Oxygen speciesNitric oxideOxidative stressHighly reactivePeroxynitriteCompoundsIntermediatesSubstancesAbstractProteinInhibitionInducesMitochondriaMetabolismRolesNeutrophilsSuperoxide DismutaseContinuously producedCombineMechanismsMammalianFormationProductionCellularOxidationLevelsAgricultureGenerationEssentialFreeEmissionsSpecificActivityTopicShown
Oxygen species20
- Reactive nitrogen species act together with reactive oxygen species (ROS) to damage cells, causing nitrosative stress. (wikipedia.org)
- superoxide) → ONOO− (peroxynitrite) Superoxide anion (O2−) is a reactive oxygen species that reacts quickly with nitric oxide (NO) in the vasculature. (wikipedia.org)
- Reactive oxygen species Reactive sulfur species Reactive carbonyl species Novo E, Parola M (2008). (wikipedia.org)
- Gene expression analysis suggests that reactive oxygen species (ROS) levels are increased in both models, and we confirmed this through measures of cellular redox state. (healthfully.org)
- The role of reactive oxygen species and its effects on aging has received considerable attention in the past 47 years since Dr. Denham Harman first proposed the "free radical theory of aging. (healthfully.org)
- Reactive oxygen species and cell death Reactive oxygen species and inflammation Are specific reactive oxygen species and antioxidants involved in modulating cellular responses? (healthfully.org)
- Oxidative stress in the cardiovascular system, including brain microvessels and/or parenchymal cells results in an accumulation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) compounds thus promoting leukocyte adhesion and increasing endothelial permeability. (nih.gov)
- Superoxide dismutases (SODs) are the primary reactive oxygen species (ROS)-scavenging enzymes of the cell and catalyze the dismutation of superoxide radicals O2- to H2O2 and molecular oxygen (O2). (nih.gov)
- During inflammation, reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated from inflammatory cells and are considered to play key roles in carcinogenesis [ 3 ]. (hindawi.com)
- The innate immune response by myeloid cells occurs as a succession of events starting at signaling through cytosolic or surface PRRs, followed by effector responses including the release of cytokines, reactive oxygen species (ROS), reactive nitrogen species (RNS), antibacterial peptides and degranulation ( Figure 1 ). (frontiersin.org)
- Formation of reactive oxygen species in neutrophils of rats with adjuvant arthritis and generation of nitric oxide in RAW 264.7. (nel.edu)
- Reactive oxygen species (ROS) have been implicated in the pathogenesis of numerous disease processes. (duke.edu)
- Dietary polyphenols have gained public interest in recent times due to their roles in the prevention of various diseases that implicate free radicals/reactive oxygen species. (frontiersin.org)
- Phagocytic activity, reactive oxygen species production, reactive nitrogen species production, myeloperoxidase, lysozyme activity, and total immunoglobulins were tested before and after challenge. (int-res.com)
- The PTEF also contains electrically charged particles, reactive oxygen species (ROS) and reactive nitrogen species (RNS) that permeate the cell's membrane leading to apoptosis (cell death). (businesswire.com)
- Activated inflammatory cel s, in- persistent inflammation cluding neutrophils and macrophag- es, produce reactive oxygen species and reactive nitrogen species. (who.int)
- phosphatidylserine (PS) externalisation and the generation of reactive oxygen species and nitrogen species. (bvsalud.org)
- Furthermore, molecular nanoprobes monitoring changes in pH and reactive oxygen species activity are developed and used to further understand SOM modifications by ECM fungi. (lu.se)
- Differences between reactive oxygen species and antioxidant defense system unbalance the redox status. (bvsalud.org)
- 2011). Larger quantities of free radicals (reactive disease, diabetes, chronic respiratory diseases, and oxygen species [ROS]) present in the cigarette cancer (WHO, 2012). (bvsalud.org)
Nitric oxide2
- Traditionally, MIRI can be due to reactive oxygen and nitrogen species (ROS/RNS) generation, a reduced availability of nitric oxide (NO), Ca 2+ overload, and mitochondrial permeability transition pore (mPTP) opening. (hindawi.com)
- In the present study, we investigate the effect of the bark methanol extract (BLM) on reactive oxygen/nitrogen species (ROS/RNS), the expression of protein and mRNA of inducible nitric oxide synthase (iNOS) in RAW 264.7 macrophages stimulated with lipopolysaccharide (LPS) and sodium nitroprusside (SNP) to provide scientific validation of the above said medicinal property. (phcog.com)
Oxidative stress3
- Though not completely understood due to the incalculable number of pathways involved, the number of manuscripts that facilitate the understanding of the underlying effects of reactive radical species on the oxidative stress on lipids, proteins, and DNA and its contribution to the aging process increases nearly exponentially each year. (healthfully.org)
- Redox-sensitive cell signalling Thiol groups and the regulation of gene expression Redox-sensitive signal transduction pathways Protein kinases Protein phosphatases Lipids and phospholipases Antioxidant (electrophile) response element Intracellular calcium signalling Transcription factors NF-?B AP-1 p53 Cellular responses to oxidative stress Cellular responses to change in redox state Proliferation Cell death Immune cell function Reactive oxygen and nitrogen species - good or bad? (healthfully.org)
- The imbalance between disposal systems and production of these species leads to dysfunction of macromolecules and cells at the heart of the phenomenon of oxidative stress. (cea.fr)
Highly reactive2
- Peroxynitrite itself is a highly reactive species which can directly react with various biological targets and components of the cell including lipids, thiols, amino acid residues, DNA bases, and low-molecular weight antioxidants. (wikipedia.org)
- Vesicants are highly reactive chemicals that combine with proteins, DNA, and other cellular components to result in cellular changes immediately after exposure. (cdc.gov)
Peroxynitrite1
- NO and its relative peroxynitrite are reactive nitrogen species that are toxic to many bacteria. (rochester.edu)
Compounds3
- Emissions of these nitrogenous species not only impact regions adjacent to their point sources, but also have the ability to influence ecosystems hundreds of kilometers away due to the long-range transport of some of these compounds. (mun.ca)
- Treatment involves compounds that increase the removal of nitrogen waste. (medscape.com)
- Substances like biogenic volatile organic compounds (BVOC), the various nitrogen oxides, carbonaceous particles, ozone or methane act in the atmosphere either directly as greenhouse gases and aerosols, or as key precursors for greenhouse gases and secondary organic aerosol. (lu.se)
Intermediates3
- These reactive nitrogen intermediates also include the inorganic PEROXYNITROUS ACID and the organic S-NITROSOTHIOLS. (ouhsc.edu)
- is a relative unreactive radical, it is able to form other reactive intermediates, which could have an effect on protein function and on the function of the entire organism. (healthfully.org)
- These reactive intermediates can trigger nitrosative damage on biomolecules, which in turn may lead to age‐related diseases due to structural alteration of proteins, inhibition of enzymatic activity, and interferences of the regulatory function. (healthfully.org)
Substances1
- But likewise, an increasing number of studies demonstrate that, beyond CO 2 , atmospherically fast reactive substances that are emitted or consumed by the terrestrial biota, including by vegetation fires, also play a significant role for our understanding of the climate system. (lu.se)
Abstract1
Protein3
- Reactive nitrogen species is required for the activation of the AMP-activated protein kinase by statin in vivo. (ouhsc.edu)
- Baumeister D, Akhtar R, Ciufolini S et al (2015) Childhood trauma and adulthood inflammation: a meta-analysis of peripheral C-reactive protein, interleukin-6 and tumour necrosis factor-α. (springer.com)
- In this context, there is abundant evidence that clinical depression is an immuno-inflammatory disorder characterized by among other things increased levels of PICs and acute phase proteins, including C-reactive protein and haptoglobin [ 11 - 20 ]. (biomedcentral.com)
Inhibition1
- Ichinose , M. et al "Xanthine oxidase inhibition reduces reactive nitrogen species production in COPD airways. (ersjournals.com)
Induces2
- Specifically, UV light induces reactive oxygen and nitrogen species, which excite an electron in melanin fragments. (genengnews.com)
- However, a 5- to 10-fold increase in ammonia in the blood induces toxic effects in most animal species, with alterations in the function of the central nervous system. (medscape.com)
Mitochondria1
- Because of the SOD2 strategic location, it represents the first mechanism of defense against the augmentation of ROS/reactive nitrogen species levels in the mitochondria for preventing further damage. (nih.gov)
Metabolism1
- Reactive nitrogen species are also continuously produced in plants as by-products of aerobic metabolism or in response to stress. (wikipedia.org)
Roles2
- The applicability of these atmospheric measurement techniques to measure and quantify HNO₃(g) and NR₃(g) has been demonstrated for remote ecosystems and will hopefully allow for a greater understanding of these two species roles' in remote environments. (mun.ca)
- Free radicals and other reactive species play seminal roles in many psychological and pathophysiological processes. (enzolifesciences.com)
Neutrophils1
Superoxide Dismutase1
- Nanomaterials, especially modified fullerenes and cerium oxide nanoparticles, have been shown to effectively protect mammalian cells against damage caused by increased reactive oxygen or nitrogen species, and has been shown to act as effective superoxide dismutase mimetic in vitro. (cam.ac.uk)
Continuously produced1
Combine1
- Dark CPDs arise when UV-induced reactive oxygen and nitrogen species combine to excite an electron in fragments of the pigment melanin. (genengnews.com)
Mechanisms2
- RONS (reactive oxygen and nitrogen species) have traditionally been perceived to be detrimental to the physiology of the cell, with reports citing mechanisms by which a range of proteins, lipids and DNA are damaged. (silverchair.com)
- Here, we use nitrogen deficiency carbon nitride as a model catalyst and propose several different reaction mechanisms of PHP based on the comprehensive analysis of experiment and simulation results. (edu.sa)
Mammalian1
- Sickness behavior is a behavioral complex that is typically induced by acute infections and tissue injury in many mammalian species. (biomedcentral.com)
Formation3
- Formation of reactive oxygen and nitrogen species in the presence of pinosylvin - an analogue of resveratrol. (nel.edu)
- Jancinova V, Nosal R, Lojek A, Ciz M, Ambrozova G, Mihalova D, Bauerova K, Harmatha J, Perecko T. Formation of reactive oxygen and nitrogen species in the presence of pinosylvin - an analogue of resveratrol. (nel.edu)
- Nitrotyrosine formation is attributable to presence of reactive oxygen and nitrogen species. (holliseden.com)
Production1
- Enzo Life Sciences ROS-ID® ROS/RNS detection kit is designed to directly monitor real time reactive oxygen and/or nitrogen species (ROS/RNS) production in live cells using fluorescence microscopy. (enzolifesciences.com)
Cellular2
- Cellular expression of DNA damage/repair and reactive oxygen/nitrogen species in human periodontitis and peri-implantitis lesions. (bvsalud.org)
- AIM OF THE STUDY To evaluate differences in the cellular expression of DNA damage /repair and reactive oxygen / nitrogen species between human periodontitis and peri-implantitis lesions. (bvsalud.org)
Oxidation1
- An assay for RNA oxidation induced abasic sites using the Aldehyde Reactive Probe. (ouhsc.edu)
Levels1
- Information-rich methods are required to quantify the relative levels of various reactive species. (enzolifesciences.com)
Agriculture1
Generation1
- No statistically significant changes were observed in reactive oxygen and reactive nitrogen species generation. (bvsalud.org)
Essential1
- Thus being able to measure these increased inputs in terrestrial, aquatic and atmospheric environments is essential to understanding how the global nitrogen cycle has been impacted since the industrial revolution. (mun.ca)
Free1
- NO2) and dinitrogen trioxide (N2O3) as well as other types of chemically reactive free radicals. (wikipedia.org)
Emissions1
- This includes representation of the full terrestrial nitrogen cycle and hence emissions of nitrogen oxides, emissions of BVOC, accounting for wetlands and emissions of methane, and inclusion of fire as a naturally- or anthropogenically-caused episodic event. (lu.se)
Specific1
- Prolonged exposure to high concentrations of ZDTPs, calcium alkyl phenates, and magnesium, sodium, and calcium sulphonates had significant effects on the reproductive organs of male rabbits (testicular atrophy and reduction or absence of spermatozoa) which appeared to be species specific. (cdc.gov)
Activity1
- Future studies should investigate different concentrations of carvacrol as well as its antifungal activity in different fish species. (int-res.com)