• binds
  • This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. (cancerindex.org)
  • When the protein binds to that cell, it is taken in through endocytosis, and the toxin kills the cell. (wikipedia.org)
  • antigens
  • Immune responses of two recombinant adenoviruses expressing VP1 antigens of FMDV fused with porcine granulocyte macrophage colony-stimulating factor," Vaccine , vol. 25, no. 49, pp. 8209-8219, 2007. (hindawi.com)
  • Likewise, the relative immunodominance of individual antigens in the fusion molecule is altered by the choice of delivery system. (mendeley.com)
  • characterization
  • In conclusion, we report the production and characterization of a long-acting, bifunctional VEGF-FSH-CTP protein that is superior to combination therapy for enhancing VEGF activity in the ovary and stimulating follicular angiogenesis in rats. (biomedsearch.com)
  • antibodies
  • Anti-CD22 immunotoxins, being tested in hairy cell leukemia Antibody-drug conjugates, most, if not all, are immunotoxins but use whole antibodies and non-protein drugs Immunopharmacology and Immunotoxicology (medical journal) Pastan I, Hassan R, FitzGerald DJ, Kreitman RJ (2007). (wikipedia.org)
  • gene
  • Alternative splicing of downstream exons of the GNAS gene is observed, which results in different forms of the stimulatory G protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. (abcam.com)
  • What does this gene/protein do? (cancerindex.org)
  • vivo
  • This product is an active protein and may elicit a biological response in vivo, handle with caution. (abcam.com)
  • It also makes it relatively non-toxic in vivo as the recognized sequence scarcely occurs in proteins. (wikipedia.org)
  • novel
  • Induction of protective immune response against both PPRV and FMDV by a novel recombinant PPRV expressing FMDV VP1," Veterinary Research , vol. 45, no. 1, article 62, 2014. (hindawi.com)
  • Coadministration of systemic FSH-CTP plus recombinant VEGF was compared with treatment with a novel, single-chain bifunctional VEGF-FSH-CTP (VFC) analog. (biomedsearch.com)
  • mediates
  • We also found that cAMP-GEFII mediates cAMP-dependent, protein kinase A (PKA)-independent insulin secretion, and that this requires interaction with both Rim2 and Piccolo ( 16 - 18 ). (diabetesjournals.org)
  • viral
  • Pneumoviruses replicate entirely in the cytoplasm, and this process begins with adsorption of the virus to the cellular receptor on the host cell, directed by the viral attachment protein, variously called G, H (hemagglutinin) or HN (hemagglutinin-neuraminidase). (wikipedia.org)
  • tumor
  • We can used specific TAAs, tumor lysates,created DC-cancer cell fusions, electroporation/transfection of DCs with total cancer cell-mRNA or tumor derived exosomes (TDEs) by the stimulation.There is also possibility of aditonal co-stimulating with cytokine "cocktails" to assure strong maturation. (wikipedia.org)
  • Interactions
  • HMPV is thought to attach to the target cell via the glycoprotein (G) protein interactions with heparan sulfate and other glycosaminoglycans. (wikipedia.org)
  • targets
  • For VFC, the FSH portion targets the protein to the ovary and stimulates follicle growth, whereas VEGF enhances local vascular development. (biomedsearch.com)
  • citation needed] These patients were treated with the recombinant immunotoxin, BL22, which targets the CD22 cell surface receptor, which is highly expressed on these leukemic cells. (wikipedia.org)
  • cells
  • Cells in which regulated exocytosis occurs share several molecules that constitute the exocytotic machinery, including SNARE proteins (VAMP/synaptobrevin, SNAP, and syntaxin), synaptotagmins, and Rab proteins ( 2 , 3 ). (diabetesjournals.org)
  • The result revealed that the fusion protein His-TAT-p53 accumulated in the nucleus and inhibited the growth of the Saos-2 cells. (biomedsearch.com)
  • The designer protein combines the binding site for two cytokines that regulate maturation, function, and survival of B cells - B-lymphocyte stimulator (BLyS) and A proliferation-inducing ligand (APRIL), with the constant region of immunoglobin. (wikipedia.org)
  • It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. (wikipedia.org)
  • activation
  • It is activated by the catecholamine epinephrine and couples to the G protein Gs to mediate adenylate cyclase activation. (abcam.com)
  • active
  • Catalytically active tetramer-dimer (in equilibrium) forms of the fusion protein were separated from inactive, aggregated forms by size-exclusion h.p.l.c. (biochemj.org)
  • single chain
  • Single-chain bifunctional vascular endothelial growth factor (VEGF)-follicle-stimulating hormone (FSH)-C-terminal peptide (CTP) is superior to the combination therapy of recombinant VEGF plus FSH-CTP in stimulating angiogenesis during ovarian folliculogenesis. (biomedsearch.com)