• Exons
  • Within the coding sequences of eukaryotes, alternatively spliced exons are known to evolve under relaxed constraints in comparison to those exons that are constitutively spliced because they are not included in all of the mature mRNA of a gene. (ox.ac.uk)
  • There were no other predicted exons within the genomic CXorf26 sequence when 3000 base pairs were added on either side in the search. (wikipedia.org)
  • Except for the signal NH2-terminal peptide, which is absent in the mature enzyme, the amino acid sequence deduced from the exons coincided with the reported primary structure of human liver ALDH2. (wikipedia.org)
  • regions
  • Secondary Structure Adopted by the Gly-Gly-X Repetitive Regions of Dra" by Geoffrey M Gray, Arjan van der Vaart et al. (usf.edu)
  • Low complexity and homopolymer sequences within coding regions are known to evolve rapidly. (ox.ac.uk)
  • Homopolymer sequences are thought to evolve mostly through replication slippage and, therefore, they may be expected to be longer in regions with relaxed selective constraint. (ox.ac.uk)
  • Repetitive structure with high intergenic and intragenic sequence conservation, both in coding and noncoding regions. (wikipedia.org)
  • Apart from the "leucine zipper" and the "basic region" which are important for dimerization and DNA-binding, the c-jun protein contains three short regions, which consist of clusters of negatively charged amino acids in its N-terminal half that are important for transcriptional activation in vivo. (wikipedia.org)
  • specificity
  • To investigate the importance of tryptophan at position 232 (W232) in AvrBs3 and to identify amino acids that broaden or change target specificity for N0 we generated avrBs3 mutant derivatives. (nih.gov)
  • Notably, slight changes in the RVD and the incorporation of "nonconventional" RVD sequences can improve targeting specificity. (wikipedia.org)
  • From these libraries, biochemists can select DARPins to bind the target of choice with picomolar affinity and specificity can be selected using ribosome display or phage display using signal sequences allowing cotranslational secretion. (wikipedia.org)
  • gene
  • Very low percentages of sequence coverage and identity of the gene's orthologs in fungi and invertebrates suggest that the gene was lost in those organisms. (wikipedia.org)
  • In this case, artificial gene synthesis is problematic because of improper annealing of the repetitive sequence found in the TALE binding domain. (wikipedia.org)
  • domain
  • The coiled-coil domain (amino acids 241-303) was identified as described (Lupas et al. (nih.gov)
  • and a transcriptional repression domain (TRD) composed of 104 amino acids The MBD domain forms a wedge and attaches to the methylated CpG sites on the DNA strands. (wikipedia.org)
  • Whenever a linear solenoid domain structure participates in protein-protein interactions, frequently at least 3 or more repetitive subunits form the ligand-binding sites. (wikipedia.org)
  • genes
  • We observed a significant relationship between alternative splicing and homopolymer sequences with alternatively spliced genes being enriched in number and length of homopolymer sequences. (ox.ac.uk)
  • fishes
  • When introduced to higher levels of acids, they are able to excrete excess acids at higher rates than most other saltwater fishes, and in much shorter times, with the majority of the transfer of ions occurring at the gill surface. (wikipedia.org)
  • domains
  • The non-repetitive N- and C-terminal domains at opposite ends are thought to regulate conversion to silk. (innovations-report.com)
  • This straightforward relationship between amino acid sequence and DNA recognition has allowed for the engineering of specific DNA-binding domains by selecting a combination of repeat segments containing the appropriate RVDs. (wikipedia.org)
  • family
  • This region is closely related to the fork head family, at the amino acid level. (wikipedia.org)
  • Mitochondrial aldehyde dehydrogenase belongs to the aldehyde dehydrogenase family of enzymes that catalyze the chemical transformation from acetaldehyde to acetic acid. (wikipedia.org)
  • important
  • Sericin has a high hydroxy amino acid content which is important for the water-binding capacity which regulates the skin's moisture content. (wikipedia.org)
  • form
  • This splice form has significantly fewer mRNA base pairs at 977, but still has a protein product of 232 amino acids. (wikipedia.org)
  • Due to the amino acid sequence and the periodicity of the helices, the leucine side chains are arranged along one face of the α helix and form a hydrophobic surface that modulates dimerization. (wikipedia.org)
  • either
  • Non-homologous end joining (NHEJ) directly ligates DNA from either side of a double-strand break where there is very little or no sequence overlap for annealing. (wikipedia.org)
  • significant
  • Here, we show that maize pollen accumulated a significant pool of hydroxyproline (Hyp) and 63% of this amino acid was localized in the pollen tube wall. (scielo.br)