• An analysis of spontaneous hypertension in spontaneously hypertensive rats by means of new recombinant inbred strains. (mcw.edu)
  • To test this hypothesis, basal extracellular concentrations of dopamine (DA) and serotonin (5-HT) in the nucleus accumbens as well as the effects of repeated ethanol pretreatment on the basal release of these transmitters were examined in alcohol-preferring (P), alcohol-nonpreferring (NP), and genetically heterogeneous Wistar rats. (aspetjournals.org)
  • A growing body of work now effectively models this "twins raised apart" situation in genetically identical strains of inbred mice or genetically similar rats. (edge.org)
  • We therefore hypothesized that genetically-determined stress response to oxycodone withdrawal drives the strain differences in oxycodone self-administration and reinstatement of oxycodone seeking. (hhs.gov)
  • Mice (around 280 strains which include inbred, out bred and genetically engineered lines), Rats (out bred stocks like Wistar, Sprague Dawley, Long Evans and several transgenic rat strains), Xenopus laevis and Zebra fish . (ncbs.res.in)
  • Our experimental models include various strains of inbred and genetically manipulated rats and mice. (augusta.edu)
  • A total of 337 F344 rats,20 Sprague Dawley rats, and 40 OF1 mice were all given initiating dose(s) of colon carcinogen, and were randomly allocated to experimental groups 7 d later. (aacrjournals.org)
  • PEG was active in F344 rats, in Sprague Dawley rats ( P =0.0005), and in OF1 mice ( P = 0.001). (aacrjournals.org)
  • Two series of experiments were performed to determine the possible involvement of Ca++ channels in the thermolytic action of ethanol administered at a room temperature of 22 degrees C. In one group of 11 adult female Sprague-Dawley rats, stainless steel guide cannulae were implanted stereotaxically above the lateral cerebral ventricle. (duke.edu)
  • differential effects in Sprague Dawley and Brown Norway rats. (cdc.gov)
  • Both the inbred Brown Norway and the outbred Sprague Dawley rat strains were included to study the influence of strain on the detection of toxicity. (cdc.gov)
  • GMA-SS exposure lowered daily sperm production compared to air controls in Sprague Dawley rats, but only in GMA-SS Brown Norway rats also fed the HF diet. (cdc.gov)
  • At week 24, bronchoalveolar lavage cell counts had returned to background levels for GMA-SS exposed Sprague Dawley rats but remained elevated in Brown Norway rats. (cdc.gov)
  • GMA-SS did not affect daily sperm production statistically significantly at this time point, but testicular weights were lowered in GMA-SS Sprague Dawley rats. (cdc.gov)
  • Serum testosterone remained lowered in Sprague Dawley rats fed the HF diet. (cdc.gov)
  • The studied reproductive outcomes seemed more prone to disruption in the Sprague Dawley compared to the Brown Norway strain. (cdc.gov)
  • Accordingly, male Sprague-Dawley (SD) and Brown Norway (BN) rats were maintained on either regular (Reg) or high fat (HF) diets for 24wk. (cdc.gov)
  • Adult male Sprague Dawley rats were evaluated for neurobehavioral, neuroinflammatory, and neural damage endpoints both acutely and longer-term (up to 72 h) post-TBI following impact with either an aluminum or stainless-steel projectile. (cdc.gov)
  • This work has been performed in order to verify whether, in male rats, the decreased secretion of LH and testosterone (T) occurring in old animals is reflected by modifications of luteinizing hormone-releasing hormone (LHRH) receptors at the level of the anterior pituitary and of the testes. (unimi.it)
  • The results obtained show that, in aged male rats, the concentration of pituitary LHRH receptors is significantly lower than that found in young animals. (unimi.it)
  • In conclusion, these results suggest that the reduced secretion of LH in old male rats may be linked, at least partially, to a decrease of the number of pituitary LHRH receptors. (unimi.it)
  • The impaired production of testosterone occurring in aged rats is accompanied by a significant increase of the number of testicular LHRH receptors, indicating that also the intratesticular mechanisms controlling testosterone release undergo significant alterations with aging. (unimi.it)
  • Effects of aging on pituitary and testicular luteinizing hormone-releasing hormone receptors in the rat / P. Limonta, D. Dondi, R. Maggi, L. Martini, F. Piva. (unimi.it)
  • In addition, MHC and Vra4 congenic strains on these backgrounds were studied to give information on MHC and non-MHC gene contribution. (nih.gov)
  • This suggestion was confirmed by the detection of significant difference in blood pressure between SHR and SHR.1N congenic strains. (mcw.edu)
  • The inbred Lou/C rat, originating from the Wistar strain, has been described as a model of resistance to diet-induced obesity, but little is known about its metabolism. (unige.ch)
  • Since this knowledge could provide some clues about the etiology of obesity/insulin resistance, this study aimed at characterizing glucose and lipid metabolism in Lou/C vs. Wistar rats. (unige.ch)
  • We developed a method, named Easy-ET, to induce pseudopregnancy in female rats by artificial stimulation using sonic vibration instead of mating with vasectomized males. (nature.com)
  • In mice and rats, females require mating stimulation for the maintenance of pregnancy. (nature.com)
  • These results demonstrate that castration of male rats significantly reduces OB noradrenergic responsiveness to K+ stimulation, an effect which was not restored following administration of silastic capsules containing testosterone. (omeka.net)
  • Improved glucose tolerance of Lou/C rats was not related to increased insulin output but was related to improved insulin sensitivity/responsiveness in the liver and in skeletal muscles. (unige.ch)
  • The Lou/C rat is a valuable model of spontaneous food restriction with associated improved insulin sensitivity. (unige.ch)
  • Examination of OLETF-derived non-insulin-dependent diabetes mellitus QTL by construction of a series of congenic rats. (mcw.edu)
  • Among them were 11 strains developed through inbreeding to study conditions such as hypertension, diabetes, and insulin resistance. (genomeweb.com)
  • abstract = 'The extent to which muscle glycogen concentrations can be increased during exposure to maximal insulin concentrations and abundant glucose was investigated in the isolated perfused rat hindquarter preparation. (ku.dk)
  • Most of my research has been studying genetic predisposition to alcohol dependence in rodent models, specifically in recombinant inbred panels of mice and rats. (cuanschutz.edu)
  • Overall, HF diet rats had lower serum testosterone levels compared to rats on regular diet. (cdc.gov)
  • Conclusion: Exposure to GMA-SS welding fumes lowered sperm production in two strains of rats, whereas high fat diet lowered serum testosterone. (cdc.gov)
  • I) as well as in castrated male rats implanted with either empty or testosterone filled silastic capsules (Expt. (omeka.net)
  • Studies utilize in vitro measurements of mRNA, protein, enzymatic activity, enzyme kinetics, and cell signaling as well as in vivo measurements of hormone levels, blood flow, blood pressure, and other indices of renal/cardiovascular function in anesthetized and conscious rats and mice. (augusta.edu)
  • Rats, Inbred Strains" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (wakehealth.edu)
  • A three-day PEG treatment was sufficient to halve the number of azoxymethane-induced aberrant crypt foci in F344 rats ( P = 0.0006). (aacrjournals.org)
  • Inbred F344. (bvsalud.org)
  • Castration reduces potassium-stimulated norepinephrine release from superfused olfactory bulbs of male rats. (omeka.net)
  • In order to investigate the possible relationship among the olfactory bulb (OB), norepinephrine (NE) and gonadal steroids, we measured NE release from superfused anterior and posterior OB in intact and castrated male rats (Expt. (omeka.net)
  • To this purpose, the affinity constant (Ka) and the maximal binding capacity (Bmax) for the LHRH analog [D-Ser(tBu)6]des-Gly10-LHRH-N-ethylamide were evaluated, by means of a receptor binding assay, in membrane preparations derived from the anterior pituitary and testicular Leydig cells of male rats of 3 and 19 months of age. (unimi.it)
  • Serum levels of LH and T are significantly lower in old than in young male rats. (unimi.it)
  • The immunomodulating properties of "Shangqiu" (LP-5), "Ququan" (H-8), and "Rangu" (R-2) points were studied in several experiments performed on male Wister rats treated bilaterally by acupuncture (A) or electro-acupuncture (EA). (mcmaster.ca)
  • The mode of blood pressure inheritance and some genetic markers of spontaneous hypertension were evaluated in a new set of recombinant inbred (RI) strains obtained by crossing of normotensive (BN.lx) and hypertensive (SHR) progenitor strains. (mcw.edu)
  • Shimada S, Abais-Battad JM, Alsheikh AJ, Yang C, Stumpf M, Kurth T, Mattson DL , Cowley, AW Jr. Renal perfusion pressure determines infiltration of leukocytes in the kidney of rats with angiotensin II induced hypertension. (augusta.edu)
  • Splenocyte transfer exacerbates salt-sensitive hypertension in rats. (augusta.edu)
  • A quick survey of the literature shows that there is lot of information on the physiological and anatomical changes in mice, rats and guinea pigs, following noise exposure. (uhhospitals.org)
  • [4] Familiar albino animals include in-bred strains of laboratory animals (rats, mice and rabbits), but populations of naturally occurring albino animals exist in the wild, e.g. (wikipedia.org)
  • However, compared to traditional laboratory animals like rats, very little is known about its behavior, either in the wild or in a laboratory setting. (researchgate.net)
  • Results: At week 12, the GMA-SS exposure induced pulmonary inflammation in both strains, without consistent changes in markers of systemic inflammation (CRP, MCP-1, IL-6 and TNFá). (cdc.gov)
  • Histological examination of liver samples revealed the presence of lymphoid aggregates, parenchymal inflammation, and macrovesicular and microvesicular steatosis in chronically infected rats. (elsevierpure.com)
  • Collectively, HF diet appeared to have a greater impact on global immune status and exposure-induced lung injury in SD rats, but a more pronounced effect on inflammation resolution in BN rats. (cdc.gov)
  • Conclusion: We developed RHV-rn1-infected rats as a fully immunocompetent and informative surrogate model to delineate the mechanisms of HCV-related viral persistence, immunity, and pathogenesis. (elsevierpure.com)
  • Results Jac-E and Jac-O of groups B and S were not significantly different, but they differed significantly from those of group C. Conclusion Prolonged use of betamethasone did not affect the progression of induced periodontitis in rats. (bvsalud.org)
  • Fat deposition was markedly lower in Lou/C than in Wistar rats, especially in visceral adipose tissue. (unige.ch)
  • In the inguinal adipose depot, expression of uncoupling protein-1 was detected in Lou/C but not in Wistar rats, in keeping with a higher expression of peroxisome proliferator-activated receptor-gamma coactivator-1 in these animals. (unige.ch)
  • In ethanol-naive rats, significant line differences were observed with high basal 5-HT release in P rats, low 5-HT release in NP rats, and intermediate 5-HT levels in Wistar rats. (aspetjournals.org)
  • In addition, ethanol pretreatment increased extracellular DA concentrations in Wistar and P rats, but not in NP rats. (aspetjournals.org)
  • The WMI and WLI inbred strains of rats we propose to use in this study were selectively bred from the stress-vulnerable Wistar Kyoto rat. (hhs.gov)
  • To determine the consistency of this preventive effect, we carried out a long-term study in rats fed the standard American Institute of Nutrition 1976 diet, and 7 short-term prevention studies in rodents. (aacrjournals.org)
  • Depending on the requirements of the approved research protocol, the ACRC imports new strains of animals from commercial suppliers and/or collaborators from abroad. (ncbs.res.in)
  • At 7wk, HF-fed animals exhibited several immune alterations (blood leukocyte/neutrophil number, lymph node B-cell proportionality)-effects which were more pronounced in SD rats. (cdc.gov)
  • however, diet appeared to preferentially impact SD rats at this time point, as several inflammatory markers (lymph node cellularity, lung neutrophils) were further elevated in HF over Reg animals. (cdc.gov)
  • In BN rats, resolution of immune alterations was further compromised by HF diet, as many exposure-induced alterations in local/systemic immune markers were still evident in HF/WF animals at 24wk. (cdc.gov)
  • Mean arterial pressure was significantly higher in conscious, chronically instrumented FHH rats than in FHL rats (121 +/- 4 vs. 109 +/- 6 mmHg). (eur.nl)
  • P and NP rats also show distinct differences with regard to brain DA transmission. (aspetjournals.org)
  • First, to date, evidence on monoaminergic differences between high and low P rats is based largely on ex vivo, whole-tissue measures of DA and 5-HT rather than extracellular measures of transmitter release. (aspetjournals.org)
  • There were also strain and sex differences in basal plasma corticosterone (CORT) and steady-state hippocampal glucocorticoid receptor (Nr3c1) expression. (hhs.gov)
  • Scholars@Duke publication: Central Ca++-channel blockade reverses ethanol-induced poikilothermia in the rat. (duke.edu)
  • Metal content in the testes was assessed in a limited number of samples in Brown Norway rats, but no increase was obsedrved. (cdc.gov)
  • This mapping strategy is supported by the high heritability, large effect size of strain on phenotypes, and existing whole genome sequencing data for the WMI and WLI strains ( ~100x coverage per strain, with ~4,400 high confidence polymorphisms between strains). (hhs.gov)
  • An Imperial College London-led group used genome sequencing to search for loci that have been subject to artificial selection in lab rats. (genomeweb.com)
  • The Rat Strain Ontology (RS) is currently being developed at the Rat Genome Database. (mcw.edu)
  • It gradually decreases in both motor neurons and motor nerve endings as the animal grows up and completely disappears from the neuromuscular junctions in adult rats, persisting only in the motor nerve endings on the intrafusal fibers. (uninsubria.it)
  • Objective The present study assessed the effect of prolonged betamethasone use in ligature-induced periodontitis in adult Fischer-344 rats. (bvsalud.org)
  • 1987. The influence of physical activity in 1 ,2dimethylhydrazine induced colon carcinogenesis in the rat. (cdc.gov)
  • Voznesenskaya, A. (2014) Macronutrient selection by seven inbred mouse strains and three taste-related knockout strains. (monell.org)
  • Cerebellin-like peptide: tissue distribution in rat and guinea-pig and its release from rat cerebellum, hypothalamus and cerebellar synaptosomes in vitro. (ox.ac.uk)
  • Modulation of gelsolin content in rat aortic smooth muscle cells during development, experimental intimal thickening and culture. (unige.ch)
  • We have investigated gelsolin modulation in rat aortic SMC by immunohistochemistry, Western blotting and Northern hybridization using three models which are known to show modulation of actin isoform expression: development, aortic intimal thickening after experimental endothelial injury, and growth in culture. (unige.ch)
  • These results indicate that autoregulation of RBF is impaired in FHH rats before the development of glomerulosclerosis and suggest that an abnormality in the control of renal vascular resistance may contribute to the development of proteinuria and renal failure in this strain of rats. (eur.nl)
  • The association between blood pressure and gene(s) within RT1 complex or gene(s) closely linked to it was found by RI strain analysis. (mcw.edu)
  • 5. Allogeneic pregnancies in which the paternal strain differed from the maternal strain only at the RT1A gene locus produced suppression of a subsequent maternal immune response. (portlandpress.com)
  • Gene expression analysis demonstrated that the intrahepatic response during RHV-rn1 infection in rats mirrors that of HCV infection, including persistent activation of interferon signaling pathways. (elsevierpure.com)
  • Using indirect immunofluorescence techniques, we have found that calcitonin gene-related peptide-like immunoreactivity is present in the neuromuscular junctions of somatic muscles as well as in almost all motor neurons of the lumbar enlargement of 1-week-old rats. (uninsubria.it)
  • 1980. Inhibition by bran of the colonic cocarcinogenicity of bile salts in rats given dimethylhydrazine. (cdc.gov)
  • Strain susceptibility and resistance to 1,2-dimethylhydrazine-induced enteric tumors in germfree rats (40146). (cdc.gov)
  • The responses to changes in renal perfusion pressure (RPP) were compared in 12-wk-old fawn-hooded hypertensive (FHH), fawn-hooded low blood pressure (FHL), and August Copenhagen Irish (ACI) rats to determine whether autoregulation of renal blood flow (RBF) is altered in the FHH rat. (eur.nl)
  • We have previously shown that dietary polyethylene-glycol (PEG)suppresses the occurrence of azoxymethane-induced cancers in an accelerated rat model of colon carcinogenesis. (aacrjournals.org)
  • Autoregulatory indexes in the range of RPPs from 100 to 150 mmHg averaged 0.96 +/- 0.12 in FHH vs. 0.42 +/- 0.04 in FHL and 0.30 +/- 0.02 in ACI rats. (eur.nl)
  • Rats were euthanized at 7, 12, and 24wk to evaluate local and systemic immune markers corresponding to the baseline, exposure, and recovery phases of the study, respectively. (cdc.gov)
  • Excretion was also independent of dosage in rats. (unicatt.it)
  • We have developed a specific radioimmunoassay for "cerebellin", a 16-amino acid peptide recently isolated from rat cerebellum. (ox.ac.uk)
  • In both rat and guinea-pig, cerebellin-like immunoreactivity was highest in the cerebellum but was also present in high concentrations elsewhere in the central nervous system, especially in the hypothalamus. (ox.ac.uk)
  • Cerebellin was concentrated in synaptosomal preparations of rat brain, and its subcellular distribution pattern in rat brain was identical to that of two other known synaptosomal peptides, vasoactive intestinal polypeptide and substance P. Studies with superfused cerebellar synaptosomes and slices of rat cerebellum and hypothalamus demonstrated calcium-dependent cerebellin release when stimulated by high potassium concentrations as well as the addition of the calcium ionophore A23187. (ox.ac.uk)
  • Finally, in terms of outcome, the EAE susceptible DA strain displayed a significantly smaller resulting lesion volume than the resistant PVG-RT1(av1) strain. (nih.gov)
  • Notably, however, at the protein level the MHC congenic PVG-RT1(av1) strain displayed much stronger MHCII(+) presentation, as shown both by immunolabeling and flow cytometry, than the PVG strain, dwarfing the effect of Ciita. (nih.gov)
  • Total and specific binding of thrombin to platelets from hypercholesterolaemic rats was significantly greater than in controls when expressed per mg platelet protein, per mumol platelet cholesterol, or per unit relative surface area. (mcmaster.ca)
  • Platelets from rats made hypercholesterolaemic with a diet enriched with milk fat and cholesterol and containing taurocholate to promote hypercholesterolaemia aggregated more extensively to a low concentration of thrombin than platelets from rats given a milk fat-enriched diet containing sitosterol. (mcmaster.ca)
  • In the brain of both species, cerebellin-like immunoreactivity consisted of a single molecular form with an elution position on gel filtration and high-performance liquid chromatography identical to that of synthetic rat cerebellin. (ox.ac.uk)
  • A method utilizing thin-layer chromatography, high performance liquid chromatography, and mass spectrometry was developed for the quantification of C9, C10, C11, and C12 dicarboxylic acids in serum, urine, and feces of human volunteers and rats after oral administration of the acids. (unicatt.it)
  • In both humans and rats, the dicarboxylic acids found in serum and urine were 2, 4, or 6 carbon atoms shorter than the corresponding administered diacid. (unicatt.it)
  • Baseline arterial pressures measured in ketamine-Inactin-anesthetized rats averaged 147 +/- 2 mmHg (n = 9) in FHH, 132 +/- 2 mmHg (n = 10) in FHL, and 123 +/- 4 mmHg (n = 9) in ACI rats. (eur.nl)
  • The aim of this study is to learn if rat BMSC express brain-derived neurotrophic factor (BDNF) and glia-derived nerve factor (GDNF) and determine if this expression varies according to the number of culture passages. (sld.cu)
  • As adenine nucleotide content has been shown to correlate with the functional recovery of transplanted livers and hearts, this study investigated the effects of 24 hr of storage in three preservation solutions, saline (SA), Euro-Collins (CO), and University of Wisconsin (UW) on adenine and nicotinamide adenine nucleotides and inosine content of the rat small intestine. (duke.edu)
  • A multiple-test study of anxiety-related behaviors in six inbred rat strains. (bvsalud.org)
  • The Lou/C rat: a model of spontan. (unige.ch)
  • Moreover, PEG is one of the most potent inhibitors of colon tumor in the standard rat model. (aacrjournals.org)
  • To follow the clinical use pattern, we developed an operant oral oxycodone self-administration model, where rats voluntarily consume oral oxycodone to obtain doses that are well above clinical prescriptions. (hhs.gov)
  • In Aim 3, we will confirm causal genes using an established knockin CAG-LSL-Cas9 rat model on the WMI/WLI genetic background. (hhs.gov)
  • Moreover, alignment of cytokine mRNA expression from the cortex of these rats with a computational model of neuronglia interaction found that the moderate-severe TBI produced by the stainless-steel projectile strongly associated with the neuroinflammatory state, while the mild TBI existed in a state between normal and inflammatory neuronglia interactions. (cdc.gov)
  • The degree of K(+)-stimulated release was significantly greater in intact compared to that of castrated rats. (omeka.net)