• acute kidney
  • Patients undergoing long-lasting, abdominal, and urogenital surgeries with risk factors such as advanced age, peripheral artery disease, diabetes mellitus, renovascular disease, and congestive heart failure are candidates for acute kidney injury (AKI) due to impaired renal perfusion and decreased functional renal reserve. (dovepress.com)
  • Stimulation of vagal afferents or efferents in mice 24 hours before IRI markedly attenuated acute kidney injury (AKI) and decreased plasma TNF. (jci.org)
  • IR injury contributes to disease and mortality in a variety of pathologies, including myocardial infarction, ischemic stroke, acute kidney injury, trauma, circulatory arrest, sickle cell disease and sleep apnea. (wikipedia.org)
  • Serum creatinine and BUN may be elevated in the setting of Acute Kidney Injury. (wikipedia.org)
  • Organs involved in filtration (e.g., the kidneys and the liver), may be overwhelmed by the high load of cellular break down products, and face injury themselves (e.g., acute kidney injury). (wikipedia.org)
  • inflammation
  • We therefore hypothesize that administration of human AM/AMBP-1, even after reperfusion, improves cardiovascular function, attenuates organ injury and inflammation responses, and reduces mortality following gut I/R injury. (sbir.gov)
  • However, during reperfusion not only some changes including bleb formation was reduced, but some other alterations including portal hepatitis, inflammation and the induction of apoptosis, were occurred. (medindia.net)
  • The results of this study indicate that the occurrence of inflammation and the subsequent cell death by apoptosis are the most important changes in the early stage of hepatic reperfusion injury and the presence of apoptotic bodies were augmented as the time of reperfusion was increased. (medindia.net)
  • 6 This protocol fits the most often reported time course of I/R injury (ie, an immediate challenge by overwhelming inflammation). (ahajournals.org)
  • The nervous and immune systems interact in complex ways to maintain homeostasis and respond to stress or injury, and rapid nerve conduction can provide instantaneous input for modulating inflammation. (jci.org)
  • Continuous pressure limits blood supply and causes ischemia, and the inflammation occurs during reperfusion. (wikipedia.org)
  • PPIB localizes to the endoplasmic reticulum (ER) and participates in many biological processes, including mitochondrial metabolism, apoptosis, redox, and inflammation, as well as in related diseases and conditions, such as ischemic reperfusion injury, AIDS, and cancer. (wikipedia.org)
  • Dysregulation of succinate synthesis, and therefore ATP synthesis, happens in some genetic mitochondrial diseases, such as Leighs disease, and Melas disease, and degradation can lead to pathological conditions, such as malignant transformation, inflammation and tissue injury. (wikipedia.org)
  • organ
  • As such, the development of effective strategies for preventing and treating circulatory collapse and organ injury after gut I/R is critical for the improvement of patient outcome under such conditions. (sbir.gov)
  • In spite of major surgical advances, better organ preservation techniques, and the development of safer and more effective immunosuppressive approaches, lung transplantation continues to be complicated by ischaemia-reperfusion injury, which significantly impacts on short- and long-term outcomes 1 , 2 . (ersjournals.com)
  • Remote ischemic conditioning (RIC) is an experimental medical procedure that aims to reduce the severity of ischaemic injury to an organ such as the heart or the brain, most commonly in the situation of a heart attack or a stroke, or during procedures such as heart surgery when the heart may temporary suffer ischaemia during the operation. (wikipedia.org)
  • apoptotic
  • 1 Therefore, it might be hypothesized that this type of injury could be attenuated if a portion of the injured myocardial cells could be rescued from an apoptotic death. (ahajournals.org)
  • These results provide a basic molecular framework for understanding one apoptotic pathway that is induced by reperfusion (Figure 1 ⇓ ), but multiple questions remain to be answered by future studies: (1) Which ROS (superoxide, hydrogen peroxide, hydroxyl radical, peroxynitrite, or others) generated by reperfusion are responsible for the induction of neutral sphingomyelinase activity? (ahajournals.org)
  • intravenous
  • The Phase II clinical trial of FX06 (F.I.R.E. study) was completed in March 2008, with data indicating a statistically significant reduction in myocardial necrosis following intravenous application of FX06 concurrent with reperfusion. (innovations-report.com)
  • We aimed to investigate the protective effects of an intravenous anesthetic remifentanil in renal I/R injury in the rat in comparison with dex. (dovepress.com)
  • reduces
  • Although we have shown that administration of rat AM plus human AMBP-1 at the beginning of reperfusion is protective, it remains unknown whether a combination of human AM and human AMBP-1 is also beneficial and, if so, whether delayed administration of AM/AMBP-1 (which is more clinically relevant) reduces gut I/R-induced mortality. (sbir.gov)
  • Therapy
  • The 12 lead ECG is used to classify patients into one of three groups: those with ST segment elevation or new bundle branch block (suspicious for acute injury and a possible candidate for acute reperfusion therapy with thrombolytics or primary PCI), those with ST segment depression or T wave inversion (suspicious for ischemia), and those with a so-called non-diagnostic or normal ECG. (wikipedia.org)
  • surgical
  • Blood samples were drawn from all animals to evaluate plasma neutrophil gelatinase-associated lipocalin (NGAL) at the beginning, 15 minutes after ischemia, 15 minutes after reperfusion, and 6 hours after the surgical procedure (T0, T1, T2, and T3, respectively). (dovepress.com)
  • The ischemia-reperfusion injury associated with surgical tourniquets is typically not clinically apparent when used for less than 2 hours. (wikipedia.org)
  • stem cells
  • While some investigations suggest a possible beneficial effect of mesenchymal stem cells on heart and kidney reperfusion injury, to date, none have explored the role of stem cells in muscle tissue exposed to ischemia-reperfusion injury. (wikipedia.org)
  • Stem cells have been implicated in the regeneration of skeletal muscle after traumatic and blast injuries, and have been shown to hone to muscle damaged after exercise. (wikipedia.org)
  • The increased production of HGF by transfected cardiomyocytes during injury has also shown to be a powerful chemo-attractant of adult mesenchymal stem cells via HGF/c-Met binding. (wikipedia.org)
  • pathway
  • 7 In parallel, angiogenic growth factors such as vascular endothelial growth factor, signaling via the phosphatidylinositol 3 (PI3)-kinase-AKT pathway, counteract I/R injury as early as 24 hours after ischemia, 8 well before functional neovascularization would occur. (ahajournals.org)
  • mechanisms
  • However, the detailed mechanisms of cell death and the structural alterations induced during different stages of reperfusion injury i.e. the early stage, are not completely determined yet. (medindia.net)
  • protective
  • In addition, the protective effect of hypothermia on IR injury was investigated using a new method for in situ hypothermic perfusion (IHP). (uva.nl)
  • treatment
  • and 3) the pharmacokinetics of AM and AMBP-1 in normal animals and after gut I/R. Our ultimate goal (SBIR Phase II and beyond) is to obtain commercial utilization of human AM/AMBP-1 as a safe and effective treatment for patients with gut I/R injury. (sbir.gov)
  • Application of endothelial progenitor cells of various origins has been put forward as a novel therapeutic concept for treatment of I/R injury in animal models 2 and patients. (ahajournals.org)
  • reduce
  • Even though numerous modalities and substances have been studied to reduce gut ischemia/reperfusion (I/R)-induced mortality, none have been entirely successful. (sbir.gov)