• acute kidney
  • Patients undergoing long-lasting, abdominal, and urogenital surgeries with risk factors such as advanced age, peripheral artery disease, diabetes mellitus, renovascular disease, and congestive heart failure are candidates for acute kidney injury (AKI) due to impaired renal perfusion and decreased functional renal reserve. (dovepress.com)
  • Stimulation of vagal afferents or efferents in mice 24 hours before IRI markedly attenuated acute kidney injury (AKI) and decreased plasma TNF. (jci.org)
  • IR injury contributes to disease and mortality in a variety of pathologies, including myocardial infarction, ischemic stroke, acute kidney injury, trauma, circulatory arrest, sickle cell disease and sleep apnea. (wikipedia.org)
  • Serum creatinine and BUN may be elevated in the setting of Acute Kidney Injury. (wikipedia.org)
  • Organs involved in filtration (e.g., the kidneys and the liver), may be overwhelmed by the high load of cellular break down products, and face injury themselves (e.g., acute kidney injury). (wikipedia.org)
  • myocardium
  • As opposed to reducing the exposure of cardiomyocytes to injurious stimuli, apoptosis of these cells is attenuated through modulation of the caspase-related proapoptotic process, and this may allow ischemic myocardium to survive even after receiving significant injury. (ahajournals.org)
  • After MI, the myocardium suffers from reperfusion injury which leads to death of cardiomyocytes and detrimental remodelling of the heart, consequently reducing proper cardiac function. (wikipedia.org)
  • organ
  • The modified annexin decreases the binding of leukocytes and platelets during post-ischemic reperfusion, thereby restoring microvascular blood flow and decreasing organ damage. (google.com)
  • One of the most important factors in the pathophysiology of liver dysfunction after hepatic surgery is the cellular damage derived from the interruption of blood flood with reperfusion of the organ. (clinicaltrials.gov)
  • Remote ischemic conditioning (RIC) is an experimental medical procedure that aims to reduce the severity of ischaemic injury to an organ such as the heart or the brain, most commonly in the situation of a heart attack or a stroke, or during procedures such as heart surgery when the heart may temporary suffer ischaemia during the operation. (wikipedia.org)
  • apoptotic
  • The results of this study indicate that the occurrence of inflammation and the subsequent cell death by apoptosis are the most important changes in the early stage of hepatic reperfusion injury and the presence of apoptotic bodies were augmented as the time of reperfusion was increased. (medindia.net)
  • 1 Therefore, it might be hypothesized that this type of injury could be attenuated if a portion of the injured myocardial cells could be rescued from an apoptotic death. (ahajournals.org)
  • These results provide a basic molecular framework for understanding one apoptotic pathway that is induced by reperfusion (Figure 1 ⇓ ), but multiple questions remain to be answered by future studies: (1) Which ROS (superoxide, hydrogen peroxide, hydroxyl radical, peroxynitrite, or others) generated by reperfusion are responsible for the induction of neutral sphingomyelinase activity? (ahajournals.org)
  • intravenous
  • The Phase II clinical trial of FX06 (F.I.R.E. study) was completed in March 2008, with data indicating a statistically significant reduction in myocardial necrosis following intravenous application of FX06 concurrent with reperfusion. (innovations-report.com)
  • We aimed to investigate the protective effects of an intravenous anesthetic remifentanil in renal I/R injury in the rat in comparison with dex. (dovepress.com)
  • inflammation
  • However, during reperfusion not only some changes including bleb formation was reduced, but some other alterations including portal hepatitis, inflammation and the induction of apoptosis, were occurred. (medindia.net)
  • 6 This protocol fits the most often reported time course of I/R injury (ie, an immediate challenge by overwhelming inflammation). (ahajournals.org)
  • The nervous and immune systems interact in complex ways to maintain homeostasis and respond to stress or injury, and rapid nerve conduction can provide instantaneous input for modulating inflammation. (jci.org)
  • Continuous pressure limits blood supply and causes ischemia, and the inflammation occurs during reperfusion. (wikipedia.org)
  • Dysregulation of succinate synthesis, and therefore ATP synthesis, happens in some genetic mitochondrial diseases, such as Leighs disease, and Melas disease, and degradation can lead to pathological conditions, such as malignant transformation, inflammation and tissue injury. (wikipedia.org)
  • cardiac
  • FX06 was administered intravenously to patients during reperfusion treatment, and the effect on heart muscle preservation was then assessed using the most advanced imaging technology: cardiac magnetic resonance imaging (CMR). (innovations-report.com)
  • The results reported by Hernandez et al 3 in this issue of Circulation Research are in agreement with a previous study linking both oxygen/glucose deprivation in cardiac myocytes and ischemia/reperfusion in the intact heart with increased ceramide production and apoptosis. (ahajournals.org)
  • Until the 1980s, the enzymes SGOT and LDH were used to assess cardiac injury. (wikipedia.org)
  • Now, the markers most widely used in detection of MI are MB subtype of the enzyme creatine kinase and cardiac troponins T and I as they are more specific for myocardial injury. (wikipedia.org)
  • Transfection with HGF plasmids in damaged cardiac tissue also promotes angiogenesis (increased capillary density compared to control subjects), as well as decreasing detrimental remodelling of the tissue at the site of injury (decreased fibrotic deposition). (wikipedia.org)
  • surgical
  • Blood samples were drawn from all animals to evaluate plasma neutrophil gelatinase-associated lipocalin (NGAL) at the beginning, 15 minutes after ischemia, 15 minutes after reperfusion, and 6 hours after the surgical procedure (T0, T1, T2, and T3, respectively). (dovepress.com)
  • The ischemia-reperfusion injury associated with surgical tourniquets is typically not clinically apparent when used for less than 2 hours. (wikipedia.org)
  • pathway
  • 7 In parallel, angiogenic growth factors such as vascular endothelial growth factor, signaling via the phosphatidylinositol 3 (PI3)-kinase-AKT pathway, counteract I/R injury as early as 24 hours after ischemia, 8 well before functional neovascularization would occur. (ahajournals.org)
  • treatment
  • Application of endothelial progenitor cells of various origins has been put forward as a novel therapeutic concept for treatment of I/R injury in animal models 2 and patients. (ahajournals.org)
  • hours
  • 7. The method of claim 4 , wherein the PS-binding agent is administered to the patient up to about 6 hours prior to reperfusion. (google.com)
  • cell death
  • However, the detailed mechanisms of cell death and the structural alterations induced during different stages of reperfusion injury i.e. the early stage, are not completely determined yet. (medindia.net)
  • cardiomyocytes
  • The increased production of HGF by transfected cardiomyocytes during injury has also shown to be a powerful chemo-attractant of adult mesenchymal stem cells via HGF/c-Met binding. (wikipedia.org)