• chromosome segment
  • After 10 generations of selective back-crossing to the SHR progenitor strain, the differential chromosome segment was fixed using the markers D1Mit3 (a microsatellite marker that maps close to C ) and Igf2 and maintained in the homozygous state by brother×sister mating and selective inbreeding of the offspring. (ahajournals.org)
  • NaCl
  • Rats with implanted femoral venous catheters (dye injection and sampling) and carotid catheters (mean arterial pressure by telemetry) were studied, while maintained on a 0.4% NaCl diet and on days 2, 5, 7, 14, and 21 after switching to 4.0% (high-salt [HS]) diet. (ahajournals.org)
  • Low-salt (LS) laboratory chow containing 0.3% NaCl was fed to 80 weaning male Dahl salt-sensitive rats (Charles River Laboratories, Wilmington, MA) until the diet was switched to high salt (HS, 8% NaCl) in approximately half of the rats at 7 weeks of age. (ahajournals.org)
  • For 3 wk before the experiment, the rats were maintained on a low-salt diet (0.4% NaCl). (physiology.org)
  • mice
  • The details and validation of this technique for determination of GFR in freely moving rats and mice have been reported by Schock-Kusch et al and Gretz et al. (ahajournals.org)
  • In addition, disease genes identified in the rat can be predicted to be in regions of synteny (homologous chromosomes) with humans and mice ( 6 ). (physiology.org)
  • humans
  • Binding sites for the antidepressant imipramine have been described in the brain and blood platelets of several species of animals, including rats and humans. (illinois.edu)
  • strain of rat
  • The dose response of aortic rings from each strain of rat to phenylephrine, acetylcholine, sodium nitroprusside, and three different levels of tissue bath hypoxia (10, 5, and 0% O 2 ) was measured and compared with the parental SS rat. (physiology.org)
  • laboratory
  • Animals exposed to a complex environment, such as a large wire cage filled with various toys, learn mazes more rapidly than rats reared in laboratory cages. (illinois.edu)
  • cells
  • Recently, we reported that IMCD cells cultured from S rats transport considerably more Na + than do IMCD cells cultured from R rats. (ahajournals.org)
  • Histofluorescence techniques were used to demonstrate that rat adrenal cortex is innervated by catecholaminergic nerve fibers which enter the adrenal in arterial plexuses and distribute among zona glomerulosa cells. (illinois.edu)
  • Tissue-type plasminogen activator in somatostatin cells of rat pancreas and hypothalamus. (ku.dk)
  • demonstrate
  • Our data demonstrate that Cpn infection accelerates macrophage foam cell formation in vivo in recruited peritoneal macrophages and coronary plaque progression leading to overt coronary artery disease in Tg53 male rats. (pubmedcentralcanada.ca)
  • progression
  • To study this, we used specific pathogen-free, inbred, transgenic-CAD Dahl salt-sensitive (S) hypertensive (Tg53) rats and control inbred, non-transgenic Dahl S (nonTg) rats to analyze the effects of Cpn infection on macrophage foam cell formation, coronary artery disease progression, and effect on survival. (pubmedcentralcanada.ca)
  • In order to address the role of Cpn in coronary plaque progression and destabilization, we investigated the effects of a onetime Cpn infection in a rat model of coronary artery disease, Tg53 rat model transgenic for human cholesteryl ester transfer protein. (pubmedcentralcanada.ca)
  • diet
  • Origin: Developed in 1972 at the Institute of Cytology and Genetics, Russian Academy of Sciences (Novosibirsk) by Salganik and Solovyova from Wistar stock by selection for susceptibility to cataractogenic effect of galactose-rich diet and brother-sister mating of highly susceptible rats ( Solovyova et al 1975 ). (jax.org)
  • animals
  • First, it is composed of a panel of cell populations that are related but have different abilities to shed metastases in inbred animals. (biologists.org)
  • blood
  • In F2 rats there was a significant (p less than 0.005) blood pressure difference of 9.7 mm Hg between phenotypes. (ahajournals.org)
  • control
  • Decreased survival was detected in Tg53- Cpn compared with control nonTg- Cpn and mock-infected Tg53-mouse pneumonitic rats ( P = 0.009) and was associated with "culprit" coronary plaques and left atrial thrombi. (pubmedcentralcanada.ca)
  • A separate group of rats were maintained on 0.4% for 21 days as a time control. (ahajournals.org)
  • Because each strain is genetically equivalent to the SS parental strain except for the introgressed chromosome, the consomic rat is an ideal control animal for the parental rat (in this case the SSMcwi). (physiology.org)