Transferrin receptor 1 Transferrin receptor 2 Soluble transferrin receptor GAPDH Qian ZM, Li H, Sun H, Ho K (December 2002). (wikipedia.org)
The method for measurement of soluble transferrin receptor (sTfR) is immuno-turbidimetry using Roche kits on the Hitachi 912 clinical analyzer. (cdc.gov)
Soluble transferrin receptor-1 (sTfR1) concentrations are increased in the plasma under two conditions that are associated with increased iron absorption, i.e. iron deficiency and increased erythropoiesis. (karger.com)
In contrast, soluble transferrin receptor (sTfR) indicates iron deficiency and is unaffected by inflammation. (nih.gov)
In areas with a limited infection pressure, soluble transferrin receptor (sTfR) has been shown to be a promising new tool for the diagnosis of deficiency of iron stores. (bmj.com)
Transferrin receptor testing is used to measure the level of soluble transferrin receptors, thereby aiding in the evaluation of iron deficiency and in the diagnosis of iron-deficiency anemia. (medscape.com)
Alpha thalassaemia is associated with increased soluble transferrin receptor levels. (ox.ac.uk)
To study this problem, we have measured the concentrations of soluble transferrin receptor (sTIR) and ferritin in 181 children from Vanuatu with heterozygous (68) and homozygous (46) alpha+ thalassaemia, and normal controls (67). (ox.ac.uk)
Soluble transferrin receptor assay may be useful in these situations because it reflects the degree of iron requirement in relation to supply and it is not an acute phase reactant. (ijbls.org)
Our aim was to evaluate the usefulness of soluble serum transferrin receptor (sTfR) in relation to serum ferritn in the diagnosis of iron deficiency and iron deficiency anaemia during pregnancy. (ijbls.org)
Serum iron and soluble transferrin receptor concentration were determined using ELISA technique while haemoglobin concentration was determined using automatic cell counter PCE-210 version 5.10 by ERMA INC. Tokyo. (ijbls.org)
Lack of difference in iron status assessed by soluble transferrin receptor between children with cerebral malaria and those with non-cerebral malaria. (espkinshasa.net)
Iron status was assessed by soluble transferrin receptor (sTfR), serum ferritin, and haemoglobin in 44 Zaïrian children: 15 with cerebral malaria, 14 with non-cerebral malaria, and 15 without malaria (age range 0.5-16 years). (espkinshasa.net)
Limiting dilutions of soluble H5 trimers complexed with horseradish peroxidase−conjugated antibodies were used in a fetuin- or transferrin-binding assay. (cdc.gov)
Combined measurement of ferritin, soluble transferrin receptor, retinol binding protein, and C-reactive protein by an inexpensive, sensitive, and simple sandwich enzyme-linked immunosorbent assay technique. (who.int)
Plasma soluble interleukin-2 and transferrin receptor in schizophrenia and major depression. (bvsalud.org)
Soluble transferrin receptor (mg/L) [Time Frame: Screening, days 1 and 57. (who.int)
Ferritin4
These are widely used in clinics and include ferritin, serum iron, serum transferrin, total iron binding capacity (TIBC) and mean cell volume (MCV). (bmj.com)
[ 2 ] Unlike ferritin, the transferrin receptor level is not affected by infection or inflammation and is therefore useful in distinguishing iron deficiency anemia from anemia of chronic disease. (medscape.com)
Along with other tests in an anemia panel (iron, ferritin, reticulocyte count, lactate dehydrogenase [LDH], vitamin B-12, folate), the type of anemia can be diagnosed based on the transferrin receptor levels. (medscape.com)
The standardized mean differences (SMD) in women who had GDM compared to pregnant women without were 0.25 µg/dL (95% CI: 0.001⁻0.50) for iron, 1.54 ng/mL (0.56⁻2.53) for ferritin, 1.05% (0.02 to 2.08) for transferrin saturation, and 0.81 g/dL (0.40⁻1.22) for hemoglobin. (nih.gov)
TfR14
TfR1 is a high affinity ubiquitously expressed receptor while expression of TfR2 is restricted to certain cell types and is unaffected by intracellular iron concentrations. (wikipedia.org)
For comparison, we also immunolabeled the specimens with antibody against transferrin receptor 1 (TfR1) which is important in DMT1-mediated transport of Fe and Mn. (cdc.gov)
These changes were associated with lower placental transferrin receptor 1 (TfR1) in syncytiotrophoblasts in both early- and late-onset PE. (lu.se)
Endocytosis2
It imports iron by internalizing the transferrin-iron complex through receptor-mediated endocytosis. (wikipedia.org)
Iron, insoluble as free Fe(3+) and toxic as free Fe(2+), is distributed through the body as Fe(3+) bound to transferrin (Tf) for delivery to cells by endocytosis of its complex with transferrin receptor (TfR). (rcsb.org)
Uptake4
The existence of a receptor for transferriniron uptake has been recognized since the late 1950s. (wikipedia.org)
Earlier two transferrin receptors in humans, transferrin receptor 1 and transferrin receptor 2 had been characterized and until recently cellular iron uptake was believed to occur chiefly via these two well documented transferrin receptors. (wikipedia.org)
Mass spectrometry study of a transferrin-based protein drug reveals the key role of protein aggregation for successful oral delivery. (umassmed.edu)
In Chinese hamster ovary (CHO) fibroblast cells the protein kinase C activating phorbol ester, phorbol myristate acetate (PMA), stimulates an increase in cell surface transferrin receptor (TR) expression by increasing the exocytic rate of the recycling pathway. (rupress.org)
A mutant human TR in which the major protein kinase C phosphorylation site, serine 24, has been replaced with the non-phosphorylatable amino acid glycine has been constructed to investigate the role of receptor phosphorylation in the PMA induced up-regulation. (rupress.org)
They specifically bind iron-bearing transferrin, are endocytosed with its ligand and then returned to the cell surface where transferrin without its iron is released. (umassmed.edu)
The advantages of using TR as a reporter molecule include the ability to monitor trafficking, in both biochemical and microscopy experiments, using the natural ligand transferrin. (rupress.org)
Glycoprotein3
Transferrin is an iron-binding glycoprotein found in the plasma. (medscape.com)
The transferrin receptor is a glycoprotein composed of disulfide-linked polypeptide chains. (ximbio.com)
CD71 is a 95 kD type II homodimeric transmembrane glycoprotein also known as T9 and transferrin receptor. (biolegend.com)
Transmembrane1
Both these receptors are transmembrane glycoproteins. (wikipedia.org)
Placental1
transferrin can transport iron from cells (intestinal, macrophages) to specific receptors on erythroblasts, placental cells, and liver cells. (msdmanuals.com)
Internalization1
To create a system for studying this pathway, we replaced the native transferrin receptor (TR) internalization motif (YTRF) with the SDYQRL TGN-targeting motif. (rupress.org)
Concentrations1
Low iron concentrations promote increased levels of transferrin receptor, to increase iron intake into the cell. (wikipedia.org)
Pathway1
Phorbol ester treatment increases the exocytic rate of the transferrin receptor recycling pathway independent of serine-24 phosphorylation. (rupress.org)
Antibody1
Western Blot: TR alpha/NR1A1/Thyroid Hormone Receptor alpha Antibody [NBP2-22523] - Analysis of 25 ug of mouse thyroid (lane 1), NIH-3T3 (lane 2) and A431 (lane 3) cell lysates onto an SDS polyacrylamide gel. (novusbio.com)
TIBC1
We did not find any differences in TIBC or transferrin concentration in women with and without GDM. (nih.gov)
Monolayer MCF7 and U118 cells were highly sensitive to antitransferrin receptor (anti-TfnR) ricin A chain (RTA)-IT (Tfn-RTA and MAb OKT9-RTA) treatment in the presence of the intracellular RTA-IT enhancing agent human serum albumin-monensin (HSA-Mo) conjugate. (univr.it)
However several essential AMG-925 nutrients and carrier proteins are thought to mix the BBB via receptors indicated on mind endothelial cells through a process known as receptor-mediated transcytosis (Rubin and Staddon 1999 Predescu et al. (biotech-angels.com)
We also found that SRC-3 depletion in cultured HESCs results in a significant attenuation in the induction of a wide-range of established biomarkers of decidualization, despite exposure of these cells to a deciduogenic stimulus and normal progesterone receptor expression. (frontiersin.org)
Myelinating OLs originate from parenchymal precursors expressing the neuron-glia antigen 2 (NG2) chondroitin sulphate proteoglycan and the platelet derived growth factor receptor alpha (PDGFRα), commonly referred to as oligodendrocyte progenitor cells (OPCs) 4 . (nature.com)
Cultured retinal pigment epithelial cells immunofluorescently labeled for transferrin receptor (TfnR) (green) and nucleus (blue). (cellimagelibrary.org)
Mediates1
Furthermore, the altered receptor mediates cellular Fe accumulation from diferric-Tf, thereby fulfilling the receptor's major biological role. (rupress.org)
Cellular localization and developmental changes of Zip8, Zip14 and transferrin receptor 1 in the inner ear of rats. (cdc.gov)
MeSH1
Receptors, Transferrin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
Plasma1
Transferrin (plasma half-life, 8 days) is extruded for reutilization. (msdmanuals.com)
Increases2
When iron levels are low, the body increases the amount of transferrin in the body in an effort to increase the availability of the iron that is there. (medicalnewstoday.com)
Synthesis of transferrin increases with iron deficiency but decreases with any type of chronic disease. (msdmanuals.com)
Transferrin receptor testing is used in the diagnosis of anemia and in deciding adequate treatment. (medscape.com)
Molecular1
Although much is understood of the transferrin endocytotic cycle, little has been uncovered of the molecular details underlying the formation of the receptor-transferrin complex. (rcsb.org)
Intake1
We also did not find any association of increased transferrin receptor or increased intake of total dietary iron, non-heme iron or supplemental iron, with increased odds ratios for GDM. (nih.gov)
Transports1
For heme synthesis, transferrin transports iron to the erythroblast mitochondria, which insert the iron into protoporphyrin IX for it to become heme. (msdmanuals.com)
Levels1
Transferrin receptor levels within the reference range indicate normal physiology. (medscape.com)
Expression1
The increased TR expression on the cell surface after PMA treatment results from an increase in the rate of exocytosis of the recycling receptors. (rupress.org)
Understood1
2007 the exact route of receptor-mediated transcytosis of Tf-TfR is not well understood in the BBB. (biotech-angels.com)
Gene1
Thyroid Hormone Receptor alpha is encoded by this gene is a nuclear hormone receptor for triiodothyronine. (novusbio.com)
Females1
Reference intervals of transferrin receptors have not been established for pregnant females, children, or recent or frequent blood donors. (medscape.com)