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  • renal
  • No change in ETA receptor expression was observed in the renal medulla following HS, however, centhaquin produced decrease (-61%) in ETA levels compared to HS. (ovid.com)
  • HS decreased (-34%) ETB receptor expression in the renal medulla which was completely reversed by centhaquin and not saline. (ovid.com)
  • Conclusions: Centhaquin was found to be an effective resuscitative agent and induced an increase in ETB receptor expression in the renal medulla could lead to vasodilator effect and promote diuresis and natriuresis, preventing injury to the renal medulla. (ovid.com)
  • This chapter provides an overview of the endothelin system as well as preclinical data of ERA studies obtained in disease models of arterial hypertension, atherosclerosis, coronary artery disease, pulmonary hypertension, heart failure, renal disease, and allograft rejection following cardiac transplantation. (springer.com)
  • Effects of endothelin on the renal artery from spontaneously hypertensive and wistar kyoto rats. (springer.com)
  • blood vessels
  • ET A receptors are found in the medial smooth muscle layers of the blood vessels, and atrial and ventricular myocardium. (ahajournals.org)
  • Widely distributed in the body, receptors for endothelin are present in blood vessels and cells of the brain, choroid plexus and peripheral nerves. (wikipedia.org)
  • 11 This agrees with the prior demonstration of normal or only slightly depressed responses to ET-1 and the absence of important downregulation of endothelin receptors in blood vessels or smooth muscle cells of SHR. (ahajournals.org)
  • downregulation
  • 6 Vascular responses to ET-1 7 and endothelin receptors and signaling 8 9 are reduced in deoxycorticosterone acetate (DOCA)-salt hypertensive rats, and we have speculated that the receptor downregulation found could result from enhanced vascular production of ET-1. (ahajournals.org)
  • To test whether downregulation of endothelial ET B R expression/activity plays a role in HTN-Preg, BP was measured in normal pregnancy (Norm-Preg) rats and rat model of HTN-Preg produced by reduction of uteroplacental perfusion pressure (RUPP), and mesenteric microvessels were isolated for measuring diameter, [Ca 2+ ] i , and endothelin receptor type-A and ET B R levels. (ahajournals.org)
  • release of nitric oxide
  • 22 The activation of ET B receptors stimulates the release of nitric oxide and prostacyclin and prevents apoptosis. (ahajournals.org)
  • ETB1 mediates vasodilation, When endothelin binds to ETB1 receptors, this leads to the release of nitric oxide (also called endothelium-derived relaxing factor), natriuresis and diuresis (the production and elimination of urine) and mechanisms that lower blood pressure. (wikipedia.org)
  • Abstract
  • Abstract We previously showed that endothelin-1 expression was increased in vascular endothelium of deoxycorticosterone acetate-salt hypertensive rats, whereas in spontaneously hypertensive rats (SHR) it is similar to or less than that in normotensive rats. (ahajournals.org)
  • Clinical
  • The Swiss affiliate is located in Baden, the German affiliate in Freiburg, the Austrian one in Vienna, the French one in Paris and the UK affiliate is located in London In 2006, the company established the Actelion Endothelin Research Award programme which supports selected clinical research projects. (wikipedia.org)
  • kidney
  • Endothelins in the kidney: physiology and pathophysiology. (springer.com)
  • Methods: We determined the effect of HS and resuscitation by hypertonic saline (saline) or centhaquin on ETA and ETB receptor levels in the brain, heart, kidney, liver, lung and abdominal aorta. (ovid.com)
  • atrial
  • Inhibitors have been designed with the aim of developing analgesic and antihypertensive agents that act by preventing neprilysin's activity against signaling peptides such as enkephalins, substance P, endothelin, and atrial natriuretic factor. (wikipedia.org)
  • enzyme
  • The elaborate structural studies of proteins from several important systems as potential drug targets such as phospholipase A2, cyclooxygenase, lipoxygenase, endothelin receptor, endothelin converting enzyme, breast cancer regression proteins and matrix metanosomal proteins as well as their complexes with natural and designed synthetic ligands have been carried out. (wikipedia.org)
  • cardiac
  • However, the arterioles of skeletal muscle, cardiac muscle, and pulmonary circulation vasodilate in response to these hormones when they act on beta-adrenergic receptors. (wikipedia.org)
  • Antibody
  • The AGE- and CML-dependent activation of NF-κBp65 and NF-κB-dependent IL-6 expression could be inhibited using the soluble form of the receptor for AGEs (RAGE) (soluble RAGE [sRAGE]), RAGE-specific antibody, or the antioxidant thioctic acid. (diabetesjournals.org)
  • alpha
  • alpha(1B)-Adrenergic receptors mediate many of the actions of the natural catecholamines, adrenaline and noradrenaline. (unam.mx)
  • Generally, norepinephrine and epinephrine (hormones produced by sympathetic nerves and the adrenal gland medulla) are vasoconstrictive acting on alpha 1-adrenergic receptors. (wikipedia.org)