Receptor nerve growth factor. Medical search. Frequent questions

The p75 neurotrophin receptor (p75NTR) was first identified in 1973 as the low-affinity nerve growth factor receptor (LNGFR) before discovery that p75NTR bound other neurotrophins equally well as nerve growth factor. (wikipedia.org)
Neurotrophic factor receptors bind Neurotrophins including Nerve growth factor, Neurotrophin-3, Brain-derived neurotrophic factor, and Neurotrophin-4. (wikipedia.org)
Nerve Growth Factor Receptor (NGFR), also known as p75, P-75NTR or CD271, is a neurotrophin receptor belonging to the tumor necrosis factor receptor family. (assaysolution.com)
Degeneration of basal forebrain cholinergic neurons contributes significantly to the cognitive deficits associated with Alzheimer's disease (AD) and has been attributed to aberrant signaling through the neurotrophin receptor p75 (p75 NTR ). (plos.org)
Dr. Longo has financial interests in PharmatrophiX, a company focused on the development of neurotrophin receptor ligands. (plos.org)
BFCN atrophy involves aberrant signaling through the neurotrophin receptor p75 (p75 NTR ). (plos.org)
The analysis of these specimens revealed the presence of the neurotrophin (NGF) and its own receptor (TrkA) in all cases: the immunohistochemical reaction between the specimens and the specific antibodies marked with FITC was seen under fluoromicroscopy, but in none of the control cases treated with FITC only. (sigmaaldrich.com)

p75NTR is a member of the tumor necrosis factor receptor superfamily. (wikipedia.org)
Unlike other members of the tumor necrosis factor receptor superfamily of transmembrane proteins, CD271 has unique intracellular domain structure (lacks catalytic activity) and downstream signaling partners. (exbio.cz)

p75NTR is an unusual member of this family due to its propensity to dimerize rather than trimerize, because of its ability to act as a tyrosine kinase co-receptor, and because the neurotrophins are structurally unrelated to the ligands, which typically bind TNFR family members. (wikipedia.org)
The purpose of this study was to prove the presence of NGF (nerve growth factor) and its receptor TrkA (tyrosine kinase receptor) with immunofluorescence. (sigmaaldrich.com)

Besides, NGF binding to TrkA receptors encouraged the intracellular Warburg effect in PC and DRG cells. (hindawi.com)
Dual RXR motifs regulate nerve growth factor-mediated intracellular retention of the delta opioid receptor. (harvard.edu)
This approach loses sight of the fact that many factors will mediate how 25-hydroxyvitamin D is converted to the active secosteroid hormone calcitriol (1,25-dihydroxyvitamin D) and the most potent metabolite of vitamin D. In addition, many pathogenic influences will alter the course of intracellular transport of calcitriol and nuclear binding to the vitamin D receptor (VDR). (wakeup-world.com)
16 , 17 Tryptase works by cleaving a specific site on the extracellular N-terminal domain of the receptor and releases a new N-terminal domain for the receptor, which acts as a tethered ligand by binding to the second extracellular loop of the receptor to induce intracellular signaling. (asahq.org)

Similar current changes after PKA activation were obtained from human embryonic kidney 293t cells transfected with the wild-type heat transducer protein vanilloid receptor 1 (VR-1). (jneurosci.org)
2015). Co-administration of transient receptor potential vanilloid 4 (TRPV4) and TRPV1 antagonists potentiate the effect of each drug in a rat model of cystitis . (up.pt)
2012). Rat detrusor overactivity induced by chronic spinalization can be abolished by a transient receptor potential vanilloid 1 (TRPV1) antagonist . (up.pt)
2012). Transient receptor potential vanilloid 1 mediates nerve growth factor-induced bladder hyperactivity and noxious input . (up.pt)

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Language": "en", "Country": "XG", "Code": "Storage Conditions (Product)" }, { "Name": "Background Information", "Value": "Nerve growth factor receptor (NGFR), also known as p75NTR, is a 75-kDa glycoprotein member of the tumor necrosis factor (TNF) receptor family essential for embryonic development of the peripheral nervous system. (roche.com)
Distribution and significance of nerve growth factor receptor (NGFR/ p75NTR) in normal, benign and malignant breast tissue. (roche.com)
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NGFR is expressed mainly in Schwann cells and neurons, as well as a number of other non-neuronal cell types, and functions during central and peripheral nervous system development to regulate neuronal growth, migration, differentiation, and cell death. (assaysolution.com)
It has been suggested that NGFR may act as a tumor suppressor indicated in prostate and urothelial cancer, and Anti-Nerve Growth Factor Receptor (NGFR) is often used in adjunct with S100, to aid in the diagnosis of desmoplastic and neurotrophic malignant melanomas. (assaysolution.com)
CD271 / NGFR, also known as p75NGFR or p75NTR, is a 75 kDa low affinity receptor for the NGF (nerve growth factor), BDNF (brain-derived growth factor), and other neurotrophins, such as NT3 and NT4/5. (exbio.cz)

Furthermore, in response to several different classes of antidiabetic peroxisome proliferator-activated receptor gamma agonists, adipose tissue resistin expression is increased in both ob/ob mice and Zucker diabetic fatty rats. (nih.gov)
These data demonstrate that experimental obesity in rodents is associated with severely defective resistin expression, and decreases in resistin expression are not required for the antidiabetic actions of peroxisome proliferator-activated receptor gamma agonists. (nih.gov)

Sortilin is required for many apoptosis-promoting p75NTR reactions, functioning as a co-receptor for the binding of neurotrophins such as BDNF. (wikipedia.org)
2015). The role of brain-derived neurotrophic factor (BDNF) in the development of neurogenic detrusor overactivity (NDO) . (up.pt)
The neurotrophins nerve growth factor (NGF) and brainderived neurotrophic factor (BDNF) are key regulatory elements of neuronal development and responsiveness and control expression of the genes encoding the precursor of the proinflammatory neurotransmitter substance P (SP) and other neuropeptides in airway sensory neurons. (cdc.gov)
In this study, we investigated the expression of NGF, BDNF and their receptors in the lungs of adult (12 wks), weanling (2 wks), and newborn (1-2 days) rats after acute inhalational exposure to titanium dioxide (Ti02) nanoparticle s. (cdc.gov)

Moreover, many of these channels are receptors for ligands that elicit distinct psychophysical sensations, such as the heat associated with capsaicin and the cold felt with menthol. (nih.gov)
Triggered by its ligands CD271 affects growth, differentiation, migration and death of the nervous system cells. (exbio.cz)

p75NTR is a neurotrophic factor receptor. (wikipedia.org)
Neurotrophic factor receptors, including p75NTR, are responsible for ensuring a proper density to target ratio of developing neurons, refining broader maps in development into precise connections. (wikipedia.org)
p75NTR/LNGFR was the first member of this large family of receptors to be characterized, that now contains about 25 receptors, including tumor necrosis factor 1 (TNFR1) and TNFR2, Fas, RANK, and CD40. (wikipedia.org)
When p75NTR initiates apoptosis, NGF binding to Tropomyosin receptor kinase A (TrkA) can negate p75NTR apoptotic effects. (wikipedia.org)

Presence of NGF and its receptor TrkA in degenerative lumbar facet joint specimens. (sigmaaldrich.com)
There is considerable evidence showing that the system constituted by the NGF and its high-affinity receptor TrkA plays a fundamental role in the molecular processes underlying the main forms of 'persistent' pain. (sigmaaldrich.com)

transient receptor potential cation. (wikigenes.org)

2013). Brain-derived neurotrophic factor, acting at the spinal cord level, participates in bladder hyperactivity and referred pain during chronic bladder inflammation . (up.pt)
Polymorphisms of Nav1.6 sodium channel, Brain-derived Neurotrophic Factor, Catechol-O-methyltransferase and Guanosine Triphosphate Cyclohydrolase 1 genes in trigeminal neuralgia. (cdc.gov)

It is widely expressed in nervous tissue and plays a role in mediating the effects of neurotrophins on growth and differentiation of neuronal cells. (bvsalud.org)

Recent research has suggested a number of roles for the LNGFR, including in development of the eyes and sensory neurons, and in repair of muscle and nerve damage in adults. (wikipedia.org)
Both platelet-derived growth factor (PDGF) A- and B-chains are expressed in mammalian neurons, but their precise roles still remain to be clarified. (jci.org)
Degeneration of basal forebrain cholinergic neurons (BFCN) and their neurites is a major contributing factor to the cognitive dysfunction associated with Alzheimer's disease (AD). (plos.org)
18 PAR-2 is a G protein-coupled receptor that is expressed in the peripheral terminals of sensory neurons and seems to play an important role in inflammatory pain. (asahq.org)
The close association between mast cells and nerves in peripheral tissues, and the fact that large amounts of tryptase are released upon mast cell degranulation, makes tryptase an ideal candidate to activate PAR-2 on peripheral neurons. (asahq.org)
Muscles contain the synaptic connection between lower motor neurons and muscle fibers, i.e., the neuromuscular junction (NMJ), as well as specialized sensory nerve endings (e.g., muscle spindles). (frontiersin.org)
We have shown that rabies enters a neuron in the peripheral nervous system by binding to a nerve growth factor receptor, responsible for the health of neurons, called p75. (medicaldaily.com)

Membrane trafficking of G protein-coupled receptors (GPCRs) tightly orchestrates the signaling from this superfamily of signaling receptors. (frontiersin.org)

Two distinct subpopulations of Olfactory ensheathing glia have been identified with high or low cell surface expression of low-affinity nerve growth factor receptor (p75). (wikipedia.org)
MATERIALS AND METHODS: Multipotent stromal cells were isolated from the bone marrow of transgenic green fluorescent protein rats by plastic adherence (rat multipotent stromal cells) or magnetic activated cell sorting using antibodies against p75 low affinity nerve growth factor receptor (p75 derived multipotent stromal cells). (cellsurgicalnetwork.com)
Delta opioid receptors bind endorphins and enkephalins with approximately equal affinity and have less affinity for dynorphins. (harvard.edu)

2015). Urinary bladder inflammation induces changes in urothelial nerve growth factor and TRPV1 channels . (up.pt)

Follicle-stimulating hormone receptor (FSHR) is a G protein-coupled receptor (GPCR) with pivotal roles in reproduction. (frontiersin.org)

Immunoglobulins against insulin-like growth factor 1 (IGF-1) receptors activate signaling in the orbital fibroblasts. (medscape.com)

This protein is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. (avivasysbio.com)
Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. (avivasysbio.com)

These findings suggest that PDGF isoforms are involved not only in the promotion of the neuroblastoma cell growth, but also in neuronal cell migration, growth, and differentiation in human brain development. (jci.org)

In the early to mid-twentieth century, a number of laboratories began to observe cold-induced electrical impulses when recording from mammalian sensory nerves. (nih.gov)

Enzyme-linked immunosorbent assay suggested that basic fibroblast growth factor secreted by p75 derived multipotent stromal cells protected the cavernous nerve after bilateral cavernous nerve crush injury. (cellsurgicalnetwork.com)

PDGF isoforms as well as nerve growth factor induced morphological changes showing neuronal cell maturation. (jci.org)
At the level of the primary afferent nerve, the site at which thermal stimuli are converted into neuronal activity, temperature-sensitive members of the TRP channel family are found. (nih.gov)
neuronal integrity and growth - NGF (nerve growth factor) which is enhanced by activating the VDR receptor. (wakeup-world.com)

2010). Sequestration of brain derived nerve factor by intravenous delivery of TrkB-Ig2 reduces bladder overactivity and noxious input in animals with chronic cystitis . (up.pt)

In vitro and in vivo characterization of the bifunctional µ and d opioid receptor ligand UFP-505. (harvard.edu)
The fibroblasts then produce hyaluronan and the cytokines interleukin (IL)-1 beta, IL-6, IL-8, IL-16, tumor necrosis factor (TNF) alpha, and CD4 ligand. (medscape.com)

Association of schizophrenia with variations in genes encoding transcription factors]. (nih.gov)
In the present studies, we examined the expression of two PDGF receptor genes in human tumor cell lines derived from neural crest. (jci.org)
Here we show through systematic epigenetic studies that the histone acetyltransferase p300/CBP-associated factor (PCAF) promotes acetylation of histone 3 Lys 9 at the promoters of established key regeneration-associated genes following a peripheral but not a central axonal injury. (nature.com)
We found that p300/CBP-associated factor (PCAF)-dependent acetylation of histone 3 lysine 9 (H3K9ac), paralleled by a reduction in methylation of H3K9 (H3K9me2), occurred at the promoters of select genes only after PNS axonal injury. (nature.com)
In contrast, radial nerve showed an unexpected level of complexity with the expression of 3,370 genes significantly altered more than two-fold with age, including genes involved in nerve function, signaling, metabolism, transcriptional regulation and chromatin modification. (nature.com)
No Association of Polymorphisms in Nav1.7 or Nerve Growth Factor Receptor Genes with Trigeminal Neuralgia. (cdc.gov)
Recent advances have been made in the of host factors, polymorphisms, and candidate genes associated characterization of the immune response to low-molecular- with occupational asthma may improve our understanding of weight agents. (cdc.gov)

In addition to these four pathways, tumors can undergo infiltration around nerve fibers and metastasis along nerves, that is, perineural invasion (PNI), which refers to the phenomenon of perineural invasion by tumor cells filling the perineurial space, wrapping around nerves in a continuous concentric sheath-like pattern, infiltration, and metastasis of extension along nerves around nerve fibers or into perineurium within the perineurium [ 7 ]. (hindawi.com)
These peripheral cold receptors, both Aδ- and C-fibers, have thermal thresholds (i.e., the temperature at which nerve impulses are generated) for cold activation between 30-20°C, temperatures considered to be innocuously cool [ 4 , 6 ]. (nih.gov)

For example, prostaglandins activate G s -protein-coupled receptors and initiate cAMP- and protein kinase A (PKA)-mediated processes. (jneurosci.org)
Phosphoinositide 3-kinase (PI3K) signaling contributes to a variety of processes, mediating many aspects of cellular function, including nutrient uptake, anabolic reactions, cell growth, proliferation, and survival. (mdpi.com)

Given the critical nature of receptor internalization and endosomal signaling for FSHR activity, we assessed whether these compounds exhibit differential abilities to alter receptor endosomal trafficking and signaling within the VEE. (frontiersin.org)
All compounds exhibited a similar requirement for receptor internalization to increase cAMP and proportion of FSHR endosomes with active Gαs, suggesting regulation of cAMP signaling induced by T1 may be altered. (frontiersin.org)

Bilateral cavernous nerve crush injury was induced in adult male Sprague-Dawley rats. (cellsurgicalnetwork.com)

These functions are activated when calcitriol binds to the site of the VDR nuclear receptor. (wakeup-world.com)
In this review article, we outline key characteristics of major gene therapy viruses-adenovirus, adeno-associated virus (AAV), and lentivirus-and summarize the mechanisms regulating important steps in the virus journey from binding at peripheral nerve terminals to nuclear delivery. (frontiersin.org)

This route is minimally invasive and therefore clinically relevant for gene therapy targeting to peripheral nerve soma. (frontiersin.org)

Killer cell inhibitory receptors. (embl.de)

The expression of alpha and/or beta PDGF receptors was detected in a wide variety of neural crest-derived human tumor cell lines such as neuroblastoma, primitive neuroectodermal tumor, and Ewing's sarcoma by RNA blot analysis, and confirmed by immunoblot analysis. (jci.org)
Metformin Enhances the Effect of Regorafenib and Inhibits Recurrence and Metastasis of Hepatic Carcinoma After Liver Resection via Regulating Expression of Hypoxia Inducible Factors 2α (HIF-2α) and 30 kDa HIV Tat-Interacting Protein (TIP30). (cancerindex.org)
DNA methylation alters glucocorticoid receptor expression through modifications of chromatin structure. (deepdyve.com)
Pharmacological reversal of the effects on chromatin structure completely eliminates the effects of maternal care on glucocorticoid receptor expression and hypothalamic-pituitary-adrenal (HPA) responses to stress, thus suggesting a causal relation between the maternally induced, epigenetic modification of the glucocorticoid receptor gene and the effects on stress responses in the offspring. (deepdyve.com)
Schatteman GC, Gibbs L, Lanahan AA, Claude P, Bothwell M: Expression of NGF receptor in the developing and adult primate central nervous system. (exbio.cz)
Aberrant expression of serine/arginine-rich splicing factor 2 (SRSF2) can lead to tumorigenesis, but its molecular mechanism in colorectal cancer is currently unknown. (bvsalud.org)

Transplantation of nonhematopoietic adult bone marrow stem/progenitor cells isolated by p75 nerve growth factor receptor into the penis rescues erectile function in a rat model of cavernous nerve injury. (cellsurgicalnetwork.com)
We investigated the effects of transplanting nonhematopoietic adult bone marrow stem/progenitor cells (multipotent stromal cells) into the corpus cavernosum in a rat model of bilateral cavernous nerve crush injury. (cellsurgicalnetwork.com)
Four weeks after the procedures we assessed erectile function by measuring the intracavernous-to-mean arterial pressure ratio and total intracavernous pressure during cavernous nerve stimulation. (cellsurgicalnetwork.com)
Neural output travels through the cavernous nerves, which traverse the posterolateral aspect of the prostate. (msdmanuals.com)

Nerve Growth Factor Receptor is also expressed in melanocytes, melanomas, neuroblastomas, pheochromocytomas, neurofibromas, neurotized nevi (type C melanocytes), and other neural crest cell or tumor derivatives. (assaysolution.com)

Then, he moved to Stanford University for a postdoctoral fellowship on the role of transcription factor Pbx1, a leukemia proto-oncogene, on B cell development. (stanford.edu)

Environmental factors that can detect specific IgE antibodies against most low-molecular- affect the initiation of occupational asthma include the intrinsic weight agents has resulted in a search for alternative or characteristics of causative agents as well as the influence of the complementary physiopathologic mechanisms leading to airway level and route of exposure at the workplace. (cdc.gov)

SPIN1 ablation activates p53, suppresses cell growth, reduces clonogenic ability, and induces apoptosis of human cancer cells. (elifesciences.org)

Receptors, Opioid, delta" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)

In turn, receptor signaling is known to drive or regulate GPCR trafficking. (frontiersin.org)

2010). Vascular endothelial growth factor (VEGF) and prostate pathology . (up.pt)

Its pathogenesis remains unknown, and it is currently only well established that family history, smoking, diabetes mellitus, obesity as well as alcohol abuse are high risk factors for PC [ 3 ]. (hindawi.com)
Treatment should not only consider lowering the blood glucose level but also should focus on the correction of any associated CVD risk factors such as smoking, hyperlipidemias, and obesity as well as monitoring of blood pressure and ~treatment of hypertension. (who.int)

Emotional stress induced by parachute jumping enhances blood nerve growth factor levels and the distribution of nerve growth factor receptors in lymphocytes. (thieme-connect.de)
The brain cell membranes contain the majority of Phosphatidylserine, which provides fluidity, enhances receptors and increases neurotransmitters. (vagarights.com)

In seminal studies conducted by Hensel and Zotterman in the 1950s, menthol elicited its "cool" sensation by increasing the threshold temperature for activation of cold receptors [ 13 ]. (nih.gov)
Indeed, the researchers hypothesized that menthol exerted its actions on "an enzyme" that was involved in the activation of these nerves [ 13 ]. (nih.gov)

P75 nerve growth factor receptor staining is superior to S100 in identifying spindle cell and desmoplastic melanoma. (roche.com)

A class of opioid receptors recognized by its pharmacological profile. (harvard.edu)

The initial event in the replicative cycle of a virus is its interaction with receptors present on the surface of a cell. (medscape.com)

We think the best evidence suggests that Bacopa monnieri promotes neuron dendrite growth. (vagarights.com)

C5DELq14.3;DEL5q14.3;MADS box transcription enhancer factor 2, polypeptide C;Myocyte enhancer factor 2C;myocyte-specific enhancer factor 2C;NEDHSIL. (avivasysbio.com)
and they are associated with altered histone acetylation and transcription factor (nerve growth factor-induced clone A [NGFIA]) binding to the glucocorticoid receptor promoter. (deepdyve.com)

A number of mechanisms are likely involved, including tissue injury related to the incision itself, secondary inflammation, and damage to nerves caused by tissue retraction during the surgery. (asahq.org)
Extraocular muscle inflammation and optic nerve compression result in visual changes in visual acuity. (medscape.com)

We have also demonstrated that PDGF receptors on the human neuroblastoma cell lines were biologically functional. (jci.org)
Cell surface receptors containing an immunoglobin domain. (embl.de)
Recent research suggests that almost every cell in our body has receptors for vitamin D, which indicates a much stronger role for this vitamin than previously thought. (wakeup-world.com)
This nootropic supports brain cell energy, nerve growth factor (NGF), and brain cell repair by increasing glucose metabolism. (vagarights.com)

Association of estrogen receptor gene polymorphisms and primary trigeminal neuralgia]. (cdc.gov)

The regenerative response initiated following axonal injury in the peripheral nervous system (PNS) versus the central nervous system (CNS) leads to differential growth capacities and repair. (nature.com)

Guanine nucleotide dissociation stimulators (GDSs, or exchange factors), such as RALGDS, are effectors of Ras-related GTPases (see MIM 190020) that participate in signaling for a variety of cellular processes. (cancerindex.org)

Anatomy59

Organisms8

Diseases14

Chemicals and Drugs114

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Phenomena and Processes35

Disciplines and Occupations1

Information Science3

Neurotrophin7

Tumor necrosis fa2

Tyrosine kinase2

Intracellular4

Vanilloid4

NGFR8

Agonists2

BDNF4

Ligands2

P75NTR4

TrkA2

Transient receptor1

Neurotrophic factor2

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Superfamily1

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TRPV11

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Insulin1

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Genes7

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Peripheral nerve1

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S1001

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