• renal
  • Am J Physiol Renal Physiol, 2017 Mar 1. (nih.gov)
  • In most of the cases, it is associated with inactivating mutations of the renal arginine vasopressin V2 receptor leading to misfolding and intracellular retention of the receptor, causing the inability of patients to concentrate their urine in response to the antidiuretic hormone. (springer.com)
  • peptides
  • Although the receptors are conserved in structure, the ligands span a large range of vastly diverse entities from peptides, small molecules, and light. (aspetjournals.org)
  • Sagan S, Chassaing G, Pradier L, et al (1996) Tachykinin peptides affect differently the second messenger pathways after binding to CHO-expressed human NK-1 receptors. (springer.com)
  • Mice
  • Consistent with Coleman's and Leibel's hypothesis, several subsequent studies from Leibel's and Friedman's labs and other groups confirmed that the ob gene encoded a novel hormone that circulated in blood and that could suppress food intake and body weight in ob and wild type mice, but not in db mice. (wikipedia.org)
  • gene encodes
  • Subsequent studies in 1995 confirmed that the db gene encodes the leptin receptor, and that it is expressed in the hypothalamus, a region of the brain known to regulate the sensation of hunger and body weight. (wikipedia.org)
  • Chronic Kidney
  • Adenomatous Colon Polyps in Diabetes: Increased Prevalence in Patients with Chronic Kidney Disease and Its Association with Parathyroid Hormone. (nih.gov)
  • Consistent with this, elevated FGF23 levels are associated with inflammatory markers as well as parathyroid hormone (PTH) in various disease states, including chronic kidney disease (CKD). (readbyqxmd.com)
  • agonist
  • Studies have been amassed in the past several years indicating that an agonist can conform a receptor into an activation state that is dependent upon an intrinsic property of the agonist usually based upon its chemical composition. (aspetjournals.org)
  • hydroxyl group
  • Because cholecalciferol already has one hydroxyl group, only two (1,25) are further specified in this nomenclature, but there are three (1,3,25-triol), as indicated in when calcitriol is used. (wikipedia.org)
  • vitamin D recept
  • However, the terminology of 1,25-dihydroxyvitamin D, or 1,25(OH)2D, is often used to refer to both types of active forms of vitamin D. Indeed, both bind to the vitamin D receptor and produce biological effects. (wikipedia.org)
  • Many of the effects of calcitriol are mediated by its interaction with the calcitriol receptor, also called the vitamin D receptor or VDR. (wikipedia.org)
  • 2002
  • Holloway AC, Qian H, Pipolo L, et al (2002) Side-chain substitutions within angiotensin II reveal different requirements for signaling, internalization, and phosphorylation of type 1A angiotensin receptors. (springer.com)
  • Dimeric
  • Sequential inter- and intrasubunit rearrangements during activation of dimeric metabotropic glutamate receptor 1. (jove.com)
  • muscarinic
  • A fluorescence resonance energy transfer-based M2 muscarinic receptor sensor reveals rapid kinetics of allosteric modulation. (jove.com)
  • Nuclear
  • There is also evidence for alternative translation initiation from non-AUG (CUG and GUG) start sites, in-frame and downstream of the initiator AUG codon, to give rise to nuclear forms of this hormone. (wikipedia.org)