• Clonidine
  • To test the effects in humans, we assessed autonomic vasomotor tone and baroreflex regulation in 9 normal young adults on 2 occasions, once with and once without clonidine. (biomedsearch.com)
  • The hypothesis will be tested by addressing 2 specific aims that will determine: 1) the efficacy and safety of clonidine in critically ill infants, and 2) pharmacokinetics and pharmacodynamics using population-based pharmacokinetics in this vulnerable infant population who have only been exposed to these drugs as part of their routine care. (clinicaltrials.gov)
  • neurons
  • These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. (wikipedia.org)
  • for example, α2A receptors are localized on prefrontal cortical neurons where they regulate higher cognitive function. (wikipedia.org)
  • Below are several key targets of general anesthetics that likely mediate their effects: GABAA receptors are chloride channels that hyperpolarize neurons and function as inhibitory CNS receptors. (wikipedia.org)
  • Evidence
  • The relative roles of different receptors is still under debate, but evidence exists for particular targets being involved with certain anaesthetics and drug effects. (wikipedia.org)
  • tissues
  • 125I]PIC should prove useful in binding assays involving tissues with a low receptor density or in small tissue samples and in studies of cloned and expressed alpha 2-AR. (biomedsearch.com)
  • epinephrine
  • In addition, the lack of any guanylylimidodiphosphate effect on the l-epinephrine competition curve observed in MHS rats suggests the uncoupling of these receptors from the guanosine 5'-triphosphate binding protein. (ahajournals.org)
  • The majority of alpha-1 receptors are directed toward the function of epinephrine, a hormone that has to do with the fight-or-flight response. (wikipedia.org)
  • Effects
  • It has several general functions in common with the α1-adrenergic receptor, but also has specific effects of its own. (wikipedia.org)
  • When methyldopa was first introduced, it was the mainstay of antihypertensive treatment, but its use has declined on account of relatively severe adverse side effects, with increased use of other safer and more tolerable agents such as alpha blockers, beta blockers, and calcium channel blockers. (wikipedia.org)