Macrophage Colony-SCSF3RHematopoiesisGeneAntigen receptorTyrosineCellsNeutrophilsThrombopoietin ReceptorAntagonistPlatelet-derivedBoneTherapeuticRecombinantMiceSignal transductionHumanCytokinesCytokine receptorBiologicAgonistsPathwaysNeutropeniaImmunoglobulinActivationInflammationProliferationLigandChemokineRegulateGenesStromalMediateEndogenousMutationsStemModulationVivoLead to immuneMechanismsInternalizationCell
Macrophage Colony-S1
- Distinct domains of the human granulocyte-macrophage colony-stimulating factor receptor alpha subunit mediate activation of Jak/Stat signaling and differentiation. (musc.edu)
CSF3R2
- The granulocyte colony-stimulating factor receptor (G-CSF-R) also known as CD114 (Cluster of Differentiation 114) is a protein that in humans is encoded by the CSF3R gene. (wikipedia.org)
- Granulocyte colony-stimulating factor receptor (G-CSFR), encoded by the CSF3R gene, represents a major regulator of neutrophil production and function in mammals, with inactivating extracellular mutations identified in a cohort of neutropenia patients unresponsive to G-CSF treatment. (nih.gov)
Hematopoiesis1
- The ability of rescuing hematopoiesis against the toxic action of cancer chemotherapeutic compounds and the presence of high-affinity IL4 receptors on human tumors provide a further promising rationale for the clinical use of melatonin. (nih.gov)
Gene8
- 4. Immunoglobulin and T-cell receptor gene rearrangements in acute lymphoblastic leukemia--a higher incidence of double rearrangements in patients with myeloid antigen expression. (nih.gov)
- ILCs in Group 1 (ILC1s) express the TBX21 gene encoding T-BET, and produce gamma interferon (IFN-g) and tumor necrosis factor alpha (TNF-a), which are both T helper (TH) 1-associated cytokines. (jle.com)
- Respondent fabricated text (p. 12) reporting that sequencing of RT-PCR products confirmed the expression of the NE mutants in the SCN patients and that no mutations were present in the granulocyte colony stimulating factor receptor (G-CSFR) gene and the Wiskott-Aldrich Syndrome (WAS) gene in SCN patients, when based on the lack of original records the experiments were not performed. (nih.gov)
- Consequently, once a bioactive compound associates with the ligand binding domain of the hybrid receptor, only the luciferase reporter gene is induced. (indigobiosciences.com)
- This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. (caslab.com)
- French: Primarily in chemical carcinogenesis using rodent models, and particularly focused on the sporadic tumor in Fisher 344 rats called large granular lymphocytic leukemia, so it was the role of molecular genetic changes in that, particularly on the c-Fms (now Csf1r) gene, which is a receptor for the granulocyte-macrophage colony-stimulating factor. (nih.gov)
- From NCBI Gene: The protein encoded by this gene is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. (nih.gov)
- In 2003, researchers at Mount Sinai School of Medicine in New York discovered that WHIM syndrome is caused by mutations in the CXC chemokine receptor 4 (CXCR4) gene. (nih.gov)
Antigen receptor2
- Associations of granulocyte colony-stimulating factor with toxicities and efficacy of chimeric antigen receptor T-cell therapy in relapsed or refractory multiple myeloma. (bvsalud.org)
- Metelitsa presented his results that demonstrated targeting of these NKT cells against neuroblastoma tumor cells using a "chimeric antigen receptor," or "CAR" specific for the GD2 ganglioside that is expressed on neuroblastoma tumor cells resulted in dramatic responses in laboratory models of neuroblastoma. (texaschildrens.org)
Tyrosine1
- Binding of G-CSF to its receptor induces dimerization or oligomerization of the receptor activating cytoplasmic tyrosine kinases. (rndsystems.com)
Cells31
- The granulocyte colony-stimulating factor receptor is present on precursor cells in the bone marrow, and, in response to stimulation by G-CSF, initiates cell proliferation and differentiation into mature neutrophilic granulocytes and macrophages. (wikipedia.org)
- Human granulocyte colony-stimulating factor (G-CSF) is a regulatory glycoprotein that stimulates the production of neutrophilic granulocytes from committed hematopoietic progenitor cells both in vitro and in vivo. (ashpublications.org)
- Granulocyte Colony Stimulating Factor (G-CSF) is a pleiotropic cytokine best known for its specific effects on the proliferation, differentiation, and activation of hematopoietic cells of the neutrophilic granulocyte lineage. (rndsystems.com)
- Activation of this putative melatonin receptor, with both physiological and pharmacological concentrations of melatonin, resulted in an enhanced production of interleukin-4 (IL4), which in turn acted on bone marrow stromal cells and induced the release of hematopoietic growth factors. (nih.gov)
- PURPOSE: To evaluate cellular protein changes in response to treatment with an approved drug, ibrutinib, in cells expressing normal or mutated granulocyte-colony stimulating factor receptor (G-CSFR). (nih.gov)
- 3. Granulocyte colony-stimulating factor receptors on human acute leukemia: biphenotypic leukemic cells possess granulocyte colony-stimulating factor receptors. (nih.gov)
- 13. Monoclonal antibodies to the human CSF-1 receptor (c-fms proto-oncogene product) detect epitopes on normal mononuclear phagocytes and on human myeloid leukemic blast cells. (nih.gov)
- 15. Correlation between the proliferative response to granulocyte colony-stimulating factor and the positivity of transferrin receptor in acute myeloblastic leukemia cells. (nih.gov)
- Although T cell receptor (TCR) activation is key for IL-17 production by CD4 + and CD8 + T cells, IL-17 production by innate immune cells is primarily driven by inflammatory cytokines, especially IL-1β and IL-23 (Box 2 ). (nature.com)
- Upon re-exposure, an antigen-antibody complex is formed and activate inflammatory cells to secrete several factors responsible for allergic immune responses [ 2 ]. (hindawi.com)
- Although primal target of antihistamines is the histamine H 1 receptor, these drugs act as inhibitors of the synthesis and release of chemical mediators and inflammatory cytokines from eosinophils and mast cells following immunological and nonimmunological stimulations [ 6 , 7 ]. (hindawi.com)
- There are several contributing factors to autoimmune disease such as self-recognizing immune cells with or without autoantibodies. (jle.com)
- Cannabinoid receptors, CB1R and CB2R, are expressed in both the central nervous system and non-central nervous system tissues, including inflammatory cells. (haematologica.org)
- These receptors are found on the surface of various cells and are activated by cytokines, which are small proteins involved in cell-to-cell communication. (indigobiosciences.com)
- Quantifying changes in luciferase expression in the treated reporter cells provides a sensitive surrogate measure of the changes in receptor activity. (indigobiosciences.com)
- INDIGO's nuclear receptor assays utilize proprietary human and non-human mammalian cells engineered to provide constitutive, high-level expression of the designated receptor. (indigobiosciences.com)
- INDIGO's other nuclear receptor assays, however, include reporter cells that express hybrid nuclear receptors. (indigobiosciences.com)
- These growth factors are mitogens for cells of mesenchymal origin. (caslab.com)
- Transplantation of bone marrow‐derived stem cells (BMSCs) has been suggested as a potential therapeutic approach to prevent neurodegenerative diseases, but it remains problematic due to issues of engraftment, potential toxicities, and other factors. (nih.gov)
- IL-4 is the major factor regulating IgE production by B cells, and is required for optimal TH2 differentiation. (bmj.com)
- These receptors are found mainly on a subset of myelomonocytic cells. (bvsalud.org)
- WHIM mutations result in excessive CXCR4 receptor activity, which traps the cells inside the bone marrow and prevents their movement into the bloodstream and the rest of the body. (nih.gov)
- The contribution of leukocyte subtypes to diabetes induced capillary degeneration was evaluated using chimeric mice lacking G-CSFR (receptor for Granulocyte Colony Stimulating Factor) in marrow derived cells, and co-culture of retinal endothelial cells with peripheral blood leukocytes immunodepleted of different leukocyte subtypes. (arvojournals.org)
- We conclude that leukocytes, especially granulocytes, play a central role in the development of diabetic retinopathy by killing retinal capillary endothelial cells. (arvojournals.org)
- Transforming growth factor beta 1 (TGF-beta 1) is known to inhibit the growth of immature hematopoietic progenitor cells, whereas more mature, lineage-restricted progenitors are not inhibited. (ox.ac.uk)
- In suspension cultures, TGF-beta 1 and GM-CSF stimulated an increase in total viable cells with markedly enhanced neutrophilic differentiation and a concomitant decrease in the number of monocytes/macrophages by day 6 in culture. (ox.ac.uk)
- TGF-beta increased the number of GM-CSF receptors on bone marrow cells. (ox.ac.uk)
- It is a glycoprotein , growth factor and cytokine produced by a number of different tissues to stimulate the bone marrow to produce granulocytes and stem cells . (en-academic.com)
- Beside the effect on the hematopoietic system, G-CSF can also act on neuronal cells as a neurotrophic factor. (en-academic.com)
- G-CSF stimulates the production of white blood cells (WBC). (en-academic.com)
- Here, we demonstrate that, in mouse DCs, TLR agonists stimulate a profound metabolic transition to aerobic glycolysis, similar to the Warburg metabolism displayed by cancer cells. (ashpublications.org)
Neutrophils4
- Decreased specific binding of 125l-G-CSF by human neutrophils was consistently observed in the presence of excess unlabeled human granulocyte-macrophage colony-stimulating factor (GM-CSF), suggesting competition or down modulation by GM-CSF of the G- CSF receptor. (ashpublications.org)
- Note: Certain human cell lines or cell types (e.g., neutrophils, monocytes) can first be treated with reagents that block receptors for the Fc regions of immunoglobulin to avoid nonspecific immunofluorescent staining mediated by Fc receptors. (bdbiosciences.com)
- 1997 ) Generation of HER-2/neu-specific cytotoxic neutrophils in vivo: efficient arming of neutrophils by combined administration of granulocyte colony-stimulating factor and Fcgamma receptor I bispecific antibodies. (academictree.org)
- G-CSF also stimulates the survival, proliferation, differentiation, and function of neutrophil precursors and mature neutrophils. (en-academic.com)
Thrombopoietin Receptor1
- 10. Patients with cancer who are actively receiving chemotherapeutic treatment or who take drugs with hematological effects such as thrombopoietin receptor agonists (such as eltrombopag), granulocyte-colony stimulating factor or erythroid stimulating agents. (nih.gov)
Antagonist3
- They are cell-based trans-activation assays, and the principal application is in the screening of test samples to quantify any functional activity, either agonist or antagonist, that the compounds may exert against the nuclear receptors. (indigobiosciences.com)
- Can you tell me what the reference agonist/antagonist is for your receptor assays? (indigobiosciences.com)
- Therefore, the aim of this study was to examine the effects of therapy involving granulocyte colony stimulating factor (G‐CSF)/AMD3100 (CXCR4 antagonist) and stromal cell‐derived factor‐1α (SDF‐1α) on endogenous BM‐derived hematopoietic progenitor cell (BM‐HPC) recruitment into the brain of an Alzheimer's disease (AD) mouse model. (nih.gov)
Platelet-derived1
- The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. (caslab.com)
Bone3
- In this report, we show that biosynthetic (recombinant) human G-CSF enhances colony formation by normal human bone marrow and the human myeloid leukemic cell lines, HL-60 and KG-1, as well as nonhematopoietic small cell lung cancer lines, H128 and H69. (ashpublications.org)
- Bone marrow progenitors obtained from mice 3 days after treatment with 5-fluorouracil responded to a combination of GM-CSF and TGF-beta 1, whereas either factor alone had no effect. (ox.ac.uk)
- G-CSF then stimulates the bone marrow to release them into the blood. (en-academic.com)
Therapeutic2
- Sargramostim is a yeast-derived, recombinant human granulocyte-macrophage colony-stimulating factor with therapeutic potential in human immunodeficiency virus (HIV) infection. (nih.gov)
- therapeutic monoclonal antibodies targeting IL-17A, both IL-17A and IL-17F, the IL-17 receptor, or IL-23 are highly effective in some of these diseases. (nature.com)
Recombinant1
- Human recombinant granulocyte colony stimulating factor (G‐CSF) is also known as Lenograstim was used for peripheral administration. (nih.gov)
Mice3
- We, therefore, examined cannabinoid receptor-specific mechanisms to mitigate mast cell activation, neurogenic inflammation and hyperalgesia, using HbSS-BERK sickle and cannabinoid receptor-2-deleted sickle mice. (haematologica.org)
- We show that cannabinoids mitigate mast cell activation, inflammation and neurogenic inflammation in sickle mice via both cannabinoid receptors 1 and 2. (haematologica.org)
- We used transgenic HbSS-BERK mice, hereafter referred to as sickle mice, which show features of pain and inflammation similar to patients with SCA, 20 5 4 and sickle mice with deletion of CB2R, to examine the contribution of each cannaboid receptor in mast cell activation, neurogenic inflammation, and pain. (haematologica.org)
Signal transduction3
- The G-CSF-R is a transmembrane receptor that consists of an extracellular ligand-binding portion, a transmembrane domain, and the cytoplasmic portion that is responsible for signal transduction. (wikipedia.org)
- GCSF-R ligand-binding is associated with dimerization of the receptor and signal transduction through proteins including Jak, Lyn, STAT, and Erk1/2. (wikipedia.org)
- The maturation of DCs is directed by signal transduction events downstream of toll-like receptors (TLRs) and other pattern recognition receptors. (ashpublications.org)
Human9
- Human leukocyte antigen (HLA)-DR expression on monocytes was analyzed by flow cytometry, lipopolysaccharide-induced tumor necrosis factor (TNF)α and interleukin-10 production of blood samples was measured by means of enzyme-linked immunoabsorbent assay. (medscape.com)
- 6. Human granulocyte-macrophage colony-stimulating factor supports the clonogenic growth of B-lineage acute lymphoblastic leukemias expressing myeloid antigens. (nih.gov)
- 8. Human granulocyte colony-stimulating factor receptors in acute myelogenous leukemia. (nih.gov)
- 16. Exogenous expression of human granulocyte colony-stimulating factor receptor in a B-lineage acute lymphoblastic leukemia cell line: a possible model for mixed lineage leukemia. (nih.gov)
- Patients with a history of serious allergic reactions to human granulocyte colony-stimulating factors such as filgrastim or pegfilgrastim. (nih.gov)
- 1993 ) Human IgG Fc receptor heterogeneity: molecular aspects and clinical implications. (academictree.org)
- 1993 ) Granulocyte-macrophage colony-stimulating factor induces sequential activation and deactivation of binding via a low-affinity IgG Fc receptor, hFc gamma RII, on human eosinophils. (academictree.org)
- 1992 ) Human low-affinity IgG receptor Fc gamma RIIa (CD32) introduced into mouse fibroblasts mediates phagocytosis of sensitized erythrocytes. (academictree.org)
- Mouse granulocyte colony-stimulating factor (G-CSF) was first recognised and purified in Walter and Eliza Hall Institute, Australia in 1983, [ 1 ] and the human form was cloned by groups from Japan and the Germany / United States in 1986. (en-academic.com)
Cytokines8
- Although it remains obscure whether bacterial components such as endotoxin (lipopolysaccharide [LPS]) or endogenous danger signals like heat shock proteins [ 1 , 2 ] are responsible for the activation of the immune system, it is well documented that trauma-induced alterations include excessive production of cytokines such as interleukin (IL)-1, IL-6, IL-8, and tumor necrosis factor (TNF)α detectable in the circulation. (medscape.com)
- Sargramostim was well tolerated, and inflammatory cytokines and surrogate markers of disease progression, such as serum levels of interleukin-10 and soluble tumor necrosis factor receptors types Iota and IotaIota, remained stable in subjects receiving sargramostim. (nih.gov)
- 5. Role in growth regulation of cytokines and cytokine receptors in acute lymphoblastic leukaemia expressing myeloid markers. (nih.gov)
- ILCs are classified into three subgroups based on their capability to express transcription factors and cytokines, which are called ILC1, ILC2, and ILC3. (jle.com)
- ILCs are identified based on the expression of CD127 and are classified into three groups according to the transcription factors (TF) and cytokines that they produce. (jle.com)
- ILCs in Group 2 (ILC2s) express GATA-3 and related orphan receptor A (RORA) and secrete TH2-related cytokines such as IL-5 and IL-3. (jle.com)
- When cytokines bind to their respective receptors on the cell surface, they initiate a cascade of events within the cell. (indigobiosciences.com)
- Interestingly, for some of these cytokines, a linkage was also established between asthma and their receptor. (bmj.com)
Cytokine receptor3
- Cell activation by G-CSF is mediated by a type I membrane protein belonging to the cytokine receptor superfamily. (rndsystems.com)
- Unveil insights into cellular signaling and immune system function with Cytokine Receptor Assay Kits from INDIGO Biosciences. (indigobiosciences.com)
- Therefore, cytokine receptor assays are crucial for developing targeted therapies and interventions for various diseases. (indigobiosciences.com)
Biologic1
- G-CSF receptor numbers ranged between 138 and 285 sites per cell with a kd of 77 to 140 pmol/L, consistent with the concentrations of G-CSF that elicit biologic responses in vitro. (ashpublications.org)
Agonists1
- Treatment involves controlling triggering factors and drug therapy, most commonly with inhaled beta-2 agonists and inhaled corticosteroids. (msdmanuals.com)
Pathways2
- This activation triggers intracellular signaling pathways, which can involve various molecules such as kinases, transcription factors, and secondary messengers. (indigobiosciences.com)
- By modulating these signaling pathways, cytokine receptors help coordinate immune responses, inflammation, and other physiological processes. (indigobiosciences.com)
Neutropenia1
- Loss of SHIP and CIS recruitment to the granulocyte colony-stimulating factor receptor contribute to hyperproliferative responses in severe congenital neutropenia/acute myelogenous leukemia. (ouhsc.edu)
Immunoglobulin2
- ILCs are morphologically similar to B and T lymphocytes, but the recombination-activating genes (RAG) in ILCs are inactive, and they are not able to carry out the rearrangement activity needed to produce a repertoire of different immunoglobulin receptors or T-cell receptors (TCR) [4] . (jle.com)
- It involves intravenous immunoglobulin, a blood product containing antibodies, or granulocyte colony-stimulating factor (G-CSF), an immune-cell-growth molecule. (nih.gov)
Activation7
- 19 18 Selective activation of peripheral cannaboid receptors is appealing because it would avoid neuropsychiatric adverse effects associated with activation of CB1R in the central nervous system. (haematologica.org)
- Evaluate amount of receptor activation quickly and easily. (indigobiosciences.com)
- Instead, the luciferase light response is measured which correlates to the activation status of the receptor (either activation or inhibition). (indigobiosciences.com)
- All other native NR functional/structural domains (ligand binding domain, hinge region, and various activation domains) are present in these hybrid receptors. (indigobiosciences.com)
- Ligand-activation of the hybrid receptor will not induce collateral expression of target genes that are otherwise regulated by the native nuclear receptor. (indigobiosciences.com)
- These factors lead to immune activation around hair follicles and hyperkeratosis, leading to follicular blockage. (dermatologytimes.com)
- Toll-like receptor (TLR)-directed dendritic cell (DC) activation is critical for the tailoring of immune responses to specific pathogens. (ashpublications.org)
Inflammation3
- 10 6 Since pain is a manifestation of complex sickle pathobiology including inflammation, vascular dysfunction and ischemia/reperfusion injury, we investigated cannabinoid receptor-specific modulation of vascular function, inflammation and hyperalgesia. (haematologica.org)
- 19 Since vascular dysfunction, ischemia/reperfusion injury and inflammation are hallmark features of SCA, we hypothesized that targeting specific cannaboid receptors may have beneficial effects on sickle pathobiology and pain. (haematologica.org)
- Additionally, the gut microbiota composition affects (and is affected by) the expression of angiotensin-converting enzyme-2 (ACE2), which is the main receptor for SARS-CoV-2 and contributes to regulate inflammation. (hindawi.com)
Proliferation1
- 2. Granulocyte-colony stimulating factor, granulocyte-macrophage colony stimulating factor, PIXY-321, stem cell factor, interleukin-3, and interleukin-7: receptor binding and effects on clonogenic proliferation in acute lymphoblastic leukemia. (nih.gov)
Ligand1
- Entry into the alveolar compartment is under the control of CXC chemokine receptor (CXCR)2 and its ligands (CXC chemokine ligand [CXCL]1-8). (biomedcentral.com)
Chemokine2
- Concentrations of cutaneous T-cell attracting chemokine, eotaxin, hepatocyte growth factor, interleukin 6 (IL-6), IL-16, and stem cell factor are significantly higher in COPD patients compared with in control patients. (dovepress.com)
- Multiple regression analysis predicts that cutaneous T-cell-attracting chemokine, eotaxin, IL-6, and stem cell factor are inversely associated with forced expiratory volume in 1 second and peak oxygen uptake change, whereas smoking is related to eotaxin and hepatocyte growth factor changes. (dovepress.com)
Regulate1
- Localized cytosolic domains of the erythropoietin receptor regulate growth signaling and down-modulate responsiveness to granulocyte-macrophage colony-stimulating factor. (google.com.sg)
Genes1
- This region includes a cluster of cytokine genes, and genes encoding IL-3, IL-4, IL-5, IL-9, IL-13, granulocyte macrophage colony stimulating factor, and the β chain of IL-12. (bmj.com)
Stromal2
- SDF, stromal cell-derived factors. (cdc.gov)
- Itescu planned in 2004 to use G-CSF to treat heart degeneration by injecting it into the blood-stream, plus SDF (stromal cell-derived factor) directly to the heart. (en-academic.com)
Mediate1
- The IL-17 family comprises six members (IL-17A to IL-17F) that mediate their biological functions through the IL-17 receptors (IL-17RA to IL-17RE). (nature.com)
Endogenous1
- An alternative strategy is pharmacological‐induced recruitment of endogenous BMSCs into an injured site by systemic administration of growth factors or chemokines. (nih.gov)
Mutations1
- Mutations in the intracellular part of this receptor are also associated with certain types of leukemia. (wikipedia.org)
Stem2
- Notably, this study identifies stem cell factor as a biomarker for COPD. (dovepress.com)
- It is thought that stability of the G-CSF mRNA is regulated by an RNA element called the G-CSF factor stem-loop destabilising element . (en-academic.com)
Modulation2
- So we had used that in a number of ways, that model, to look at the modulation of the leukemia, the insulin growth factor 1 hormone, IGF1, and the role of caloric restriction in chemical interactions on them. (nih.gov)
- 1999 ) Modulation of the humoral immune response by antibody-mediated antigen targeting to complement receptors and Fc receptors. (academictree.org)
Vivo1
- Ex vivo treatment of blood specimens with GM-CSF increased HLA-DR expression and TNFα production stimulated by lipopolysaccharides in both healthy volunteers and patients on day 1 after trauma. (medscape.com)
Lead to immune1
- Dysregulation or malfunctioning of cytokine receptors can lead to immune disorders, autoimmune diseases, and other pathological conditions. (indigobiosciences.com)
Mechanisms1
- Analogous with other cytokine signaling mechanisms, CD131 is also shared with the cytokine specific alpha-subunits of the IL-3 and IL-5 receptors. (reliatech.de)
Internalization1
- The class IV isoform defective for both internalization and differentiation signaling, and colony-stimulating. (wikipedia.org)
Cell6
- G-CSF-R is a cell-surface receptor for the granulocyte colony-stimulating factor (G-CSF). (wikipedia.org)
- This study provides 'proof of principle' for the potential of cannabinoid/cannabinoid receptor-based therapeutics to treat several manifestations of sickle cell anemia. (haematologica.org)
- 3 Cannaboid receptors are important modulators of vascular function with an anti-ischemic effect and direct anti-inflammatory effects by inhibiting mast cell degranulation. (haematologica.org)
- Cytokine receptors are integral components of the immune system and play a crucial role in cell signaling. (indigobiosciences.com)
- the progenitor cell is tentatively designated granulocyte burst-forming unit. (ox.ac.uk)
- Enzalutamide is a second-generation antiandrogen that inhibits androgen binding to androgen receptors, inhibits androgen receptors from entering the cell nucleus, and inhibits androgen receptors from binding to DNA and from serving as a transcription factor. (snmjournals.org)