• proteins
  • HCV core protein is among the most conserved proteins in HCV and is known to induce sensitization of cytotoxic T lymphocytes (CTL). (abcam.com)
  • SIRT1 depletion caused significant down-regulation of heat shock factor 1 (HSF1)/heat shock proteins (Hsps) as well as these CSC-related molecules, which led to the sensitization of CD44 high K562 cells to Hsp90 inhibitor by SIRT1 inhibitor. (ijbs.com)
  • target
  • Restoring SRF activity antagonizes Myc repression of SRF target genes, attenuates Myc‐induced apoptosis, and reverts a Myc‐dependent decrease in Akt phosphorylation and activity, a well‐characterized suppressor of Myc‐induced apoptosis. (embopress.org)
  • The level of HSP70 is also a target for post-transcriptional repression by MiR-1. (wikipedia.org)
  • expression
  • ΔFosB expression in D1-type nucleus accumbens medium spiny neurons directly and positively regulates drug self-administration and reward sensitization through positive reinforcement while decreasing sensitivity to aversion. (wikipedia.org)
  • ΔFosB is the most significant biomolecular mechanism in addiction because the overexpression of ΔFosB in the D1-type medium spiny neurons in the nucleus accumbens is necessary and sufficient for many of the neural adaptations and behavioral effects (e.g., expression-dependent increases in drug self-administration and reward sensitization) seen in drug addiction. (wikipedia.org)
  • Effects
  • Home / Test Division / Reference Database / 1970 to 1979 / 1971 / Effects of differential anxiety level and the repression-sensitization dimension in. (umn.edu)
  • Research on the interaction between natural and drug rewards suggests that dopaminergic psychostimulants (e.g., amphetamine) and sexual behavior act on similar biomolecular mechanisms to induce ΔFosB in the nucleus accumbens and possess bidirectional reward cross-sensitization effects that are mediated through ΔFosB. (wikipedia.org)