• protein-coupled
  • Previous reports showed that the natural sphingolipid ceramide 1-phosphate (C1P) stimulates macrophages migration, while the synthetic C1P mimic, phospho-ceramide analogue-1 (PCERA-1), suppresses production of the key pro-inflammatory cytokine TNFα and amplifies production of the key anti-inflammatory cytokine IL-10 in LPS-stimulated macrophages, via one or more unidentified G-protein coupled receptors. (sigmaaldrich.com)
  • novel
  • FHL2, a novel tissue-specific coactivator of the androgen receptor. (sigmaaldrich.com)
  • Here we characterize a novel tissue-specific coactivator for the androgen receptor (AR), which is identical to a previously reported protein FHL2/DRAL with unknown function. (sigmaaldrich.com)
  • Novel roles of ginsenoside Rg3 in apoptosis through downregulation of epidermal growth factor receptor. (sigmaaldrich.com)
  • Identification of these receptors will be instrumental for elucidation of novel activities of extra-cellular sphingolipids, and may pave the way for the design of new sphingolipid mimics for the treatment of inflammatory diseases, and pathologies which depend on cell migration, as in metastatic tumors. (sigmaaldrich.com)
  • proteins
  • Some ubiquitin-like (UBL) domain-containing proteins are known to play roles in receptor trafficking. (sigmaaldrich.com)
  • Hrr25 triggers selective autophagy-related pathways by phosphorylating receptor proteins. (sigmaaldrich.com)
  • Hrr25 is responsible for the phosphorylation of two receptor proteins: Atg19, which recognizes the assembly of vacuolar enzymes in the cytoplasm-to-vacuole targeting pathway, and Atg36, which recognizes superfluous peroxisomes in pexophagy. (sigmaaldrich.com)
  • Hrr25-mediated phosphorylation enhances the interactions of these receptors with the common adaptor Atg11, which recruits the core autophagy-related proteins that mediate the formation of the autophagosomal membrane. (sigmaaldrich.com)
  • The sigma-2 receptor is found in several areas of the brain, including high densities in the cerebellum, motor cortex, hippocampus, and substantia nigra, though it shows no homology with other proteins present in brain tissue. (wikipedia.org)
  • mechanisms
  • However, the exact mechanisms by which nuclear receptor-cofactor interactions result in tissue-specific gene regulation are unclear. (sigmaaldrich.com)
  • Our results suggest that activation of the dopaminergic system, especially via D2 receptors may be required for the development of MAP-associated anticipatory activity increases and that N-methyl-D-aspartate receptors and sigma receptor mechanisms are also involved in the development of this behavior. (aspetjournals.org)
  • neurotransmitters
  • When this effect ceases due to metabolism of cocaine, depletion of associated neurotransmitters, and receptor down-regulation (tachyphylaxis), the cocaine user may experience dysphoria, or a "crash" after the initial high. (wikipedia.org)
  • pathways
  • Thus, this study introduces regulation of selective autophagy as a new role of Hrr25 and, together with other recent studies, reveals that different selective autophagy-related pathways are regulated by a uniform mechanism: phosphoregulation of the receptor-adaptor interaction. (sigmaaldrich.com)
  • pharmacological
  • Pharmacological assessments demonstrated that CamKIIαNampt(-/-) mice also display dysfunction of synaptic GluN2B (NR2B)-containing N-methyl-d-aspartate receptors (NMDARs) prior to changes in NMDAR subunit expression. (sigmaaldrich.com)
  • The σ1 receptor is defined by its unique pharmacological profile. (wikipedia.org)
  • roles
  • The sigma-2 receptor takes part in a number of normal-function roles, including cell proliferation, and non-neuronal, and neuronal signaling. (wikipedia.org)
  • gene
  • The control of target gene expression by nuclear receptors requires the recruitment of multiple cofactors. (sigmaaldrich.com)
  • In humans, the σ1 receptor is encoded by the SIGMAR1 gene. (wikipedia.org)
  • The receptor has recently been identified with TMEM97, a protein for which gene and protein sequence is available that had been known to be involved in cholesterol homeostasis. (wikipedia.org)
  • found
  • Sigma-2 receptors have been found to be highly expressed in proliferating cells, including tumor cells, and to play a role in the differentiation, morphology, and survival of those cells. (wikipedia.org)
  • mechanism
  • Because sigma-2 receptors are highly expressed in tumor cells and are part of the cell proliferation mechanism, PET scans using sigma-2 targeted tracers can reveal if a tumor is proliferating and what its growth rate is. (wikipedia.org)
  • role
  • The aim of this work was to study the role of insulin- and IGF1-receptors (IR and IGF1R) in insulin-like signaling induced by copper in HepG2 human hepatoma cells. (sigmaaldrich.com)
  • Chemokines play a prominent role as a mediator between neuron-glial cell communication since both cell types express chemokine receptors. (wikipedia.org)