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Interleukin-1Interleukin-2Receptors, InterleukinInterleukin-6CytokinesInterleukin-4Interleukin-10InterleukinsInterleukin-8Interleukin 1 Receptor Antagonist ProteinTumor Necrosis Factor-alphaCells, CulturedReceptors, Interleukin-2Interferon-gammaT-LymphocytesInterleukin-12Lymphocyte ActivationRNA, MessengerRecombinant ProteinsReceptors, Interleukin-1Interleukin-1betaInterleukin-3Mice, Inbred C57BLInterleukin-5Interleukin-18Mice, Inbred BALB CLipopolysaccharidesReceptors, Interleukin-4InflammationInterleukin-13Cell LineReceptors, Interleukin-6Interleukin-11MonocytesCell DivisionGene Expression RegulationSignal TransductionReceptors, ImmunologicTh2 CellsEnzyme-Linked Immunosorbent AssayInterleukin-17Flow CytometryAntigens, CDMacrophagesSpleenInterleukin-15Molecular Sequence DataInterleukin-7Leukocytes, MononuclearCD4-Positive T-LymphocytesTumor Cells, CulturedGene ExpressionTh1 CellsKiller Cells, NaturalAntibodies, MonoclonalNF-kappa BInterleukin-13 Receptor alpha1 SubunitInflammation MediatorsBase SequenceReceptors, Interleukin-13B-LymphocytesReverse Transcriptase Polymerase Chain ReactionLymphokinesMice, KnockoutT-Lymphocytes, Helper-InducerCytotoxicity, ImmunologicCell DifferentiationSialoglycoproteinsDose-Response Relationship, DrugSTAT3 Transcription FactorLymphocytesAntigens, Differentiation, T-LymphocyteKiller Cells, Lymphokine-ActivatedGrowth SubstancesDendritic CellsMice, Inbred C3HTime FactorsDisease Models, AnimalTransfectionUp-RegulationInterleukin-1alphaAntigens, CD3KineticsPhytohemagglutininsInterleukin-23Receptors, Interleukin-1 Type IBiological MarkersMice, Inbred StrainsCytokine Receptor gp130Receptors, Interleukin-5Caspase 1Transcription, GeneticSTAT6 Transcription FactorMembrane GlycoproteinsDinoprostoneImmunoglobulin EReceptors, Interleukin-10ImmunotherapyReceptors, Interleukin-7Receptors, Interleukin-3
High bindingProteinTLR4KinaseLigandAntigenShared receptor componentSurface of macrophagesTumour necrosIL4RGenesSerumChemokine receptorTransmembrane receptorCytokinesSIGNALINGAntagonistType I cytokiAlphaBindsGene encodesTumorBETA SUBUNITExpressionSpecificityInflammatory responsesLipopolysaccharideIntracellularAtherosclerosisRegulatesInhibitorsMyd88Extracellular domainEnzymesCytoplasmicInflammationHuman chromosomeInnate immunitySplice variantFamilyIL13DupilumabFactorEpitopeResponses
High binding1
  • The present invention discloses antibodies and blocking antibodies to canine IL-4 receptor alpha that have specific sequences and a high binding affinity for canine IL-4 receptor or α. (covalx.com)
Protein13
  • This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE antibody production in B cells. (wikipedia.org)
  • Among T cells, the encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. (wikipedia.org)
  • LPS binds to the cell-surface receptor, Toll-like receptor 4 (TLR4), which initiates a signal transduction cascade, including recruitment of the Toll-interleukin 1 receptor domain-containing adaptor protein (TIRAP). (aspetjournals.org)
  • The encoded protein is a subunit of the receptor for interleukin 20, a cytokine that may be involved in epidermal function. (nih.gov)
  • The interleukin 20 receptor is a heterodimeric complex consisting of the encoded protein and interleukin 20 receptor beta. (nih.gov)
  • Here we show by genetargeting that IRAK-4, an IRAK molecule closely related to the Drosophila Pelle protein, is indispensable for the responses of animals and cultured cells to IL-1 and ligands that stimulate various TLRs. (elsevierpure.com)
  • Also, Interleukin-4 antagonizes the activity of interleukin-1 by inducing the expression and release of this protein. (prospecbio.com)
  • Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. (wikidoc.org)
  • TRAIL, also called Apo2L, is a cytotoxic protein that induces apoptosis of many transformed cell lines but not of normal tissues, even though its death domain-containing receptor, DR4, is expressed on both cell types. (embl-heidelberg.de)
  • It seemed possible therefore, that the ability of IL-4 to promote increases in intracellular calcium, protein kinase C activation and cAMP generation might have a role in IL-4-induced CD25 expression. (gla.ac.uk)
  • Additionally, we have demonstrated that IL-4-induced cAMP production is dose dependent and leads to the activation of the cAMP-dependent protein kinase, PKA, in primary human B cells. (gla.ac.uk)
  • Results Plasma fatty acid-binding protein 4, interleukin-1 receptor antagonist, interleukin-6 and leptin were negatively associated with FEV 1 and paraoxonase 3 was positively associated therewith. (lu.se)
  • Fatty acid-binding protein 4, fibroblast growth factor 21, interleukin-1 receptor antagonist, interleukin-6 and leptin were negatively associated with FVC and agouti-related protein, insulin-like growth factor-binding protein 2, paraoxonase 3 and receptor for advanced glycation end products were positively associated therewith. (lu.se)
TLR44
  • Induction of hepatic cytokines (interleukin-1β, tumor necrosis factor-α, and interleukin-6), c-Jun N-terminal kinase, and nuclear factor-κB was blocked in TLR4-mutant mice. (aspetjournals.org)
  • An observational cross-sectional case control study was conducted to estimate the association between Toll-like receptor 4 (TLR4) expression and interleukin (IL)-17A serum levels in patients with controlled and non-controlled hypertension. (kbco.hr)
  • Clones that neutralised FBG activation of toll-like receptor 4 (TLR4), without impacting pathogenic TLR4 activation, were epitope mapped by crystallography. (bmj.com)
  • Activation of toll-like receptor 4 (TLR4) by tenascin-C, a matrix molecule persistently expressed at high levels in people with RA, drives chronic inflammation in models of rheumatoid arthritis (RA). (bmj.com)
Kinase1
  • Signal transduction between MyD88 and TRAF6 is known to involve the serine-threonine kinase IL-1 receptor-associated kinase 1 (IRAK-1) and two homologous proteins, IRAK-2 (ref. 12) and IRAK-M. However, the physiological functions of the IRAK molecules remain unclear, and gene-targeting studies have shown that IRAK-1 is only partially required for IL-1R and TLR signalling. (elsevierpure.com)
Ligand5
  • IL4R is the common ligand binding subunit shared by the IL-4 receptors type I (receptor for IL-4) and type II (receptor for IL-4 and IL-13). (guidetomalariapharmacology.org)
  • This cytokine is a ligand for interleukin 4 receptor. (antibodies-online.com)
  • Increased expression of IL-6 and chemokine (C-X-C motif) ligand 1 in the bronchoalveolar lavage and serum was also dependent on TLR-4 activation. (nih.gov)
  • Interleukin-4 (IL-4) is a pleiotropic, immune-modulatory cytokine produced by activated T cells, and serves as a ligand for interleukin 4 receptor. (fishersci.com)
  • To determine the binding contributions of the individual components of the IL-13 receptor to IL-13, we have employed surface plasmon resonance and equilibrium binding assays to investigate the ligand binding characteristics of shIL-13R?1, shIL-13R?2, and IL-4R? (soton.ac.uk)
Antigen2
  • Toll-like receptors (TLR) are host cell receptors for bacterial-associated molecules and play an important role in modulating immune responses by activating antigen-presenting cells. (aber.ac.uk)
  • Second, T cell therapies using Tregs (either polyclonal, antigen-specific, or genetically engineered to express chimeric antigen receptors) to establish active dominant immune tolerance or T cells (engineered to express chimeric antigen receptors) to delete pathogenic immune cells. (frontiersin.org)
Shared receptor component1
Surface of macrophages1
Tumour necros2
  • Each oxysterol stimulated secretion of the inflammatory chemokine interleukin-8 (IL-8), but not I?B degradation or tumour necrosis factor- release from monocytic THP-1 cells. (aston.ac.uk)
  • Serum interleukin (IL)-1, IL-6, tumour necrosis factor (TNF) and quantitative urinary -2-microglobulin (-2-m) excretion were estimated. (who.int)
IL4R1
  • IL4R is the human gene coding for IL-4Rα, the subunit which combines with either common gamma chain (γc, forming the type I IL4 receptor) or with IL-13Rα1 (forming the type II IL4 receptor). (wikipedia.org)
Genes1
  • Objective: To determine if specific single nucleotide polymorphisms (SNPs) of interleukin 4 receptor alpha (IL4RA), IL-13, and CD14 promoter genes are associated with DA. (cdc.gov)
Serum2
  • The concentration of albumin in serum is 40 g/L, while the estimated concentration of albumin in primary urine is 4 mg/L, or 0.1% of its concentration in plasma. (medscape.com)
  • [ 4 ] Because increased serum quinolinic acid concentrations have been recorded in eosinophilic fasciitis, these data support a relationship between EMS and eosinophilic fasciitis. (medscape.com)
Chemokine receptor3
  • The concept of the polarization of chemokine receptor expression by T(H)1 and T(H)2 cells provides an attractive mechanism for their differential recruitment to tissue, which could be subject to disease-specific therapeutic intervention. (nih.gov)
  • We used single-cell analysis to investigate the relationship between chemokine receptor expression and cytokine production on peripheral blood and bronchoalveolar lavage fluid T cells in patients with asthma, a putative T(H)2 disease, as well as in healthy control subjects. (nih.gov)
  • PF4 is chemotactic for neutrophils , fibroblasts and monocytes , and interacts with a splice variant of the chemokine receptor CXCR3 , known as CXCR3B. (wikidoc.org)
Transmembrane receptor1
  • Classic signaling involves IL-6 binding to a specific transmembrane receptor termed IL-6Rα. (jneurosci.org)
Cytokines2
SIGNALING10
  • IL-4/IL-13 signaling beyond JAK/STAT". J. Allergy Clin. (wikipedia.org)
  • Portions of this work were in Regulation of Drug Metabolizing Enzymes in Inflammation: Role of the Toll-Like Receptor 4 Signaling Pathway (R. Ghose, D. White, J. Vallejo, and S. J. Karpen), which was presented at Experimental Biology 2007 in Washington, DC, April 28-May 2, 2007. (aspetjournals.org)
  • IL1R2 binds IL1A, IL1B and IL1RN preventing them from binding to their regular receptors and thus inhibiting the transduction of their signaling. (prospecbio.com)
  • IL-1 receptor-associated kinases (IRAKs) are serine/threonine kinases that help mediate signaling from Toll-like receptor (TLR) and IL-1 receptor family members. (rndsystems.com)
  • Although some aspects of the signaling pathways downstream of p75 have been elucidated recently, mechanisms of receptor activation and proximal signaling events are unknown. (embl-heidelberg.de)
  • Unlike the death domains involved in signaling by the TNF receptor and Fas, p75ICD does not self-associate in solution. (embl-heidelberg.de)
  • The molecular underpinnings common to and connecting these disorders are not known, but may include shared genetic risk factors ( 1 , 8 ), regulation of brain cations ( 9 , 10 ), or common receptor signaling events that activate pain ( 11 ), inflammation ( 12 ), or oxidative ( 13 ) pathways. (frontiersin.org)
  • Detailed kinetic analyses of the binding properties of the heteromeric complexes suggested a sequential mechanism for the binding of IL-13 to its signaling receptor, in which IL-13 first binds to IL-13R?1 and this then recruits IL-4? (soton.ac.uk)
  • CD36 functions as both a signaling receptor and fatty acid transporter in various immune and non-immune cells. (rupress.org)
  • A family of intracellular signaling kinases that were identified by their ability to signal from the activated INTERLEUKIN-1 RECEPTORS. (bvsalud.org)
Antagonist2
  • An antagonist decoy receptor and a death domain-containing receptor for TRAIL. (embl-heidelberg.de)
  • An antagonist decoy receptor (designated as TRID for TRAIL receptor without an intracellular domain) that may explain the resistant phenotype of normal tissues was identified. (embl-heidelberg.de)
Type I cytoki1
  • The interleukin 4 receptor is a type I cytokine receptor. (wikipedia.org)
Alpha14
  • They are required for binding of interleukin-4 to the receptor alpha chain, which is a crucial event for the generation of a Th2-dominated early immune response. (wikipedia.org)
  • The present invention further discloses unique epitopes that bind to the antibodies to canine IL-4 receptor alpha. (covalx.com)
  • In order to identify the epitopes that are recognized by anti-canine IL-4 receptor alpha mAbs, CovalX completed epitope mapping. (covalx.com)
  • From this service, it was able to be determined that the 6 mAbs recognized specific peptide epitopes (two or three per antibody tested) that are within the extracellular domain of canine IL-4 receptor alpha. (covalx.com)
  • Thus, it can be suggested that because of the overlap with the epitopes recognized by the six monoclonal antibodies, there is a limited number of portions of canine Il-4 receptor alpha that these antibodies can identify within the extracellular domain. (covalx.com)
  • IL-6 Receptor (IL-6R, gp80) is 80 kDa alpha subunit, transmembrane glycoprotein that is 449 aa long. (sbhsciences.com)
  • Upon binding of IL-6 to the receptor (alpha subunit), gp130 is homodimerized and is subsequently involved in down-stream signal processes binding tyrosine kinases and activating STAT1 and STAT3 transcriptional factors. (sbhsciences.com)
  • Interleukin-5 Receptor alpha Subunit" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • Several isoforms of the interleukin-5 receptor alpha subunit exist due to multiple ALTERNATIVE SPLICING. (harvard.edu)
  • This graph shows the total number of publications written about "Interleukin-5 Receptor alpha Subunit" by people in Harvard Catalyst Profiles by year, and whether "Interleukin-5 Receptor alpha Subunit" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Interleukin-5 Receptor alpha Subunit" by people in Profiles. (harvard.edu)
  • CD25 is the alpha chain of the multi- component interleukin-2 receptor complex and is a requirement for formation of high affinity interleukin-2 receptors. (gla.ac.uk)
  • AstraZeneca agreed to pay Pieris $45 million upfront and $12.5 million tied to initiating a Phase I trial of Pieris' lead preclinical candidate, PRS-060, an interleukin-4 receptor alpha agonist designed to treat moderate to severe asthma. (genengnews.com)
  • rs1801275 Interleukin-4 receptor alpha polymorphism in familial hypercholesterolemia. (cdc.gov)
Binds1
  • The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. (antibodies-online.com)
Gene encodes1
  • This gene encodes a member of the type II cytokine receptor family. (nih.gov)
Tumor1
  • The intracellular domain of the p75 neurotrophin receptor (p75ICD) lacks catalytic activity but contains a motif similar to death domains found in the cytoplasmic regions of members of the tumor necrosis factor receptor family and their downstream targets. (embl-heidelberg.de)
BETA SUBUNIT1
Expression4
  • An excess of the proinflammatory substance IL-18 is present in joints of patients with rheumatoid arthritis (RA), and expression of IL-18 receptor (IL-18R) regulates IL-18 bioactivity in various cell types. (uni-frankfurt.de)
  • We have found in both asthmatic and control subjects that IL-4-expressing blood and bronchoalveolar lavage fluid T cells are significantly more likely to express the T(H)2 type 2 chemokine receptors CCR 3 and CCR 4, with 10-fold and 2-fold differences in expression, respectively, compared with IFN-gamma-expressing cells. (nih.gov)
  • We have provided evidence that polarization of T(H)2-type chemokine receptors on IL-4-expressing cells can be demonstrated in an in vivo setting and therefore that these cells might indeed be susceptible to differential patterns of recruitment as a result of expression of the relevant chemokines at inflammatory sites. (nih.gov)
  • This thesis describes the regulation of CD25 gene expression by interleukin-4-activated signal transduction pathways in quiescent human B lymphocytes. (gla.ac.uk)
Specificity1
Inflammatory responses1
  • Interleukin-6 is oedema, hypercholesterolaemia and gene- involved in inflammatory responses and im- ralized hyperlipidaemia [ 1 ]. (who.int)
Lipopolysaccharide1
  • IRAK-4-deficient animals are completely resistant to a lethal dose of lipopolysaccharide (LPS). (elsevierpure.com)
Intracellular1
  • Additionally, chelation of intracellular calcium and down-regulation of PKC, by chronic phorbol ester treatment, attenuates the ability of IL-4 to up-regulate CD25. (gla.ac.uk)
Atherosclerosis1
  • Recent studies have shown that Toll-like receptor (TLR)- signalling contributes significantly to the inflammatory events of atherosclerosis. (aston.ac.uk)
Regulates1
  • Interleukin-6 (IL-6) is a multifunctional cytokine that regulates pleiotropic roles in immune regulation, inflammation, hematopoiesis, and oncogenesis. (sbhsciences.com)
Inhibitors1
  • Angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs) can reduce hypertension and may also contribute to reducing proteinuria. (medscape.com)
Myd882
  • We hypothesized that the TLR-4, in an MyD88-dependent manner, may also participate in the response to lung injury. (nih.gov)
  • Comparisons were made between wild-type mice and mice deficient in TLR-4 or MyD88. (nih.gov)
Extracellular domain1
  • The Toll-like receptor (TLR) family in mammals comprises a set of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain, and in the IL-1 receptor motif in the cytoplasmic domain. (novusbio.com)
Enzymes1
  • MCs can secrete nociceptor sensitizing and activating agents, such as serotonin, prostaglandins, histamine, and proteolytic enzymes that can also activate the pain-mediating transient receptor potential vanilloid channels. (frontiersin.org)
Cytoplasmic1
  • Toll-like receptors (TLRs), which recognize pathogen-associated molecular patterns, and members of the pro-inflammatory interleukin-1 receptor (IL-1R) family, share homologies in their cytoplasmic domains called Toll/IL-IR/plant R gene homology (TIR) domains. (elsevierpure.com)
Inflammation1
  • Interactions of IL-4 with TNFα promote structural changes to vascular endothelial cells, thus playing an important role in tissue inflammation. (wikipedia.org)
Human chromosome1
  • The gene for human PF4 is located on human chromosome 4 . (wikidoc.org)
Innate immunity1
  • Our results indicate that IRAK-4 has an essential role in innate immunity. (elsevierpure.com)
Splice variant1
Family3
  • IL1R2 is a cytokine receptor which is a part of the interleukin-1 receptor family. (prospecbio.com)
  • [ 4 ] In doing so, they noted that 1 in 5 patients with younger-onset colon cancer have pathogenic germline variants regardless of their family history. (medscape.com)
  • Interleukin (IL)-2, IL-4, IL-7, IL-9, IL-15, and IL-21 comprise a cytokine family based on sharing a receptor component, the common cytokine receptor γ chain (γc). (news-medical.net)
IL132
  • In particular, IL-4 is located in close proximity to IL13 on the chromosome. (fishersci.com)
  • Further, the IL-4 gene, IL13 and IL5 are found to be coordinated by several long-range regulatory elements over a 120 kilobase range on the chromosome. (fishersci.com)
Dupilumab1
  • dupilumab, adenovirus types 4 and 7 live, oral. (medscape.com)
Factor1
  • The human platelet factor 4 kills malaria parasites within erythrocytes by selectively lysing the parasite's digestive vacuole. (wikidoc.org)
Epitope1
Responses2
  • In addition, animals lacking IRAK-4 are severely impaired in their responses to viral and bacterial challenges. (elsevierpure.com)
  • We found TLR-4-dependent responses to pulmonary contusion that include hypoxemia, edema, and neutrophil infiltration. (nih.gov)