• We undertook this study to investigate receptor (IL-2R) accumulation is related to whether the cytokine accumulation in PCs the leukocyte content of the platelet comc obtained from single apheresis donors was ponent and can be reduced by prestorage beyond the acceptable limits of WBC conc leukocyte depletion [ 3 ]. (who.int)
  • This gene encodes a member of the type II cytokine receptor family. (nih.gov)
  • The encoded protein is a subunit of the receptor for interleukin 20, a cytokine that may be involved in epidermal function. (nih.gov)
  • GO analysis revealed that the DEGs were enriched in biological processes related to inflammation, and the enriched pathways in the KEGG pathway analysis were cytokine-cytokine receptor interaction, chemokine signalling pathway and NF-κB signalling pathway. (researchsquare.com)
  • Interleukin-33 (IL-33) is a recently identified cytokine, an important member of the interleukin-1 family. (frontiersin.org)
  • IL-33 is an endogenous ligand for the ST2/T1 receptor, and depending on the cellular and cytokine context, participates in many immune diseases with dual, pro-inflammatory, or protective roles. (frontiersin.org)
  • Interleukin-6 (IL-6) is a multifunctional cytokine that regulates pleiotropic roles in immune regulation, inflammation, hematopoiesis, and oncogenesis. (sbhsciences.com)
  • In vitro, long-term exposure to high glucose and the peptide hormone leptin secreted by adipose tissue induce β-cell apoptosis and production of the proinflammatory cytokine interleukin (IL)-1 in β-cells and pancreatic islets, respectively ( 7 , 8 ). (diabetesjournals.org)
  • Interleukin-8 (IL-8), a member of a family of structurally related cytokines, is a neutrophil chemotactic cytokine that can signal through the CXCR1 and CXCR2 receptor. (genscript.com)
  • The protein encoded by this gene belongs to the cytokine receptor family. (creativebiomart.net)
  • This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21. (creativebiomart.net)
  • We selected most pathways IL10RB participated on our site, such as Cytokine-cytokine receptor interaction, Epstein-Barr virus infection, Jak-STAT signaling pathway, which may be useful for your reference. (creativebiomart.net)
  • IL-8RB binds to IL-8 with the same affinity as IL-8RA, but also binds to neutrophil-activating protein 2 (NAP-2) and other small receptor molecules of the CXC chemokine family with lower affinity than IL-8 binding, exhibiting a "shared" binding behavior. (wikipedia.org)
  • From these data, it can be concluded that, in addition to IL-8, GCP-2, but not ENA-78, efficiently binds to both CXCR1 and CXCR2. (tau.ac.il)
  • This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. (cancerindex.org)
  • Binds to IL-8 with high affinity. (joplink.net)
  • IL-33 binds to its receptor ST2 to induce type 2 cytokines and exert both pro-inflammatory and protective functions in host defense and disease. (frontiersin.org)
  • IL-8, released in response to inflammatory stimuli, binds to the extracellular side of CXCR1. (rcsb.org)
  • The interleukin-1 receptor antagonist (IL-1Ra) is a member of the interleukin (IL)-1 family that binds to IL-1 receptors without inducing a cellular response, thereby antagonizing the effects of IL-1α and -1β ( 1 ). (diabetesjournals.org)
  • IL-8 augmented the [Ca 2+ ](i) more efficiently in CXCR1-transfectants than in CXCR2-transfectants, whereas for ENA-78, threefold higher concentrations were necessary to obtain a calcium response in CXCR1-transfected cells than in CXCR2-transfectants. (tau.ac.il)
  • GCP-2 desensitized the calcium increase induced by IL-8 in both CXCR1-transfected and CXCR2-transfected cells, but ENA-78 only affected the IL-8-induced calcium response in CXCR2-transfectants. (tau.ac.il)
  • The half-maximal effective concentrations for migration of CXCR2-transfectants in response to GCP-2 and ENA-78 were similar (0.1 nM), whereas GCP-2 was tenfold more potent than ENA-78 on CXCR1-transfectants, Half-maximal migration of CXCR1-transfected and CXCR2-transfected cells was obtained with IL-8 at concentrations of no more than 0.01 nM. (tau.ac.il)
  • Radiolabeled IL-8 could efficiently be displaced from CXCR2 by IL-8, GCP-2 and ENA-78. (tau.ac.il)
  • However, ABF was unable to fully desensitize the response to IL-8, and binding to CXCR1 or CXCR2 was excluded in experiments using RBL-2H3 cells transfected with the two human IL-8 receptors. (ed.ac.uk)
  • Les numérations plaquettaire et leucocytaire ainsi que la concentration en cytokines (IL-2R, IL-8 et TNF-) ont été me- surées. (who.int)
  • The fibroblasts then produce hyaluronan and the cytokines interleukin (IL)-1 beta, IL-6, IL-8, IL-16, tumor necrosis factor (TNF) alpha, and CD4 ligand. (medscape.com)
  • The interleukin-1 (IL-1) family is a growing group of cytokines, consisting of at least 11 members, and the balance between pro- and anti-inflammatory cytokines is crucial in the pathogenesis of many human diseases ( 3 ). (frontiersin.org)
  • Deletion of IL-33/ST2 function enhances cytotoxicity of NK cells and increases levels of TNF-α, IFN-γ, and IL-17, and systemic pro-inflammatory cytokines, leading to attenuated tumor growth ( 8 ). (frontiersin.org)
  • Its biological activities are shared by IL-6-family of cytokines such as leukemia inhibitory factor and oncostatin M. IL-6 exerts its biological activities through interaction with specific receptors expressed on the surface of target cells. (sbhsciences.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Interleukin 8 Receptor Beta (IL8Rb) in serum, plasma, tissue homogenates, cell lysates and other biological fluids. (scalegen.com)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Rat Interleukin 8 Receptor Beta (IL8Rb) in samples from Serum, plasma, tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (scalegen.com)
  • Intra-assay Precision (Precision within an assay): 3 samples with low, middle and high level Interleukin 8 Receptor Beta (IL8Rb) were tested 20 times on one plate, respectively. (biomatik.com)
  • Inter-assay Precision (Precision between assays): 3 samples with low, middle and high level Interleukin 8 Receptor Beta (IL8Rb) were tested on 3 different plates, 8 replicates in each plate. (biomatik.com)
  • This assay has high sensitivity and excellent specificity for detection of Interleukin 8 Receptor Beta (IL8Rb). (biomatik.com)
  • No significant cross-reactivity or interference between Interleukin 8 Receptor Beta (IL8Rb) and analogues was observed. (biomatik.com)
  • This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. (cancerindex.org)
  • The differential receptor usage of the structurally related ELR + CXC chemokines GCP-2 and ENA-78 is indicative of a different role in inflammatory reactions. (tau.ac.il)
  • [8] The gene for CXCL1 is located on human chromosome 4 amongst genes for other CXC chemokines. (wikidoc.org)
  • These receptors are generally found on human neutrophils, a type of white blood cell of the myeloid lineage, with approximately 65,000 receptors per neutrophil. (wikipedia.org)
  • The reported size of the translated protein is approximately 40kD, differing from the native purified receptors from the surface of neutrophils by 20kD. (wikipedia.org)
  • Patients with COPD showed significantly higher percentages of neutrophils and levels of sTNF-R55 and IL-8 in sputum as compared with control subjects, whereas sputum sTNF-R75 levels tended to be higher in COPD. (nih.gov)
  • IL-8 was found in neutrophils, epithelial cells, and macrophages. (nih.gov)
  • The epithelial IL-8 expression did not correlate with the numbers of neutrophils, macrophages, CD45RO+, CD8+, or mast cells. (nih.gov)
  • IL-8 endothelial-derived chemokine involved in recruiting neutrophils to sites of injury and stimulating their response. (randox.com)
  • Binding of IL-8 to the receptor causes activation of neutrophils. (joplink.net)
  • This augmentation was blocked by the CB1 receptor antagonist SR141716A or the D2 antagonist sulpride. (jneurosci.org)
  • Interleukin (IL)-β plays a central role in inflammation and atherosclerosis, but levels of IL-1β, its natural antagonist, IL-1Ra, and their balance in human atherosclerotic lesions, are unknown. (go.jp)
  • The secreted form of the interleukin-1 receptor antagonist (IL-1Ra) is an acute-phase protein intervening in the counterregulation of inflammatory processes. (diabetesjournals.org)
  • Pancreatic β-cell IL-1 expression is increased and interleukin-1 receptor antagonist (IL-1Ra) expression reduced in patients with type 2 diabetes. (diabetesjournals.org)
  • This study aimed to elucidate the relationship between local and systemic inflammation in smoking-induced COPD by assessing levels of soluble (s) tumor necrosis factor (TNF) receptors, TNF-alpha, and interleukin-8 (IL-8) in induced sputum and in plasma. (nih.gov)
  • The HER (erbB) family of transmembrane receptor tyrosine kinases is one of the cytostatic targets in tumor cell growth and survival. (medscape.com)
  • NK cells contribute to cancer immune surveillance not only by their direct natural cytotoxicity which is triggered rapidly upon stimulation through germline-encoded cell surface receptors, but also by modulating T-cell mediated antitumor immune responses through maintaining the quality of dendritic cells and enhancing the presentation of tumor antigens. (frontiersin.org)
  • Expression of the pro-inflammatory chemokineIL-8 was measured to confirm the status of an inflamed uterus. (aber.ac.uk)
  • Recent studies have shown that Toll-like receptor (TLR)- signalling contributes significantly to the inflammatory events of atherosclerosis. (aston.ac.uk)
  • Each oxysterol stimulated secretion of the inflammatory chemokine interleukin-8 (IL-8), but not I?B degradation or tumour necrosis factor- release from monocytic THP-1 cells. (aston.ac.uk)
  • Dust extract induction of IL-8 gene expression was associated with increased DHE-fluorescence and 4-HNE staining, and antioxidants suppressed inflammatory gene induction. (cdc.gov)
  • CXCR1 is one of two high-affinity receptors for the CXC chemokine interleukin-8 (IL-8), a major mediator of immune and inflammatory responses implicated in many disorders, including tumour growth. (rcsb.org)
  • Analytes include soluble growth and differentiation factors, extracellular matrix components, proteases, membrane-bound receptors, and intracellular signaling molecules. (rndsystems.com)
  • CSF immune activation markers interferon-gamma-inducible protein (IP-10, P =0.059), interleukin (IL)-8 ( P =0.059), and immunovascular markers vascular endothelial growth factor-C (VEGF-C, P =0.095) and VEGFR-1 (the soluble receptor for VEGFs, P =0.059) also trended higher in people with post-COVID cognitive changes, the researchers said. (medpagetoday.com)
  • Results In vitro, PR3 promoted monocyte-derived MGC formation using cells from patients with GPA but not from patients with MPA, and this was dependent on soluble interleukin 6 (IL-6), as well as monocyte MAC-1 and protease-activated receptor-2, found to be overexpressed in the cells of patients with GPA. (bmj.com)
  • The interleukin-8 receptors (IL-8R) are two 7-transmembrane proteins in the G-protein coupled-receptor family: interleukin-8 receptor A (IL-8RA) and interleukin-8 receptor B (IL-8RB). (wikipedia.org)
  • Both receptors have a size of 60kDa, are glycosylated (contains covalent attachments and modifications) and G-protein linked, and can cause an increase in intracellular Ca2+ levels. (wikipedia.org)
  • The amino terminus of the receptors is located on the extracellular side of the protein, and function to determine the binding specificity of ligands to the receptor. (wikipedia.org)
  • The carboxyl terminus of the receptors is located on the intracellular side of the protein, and is rich in serine and threonine residues (a characteristic of many proteins of the 7-transmembrane G-protein coupled receptor family). (wikipedia.org)
  • The receptor usage of the CXC chemokine granulocyte chemotactic protein-2 (GCP-2) was compared with that of interleukin-8 (IL-8) and epithelial-cell-derived neutrophil attractant-78 (ENA-78). (tau.ac.il)
  • Calcium mobilization in response to A. suum-derived products was completely abrogated by pretreatment with pertussis toxin, implicating a classical G protein-coupled receptor mechanism in the response to ABF. (ed.ac.uk)
  • Our results provide the first evidence for a direct interaction between a parasite-derived chemotactic factor and the host's chemotactic network, via a novel G protein-coupled receptor which interacts with the IL-8 receptor pathway. (ed.ac.uk)
  • Cannabinoids act at the CB1 receptor to inhibit adenylate cyclase activity via a pertussis toxin-sensitive G-protein. (jneurosci.org)
  • Treatment of the pertussis toxin-treated cells with cholera toxin before CB1 receptor activation amplified the stimulatory pathway, suggesting that this response was mediated through a G s -type G-protein. (jneurosci.org)
  • Cannabinoids exert many of their effects through activation of G i -protein-coupled receptors. (jneurosci.org)
  • The interleukin 20 receptor is a heterodimeric complex consisting of the encoded protein and interleukin 20 receptor beta. (nih.gov)
  • The protein encoded by this gene is a member of the G-protein-coupled receptor family. (cancerindex.org)
  • This protein is a receptor for interleukin 8 (IL8). (cancerindex.org)
  • Protease inhibitors and antioxidants suppressed protein kinase C and NF-kappaB activation and induction of IL-8 promoter activity in cells exposed to dust extract. (cdc.gov)
  • CXCR1 is a class A, rhodopsin-like G-protein-coupled receptor (GPCR), the largest class of integral membrane proteins responsible for cellular signal transduction and targeted as drug receptors. (rcsb.org)
  • Recent structural determination of GPCRs has advanced by modifying the receptors with stabilizing mutations, insertion of the protein T4 lysozyme and truncations of their amino acid sequences, as well as addition of stabilizing antibodies and small molecules that facilitate crystallization in cubic phase monoolein mixtures. (rcsb.org)
  • Parasite-derived chemotactic factors which selectively recruit granulocytes have been described, but nothing is known about which cellular receptors respond to these agents. (ed.ac.uk)
  • Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. (joplink.net)
  • IL-8RA is highly specific for interleukin-8 and only responds when this particular ligand is bound to its receptor site, exhibiting "specific" binding behavior. (wikipedia.org)
  • In that study, there was significant upregulation of Toll-like receptor (TLR)2 gene expression and a corresponding increase in CXC ligand 8 (interleukin (IL)-8) in NA. (ersjournals.com)
  • IL-6 Receptor (IL-6R, gp80) is 80 kDa alpha subunit, transmembrane glycoprotein that is 449 aa long. (sbhsciences.com)
  • Upon binding of IL-6 to the receptor (alpha subunit), gp130 is homodimerized and is subsequently involved in down-stream signal processes binding tyrosine kinases and activating STAT1 and STAT3 transcriptional factors. (sbhsciences.com)
  • In addition, sputum sTNF receptors were inversely related to the FEV(1) in patients with COPD, whereas circulating sTNF receptors were not, suggesting different regulation of inflammation in the pulmonary and systemic compartment. (nih.gov)
  • When subjects were divided according to their current smoking status, levels of sTNF-R55, sTNF-R75, and IL-8 in sputum were significantly elevated in ex-smoking versus currently smoking patients with COPD, suggesting ongoing inflammation in airways and circulation of patients with COPD after smoking cessation. (nih.gov)
  • This receptor mediates neutrophil migration to sites of inflammation. (cancerindex.org)
  • The selectin adhesion molecules and chemoattractant receptors synergistically regulate leukocyte migration into lymphoid tissues and sites of inflammation, but little is known about how these families of receptors modulate each other's function. (upenn.edu)
  • Endometrial biopsies were collected from 6 RM and 9 SM during oestrus and 24 h after infusion of frozen/thawed spermatozoa and the mRNA expression of TLR4 and IL-8 was quantified by rt-PCR. (aber.ac.uk)
  • It was demonstrated that expression of interleukin‑8 (IL‑8) mRNA was significantly upregulated in Gem‑R PaCa cells by cDNA microarray and RT‑qPCR analyses. (cancerindex.org)
  • Chemokine activities were evaluated by measurement of intracellular calcium increase and by chemotasis and binding assays, using CXC chemokine receptor (CXCR)-transfected cell lines. (tau.ac.il)
  • Description: A sandwich ELISA kit for detection of Interleukin 8 Receptor Beta from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (scalegen.com)
  • Description: A sandwich ELISA kit for detection of Interleukin 10 Receptor Alpha from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (tuberculosisdrugresearch.org)
  • Several other HT have been associated with SCD-related complications, notably elevated white blood cell (WBC) count and neutrophil count with survival, 2 , 6 , 7 low hemoglobin (Hb) levels with composite severe outcomes and death, 7 , 8 and platelet (PLT) count with ACS. (haematologica.org)
  • Moreover, pretreatment with interleukin-8 (IL-8) completely abrogated the response to ABF, demonstrating desensitization of a common pathway. (ed.ac.uk)
  • Stimulation of cAMP accumulation was not observed after pertussis toxin treatment of CHO cells expressing the human CB2 receptor, suggesting that this novel signaling pathway is unique to the cannabinoid CB1 receptor. (jneurosci.org)
  • The genes for both receptors are located on chromosome 2q35 and are each encoded by a single exon, and are 20 kb apart in distance. (wikipedia.org)
  • BACKGROUND/AIMS: Angiogenesis, which is a critical step in the initiation and progression of rheumatoid arthritis (RA), involves pro-angiogenic factors, including interleukin (IL)-8 and vascular endothelial growth factor (VEGF). (koreamed.org)
  • An excess of the proinflammatory substance IL-18 is present in joints of patients with rheumatoid arthritis (RA), and expression of IL-18 receptor (IL-18R) regulates IL-18 bioactivity in various cell types. (uni-frankfurt.de)
  • However, an interaction between D2 and CB1 receptors has not been established. (jneurosci.org)
  • Toll-like receptors (TLR) are host cell receptors for bacterial-associated molecules and play an important role in modulating immune responses by activating antigen-presenting cells. (aber.ac.uk)
  • Furthermore, similar to T cells, specific recognition and elimination of cancer cells by NK cells can be markedly enhanced through expression of chimeric antigen receptors (CARs), which provides an opportunity to generate NK-cell therapeutics of defined specificity for cancer immunotherapy. (frontiersin.org)
  • This family, which includes epidermal growth factor receptor (EGFR), plays a pivotal role in normal cell growth, lineage determination, repair, and functional differentiation. (medscape.com)
  • GenScript Human IL-8 ELISA Detection Kit is a solid phase sandwich ELISA for quantitative measurement of human IL-8 in serum, plasma and cell culture supernatant. (genscript.com)
  • Acquisition of gemcitabine resistance enhances angiogenesis via upregulation of IL‑8 production in pancreatic cancer. (cancerindex.org)
  • Immunoglobulins against insulin-like growth factor 1 (IGF-1) receptors activate signaling in the orbital fibroblasts. (medscape.com)
  • In addition, the evolutionary success of the CC- chemokine receptor null mutation, CCR532, believed to have fi rst appeared in northern Europe up to 3,500 years ago in a single person, is a good example of the importance of smallpox in human immune evolution ( 16 ). (cdc.gov)
  • Description: A sandwich quantitative ELISA assay kit for detection of Human Interleukin 10 Receptor Alpha (IL10Ra) in samples from tissue homogenates, cell lysates or other biological fluids. (tuberculosisdrugresearch.org)
  • Interactions between L-selectin and chemoattractant receptors were therefore examined using transfected rat basophilic leukemia cell lines (RBL-2H3) that expressed human L-selectin along with human leukocyte chemoattractant receptors. (upenn.edu)
  • However, all FLS cultures studied were either resistant or barely responsive to IL-18 stimulation as regards cell proliferation, expression of adhesion molecules ICAM-1 and vascular cell adhesion molecule (VCAM)-1, and the release of interstitial collagenase and stromelysin, IL-6 and IL-8, prostaglandin E2, or nitric oxide. (uni-frankfurt.de)
  • When comparing sTNF receptors in sputum and plasma, no direct correlations were found despite elevation of circulating sTNF-R75 levels in patients with COPD. (nih.gov)
  • Une étude a été menée dans des unités de soins intensifs en chirurgie pour adultes de l'hôpital universitaire de Zagazig, (Égypte) auprès de 25 patients atteints de septicémie, de 27 patients atteints d'une septicémie sévère et de 28 témoins. (who.int)
  • Similar augmentation of cAMP accumulation after pertussis toxin treatment was observed in Chinese hamster ovary (CHO) cells transfected with, and stably expressing, the CB1 receptor. (jneurosci.org)
  • Interleukin-33 (IL-33) is an important member of the IL-1 family, and in humans is expressed predominantly in skin, lung, adipocytes, and synovial fibroblasts ( 4 ). (frontiersin.org)
  • In contrast, catabolic markers and IL-8 expression were upregulated by 41.5-EVi1. (bvsalud.org)
  • European descent, preventing expression of the as-yet mostly inscrutable CCR5 receptor on the surface of many that were collected during the Cold War as potential different subsets of immune cells. (cdc.gov)
  • In the Ingenuity Pathways Analysis of RNA expression data, the CDAA-HF-T(-) feeding revealed common signal changes in nontumoral and tumoral liver tissues, including increased IL-8 and RhoGTPases signaling and decreased lipid metabolism. (bvsalud.org)
  • Neuropilin 1 (NP1) is a part of essential receptor complexes mediating both semaphorin3A (SEMA3A) and vascular endothelial growth factor (VEGF) which is one of important mediators involved in the pathogenesis. (koreamed.org)
  • Transforming Growth Factor- (-509), IL-8 (-251), and IL-13 (1055) SNPs were also analyzed, but no association with decline in FEV1 was found. (cdc.gov)
  • Previously, CB1 receptors have been shown to inhibit D1 receptor-mediated cAMP accumulation ( Bidaut-Russell and Howlett, 1991 ). (jneurosci.org)
  • [ 5 ] Ideally, SCID can be detected in a newborn before the onset of infections, with one well-documented example by screening of T-cell-receptor excision circles. (medscape.com)