EPHA1, EPHA2, EFNA3, and EFNA4 mRNA expression was significantly higher in human epidermal growth factor receptor 2- (HER2-) positive tumors than in HER2-negative tumors. (hindawi.com)
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase (RTK) commonly targeted for inhibition by anti-cancer therapeutics. (biorxiv.org)
The epidermal growth factor receptor (EGFR) is a HER-family receptor tyrosine kinase (RTK) that is involved in cell signaling in healthy tissue. (biorxiv.org)
It is also frequently called HER2 (from human epidermal growth factor receptor 2 ) or HER2/neu . (iiab.me)
HER2 is a member of the human epidermal growth factor receptor (HER/EGFR/ERBB) family. (iiab.me)
HER2 is so named because it has a similar structure to human epidermal growth factor receptor, or HER1. (iiab.me)
Type-A receptor1
EPH receptor A1 (ephrin type-A receptor 1) is a protein that in humans is encoded by the EPHA1 gene. (wikipedia.org)
EPHA6
Family A receptors (EPHA) and ligands (EFNA) can act as oncogenes or tumor suppressors and are implicated in chemoresistance. (hindawi.com)
Ephrin family A includes ten receptors named EPHA (1-10) and five ligands designated as EFNA (1-5) [ 6 ]. (hindawi.com)
In general, class EphA receptors bind GPI-anchored ephrin-A ligands. (umbc.edu)
There are ten vertebrate EphA receptors (EphA1-10), which display promiscuous interactions with six ephrin-A ligands. (umbc.edu)
The Eph family of receptor tyrosine kinases (comprising EphA and EphB receptors) has been implicated in synapse formation and the regulation of synaptic function and plasticity6. (betalifesci.com)
It binds preferentially to ephA receptors ( EPH FAMILY RECEPTORS ) with the exception of the EPHA1 RECEPTOR . (nih.gov)
Ligands9
The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. (wikipedia.org)
Unified nomenclature for Eph family receptors and their ligands, the ephrins. (wikipedia.org)
The Eph receptor tyrosine kinases and their membrane-bound ephrin ligands control a diverse array of cell-cell interactions in the developing and adult organisms. (rcsb.org)
Ephrins, also known as ephrin ligands, and Eph receptors (Ephs), which are RTKs, are key regulators of physiological and pathological processes involved in development and disease, such as cellular motility, cell repulsion, and cell adhesion [ 4 ]. (hindawi.com)
Both receptors and ligands are membrane-bound proteins that require direct cell-cell interaction for activation. (hindawi.com)
The interaction between ligands and receptors via bidirectional signaling and its involvement in cancer biology are mediated by complex processes [ 7 , 8 ]. (hindawi.com)
The Eph subfamily represents the largest group of receptor protein tyrosine kinases identified to date and their ligands, the ephrins,can be subdivided into two major subclasses, ephrin-A and ephrin-B. Interaction of Eph receptor tyrosine kinases with their membrane bound ephrin ligands initiates bidirectional signaling events that regulate cell migratory and adhesive behavior, particularly in the nervous system. (affbiotech.cn)
Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. (affbiotech.cn)
The conserved Eph receptors and their Ephrin ligands regulate a number of developmental processes, including axon guidance. (arizona.edu)
EphA22
Spatial structure of dimeric transmembrane domain of EphA2 receptor embedded into lipid bicelle was obtained by solution NMR, showing a left-handed parallel packing of the transmembrane helices (535-559)(2). (rcsb.org)
The EphA2 receptor is overexpressed in tumor cells and tumor blood vessels in a variety of cancers including breast, prostate, lung, and colon. (umbc.edu)
Protein7
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. (wikipedia.org)
These findings serve as an instructive example of the diversity of transmembrane domain formation within the same family of protein kinases and seem to favor the assumption that the so-called rotation-coupled activation mechanism may take place during the Eph receptor signaling. (rcsb.org)
EPH receptor A1 (EphA1), with 976-amino acid protein(about 107 kDa), belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. (affbiotech.cn)
In a cross-sectional study of 48 AD patients without diabetes, 20 cognitively normal diabetic patients, 16 patients with frontotemporal dementia, and 84 cognitively normal controls, researchers found that dysfunctionally phosphorylated insulin receptor substrate-1 (IRS-1), a neuronal protein, is detectable in blood using exosome-based technology and may be able to predict AD up to 10 years before the appearance of symptoms. (medscape.com)
Catalytic domain of the Protein Tyrosine Kinase, Ephrin Receptor A10. (umbc.edu)
G protein-coupled P2Y receptors participate in the nucleotide receptor G protein-coupled receptor (GPCR) family members and also have eight mammalian subtypes (P2Y1, 2, 4, 6, 11-14) (Kim et al. (aboutsciencenow.info)
Receptor tyrosine-protein kinase erbB-2 , also known as CD340 (cluster of differentiation 340), proto-oncogene Neu , Erbb2 (rodent), or ERBB2 (human), is a protein that in humans is encoded by the ERBB2 gene. (iiab.me)
Monoclonal2
The pieces had been precontracted with 1 molL?1 phenylephrine which induced a suffered contraction Mouse monoclonal to EphA1 above basal pressure of just one 1.9 0.4 g (= 71). (nonamimaho.com)
The pocket for MRS2500 binding to Mouse monoclonal to EphA1 P2Y1R described by residues through the N terminus generally, ECL2, and its own helices buildings. (aboutsciencenow.info)
RTKs3
Receptor tyrosine kinases (RTKs) play an important role in a variety of cellular processes in cancer [ 3 ]. (hindawi.com)
EphRs comprise the largest subfamily of receptor tyr kinases (RTKs). (umbc.edu)
Ephrin receptors are components of cell signalling pathways involved in animal growth and development, forming the largest sub-family of receptor tyrosine kinases (RTKs). (betalifesci.com)
CD332
Common variants at ABCA7 , MS4A6A/MS4A4E , EPHA1 , CD33 and CD2AP are associated with Alzheimer's disease. (jamanetwork.com)
Common variants at MS4A4/MS4A6E , CD2AP , CD33 and EPHA1 are associated with late-onset Alzheimer's disease. (jamanetwork.com)
Vertebrate2
Roles for Eph receptor tyrosine kinase signaling in the formation of topographic patterns of axonal connectivity have been well established in vertebrate visual systems. (sdbonline.org)
In contrast to the large vertebrate Eph/Ephrin family, Drosophila has a single Eph receptor and a single Ephrin ligand, both of which are expressed within the developing nervous system. (arizona.edu)
Subfamily1
Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. (wikipedia.org)
Drosophila Eph2
A role for a Drosophila Eph receptor tyrosine kinase (Eph) in the control of photoreceptor axon and cortical axon topography in the developing visual system is described. (sdbonline.org)
Thomas, John B. / Drosophila Eph receptor guides specific axon branches of mushroom body neurons . (arizona.edu)
Transmembrane1
Importantly, a similar motif AX(3)GX(3)G as was found is responsible for right-handed dimerization of transmembrane domain of the EphA1 receptor. (rcsb.org)
EPHA101
EphA10, which contains an inactive tyr kinase domain, may function to attenuate signals of co-clustered active receptors. (umbc.edu)
Membrane-bound1
The ErbB family consists of four plasma membrane-bound receptor tyrosine kinases. (iiab.me)
Proteins1
The individual P2Y1 receptor proteins framework and its own two ligand-binding sites for the nucleotide-like antagonist MRS2500 and allosteric antagonist 1-(2-(2-tert-butylphenoxy)pyridin-3-yl)-3-(4-(trifluoromethoxy)phenyl)urea (BPTU) had been reported in 2015 (Proteins Database [PDB] Identification: 4XNW, 4XNV) (Zhang et al. (aboutsciencenow.info)
Binds2
This substance binds the recombinant individual P2Y1 receptor and inhibits the platelet aggregation due to ADP with an 50% inhibitory focus (IC50) worth in the nanomolar range. (aboutsciencenow.info)
EphA5, also known as Ehk1, Bsk, Cek7, Hek7, and Rek7, is a member of the Eph receptor tyrosine kinase family which binds members of the Ephrin ligand family (1 - 4). (rndsystems.com)
Recombinant1
Purified recombinant fragment of human EphA1 expressed in E. Coli. (affbiotech.cn)
HER21
[10] [11] HER2 can heterodimerise with any of the other three receptors and is considered to be the preferred dimerisation partner of the other ErbB receptors. (iiab.me)
Roles1
Ligand-mediated activation of Ephs induce various important downstream effects and Eph receptors have been studied for their potential roles in the development of cancer. (betalifesci.com)
Mammalian1
Comparative studies of mammalian estrogen receptors from tissue culture and rats. (edu.au)
Serotonin1
2015). ADP may be the initial small-molecular pounds platelet agonist, and its own receptors, such as for example P2Y1 receptors, can few to turned on phospholipase C. The activation of serotonin receptor products signaling through the P2Y1 receptor, demonstrating that it's a particular antagonist in a position to stop ADP-induced platelet aggregation (Jin and Kunapuli, 1998). (aboutsciencenow.info)
Residues1
Dimerisation results in the autophosphorylation of tyrosine residues within the cytoplasmic domain of the receptors and initiates a variety of signaling pathways. (iiab.me)
Antagonist2
Ivacaftor hydrate Ramifications of 5-HT receptor antagonists on relaxations to 5-HT The 5-HT7 receptor selective antagonist SB 269970 (100 nmolL?1 and 300 nmolL?1) caused maximal rightwards displacements from the rest concentration-response curve to 5-HT (Shape 2A,B, Desk 2) and 5-CT (Shape 2C, Desk 2). (nonamimaho.com)
In P2Y1R, the antagonist MRS2500 possibly prevents the actions of the helices and stabilized the receptor within an inactive condition by getting together with helices In the P2Y1RCMRS2500 framework, each terminal air of both phosphates forms at least one connection with the receptor. (aboutsciencenow.info)
Apoptosis1
In summary, signaling through the ErbB family of receptors promotes cell proliferation and opposes apoptosis, and therefore must be tightly regulated to prevent uncontrolled cell growth from occurring. (iiab.me)
Signal1
Eph/ephrin signal transduction occurs not only in the receptor-expressing cell but also in the ligand-expressing cell via bidirectional signaling [ 5 ]. (hindawi.com)
Human1
Utilising fly genetics, this study generated the first Drosophila model of human wild-type and P460L mutant EphA1 and tested the effects of Eph /ephrin signalling on AD-relevant behaviour and neurophysiology. (sdbonline.org)
Channels1
Prejunctional 5-HT1A Kv and receptors channels modulated 5-HT-induced relaxations whereas postjunctional K+ channels weren't involved with such responses. (nonamimaho.com)
Developmental1
EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. (wikipedia.org)
Activation1
Eph receptor-mediated signaling, which is triggered by ephrins7, probably modifies the properties of synapses during synaptic activation and remodeling. (betalifesci.com)
Expression2
EphA1 mis-expression did not cause neurodegeneration, shorten lifespan or affect memory but flies mis-expressing the wild-type or mutant receptor were hyper-aroused, had reduced sleep , a stronger circadian rhythm and increased clock neuron activity and excitability. (sdbonline.org)
Furthermore, diverse structural alterations have been identified that cause ligand-independent firing of this receptor, doing so in the absence of receptor over-expression. (iiab.me)