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  • lipid
  • The present study was aimed at investigating the safety of Lacidipine (LCDP) loaded nanostructured lipid carriers (NLCs) in Wistar rats. (hindawi.com)
  • In this study liver nodules were produced in Wistar rats by intermittent feeding with dietary 2-acetylaminofluorene, and the lipid compositions of isolated microsomes, mitochondria, and lysosomes were examined. (aacrjournals.org)
  • Adebayo AH, Aliyu R, Gatsing D, Garba IH (2006) The effects of ethanolic leaf extract of Commiphora africana (Buseraceae) on lipid profile in rats. (springer.com)
  • Tumors
  • Play media A 1972 study compared neoplasms in "Sprague-Dawley" rats from six different commercial suppliers and found highly significant differences in the incidences of endocrine and mammary tumors. (wikipedia.org)
  • There were even significant variations in the incidences of adrenal medulla tumors among rats from the same source raised in different laboratories. (wikipedia.org)
  • Inhalation of dichloroacetylene also causes benign tumors of the livers and kidneys of rats. (wikipedia.org)
  • acute
  • Collectively, the data describe decreased adrenomedullary response to cholinergic stimulation in spontaneously diabetic rats as early as 2 weeks after the onset of diabetes and that a similar, although more severe, hyposecretion occurs after acute, severe hypoglycemia. (diabetesjournals.org)
  • intermittent
  • The rats were tested in the open field prior to the Y-maze and then given voluntary intermittent access to alcohol or water in the home cage for 6 weeks, where after, naltrexone in three different doses or saline was administered in a Latin square design over 4 weeks and alcohol intake and preference was measured. (diva-portal.org)
  • However, supplier-dependent differences and concomitant skew subgroup formations, primarily in open field behavior and intermittent alcohol intake, resulted in a shifted focus to instead study voluntary alcohol intake and preference, and the ensuing response to naltrexone in Wistar rats from three different suppliers. (diva-portal.org)
  • In this study, types of fibers constituting male Wistar rats semitendinous and their myosin heavy chains, as well as influence of intermittent training on hypertrophy of these fibers have been checked through MATPase histochemical technique and electrophoretic proteins separation. (scielo.cl)
  • mice
  • While less commonly used for research than mice, rats have served as an important animal model for research in psychology and biomedical science. (wikipedia.org)
  • This was the first in a series of development that have begun to make rats tractable as genetic research subjects, although they still lag behind mice, which lend themselves better to the embryonic stem cell techniques typically used for genetic manipulation. (wikipedia.org)
  • Many investigators who wish to trace observations on behavior and physiology to underlying genes regard aspects of these in rats as more relevant to humans and easier to observe than in mice, giving impetus to the development of genetic research techniques applicable to rat. (wikipedia.org)
  • and C57BL/6N mice and Wistar rats (mammals) via the PGP gene product. (wikipedia.org)
  • liver
  • Significant increase in left testis weight and liver weight was observed in male and female rats, respectively. (hindawi.com)
  • Some of the liver drug metabolizing and detoxifying enzymes were depleted under toxic conditions compared with non-toxic rats. (mdpi.com)
  • 1988). After oral administration of AAI to male Wistar rats DNA-AAI adducts in forestomach, stomach, liver, kidney, bladder and lung could be detected by use of the 32 P-postlabeling method. (springer.com)
  • This study assessed the effect of co-administration of artemisinin and Ricinodendron heudelotii extract on certain liver and antioxidant indices in rats. (springer.com)
  • Adedosu OT, Adedosu AN, Badmus JA, Adeleke GE, Akintola AO, Oyeyomi SA (2015) Co-administration of artesunate and Azadirachta indica extract: effects on antioxidants and certain liver parameters in male Wistar rats. (springer.com)
  • Aliyu R, Adebayo AH, Gatsing D, Garba H (2007) The effects of ethanolic leaf extract of Commiphora africana (Burseraceae) on rat liver and kidney functions. (springer.com)
  • parameters
  • Since hypoxanthine is a purine closely related to ATP formation, the aim of this study was to investigate the effect of intrastriatal hypoxanthine administration on neuroenergetic parameters (pyruvate kinase, succinate dehydrogenase, complex II, cytochrome c oxidase, and ATP levels) and mitochondrial function (mitochondrial mass and membrane potential) in striatum of rats. (springer.com)
  • Four groups containing ten rats each were administered distilled water (group A), artemisinin only (group B), artemisinin with R . heudelotii extract (group C), and R . heudelotii extract only (group D). Serum biochemical values and antioxidant parameters were determined using standard methods respectively. (springer.com)
  • adrenal
  • We have demonstrated previously that spontaneously diabetic BB-Wistar rats exhibit decreased adrenal medullary catecholamine secretion in response to splanchnic nerve terminal stimulation. (diabetesjournals.org)
  • To study this hypothesis, we isolated adrenal glands from control and spontaneously diabetic BB-Wistar rats, perfused them with ACh, and measured catecholamine secretion. (diabetesjournals.org)
  • Adrenal catecholamine release in response to ACh was significantly decreased at 2, 8, and 16 weeks after the onset of diabetes compared with age-matched, nondiabetic control rats. (diabetesjournals.org)
  • Domestic rats differ from wild rats in many ways: they are calmer and significantly less likely to bite, they can tolerate greater crowding, they breed earlier and produce more offspring, and their brains, livers, kidneys, adrenal glands, and hearts are smaller. (wikipedia.org)
  • Male
  • Haematological estimation revealed significant decrease in haemoglobin count in male rats while female rats showed significant increase in granulocyte count. (hindawi.com)
  • Studies on male rats and rabbits have shown that inhalation of dichloroacetylene can cause tubular necrosis, focal necrosis, and other nephrotoxic effects. (wikipedia.org)
  • 3.5% of a does of dichloroacetylene remains in the corpses of male Wistar rats. (wikipedia.org)
  • chemistry
  • LCDP was also tested in normotensive rats and results obtained from chemistry analysis revealed slight variations in the levels of creatinine kinase (CK), serum glutamate oxaloacetic transaminase (SGOT), and alanine transaminase (ALT) levels. (hindawi.com)
  • Study
  • We therefore undertook this study to evaluate pharmacodynamics and toxicological profile of oral administration of PartySmart in rats. (redorbit.com)
  • effects
  • Eighteen pregnant white rats were used for studies of the effects of microgravity and radiation. (wikipedia.org)
  • A neuroontogeny experiment was conducted to investigate space flight effects on the sensory development of rats that spent part of their prenatal gestation period in space. (wikipedia.org)
  • In rats, the Tityustoxin caused dramatic effects on the circulatory and respiratory systems, consisting of hypotension, tachypnea, hyperpnea, ataxic and gasping breathing. (wikipedia.org)
  • protein
  • The first rat colony in America used for nutrition research was started in January 1908 by Elmer McCollum, and then nutritive requirements of rats were used by Thomas Burr Osborne and Lafayette Mendel to determine the details of protein nutrition. (wikipedia.org)
  • variations
  • Over time, breeding the rats for these contests may have produced variations in color, notably the albino and hooded varieties. (wikipedia.org)
  • response
  • The decreased responsiveness of diabetic rat adrenals to perfusion with ACh was significantly correlated with a decrease in the release of catecholamines in response to splanchnic nerve stimulation. (diabetesjournals.org)
  • administration
  • Conversely, nondiabetic BB-Wistar rats made diabetic with streptozocin (STZ) and maintained in a hyperglycemic state did not exhibit catecholamine hyposecretion 2 weeks after STZ administration. (diabetesjournals.org)
  • single
  • Therefore, the metabolism of myosmine has been studied in Wistar rats treated with single oral doses of [pyridine-5-3H]myosmine at 0.001, 0.005, 0.5, and 50 micromol/kg body weight. (biomedsearch.com)
  • Genetic analysis of 117 albino rat strains collected from all parts of the world carried out by a team led by Takashi Kuramoto at Kyoto University in 2012, showed that the albino rats descended from hooded rats and all the albino rats descended from a single ancestor. (wikipedia.org)
  • results
  • The results indicate that developed LCDP loaded NLCs are safe when administered orally in rats. (hindawi.com)
  • period
  • In Japan, there was a widespread practice of keeping rats as a domesticated pet during the Edo period and in the 18th century guidebooks on keeping domestic rats were published by Youso Tamanokakehashi (1775) and Chingan Sodategusa (1787). (wikipedia.org)
  • Institute
  • The genetics of rats was studied by William Ernest Castle at the Bussey Institute of Harvard University until it closed in 1994. (wikipedia.org)
  • Food
  • Rat-catchers would not only make money by trapping the rodents, but also by selling them for food, or more commonly, for rat-baiting. (wikipedia.org)
  • blood
  • To identify the effective constituent in Dragon's blood that favors wound healing, we experimentally determined the mechanism by which DP accelerates wound healing on Wistar rat skin. (hindawi.com)
  • less
  • The wires had to be anchored to reduce the probability of the rats' removal of the sensor, but the sensors showed less variation in glucose sensitivity over time than prior biosensors. (pubmedcentralcanada.ca)
  • SHRSP
  • Evidence was found for different outcomes to middle cerebral artery occlusion in the young genetically hypertensive stroke-prone rat (SHRSP) compared to sham operated controls and the Wistar Kyoto rat (WKY). (ahajournals.org)
  • 2) Is the calcium sensitivity of calcium-activated potassium channels in lymphocytes from SHRSP different as compared with that of those from WKY rats? (ahajournals.org)
  • Potassium currents were recorded that had a slope conductance of 18.1 +/- 1.49, n = 6, and 18.5 +/- 1.44, n = 7, in WKY rat and SHRSP thymocytes, respectively. (ahajournals.org)