• tumors
  • Eighty-seven per cent of all tumors appeared after the rats were 540 days of age, and the mean lifespan after a tumor was first observed was 140 days. (aacrjournals.org)
  • Play media A 1972 study compared neoplasms in "Sprague-Dawley" rats from six different commercial suppliers and found highly significant differences in the incidences of endocrine and mammary tumors. (wikipedia.org)
  • There were even significant variations in the incidences of adrenal medulla tumors among rats from the same source raised in different laboratories. (wikipedia.org)
  • strains
  • Genetic analysis of 117 albino rat strains collected from all parts of the world carried out by a team led by Takashi Kuramoto at Kyoto University in 2012, showed that the albino rats descended from hooded rats and all the albino rats descended from a single ancestor. (wikipedia.org)
  • Scientists have bred many strains or "lines" of rats specifically for experimentation. (wikipedia.org)
  • mice
  • The rat had been on a 12hour light:dark cycle (lights on at 07:00) and had access ad libitum to drinking water and a diet of commercially available cubes for mice (Epol, South Africa). (scielo.org.za)
  • While less commonly used for research than mice, rats have served as an important animal model for research in psychology and biomedical science. (wikipedia.org)
  • This was the first in a series of development that have begun to make rats tractable as genetic research subjects, although they still lag behind mice, which lend themselves better to the embryonic stem cell techniques typically used for genetic manipulation. (wikipedia.org)
  • Many investigators who wish to trace observations on behavior and physiology to underlying genes regard aspects of these in rats as more relevant to humans and easier to observe than in mice, giving impetus to the development of genetic research techniques applicable to rat. (wikipedia.org)
  • significantly
  • Serum creatinine and blood urea nitrogen levels were also significantly increased in rats intoxicated with GO compared with the control group. (mdpi.com)
  • Domestic rats differ from wild rats in many ways: they are calmer and significantly less likely to bite, they can tolerate greater crowding, they breed earlier and produce more offspring, and their brains, livers, kidneys, adrenal glands, and hearts are smaller. (wikipedia.org)
  • humans
  • Studies in rats have shown that p-cresol is primarily conjugated with glucuronide to produce p-cresylglucuronide, though this may not be applicable to humans. (wikipedia.org)
  • study
  • High-fructose-fed rat model is a well-established animal model to elucidate mechanisms involved in fructose-induced MS development and also to study the effect of various nutrient and drug interventions on MS [ 8 ]. (hindawi.com)
  • found
  • Atomoxetine has been found to act as an NMDA receptor antagonist in rat cortical neurons at therapeutic concentrations. (wikipedia.org)
  • diet
  • One hundred similar rats on a special fatrich diet developed an 80 per cent tumor incidence. (aacrjournals.org)
  • The no-observed-effect-level (NOEL) for carcinogenicity of cyadox fed to rats was 2000 mg/kg diet (132.18-156.28 mg/kg b.w./day). (ovid.com)
  • control animals
  • There was a significant elevation in the levels of hydrogen peroxide and lipid hydro peroxide in GOs-treated rats compared to control animals. (mdpi.com)
  • levels
  • The test chemical was administered to pregnant rats by gavage at dose levels of 0, 10, 30, and 90mg/kg per day (n=10 for each group). (sigmaaldrich.com)
  • Increased fructose consumption is linked to the development of metabolic syndrome (MS). Here we investigated the time course of development of MS features in high-fructose-fed Sprague Dawley rats along with circulatory testosterone and homocysteine levels. (hindawi.com)
  • Popular
  • Rat-baiting was a popular sport which involved filling a pit with rats and timing how long it took for a terrier to kill them all. (wikipedia.org)
  • less
  • The animal attendant indicated that he had not noticed any untoward behaviour or sickness in the rat during the previous cage change 48 hours earlier However, about 12 hours before death the rat was less active than usual. (scielo.org.za)
  • rate
  • Atomoxetine's ability to increase prefrontal cortex firing rate in anesthetized rats could not be blocked by D1 or α2-adrenergic receptor antagonists, but could be potentiated by NMDA or an α1-adrenergic receptor antagonist, suggesting a glutamatergic mechanism. (wikipedia.org)
  • Techniques
  • Our rat hepatocytes are prepared using the same careful isolation and cryopreservation techniques as our human lots. (thermofisher.com)
  • significant
  • Histopathological evaluation showed significant morphological alterations of kidneys in GO-treated rats compared to controls. (mdpi.com)