We took advantage of the fact that many of the killer cells' receptors bind to specific target cell surface proteins, much like antibodies bind to specific antigens. (igem.org)
They can be activated rapidly via germ-line encoded receptors that recognize the presence of stress ligands or absence of self-antigens on target cells ( 1 - 5 ). (frontiersin.org)
A family of receptors found on NK CELLS that have specificity for a variety of HLA ANTIGENS. (umassmed.edu)
KIR receptors contain up to three different extracellular immunoglobulin-like domains referred to as D0, D1, and D2 and play an important role in blocking NK cell activation against cells expressing the appropriate HLA antigens thus preventing cell lysis. (umassmed.edu)
The goal of the current study was to assess the association of COVID-19 clinical courses controlled by patients' adaptive immune responses without progression to severe disease with patients' Human Leukocyte Antigen (HLA) genetics, AB0 blood group antigens, and the presence or absence of near-loss-of-function delta 32 deletion mutant of the C-C chemokine receptor type 5 (CCR5). (biomedcentral.com)
Proteins3
KIR receptors have no structural orthologs in non-primates, although mouse Ly-49 proteins are functional orthologs (3). (rndsystems.com)
So why not replace the receptors' recognition domains with different antibodies to create new receptors to recognize the many surface proteins on cells? (igem.org)
Further understanding of the function of Cx43 in the exosomes will have implications for the development of new therapeutic approaches as drug carries and delivery automobiles to combat metastasis in melanoma.Background: We have previous KIR3DL1 Proteins site demonstrated that Ha-Ras V12 overexpressing cells develop a certain mechanical phenotype which involves cell softening and loss of stiffness sensing. (angiotensinreceptor.com)
Inhibitory9
This phenomenon is determined by MHC class I-specific inhibitory receptors that functionally dominate the triggering potentials induced by activating receptors Thus, NK cells use a complex array of inhibitory or activating receptor/ligand interactions, the balance of which regulates NK cell function and cytolytic activity. (wikipedia.org)
Thus, in primates and a few other species, evolved MHC class I-inhibitory receptors belong to the KIR immunoglobulin superfamily, while in rodents and other species the same function is under the control of type II integral transmembrane glycoproteins, structurally characterized as disulfide-linked homodimers belonging to the Ly49 protein family. (wikipedia.org)
Natural killer cell cytolysis of target cells and cytokine production is controlled by a balance of inhibitory and activating signals, which are facilitated by NK cell receptors. (wikipedia.org)
NK cell inhibitory receptors are part of either the immunoglobulin-like (IgSF) superfamily or the C-type lectin-like receptor (CTLR) superfamily. (wikipedia.org)
CTLR inhibitory receptors include the CD94/NKG2A and the murine Ly49, which is probably analogous to the human KIR. (wikipedia.org)
With the exception of KIR2DL4, which has both activating and inhibitory capabilities, KIR receptors with long cytoplasmic tails are inhibitory and those with short tails are activating. (wikipedia.org)
Although they are often referred to as being inhibitory receptors, a subset of KIR receptors may also play an activating role in NK cells. (umassmed.edu)
An inhibitory KIR receptor that contains D0 and D1 extracellular immunoglobulin-like domains and a long cytoplasmic tail. (childrensmercy.org)
The inhibitory KIRs 2DL1 (CD158a), 2DL2/3 (CD158b), and 3DL1 (CD158e1) are such surface receptors and allow adoptively transferred donor NK cells to exert potent antileukemic effects if the cognate HLA class I ligands are absent in the recipients [ 3 ]. (biomedcentral.com)
Chemokine2
First, we were interested in elucidating the potential impact of CCR5 delta32 (CD195), a near-loss-of-function mutant of the C-C chemokine receptor type 5 on the COVID-19 clinical course. (biomedcentral.com)
These co-receptors are chemokine receptors CCR5 or CXCR4 . (wikidoc.org)
Recognition5
Crystal structures and KIR3DL1 recognition of three immunodominant viral peptides complexed to HLA-B*2705. (ox.ac.uk)
Substitution of EBV P8 glutamate to threonine allowed recognition by KIR3DL1. (ox.ac.uk)
Cell-surface expression and immune receptor recognition of HLA-B27 homodimers. (ox.ac.uk)
I have unearthed structural mechanisms of HLA polymorphism impacting on drug and food hypersensitivities, as well as Natural Killer cell receptor recognition. (cardiff.ac.uk)
KLRC3 codes for a protein that works as a receptor for the recognition of MHC molecules by natural killers, and in some cases cytotoxic T-cells. (novusbio.com)
Interleukin-5 recept5
Interleukin-5 Receptor alpha Subunit" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
A low affinity interleukin-5 receptor subunit that combines with the CYTOKINE RECEPTOR COMMON BETA SUBUNIT to form a high affinity receptor for INTERLEUKIN-5. (harvard.edu)
Several isoforms of the interleukin-5 receptor alpha subunit exist due to multiple ALTERNATIVE SPLICING. (harvard.edu)
This graph shows the total number of publications written about "Interleukin-5 Receptor alpha Subunit" by people in Harvard Catalyst Profiles by year, and whether "Interleukin-5 Receptor alpha Subunit" was a major or minor topic of these publication. (harvard.edu)
Below are the most recent publications written about "Interleukin-5 Receptor alpha Subunit" by people in Profiles. (harvard.edu)
Immune4
Moreover, these receptors are functional, as treatment of FRT tissue cells with ligands for TLR and NOD induces production of proinflammatory CXCL8 [ 13 ], and those receptors actively participate in immune response to pathogens, as Neisseria gonorrhea and HIV-1 [ 14 ]. (hindawi.com)
The analysis of Fc gamma receptor FCgammaRIIIA 158 V/f gene polymorphism showed that all 100 immune thrombocytopenic purpura (ITP) patients carry the wild FcgammaRIIIa (FF) genotype. (cusabio.com)
2023. DeepAIR: A deep learning framework for effective integration of sequence and 3D structure to enable adaptive immune receptor analysis . (cardiff.ac.uk)
Dissecting effectivity of a 5′ quick amplification of cDNA ends (5′-RACE) technique for profiling T-cell receptor beta repertoire Deep sequencing of T-cell receptor (TCR) genes is extremely efficient at profiling immune repertoire. (master-sistemisanitari-medicinenonconvenzionali.org)
LILRB11
The expression of KIR2DL1, KIR2DL3/L2/S2, KIR3DL1, LILRB1, and NKG2A was examined by nine-color flow cytometry in matched pbNK and dNK from 21 donors. (bio-rad-antibodies.com)
Killer11
ImmunOs Therapeutics´ lead program is a multi-functional fusion protein that blocks specific LILRB (leukocyte immunoglobulin-like) and KIR (killer cell immunoglobulin-like) receptors and activates anti-tumor responses. (globenewswire.com)
Killer-cell immunoglobulin-like receptors (KIRs), are a family of type I transmembrane glycoproteins expressed on the plasma membrane of natural killer (NK) cells and a minority of T cells. (wikipedia.org)
Members of the IgSF family include the human killer cell immunoglobulin-like receptor (KIR) and the Immunoglobulin-like transcripts (ILT). (wikipedia.org)
KIR3DL2 (3DL2, p140, CD158k) is a type I transmembrane protein of the p70 family of killer cell Ig-like receptors (KIR). (rndsystems.com)
Immunogenomics of Killer Cell Immunoglobulin-Like Receptor (KIR) and HLA Class I: Coevolution and Consequences for Human Health. (ucdenver.edu)
High-throughput Interpretation of Killer-cell Immunoglobulin-like Receptor Short-read Sequencing Data with PING. (cuanschutz.edu)
Tetrameric complexes of HLA-B*2705 with the HIV and flu but not EBV peptides bound strongly to the killer-Ig-like receptor (KIR)3DL1. (ox.ac.uk)
Association of killer cell immunoglobulin-like receptors with endemic Burkitt lymphoma in Kenyan children. (umassmed.edu)
Donor-recipient killer immunoglobulin like receptor (KIR) genotype matching has a protective effect on chronic graft versus host disease and relapse incidence following HLA-identical sibling hematopoietic stem cell transplantation. (cdc.gov)
We determined if adoptive transfer of natural killer (NK) cells from haploidentical killer immunoglobulin-like receptor (KIR)-human leukocyte antigen (HLA)-mismatched donors may prolong event-free survival in children with intermediate-risk AML who were in first complete remission after chemotherapy. (biomedcentral.com)
The first evidence for the therapeutic effectiveness of natural killer (NK) cells in AML was established in a study of 57 adult patients, in which none of the 20 individuals who received haploidentical cell transplantation from a killer immunoglobulin-like receptor (KIR)-human leukocyte antigen (HLA)-mismatched donor experienced disease relapse [ 2 ]. (biomedcentral.com)
Genes3
At least 15 genes and 2 pseudogenes encoding KIR map in a 150-kb region of the leukocyte receptor complex (LRC) on human chromosome 19q13.4. (wikipedia.org)
Receptors displaying this function evolved during phylogenesis following the rapid evolution of genes coding for MHC class I molecules. (wikipedia.org)
STARD12 co-expressed genes participated in cell cycle and DNA replication, and STARD14 were enriched in ECM-receptor interaction. (medsci.org)
CCR51
CCR5 is known to play a decisive role as a chemotactic receptor abundantly expressed on monocytes, macrophages and T-cells and its heterozygous mutation-related deficiency implies impaired memory CD4 + T-cell response [ 5 ]. (biomedcentral.com)
Immunoglobulin superfamily1
Like many cell surface receptors/markers, CD4 is a member of the immunoglobulin superfamily . (wikidoc.org)
Monocytes1
Populations of synovial and peripheral blood monocytes, and B and T lymphocytes from patients with spondylarthritis, and controls carried receptors for HLA-B27 homodimers. (ox.ac.uk)
Peptide1
2023. Complimentary electrostatics dominate T-cell receptor binding to a psoriasis-associated peptide antigen presented by human leukocyte antigen C∗06:02 . (cardiff.ac.uk)
KIR3DL22
The closest relative, KIR3DL1 shows 86% aa identity with KIR3DL2 within the ECD. (rndsystems.com)
Experiments with transfected cell lines demonstrated that KIR3DL1 and KIR3DL2, and immunoglobulin-like transcript 4 (ILT4), but not ILT2, are receptors for HLA-B27 homodimers. (ox.ac.uk)
Gene3
Unlike T cells, NK cell receptors are germline encoded, and therefore do not require somatic gene rearrangements. (wikipedia.org)
Single substitutions, insertions, or deletions in the genetic material that encodes KIR receptors changes the site of termination for the gene, causing the cytoplasmic tail to be long or short, depending on the site of the stop codon. (wikipedia.org)
To better understand the molecular mechanisms of postoperative recovery and the regulatory role of DNA methylation in gene expression, we analyzed the changes in DNA methylation levels after allotransplantation in pearl oyster Pinctada fucata martensii, and elucidated the regulatory function of DNA methylation in promoter activity of nicotinic acetylcholine receptor (nAChR) gene. (bvsalud.org)
Specificity1
A tumor necrosis factor receptor subtype that has specificity for TUMOR NECROSIS FACTOR ALPHA and LYMPHOTOXIN ALPHA. (childrensmercy.org)
Leukocyte1
I have used structural biology to explain pre-T-cell receptor (TCR) self-association in T-cell development, and how the TCR specifically recognises polymorphic Human Leukocyte Antigen (HLA) molecules in the context of viral immunity and aberrant T-cell reactivity. (cardiff.ac.uk)
Subset1
The receptor combination for each subset is denoted by black-filled circles, with total number of iNKR in each subset indicated beneath. (bio-rad-antibodies.com)
Extracellular1
KIR receptors are named based on the number of their extracellular Ig-like domains (2D or 3D) and by the length of their cytoplasmic tail (long (L), short (S), or pseudogene (P)). The number following the L, S, or P in the case of a pseudogene, differentiates KIR receptors with the same number of extracellular domains and length of cytoplasmic tail. (wikipedia.org)
Ligands1
Unlike cytotoxic T cells, they do not require prior sensitization to eliminate tumor cells but mediate cytotoxicity through complex interactions between NK cell surface receptors and their cognate ligands expressed on their respective target cells [ 6 ]. (biomedcentral.com)
Cell4
The influence of glucocorticoid receptor single nucleotide polymorphisms on outcome after haematopoietic stem cell transplantation. (cdc.gov)
Cell surface receptors containing an immunoglobin domain. (embl.de)
CD4 is a co-receptor of the T cell receptor (TCR) and assists the latter in communicating with antigen-presenting cells . (wikidoc.org)
[12] The binding to CD4 creates a shift in the conformation of gp120 allowing HIV-1 to bind to a co-receptor expressed on the host cell. (wikidoc.org)
Cells2
KIR receptors can distinguish between MHC I allelic variants, which allows them to detect virally infected cells or transformed cells. (wikipedia.org)
KIR and CD94 (CTLR) receptors are expressed by 5% of peripheral blood T cells. (wikipedia.org)
Signaling molecules1
When activated the receptor undergoes autophosphorylation, phosphorylation of down-stream signaling molecules and rapid down-regulation. (rush.edu)
Signals1
The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM. (childrensmercy.org)
Structure1
In the HLA-B*2705-EBV structure the P8 glutamate side chain is solvent-exposed and may inhibit KIR3DL1 binding through electrostatic forces. (ox.ac.uk)
Type1
Receptors, Tumor Necrosis Factor, Type I" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)
Profiles2
Below are the most recent publications written about "Receptors, KIR" by people in Profiles. (umassmed.edu)
Below are the most recent publications written about "Receptor, Macrophage Colony-Stimulating Factor" by people in Profiles. (rush.edu)
We undertook this study to ascertain if patients with spondylarthritis express beta(2)-microglobulin-free HLA-B27 heavy chains in the form of homodimers and receptors for HLA-B27 homodimers. (ox.ac.uk)