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Receptors, CXCR4Receptors, CXCR3Receptors, CXCRChemokine CXCL12Receptors, CXCR5Receptors, Interleukin-8BChemokines, CXCReceptors, Interleukin-8AHeterocyclic CompoundsReceptors, ChemokineChemokine CXCL11Chemokine CXCL10Chemokine CXCL9ChemotaxisChemokine CXCL6Cell MovementChemokine CXCL1Chemotaxis, LeukocyteChemokine CXCL13ChemokinesInterleukin-8Flow CytometryReceptors, CCR7Signal TransductionReceptors, CCR4Cells, CulturedMice, Inbred C57BLLigandsWartsCell Line, TumorMice, KnockoutReceptors, HIVReceptors, CytokineImmunohistochemistryUp-RegulationReverse Transcriptase Polymerase Chain ReactionReceptors, CCR5T-LymphocytesCell LineNeutrophilsChemokine CXCL5Cell ProliferationHIV-1RNA, MessengerStromal CellsReceptors, ScavengerImmunodeficiency Virus, FelineHIV Envelope Protein gp120Lateral Line SystemMice, SCIDArrestinsNeoplasm InvasivenessChemokine CXCL2Chemotactic FactorsIntercellular Signaling Peptides and ProteinsNeutrophil InfiltrationChemokine CCL21Jurkat CellsMice, Inbred BALB CReceptor Cross-TalkProtein BindingBone Marrow CellsAntigens, CD4Down-RegulationMolecular Sequence DataCD4-Positive T-LymphocytesNeoplasm MetastasisCell AdhesionTransfectionZebrafishGene Expression Regulation, NeoplasticEndothelial CellsAmino Acid SequenceChemokines, CCReceptors, VirusMice, Inbred NODReceptors, InterleukinGene Expression RegulationCell DifferentiationInterferon-gammaReceptors, G-Protein-CoupledPhosphorylationBlotting, WesternDisease Models, AnimalCell MembraneTumor Cells, CulturedHematopoietic Stem CellsExtracellular Signal-Regulated MAP KinasesZebrafish ProteinsT-Lymphocyte SubsetsStem CellsRadioligand AssayMicroscopy, ConfocalCell SeparationInflammationEndocytosisGene ExpressionMice, NudeImmunologic Deficiency SyndromesLymphocyte Activation
CXCR4Motif chemokine receptorFusinCXCR2Seven transmembraneGeneCytokineProteinChemokine receptor expressionCCR3AntigenAdenosine ReceptorCXCR7CytokinesChemotacticChemokinesEstrogen ReceptorCaSRCXCR6InfectVEGFExpressionMigrationBindsApoptosisTypeCXCR5StromalCXCL12CXCL16Endothelial cellsHematopoieticEndogenousHumanCalciumCells
CXCR413
  • CXCR4 (also known as fusin) is the receptor for a chemokine known as CXCL12 (or SDF-1) and, as with CCR5, is utilized by HIV-1 to gain entry into target cells. (wikipedia.org)
  • ACKR3 was originally called RDC-1 (an orphan receptor) but has since been shown to cause chemotaxis in T lymphocytes in response to CXCL12 (the ligand for CXCR4) prompting the renaming of this molecule as CXCR7. (wikipedia.org)
  • C-X-C chemokine receptor type 4 ( CXCR-4 ) also known as fusin or CD184 (cluster of differentiation 184) is a protein that in humans is encoded by the CXCR4 gene . (wikidoc.org)
  • CXCR4 is one of several chemokine receptors that HIV can use to infect CD4+ T cells . (wikidoc.org)
  • CXCR4 is upregulated during the implantation window in natural and hormone replacement therapy cycles in the endometrium, producing, in presence of a human blastocyst , a surface polarization of the CXCR4 receptors suggesting that this receptor is implicated in the adhesion phase of human implantation . (wikidoc.org)
  • Until recently, SDF-1 and CXCR4 were believed to be a relatively monogamous ligand-receptor pair (other chemokines are promiscuous, tending to use several different chemokine receptors). (wikidoc.org)
  • Drugs that block the CXCR4 receptor appear to be capable of "mobilizing" hematopoietic stem cells into the bloodstream as peripheral blood stem cells . (wikidoc.org)
  • Plerixafor (AMD3100) is a drug, approved for routine clinical use, [7] which directly blocks the CXCR4 receptor. (wikidoc.org)
  • CXCL12 (over-)expressing cancers might not sense the CXCL12 gradient released from the metastasis target tissues since the receptor, CXCR4, is saturated with the ligand produced in an autocrine manner. (wikidoc.org)
  • CXCR4 (short for CXC motif chemokine receptor 4) is a receptor protein of the chemokine receptor family. (reliatech.de)
  • In addition, CXCR4 is the primary co-receptor for T cell-using (T-tropic) HI viruses. (reliatech.de)
  • Some G protein- coupled receptors in the chemokine receptor family, including CCR5, CXCR4, CCR3, CCR2b, and CCR8 in the chemokine receptor family, have been identified as HIV coreceptors. (qedbio.com)
  • Homo sapiens chemokine (C-X-C motif) receptor 4 (CXCR4), mRNA. (lu.se)
Motif chemokine receptor2
  • We found SI DCs to be most efficient in metabolising vitamin A derivatives which enhances their capacity to induce the retinoic acid (RA) dependent gut-homing factors CC type motif chemokine receptor (CCR) 9 and integrin alpha 4 beta 7 (Intα4β7) on newly activated T cells. (rwth-aachen.de)
  • Thus, recently activated T cells that had migrated to the SI, colon and liver expressed high levels of CCR9, G protein coupled receptor (GPR) 15 and CXC-type motif chemokine receptor (CXCR) 3 respectively, suggesting a directed migration process to specific tissues orchestrated during T cell differentiation. (rwth-aachen.de)
Fusin1
  • C-X-C chemokine receptor type 4 (CXC-R4) (CXCR-4) (Stromal cell- derived factor 1 receptor) (SDF-1 receptor) (Fusin) (Leukocyte-derived seven transmembrane domain receptor) (LESTR) (LCR1) (FB22) (NPYRL) (HM89) (CD184 antigen). (lu.se)
CXCR21
  • CXCR1 and CXCR2 are closely related receptors that recognize CXC chemokines that possess an E-L-R amino acid motif immediately adjacent to their CXC motif. (wikipedia.org)
Seven transmembrane3
  • They represent one subfamily of chemokine receptors, a large family of G protein-linked receptors that are known as seven transmembrane (7-TM) proteins, since they span the cell membrane seven times. (wikipedia.org)
  • CXCR5 is a seven-transmembrane, G-protein-coupled receptor that is specific for the CXC chemokine, CXCL13/BLC/BCA-1. (bdbiosciences.com)
  • Intro The extracellular calcium-sensing receptor CaSR is definitely a classic seven-transmembrane-spanning G protein-coupled receptor (GPCR) belonging to Family C of the superfamily of GPCRs [1]. (immune-source.com)
Gene8
  • CXCR6 was formerly called three different names (STRL33, BONZO, and TYMSTR) before being assigned CXCR6 based on its chromosomal location (within the chemokine receptor cluster on human chromosome 3p21) and its similarity to other chemokine receptors in its gene sequence. (wikipedia.org)
  • The protein encoded by this gene is a member of the G-protein-coupled receptor family. (cancerindex.org)
  • This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. (cancerindex.org)
  • From NCBI Gene: This gene encodes a member of the G-protein coupled receptor family. (nih.gov)
  • Upon binding to their receptors, cytokines activate JAKs which then phosphorylate the cytokine receptor, thereby creating docking sites for signaling molecules, notably, members of the signal transducer and activator of transcription (STAT) family that ultimately lead to gene expression. (justia.com)
  • Homo sapiens chemokine receptor (CXCR-4) gene, complete cds. (lu.se)
  • One example of a gene-edited cell line isthe soluble receptor for advanced glycation end product (sRAGE) secreting stem cells, and much attention is paid to the remedial role of sRAGE molecules in advanced glycation end product (AGE)-associated disorders [3-6]. (heraldopenaccess.us)
  • Genetic testing suggested mutation of the epidermal growth factor receptor (EGFR) gene at exon 19. (hho-bulgaria.com)
Cytokine2
  • We used single-cell analysis to investigate the relationship between chemokine receptor expression and cytokine production on peripheral blood and bronchoalveolar lavage fluid T cells in patients with asthma, a putative T(H)2 disease, as well as in healthy control subjects. (nih.gov)
  • This receptor is activated by the chemokine CXCL12 and the cytokine macrophage migration inhibitory factor (MIF). (reliatech.de)
Protein6
  • This protein is a receptor for interleukin 8 (IL8). (cancerindex.org)
  • This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. (cancerindex.org)
  • The G protein-coupled receptor, RDC1, belongs to a subgroup of chemokine receptors and has been designated CXCR7. (rndsystems.com)
  • Although this protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP), it is now considered to be an orphan receptor, in that its endogenous ligand has not been identified. (nih.gov)
  • The receptor usage of the CXC chemokine granulocyte chemotactic protein-2 (GCP-2) was compared with that of interleukin-8 (IL-8) and epithelial-cell-derived neutrophil attractant-78 (ENA-78). (tau.ac.il)
  • These classes express different matches of genes related to their functions: receptor (Type II) cells express G-protein coupled taste receptors and transduction LY 2183240 machinery. (immune-source.com)
Chemokine receptor expression2
  • The concept of the polarization of chemokine receptor expression by T(H)1 and T(H)2 cells provides an attractive mechanism for their differential recruitment to tissue, which could be subject to disease-specific therapeutic intervention. (nih.gov)
  • Further studies will be necessary to characterise the molecular mechanisms that are responsible for the differential induction of chemokine receptor expression as well as delineate the relative contribution of the migrating DCs and the LN microenvironment in this process. (rwth-aachen.de)
CCR31
  • Lazucirnon (KST4290, ALK4290) is a small molecule, orally active inhibitor against CCR3, the natural receptor for chemokine eotaxin, decreases inflammatory cytokines in preclinical models. (probechem.com)
Antigen1
  • To expand the particular specialized medical application of adoptive immunotherapy towards malignancies, private investigators allow us powerful programs for that genetic customization and characterization regarding T tissue indicating released chimeric antigen receptors (Automobiles) to reroute nature. (cxcr-signal.com)
Adenosine Receptor1
  • Aminophylline is a nonselective adenosine receptor antagonist and phosphodiesterase inhibitor capable of reversing ischemia-induced bradyasystole. (adooq.com)
CXCR71
  • In contrast, based on ligand binding analysis and receptor level (as assessed using anti‑CXCR7, clone 11G8), surface expression of CXCR7 was reported to be restricted to tumor cells, activated endothelial cells, fetal liver cells, and few other cell types (3). (rndsystems.com)
Cytokines2
  • CXC chemokine receptors are integral membrane proteins that specifically bind and respond to cytokines of the CXC chemokine family. (wikipedia.org)
  • The integration of pathogen-associated molecular patterns (PAMPs) from microorganisms with their surface receptors in the immune cells, induces the production of several cytokines and chemokines that presents either a pro- and/or anti-inflammatory role by stimulating the secretion of a great variety of antibody subtypes and the activation of mechanisms of controlling the disease, such as the regulatory T cells. (bvsalud.org)
Chemotactic3
  • CXCR-4 is an alpha- chemokine receptor specific for stromal-derived-factor-1 ( SDF-1 also called CXCL12), a molecule endowed with potent chemotactic activity for lymphocytes . (wikidoc.org)
  • Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. (joplink.net)
  • Notably, T cell homing correlated to a site-specific expression of chemotactic receptors. (rwth-aachen.de)
Chemokines2
  • We have provided evidence that polarization of T(H)2-type chemokine receptors on IL-4-expressing cells can be demonstrated in an in vivo setting and therefore that these cells might indeed be susceptible to differential patterns of recruitment as a result of expression of the relevant chemokines at inflammatory sites. (nih.gov)
  • The differential receptor usage of the structurally related ELR + CXC chemokines GCP-2 and ENA-78 is indicative of a different role in inflammatory reactions. (tau.ac.il)
Estrogen Receptor2
  • Taken together with the fact that 60-70% of human breast cancers are estrogen receptor-alpha positive[ 7 ], the evidence suggests an etiological significance of estrogen in breast cancer initiation and progression. (biomedcentral.com)
  • Estrogen mediates its effects by binding to its cognate estrogen receptor(s), either estrogen receptor alpha (ERα) or estrogen receptor beta (ERβ), leading to ER dimerization and association with various co-factors. (biomedcentral.com)
CaSR4
  • Recently we reported that calcium-sensing receptor (CaSR) is a receptor for substances which enhance the intensities of salty sweet and umami LY 2183240 tastes. (immune-source.com)
  • CaSR-expressing taste cells are a different subset of cells from your T1R3-expressing umami or lovely taste receptor cells. (immune-source.com)
  • These observations show that CaSR-expressing taste cells are the main detectors of substances and that they are an independent population from your influenced basic taste receptor cells at least in the case of lovely and umami. (immune-source.com)
  • CaSR is normally expressed within a subpopulation of flavor cells in mice and rats [4] [5] recommending potential roles because of this receptor in flavor mobile biology. (immune-source.com)
CXCR62
  • There are currently six known CXC chemokine receptors in mammals, named CXCR1 through CXCR6. (wikipedia.org)
  • However, CXCR6 is more closely related in structure to CC chemokine receptors than to other CXC chemokine receptors. (wikipedia.org)
Infect1
  • HIV being one as HIV is specialised to infect human co-receptor such as CXCR-4 and CCR-5 etc. (bio.net)
VEGF1
  • Upon culture in endothelial growth media, these cells expressed endothelial lineage markers, such as CD31, Tie2, and VEGF receptor 2 (VEGFR2), and incorporated into blood vessels in ischemic tissues. (hindawi.com)
Expression5
  • This receptor has a wide cellular distribution, with expression on most immature and mature hematopoietic cell types (e.g. neutrophils, monocytes, T and B cells, dendritic cells, Langerhans cells and macrophages). (wikipedia.org)
  • Expression of this receptor in cancer cells has been linked to metastasis to tissues containing a high concentration of CXCL12, such as lungs, liver and bone marrow. (wikidoc.org)
  • We have found in both asthmatic and control subjects that IL-4-expressing blood and bronchoalveolar lavage fluid T cells are significantly more likely to express the T(H)2 type 2 chemokine receptors CCR 3 and CCR 4, with 10-fold and 2-fold differences in expression, respectively, compared with IFN-gamma-expressing cells. (nih.gov)
  • No differences in spontaneous, SDF-1-induced migration or CXCR-4 expression were observed between the different AML subtypes. (johnshopkins.edu)
  • Cloning and functional expression of a human neuropeptide Y/peptide YY receptor of the Y1 type. (google.se)
Migration1
Binds1
  • The 2G8 monoclonal antibody specifically binds to the mouse C-X-C Chemokine Receptor type 5, CXCR5. (bdbiosciences.com)
Apoptosis1
  • At the same time, sRAGE is known to compete for RAGE, the main receptor for AGEs, and it has been shown that their interaction contributes to cell apoptosis, as discussed in this review. (heraldopenaccess.us)
Type3
  • Cytology detection is the conventional method used to distinguish tumor cells in pleural effusions, C-X-C chemokine receptor type 7 (CXCR-7) as described in the International Union Against Cancer/American Joint Committee on Cancer's tumor-node metastasis (TNM) classification system [3]. (pkainhibitors.com)
  • is definitely expressed inside a subset of type II (receptor) and type III (presynaptic) cells Mammalian taste buds contain three unique classes of cells [13]-[15]. (immune-source.com)
  • A heterogeneous human population of mammalian taste cells includes morphologically and functionally different taste cells classified into three subtypes type I (glial-like cells) type II (receptor cells) and type III (presynaptic) taste cells [16]. (immune-source.com)
CXCR51
  • The chemokine receptor CXCR5 is expressed on B cells and CD4+ Tfh cells and is involved in lymphocyte homing and the development of normal lymphoid tissue. (wikipedia.org)
Stromal1
  • The chemokine stromal cell-derived factor-1 (SDF-1) and its receptor CXCR-4 contribute to stem cell homing and may play a role in the trafficking of leukemic cells. (johnshopkins.edu)
CXCL121
  • Biological Function Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation (PubMed:10452968, PubMed:28978524, PubMed:18799424, PubMed:24912431). (qedbio.com)
CXCL162
  • Receptores CXCR específicos para la QUIMIOCINA CXCL16. (bvsalud.org)
  • CXCR receptors that are specific for CHEMOKINE CXCL16. (bvsalud.org)
Endothelial cells1
Hematopoietic1
  • Here we describe a complementary strategy intended to improve repopulation through upregulation of chemokine receptor (CXCR) 4, a principal factor in hematopoietic homing. (elsevierpure.com)
Endogenous1
  • Pregnenolone is an endogenous steroid hormone for inhibition of M1 receptor- and M3 receptor-mediated currents with IC50 of 11.4 μM and 6.0 μM, respectively. (adooq.com)
Human2
  • Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) for human immunodeficiency virus-1/HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. (qedbio.com)
  • Meclizine is a human pregnane X receptor (hPXR) agonist. (adooq.com)
Calcium1
  • Chemokine activities were evaluated by measurement of intracellular calcium increase and by chemotasis and binding assays, using CXC chemokine receptor (CXCR)-transfected cell lines. (tau.ac.il)
Cells1
  • This receptor has also been identified on memory B cells. (wikipedia.org)