery to particular parts of a cell, or mark them for phosphorylation. (wikipedia.org)
  • the phosphorylated eIF-2 forms an inactive complex with another protein, called eIF2B, to reduce protein synthesis within the cell. (wikipedia.org)
  • A promoter is induced in response to changes in abundance or conformation of regulatory proteins in a cell, which enable activating transcription factors to recruit RNA polymerase. (wikipedia.org)
  • affinity
  • For example, many DNA binding proteins that have affinity for specific DNA binding sites bind DNA in only its double-helical form. (wikipedia.org)
  • repression
  • Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. (wikipedia.org)
  • Regulation of p16 is complex and involves the interaction of several transcription factors, as well as several proteins involved in epigenetic modification through methylation and repression of the promoter region. (wikipedia.org)
  • regulatory
  • Whereas the roles of proteins as regulatory factors in development and adaptation to the environment are well known, the involvement of regulatory small RNA molecules is just emerging ( Carrington and Ambros, 2003 ). (plantcell.org)
  • expression
  • Expression of mislocalized mutant syntaxin 3 in Madin-Darby canine kidney cells leads to basolateral mistargeting of apical membrane proteins, disturbance of tight junction formation, and loss of ability to form an organized polarized epithelium. (rupress.org)
  • 290. Mitra S., Ghantasala S., Sameer Kumar GS, Lakshmi BJ, Thakur SS, Kumar S. Absence of Wdr13 gene predisposes mice to mild social isolation - chronic stress, leading to depression-like phenotype associated with differential expression of synaptic proteins. (gov.pl)
  • Daxx is uniformly expressed throughout the body, except in the testes and thymus, which have especially high expression of the protein. (wikipedia.org)
  • The name refers to "ten-a" (from "tenascin-like protein, accessory") and "neurons", the primary site of teneurin expression. (wikipedia.org)
  • Regulation
  • Deposition of matricellular proteins modulates growth factor signaling and contributes to the spatial and temporal regulation of the reparative response. (jci.org)
  • In this case, it is a one-gene issue with a mutation that switches one amino acid for another at a specific position in a protein regulation formulation of those seed shells. (farmindustrynews.com)
  • Phosphorylation
  • The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. (wikipedia.org)
  • computational
  • In this study, we developed and applied a novel method utilizing biochemistry, quantitative proteomics and computational approaches in order to characterize the organization of proteins in a complex. (embopress.org)
  • complex
  • However, those approaches are insufficient to provide information about the spatial arrangement and the interrelationship of the proteins of the respective complex. (embopress.org)
  • The key of our method is the systematic purification of several tagged components of the protein complex in multiple genetic deletion strains, which serve to compromise the integrity of the complex. (embopress.org)
  • intracellular
  • The intracellular domains of Ten-a, Ten-m/Odz and C. elegans Ten-1 are significantly different, both in size and structure, from the comparable domains of vertebrate teneurins, but the extracellular domains of all of these proteins are remarkably similar. (wikipedia.org)
  • There is considerable divergence between intracellular domains of invertebrate and vertebrate teneurins as well as between different invertebrate proteins. (wikipedia.org)