• He said there has been renewed interest in looking at plasma renin activity, since some of the newer pharmacologic therapies, particularly the direct renin inhibitors, appear to work in part by reducing plasma renin activity. (medscape.com)
  • Currently, Verma said he doesn't envision plasma renin activity being used as a biomarker of cardiovascular risk , but these new data support ongoing studies of direct renin inhibitors, including their role outside of traditional heart-failure patients. (medscape.com)
  • Based on the available structural information concerning renin-substrate interactions, we synthesized inhibitors in which the peptide portion was replaced by lipophilic moieties that interact with the large hydrophobic S1/S3-binding pocket in renin. (rcsb.org)
  • The present study is aimed at assessing the effects of different antihypertensive drug combination regimens involving renin-angiotensin-aldosterone system (RAAS) inhibitors on CABP indices in Indian patients with hypertension. (hindawi.com)
  • Renin-angiotensin-aldosterone system (RAAS) inhibitors, calcium channel blockers (CCBs), diuretics, and β -blockers are the commonly recommended antihypertensive drugs. (hindawi.com)
  • The first generation of orally active renin inhibitors were never used clinically because of low bioavailability and weak blood-pressure-lowering activity. (nih.gov)
  • This Review summarises the development of oral renin inhibitors and their pharmacokinetic and pharmacodynamic properties, with a focus on aliskiren. (nih.gov)
  • Does Heterogeneity Exist in Treatment Associations with Renin-Angiotensin-System Inhibitors or Beta-blockers According to Phenotype Clusters in Heart Failure with Preserved Ejection Fraction? (physiciansweekly.com)
  • To explore the association between use of renin-angiotensin-system inhibitors (RASi) and beta-blockers, with mortality/morbidity in 5 previously identified clusters of patients with heart failure and preserved ejection fraction (HFpEF). (physiciansweekly.com)
  • The enormous success of ACE inhibitors in hypertension and heart failure spurred hope that adding a second drug to block the renin-angiotensin system would yield improved outcomes. (jwatch.org)
  • In type 1 diabetes (T1D), adjuvant treatment with inhibitors of the renin-angiotensin-aldosterone system (RAAS), which dilate the efferent arteriole, is associated with prevention of progressive albuminuria and renal dysfunction. (jci.org)
  • Angiotensin-converting enzyme inhibitor or angiotensin receptor blocker therapy (renin-angiotensin-aldosterone system [RAAS] inhibitor) to control proteinuria in primary and genetic focal segmental glomerulosclerosis (FSGS) follows guidelines based on other proteinuria-related kidney diseases. (nih.gov)
  • To determine the effects of renin inhibition on atherosclerosis, we administered the novel renin inhibitor aliskiren over a broad dose range to fat-fed LDL receptor-deficient (Ldlr-/-) mice. (jci.org)
  • The Crystal Structures of Recombinant Glycosylated Human Renin Alone and in Complex with a Transition State Analog Inhibitor. (rcsb.org)
  • At present, aliskiren is the first non-peptide orally active renin inhibitor to progress to phase-III clinical trials. (nih.gov)
  • It might become the first renin inhibitor with indications for the treatment of hypertension and cardiovascular and renal disorders. (nih.gov)
  • Direct renin inhibitor (DRI) has the theoretical benefit of upstream RAAS inhibition at the point of pathway activation. (elsevierpure.com)
  • The renin-aldolsterone link is mediated by angiotensin, so coadministration of an ACE inhibitor tends to reverse the potassium loss associated with these diuretics. (drugs.com)
  • METHODS: In 178 patients with persistent hypertension despite the use of at least two antihypertensives, plasma renin and aldosterone were assessed twice within an interval of 4 weeks. (eur.nl)
  • The beneficial effects of enalapril in hypertension and heart failure appear to result primarily from suppression of the renin-angiotensin-aldosterone system. (nih.gov)
  • While the mechanism through which enalapril maleate lowers blood pressure is believed to be primarily suppression of the renin-angiotensin-aldosterone system, enalapril maleate is antihypertensive even in patients with low-renin hypertension. (nih.gov)
  • Studying the causal roles of components of the renin-angiotensin-aldosterone system (including angiotensin-(1-7) (Ang-(1-7)), angiotensin-converting enzyme 2 (ACE2), Ang II, and ACE), uric acid, and klotho in pediatric hypertension and related target organ injury, including in the heart, kidneys, vasculature, and brain. (nih.gov)
  • While the principal mechanism of antihypertensive effect is thought to be through the renin-angiotensin-aldosterone system, quinapril exerts antihypertensive actions even in patients with low renin hypertension. (drugs.com)
  • Lead, hypertension, and the renin-angiotensin system in rats. (cdc.gov)
  • This is the most direct causal link between blood pressure and renin secretion (the other two methods operate via longer pathways). (wikipedia.org)
  • Human renin is secreted by at least 2 cellular pathways: a constitutive pathway for the secretion of the precursor prorenin and a regulated pathway for the secretion of mature renin. (wikipedia.org)
  • Renin secretion is also stimulated by sympathetic nervous stimulation, mainly through β1 adrenoreceptor activation. (wikipedia.org)
  • this is presumptive evidence for increased renin secretion. (nih.gov)
  • Removal of angiotensin II negative feedback on renin secretion leads to increased plasma renin activity. (nih.gov)
  • Indirectly, the diuretic action of hydrochlorothiazide reduces plasma volume, with consequent increases in plasma renin activity, increases in aldosterone secretion, increases in urinary potassium loss, and decreases in serum potassium. (drugs.com)
  • Renin (etymology and pronunciation), also known as an angiotensinogenase, is an aspartic protease protein and enzyme secreted by the kidneys that participates in the body's renin-angiotensin-aldosterone system (RAAS)-also known as the renin-angiotensin-aldosterone axis-that increases the volume of extracellular fluid (blood plasma, lymph and interstitial fluid) and causes arterial vasoconstriction. (wikipedia.org)
  • The renin-angiotensin-aldosterone system (RAAS) plays an important role in regulating blood volume and systemic vascular resistance, which together influence cardiac output and arterial pressure. (southtees.nhs.uk)
  • The renin-angiotensin-aldosterone system (RAAS) is a hormone system that plays a key role in regulating blood pressure and fluid balance in the body . (osmosis.org)
  • Renin-angiotensin-aldosterone system (RAAS) and sympathetic nervous system play crucial roles in heart failure with reduced ejection fraction (HFrEF). (elsevierpure.com)
  • Renin inhibition resulted in striking reductions of atherosclerotic lesion size in both the aortic arch and the root. (jci.org)
  • Therefore, although previous work suggests that angiotensin peptides have conflicting effects on atherogenesis, we found that renin inhibition profoundly decreased lesion development in mice. (jci.org)
  • Could renin inhibition be the next step forward in the treatment of diabetic kidney disease" Nature Clinical Practice Endocrinology & Metabolism Vol. 5 Iss. (bepress.com)
  • The idea of blocking the renin system at its origin by inhibition of renin has existed for more than 30 years. (nih.gov)
  • Renin inhibition suppresses the generation of the active peptide angiotensin II. (nih.gov)
  • The future of renin inhibition]. (nih.gov)
  • However, the results from clinical trials do not support upstream renin inhibition by DRI in addition to standard therapy with ACEI in patients with HFrEF. (elsevierpure.com)
  • Renin is not commonly referred to as a hormone, albeit it having a receptor, the (pro)renin receptor, also known as the renin receptor and prorenin receptor (see also below), as well as enzymatic activity with which it hydrolyzes angiotensinogen to angiotensin I. The primary structure of renin precursor consists of 406 amino acids with a pre- and a pro-segment carrying 20 and 46 amino acids, respectively. (wikipedia.org)
  • The (pro)renin receptor to which renin and prorenin bind is encoded by the gene ATP6ap2, ATPase H(+)-transporting lysosomal accessory protein 2, which results in a fourfold increase in the conversion of angiotensinogen to angiotensin I over that shown by soluble renin as well as non-hydrolytic activation of prorenin via a conformational change in prorenin which exposes the catalytic site to angiotensinogen substrate. (wikipedia.org)
  • The renal juxtaglomerular apparatus generates renin, an enzyme that converts angiotensinogen to angiotensin I. Angiotensinogen, derived from the liver, is an alpha-2-globulin. (loinc.org)
  • Whenever there's a decrease in blood pressure as detected by the baroreceptors of the carotid sinus or aortic arch or the juxtaglomerular cells, the sympathetic nerves getting stimulated, or the macula densa cells sensing less sodium and chloride ions flowing through the tubules, kidneys secrete renin that converts angiotensinogen to angiotensin I, and then angiotensin-converting enzyme converts angiotensin I to angiotensin II. (osmosis.org)
  • Renin is a hormone made by the kidneys. (medlineplus.gov)
  • Renin is a hormone secreted into the blood by the kidneys in response to stress. (daviddarling.info)
  • When blood pressure falls (for systolic, to 100 mm Hg or lower), the kidneys release the enzyme renin into the bloodstream. (merckmanuals.com)
  • Renin, which is primarily released by the kidneys, stimulates the formation of angiotensin in blood and tissues, which in turn stimulates the release of aldosterone from the adrenal cortex. (southtees.nhs.uk)
  • Renin is a proteolytic enzyme that is released into the circulation primarily by the kidneys. (southtees.nhs.uk)
  • Angiotensin I is converted to Angiotensin II with the substance called renin in the distal renal tubules of the kidneys. (triadofhealth.net)
  • Random aldosterone/renin ratio is now the main sample of choice. (southtees.nhs.uk)
  • The macula densa senses changes in sodium delivery to the distal tubule, and responds to a drop in tubular sodium load by stimulating renin release in the juxtaglomerular cells. (wikipedia.org)
  • Renin activates the renin-angiotensin system by using its endopeptidase activity to cleave the peptide bonds between leucine and valine residues in angiotensinogen, produced by the liver, to yield angiotensin I, which is further converted into angiotensin II by ACE, the angiotensin-converting enzyme primarily within the capillaries of the lungs. (wikipedia.org)
  • November 16, 2009 (Orlando, Florida) - An analysis of the Heart Outcomes Prevention Evaluation (HOPE) study has potentially identified a new biomarker of renin angiotensin system (RAS) activation that helps predict cardiovascular disease risk. (medscape.com)
  • The role of the renin angiotensin system (RAS) in atherosclerosis is complex because of the involvement of multiple peptides and receptors. (jci.org)
  • Chronic effects of lead on the renin-angiotensin system. (nih.gov)
  • This paper reviews the chronic effects of lead exposure on the renin-angiotensin system in experimental animals and human beings. (nih.gov)
  • 7. It is concluded that pituitary hormones, including gonadotrophins and gonadal factors as well as adrenal sex steroids, appear to affect significantly the interplay between antidiuretic hormone and the renin-angiotensin system. (portlandpress.com)
  • Use of drugs that inhibit the renin-angiotensin system is an effective way to intervene in the pathogenesis of cardiovascular and renal disorders. (nih.gov)
  • Aliskiren, the future of renin-angiotensin system blockade? (nih.gov)
  • The renin-angiotensin-aldosterone system is a series of reactions designed to help regulate blood pressure. (merckmanuals.com)
  • The renin angiotensin system plays an important role in the control of blood pressure and of renal function. (soton.ac.uk)
  • Although definitive evidence supporting dual blockade of the renin-angiotensin system has never been found, more than 200,000 patients in the U.S. currently receive this therapy. (jwatch.org)
  • In a paper published online in BMJ , Harikrishna Makani and colleagues at Columbia University and New York University performed a meta-analysis of more than 68,000 patients who were enrolled in clinical trials comparing dual blockade of the renin-angiotensin system with monotherapy. (jwatch.org)
  • The present data evolving from studies with dual blockade of the renin-angiotensin system should be a reminder that many purported benefits of such therapy was solely based on data using surrogate endpoints. (jwatch.org)
  • Although dual blockade of the renin-angiotensin system may have seemingly beneficial effects on certain surrogate endpoints, it failed to reduce mortality and was associated with an excessive risk of adverse events such as hyperkalaemia, hypotension, and renal failure when compared with monotherapy. (jwatch.org)
  • The brain renin-angiotensin system continues to be enigmatic more than 40 years after the brain was first recognized to be a site of action of angiotensin II. (nova.edu)
  • Scholars@Duke publication: The feedback regulation of angiotensinogen production by components of the renin-angiotensin system. (duke.edu)
  • In this study, we examined the feedback regulation of angiotensinogen synthesis and release by various components of the renin-angiotensin system, using an in vitro rat liver slice system. (duke.edu)
  • Indeed, when conditions were such that the renin-angiotensin system was completely suppressed, such as binephrectomy and antirenin antibody infusion, angiotensinogen release rate was markedly stimulated. (duke.edu)
  • Thus, angiotensinogen release rate is subject to a complex feedback control by other components of the renin-angiotensin system. (duke.edu)
  • The renin / angiotensin system is dependent upon aldosterone. (triadofhealth.net)
  • A major way the body does that is through a set of hormones that make up the renin- angiotensin- aldosterone system. (osmosis.org)
  • Local bone marrow (BM) renin-angiotensin system (RAS) is an autocrine-paracrine system affecting normal and neoplastic hematopoiesis. (gazi.edu.tr)
  • Assessment Serial Evaluation Subsequent Sequelae in Acute Kidney Injury (ASSESS-AKI) study investigators 2021, ' Prospective cohort study of renin-angiotensin system blocker usage after hospitalized acute kidney injury ', Clinical Journal of the American Society of Nephrology , vol. 16, no. 1, pp. 26-36. (johnshopkins.edu)
  • Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus. (nih.gov)
  • Study on the role of renin angiotensin system in pathogenesis of nonalcoholic fatty liver disease. (elisakit.cc)
  • The renin-angiotensin system (RAS) is most well-known for its role in regulation and dysregulation of blood pressure as well as fluid and electrolyte homeostasis. (nova.edu)
  • Review: The renin-angiotensin-aldosterone system and Alzheimer's disease? (bris.ac.uk)
  • Finally, this paper discusses very recent biological evidence that further supports a role for ACE1 and hypothesises a number of readily testable mechanisms by which the ACE1 enzyme and other components of the renin-angiotensin-aldosterone system may be implicated in increased risk and/or the progression of AD. (bris.ac.uk)
  • Dive into the research topics of 'Review: The renin-angiotensin-aldosterone system and Alzheimer's disease? (bris.ac.uk)
  • Journal of the Renin-Angiotensin-Aldosterone-System , 4 (2), 80-93. (bris.ac.uk)
  • The enzyme renin is secreted by pericytes in the vicinity of the afferent arterioles and similar microvessels of the kidney from specialized cells of the juxtaglomerular apparatus-the juxtaglomerular cells, in response to three stimuli: A decrease in arterial blood pressure (that could be related to a decrease in blood volume) as detected by baroreceptors (pressure-sensitive cells). (wikipedia.org)
  • Renal Renin (Renin-1) is synthesized as a 381 aa proform (aa 22 - 402). (rndsystems.com)
  • In contrast, older animals whose exposure was begun in utero manifest no change or a decrease in their PRA and renal renin concentration. (nih.gov)
  • Mouse Renin is a secreted, 42 - 47 kDa glycosylated member of the peptidase A1 family. (rndsystems.com)
  • Optimized DNA sequence encoding extracellular domain of Mouse Renin (LEU22 -ARG402) including a C-terminal His tag was expressed in HEK293 cells. (reprokine.com)
  • Recombinant Mouse Renin is a protein consisting of 390 amino acid residue subunits,due to glycosylation migrates as an approximately 45kDa protein on reduced SDS-PAGE. (reprokine.com)
  • Recombinant Mouse Renin is lyophilized from 0.2 μm filtered PBS solution, pH7.2 , 5% Trehalose. (reprokine.com)
  • Coupled Receptor Signaling in Renin-Producing Cells Leads to Renal Endothelial Damage. (bvsalud.org)
  • In a small preliminary study, blood lead concentration was found to be higher in high-renin hypertensive persons than in normotensive persons. (nih.gov)
  • Although enalapril maleate was antihypertensive in all races studied, black hypertensive patients (usually a low-renin hypertensive population) had a smaller average response to enalapril monotherapy than non-black patients. (nih.gov)
  • Hypophysectomized male rats, with depressed basal plasma renin activities, also showed a reduced PRA after ADH. (portlandpress.com)
  • The normal concentration of renin in adult human plasma is 1.98-24.6 ng/L in the upright position. (wikipedia.org)
  • In HOPE, patients with elevated levels of plasma renin activity at baseline were at an increased risk of cardiovascular death, total mortality, and heart failure . (medscape.com)
  • The association between plasma renin activity and cardiovascular outcomes persisted after adjustment for multiple risk factors, including C-reactive protein (CRP) and brain natriuretic peptide (BNP). (medscape.com)
  • After adjustment for this risk score, CRP, and BNP, the predictive value of measuring plasma renin activity at baseline persists, with close to a twofold increase in total mortality or cardiovascular death. (medscape.com)
  • In an interview with heart wire , Verma explained that it has been suggested that plasma renin activity is a marker of RAS activation. (medscape.com)
  • Recent studies in heart-failure patients have shown a link between high levels of plasma renin activity and adverse outcomes, including mortality. (medscape.com)
  • In this HOPE analysis, a study that includes patients with stable vascular disease or diabetes but without heart failure or left ventricular dysfunction, researchers measured baseline plasma renin activity in 2913 patients in the Canadian cohort. (medscape.com)
  • Compared with patients in lowest quintile, patients with increased levels of plasma renin activity, those in the highest quintile, had a significantly increased risk of cardiovascular death and total mortality. (medscape.com)
  • This is an important point, because you'd appreciate that if somebody has increased plasma renin activity, and if this is a surrogate for RAS activation, then in patients who received ramipril therapy, the strength of that association should be lowered by receiving RAS blockade," he said. (medscape.com)
  • This suggests that plasma renin activity might be an important biomarker of residual risk in patients who receive conventional RAS blockers. (medscape.com)
  • 1. The influence of gonadal and pituitary factors on the plasma renin response to exogenous vasopressin was examined in anaesthetized rats. (portlandpress.com)
  • 2. Plasma renin activity (PRA) was measured in Brattleboro rats (with and without hypothalamic diabetes insipidus) and Long-Evans male and female rats, before and after single intravenous injection of antidiuretic hormone (ADH) or saline. (portlandpress.com)
  • Plasma renin concentration, which was also measured with PRA in intact and nephrectomized male and female rats with diabetes insipidus, increased in the females and decreased in the males after ADH. (portlandpress.com)
  • The in vivo generation of angiotensin appears to be dependent on both plasma renin and angiotensinogen concentrations. (duke.edu)
  • However, infusion of angiotensin I (with simultaneous suppression of plasma renin by antirenin antibody infusion and angiotensin II production by captopril administration) had no effect on the angiotensinogen release rate. (duke.edu)
  • Blood pressure, plasma renin activity and aldosterone concentrations in vegans and omnivore controls. (ox.ac.uk)
  • Blood pressure, plasma renin activity and the concentrations of aldosterone and cholesterol in plasma and sodium and potassium in urine (48-h collections) and nutrient intakes were determined in 22 vegans (11 male and 11 female) and omnivore controls matched for age, sex and body build. (ox.ac.uk)
  • Plasma renin and cholesterol concentrations were lower in the male but not female vegans compared with their respective controls. (ox.ac.uk)
  • Decreased intracellular [Ca ++ ] stimulates renin release, an effect which may either occur distal to changes in cAMP, or may be part of an independent pathway mediating renin release. (soton.ac.uk)
  • In volume-depleted states, GFR and chloride delivery to the distal nephrons decreases, causing release of renin. (msdmanuals.com)
  • Sheep Anti Mouse/Rat Prorenin/Renin Polyclonal Affinity Purified Biotin Labeled from Innovative Research is a polyclonal antibody that has been purified by immobilized prorenin followed by biotin conjugation. (innov-research.com)
  • Standards or samples are then added to the microtiter plate wells and Renin if present, will bind to the antibody pre-coated wells. (elisakit.cc)
  • In order to quantitatively determine the amount of Renin present in the sample, a standardized preparation of horseradish peroxidase (HRP)-conjugated polyclonal antibody, specific for Renin are added to each well to "sandwich" the Renin immobilized on the plate. (elisakit.cc)
  • Only those wells that contain Renin and enzyme-conjugated antibody will exhibit a change in color. (elisakit.cc)
  • The juxtaglomerular cells are also stimulated to release renin by signaling from the macula densa. (wikipedia.org)
  • The major source of renin is the juxtaglomerular cells of the kidney. (soton.ac.uk)
  • To determine the role of macrophage-derived angiotensin in the development of atherosclerosis, we transplanted renin-deficient bone marrow to irradiated Ldlr-/- mice and observed a profound decrease in the size of atherosclerotic lesions. (jci.org)
  • The aspartic proteinase renin plays an important physiological role in the regulation of blood pressure. (rcsb.org)
  • Indirect reduction of intracellular [Ca ++ ], using Ca channel antagonists or by reducing extracellular [Ca ++ ], stimulated renin release but did not affect cAMP release. (soton.ac.uk)
  • Renin activity is affected by diuretics and low sodium stimulates activity. (loinc.org)
  • The renin-angiotensin-aldosterone axis is the main regulatory mechanism of renal sodium excretion. (msdmanuals.com)
  • No significant cross-reactivity or interference between Renin and analogues was observed. (elisakit.cc)
  • Renin is secreted from juxtaglomerular kidney cells, which sense changes in renal perfusion pressure, via stretch receptors in the vascular walls. (wikipedia.org)
  • Renin is secreted from juxtaglomerular kidney cells. (reninsignaling.com)
  • Intracellular cAMP, the production of which is catalyzed by the α-subunit of the stimulatory G protein (Gsα), controls renin synthesis and release by juxtaglomerular (JG) cells of the kidney , but may also have relevance for the physiologic integrity of the kidney . (bvsalud.org)
  • In addition, renin and prorenin binding results in phosphorylation of serine and tyrosine residues of ATP6AP2. (wikipedia.org)
  • Select this product for Molecular Innovations name, Biotin-labeled sheep anti rat & mouse prorenin/renin IgG fraction, High Titer and product number, SASRREN-GF-HT-BIO . (innov-research.com)
  • A wide variety of stimulatory and inhibitory influences control the release of renin into the circulation, however the intracellular events regulating renin release are poorly understood. (soton.ac.uk)
  • Cyclic AMP release was stimulated by catecholamines and factors which elevate intracellular cAMP were found to stimulate renin release. (soton.ac.uk)
  • There appears to be an inverse relationship between intracellular [Ca ++ ] and renin release, in contrast to most other secretory systems. (soton.ac.uk)
  • Much less is known about the control of hepatic angiotensinogen synthesis and release, as compared to that of renin. (duke.edu)
  • The Renin concentration in each sample is interpolated from this standard curve. (elisakit.cc)
  • The Rat Renin ELISA kit can be used to identify samples from the rat species. (elisakit.cc)
  • Renin ELISA kit applies the quantitative sandwich enzyme immunoassay technique. (elisakit.cc)
  • BACKGROUND: The aldosterone-to-renin ratio (ARR) is a widely used screening test for primary aldosteronism. (eur.nl)
  • Mature renin contains 340 amino acids and has a mass of 37 kDa. (wikipedia.org)
  • The amino acid sequence of human Renin is 100%, 73%, 71% and 67% identical to that of chimpanzee, canine, mouse and rat. (rndsystems.com)
  • The two mature Renin molecules are 95% amino acid (aa) identical. (rndsystems.com)
  • If you suspect that your decrease in heart rate and renin is caused by the Beta Blockers you take, contact your doctor to discuss the issue! (wellbuzz.com)
  • Diagnosis of, and differentiation between, primary and secondary causes of hyper- or hypoaldosteronism, management of renal artery stenosis, diagnosis and location of renin secreting tumours & monitoring mineralocorticoid replacement therapy. (southtees.nhs.uk)
  • Extrarenal renin activity (nephrectomized rats) gave qualitatively similar responses to ADH. (portlandpress.com)
  • Direct infusion of renin in rats treated with captopril resulted in further suppression of the angiotensinogen release rate, compared with those given captopril alone. (duke.edu)
  • It appears that an α-adrenoceptor similarly located inhibits renin release. (soton.ac.uk)
  • RÉSUMÉ Afin de déterminer les effets du jeûne du ramadan sur la sécrétion d'hormones sexuelles chez des hommes célibataires en bonne santé, nous avons mesuré les concentrations sanguines de testostérone et d'hormones lutéinisante (LH) et folliculostimulante (FSH) chez 52 étudiants célibataires âgés de 18 à 24 ans qui jeûnaient pendant 12 heures ou plus pendant le ramadan. (who.int)
  • Mouse pro-renin shares 70% and 85% aa sequence identity with human and rat pro-renin, respectively. (rndsystems.com)
  • Renin activity is elevated in renal vascular diseases and suppressed in primary hyperaldosteronism. (loinc.org)
  • This suggests that cAMP acts as a stimulatory second messenger in the control of renin release. (soton.ac.uk)
  • Furthermore, in vitro studies demonstrated that coculture with renin-expressing macrophages augmented monocyte adhesion to endothelial cells. (jci.org)
  • 5. Ovariectomy had little effect on the ADH-induced renin release and the response was similar at oestrus, metoestrus and dioestrus. (portlandpress.com)
  • The experiments described in this thesis set out to investigate the regulation of renin release using a preparation which is relatively free from indirect influences. (soton.ac.uk)
  • The data suggest that catecholamine induced renin release is mediated by a β-adrenoceptor located on the JG cells. (soton.ac.uk)
  • The roles of cAMP and Ca ++ in the control of renin release were investigated. (soton.ac.uk)
  • The fundamental hypothesis is that catecholamines appear to stimulate renin release, an effect mediated by cAMP. (soton.ac.uk)