Rats inbred bn. Medical search. Frequent questions

BDII females were crossed to males from inbred strains with low EAC incidence (SPRD or BN). (mcw.edu)
Effect of diet and occupational exposure in different rat strains on serum biomarkers and peripheral blood mononuclear cell telomere length: development of an animal model to examine the exposome. (cdc.gov)
Genetic contributions were assessed using three strains of male rats with different genetic backgrounds [Fischer-344 (F344), Sprague-Dawley (SD), Brown-Norway (BN)] maintained on a standard or high fat (HF) diet for 24 wk. (cdc.gov)
Generally, the exposome components of diet and WF exposure had the greater influence on the parameters measured compared to the changes associated with rat strain except for the body weight changes observed with the HF diet that were more pronounced in the inbred F344 and BN strains. (cdc.gov)
An analysis of spontaneous hypertension in spontaneously hypertensive rats by means of new recombinant inbred strains. (mcw.edu)
The mode of blood pressure inheritance and some genetic markers of spontaneous hypertension were evaluated in a new set of recombinant inbred (RI) strains obtained by crossing of normotensive (BN.lx) and hypertensive (SHR) progenitor strains. (mcw.edu)
Transplantation between genetically identical individuals, i.e., members of the same species with identical histocompatibility antigens, such as monozygotic twins, members of the same inbred strain, or members of a hybrid population produced by crossing certain inbred strains. (lookformedical.com)
Recently, we identified a recessive mutation, an abnormal coat appearance in BXH6 strain, a member of the HXB/BXH set of recombinant inbred (RI) strains. (bvsalud.org)
The RI strains were derived from the SHR (spontaneously hypertensive rat) and BN-Lx (Brown Norway rat) progenitors. (bvsalud.org)
Analysis of mammary ductal growth and branching in 43 strains of inbred mice identified 20 QTL. (diethylstilbestrol.co.uk)
In the beginning preimplantation blastocysts (embryonic day time 4.5) from an outbred strain of CD:VRL1 rats (also called Sprague-Dawley (SD)) and inbred strains of Fischer 344 and Brown-Norway (BN) rats were individually seeded onto mitomycin C-treated mouse embryonic fibroblast cells in N2B27 medium supplemented with 2i-LIF (Supplementary info Data S1 Number 1A and ?and1B).1B). (researchhunt.com)
We sought to establish differences in global miRNA expression in two insulin-target tissues from inbred rats of spontaneously diabetic and normoglycaemic strains. (diabetestalk.net)
We used a miRNA microarray platform to measure global miRNA expression in two insulin-target tissues: liver and adipose tissue from inbred rats of spontaneously diabetic (Goto-Kakizaki [GK]) and normoglycaemic (Brown-Norway [BN]) strains which are extensively used in genetic studies of T2D. (diabetestalk.net)
The F344/Stm rat is a parental strain of the LEXF/FXLE recombinant inbred (RI) strains. (nig.ac.jp)
This graph shows the total number of publications written about "Rats, Inbred Strains" by people in this website by year, and whether "Rats, Inbred Strains" was a major or minor topic of these publications. (wakehealth.edu)
Below are the most recent publications written about "Rats, Inbred Strains" by people in Profiles. (wakehealth.edu)
Genetic differences in the tail-suspension test and its relationship to imipramine response among 11 inbred strains of mice. (ijbcp.com)

To identify genes commonly affected by both mood stabilizers and to assess potential epigenetic mechanisms that may be involved in their mechanism of action, we administered Li (N = 12), VPA (N = 12), and normal chow (N = 12) to Brown Norway rats for 30 days. (nih.gov)
The Brown Norway (BN) rat model has been extensively characterized and appears to be among the best animal models thus far described. (indexarticles.com)
Strategies and Components Cryopreserved stomach aortic grafts were transplanted between Brown-Norway and Lewis Rabbit polyclonal to Albumin rats. (pkc-inhibitor.com)
To contribute to the hazard identification of low molecular weight (LMW) respiratory allergens, respiratory allergy induced by trimellitic anhydride (TMA) was characterized by whole genome analysis of lung tissue and blood proteomics in Brown Norway rats. (cdc.gov)
Accordingly, male Sprague-Dawley (SD) and Brown Norway (BN) rats were maintained on either regular (Reg) or high fat (HF) diets for 24wk. (cdc.gov)

QTL associated with regression of testes induced by DES were identified on chromosomes 1 and 7 in recombinant inbred male rats. (diethylstilbestrol.co.uk)
Analysis of the lyp phenotype in the F344 DNA recombinant rats helped us define the critical lyp interval as a region of approximately 33 Kb between D4Rhw6 (76.83 Mb) and IIsnp3 (77.16 Mb) containing Gimap1 , Gimap5 , and Gimap3 (formerly known as Ian2 , Ian5 , and Ian4 , resp. (hindawi.com)

In rats, the F433 strain was most responsive in pituitary and uterine tissues, but DES-induced thymic regression was greatest in the SD strain compared to F344 and BN. (diethylstilbestrol.co.uk)
When pituitary weight was used as a phenotypic indicator of estrogen stimulated lactotroph proliferation, five QTL were identified upon characterization of DES treated female F2 progeny generated in an intercross between F344 and BN rats. (diethylstilbestrol.co.uk)

A separate set of rats from each strain were allowed to recover from WF exposure until the end of the 24 wk period. (cdc.gov)
These rats are then backcrossed with the parental SS strain. (comprehensivephysiology.com)
These rats are then inbred to produce a stable inbred consomic strain with the substitution of one entire chromosome from the BN strain into the background of the SS strain. (comprehensivephysiology.com)
Example of reduced blood pressure salt sensitivity resulting from substitution of chromosome 13 from the BN into the SS/Mcwi strain (SS‐13 BN consomic rat). (comprehensivephysiology.com)
Conversely, substitution of chromosome 18 from SS to the BN strain (BN‐18 SS ) resulted in a relatively small increase in MAP in response to the high‐salt diet. (comprehensivephysiology.com)
Consomic rat panel in which each of the 20 autosomes and the X and Y chromosomes from the BN strain were transferred onto the SS genetic background. (comprehensivephysiology.com)
The polymorphic rate of our 357 SSLP makers is 83% against BN/SsNHsd strain and 73% against LE/Stm strain. (nig.ac.jp)
An inbred strain of rat that is used for general BIOMEDICAL RESEARCH purposes. (jefferson.edu)
A strain of Rattus norvegicus used as a normotensive control for the spontaneous hypertensive rats (SHR). (wakehealth.edu)
EC development in BDII rats has similarities in pathogenesis, histopathological and molecular properties to human EC, and thus the inbred BDII strain represents a unique model for analysis of EC tumorigenesis [ 14 ]. (biomedcentral.com)
A cinnamon-colored strain of Long-Evans rats which carries a mutation causing fulminant hepatitis and jaundice, with an associated gross accumulation of copper in the liver. (nih.gov)

P, Cervenka L, Falck JR, Imig JD, Kompanowska-Jezierska E. Combined treatment with epoxyeicosatrienoic acid analog and 20-hydroxyeicosatetraenoic acid antagonist provides substantial hypotensive effect in spontaneously hypertensive rats. (uams.edu)
Epoxyeicosatrienoic acid analog EET-B attenuates post-myocardial infarction remodeling in spontaneously hypertensive rats. (uams.edu)

Whole genome sequencing of the mutant rats identified the 195875980 G/A mutation in the Tuft1 (tuftelin 1) gene on chromosome 2, which resulted in a premature stop codon. (bvsalud.org)
A second QTL, Eutr2 was mapped to the same region of chromosome 5 through characterization of DES treated congenic rats in which BN alleles across proximal chromosome 5 were introgressed onto the F344 genetic background. (diethylstilbestrol.co.uk)
Treatment with DES identified QTL influencing repression on chromosome 10 (Esta1) and chromosome 2 (Esta2 and Esta3) in a study using male F2 progeny from a BN x ACI intercross. (diethylstilbestrol.co.uk)
The N2 rats that are determined by genotyping to be heterozygous along the target chromosome are then backcrossed for ∼4 to 8 generations [e.g., marker assister selection for rats with most SS (blue) alleles]. (comprehensivephysiology.com)
This yields offspring with an isogenic SS background for all but the target chromosome as shown in (B). Selected male and female rats are then mated resulting in approximately 25% of the offspring being homozygous for the chromosome of interest. (comprehensivephysiology.com)
Generation of chromosome Y (chrY) consomic rats. (comprehensivephysiology.com)
The most recurrent numerical alterations were gains in rat chromosome 4 (RNO4) and losses in RNO15. (biomedcentral.com)
Positional cloning of lymphopenia ( lyp ) in the BB rat revealed a frameshift mutation in Gimap5 , a member of at least seven related GTPase Immune Associated Protein genes located on rat chromosome 4q24. (hindawi.com)
Gimap5 is a member of at least seven related GTPase Immune Associated Protein ( Gimap ) genes located within 150 Kilobases (Kb) on rat chromosome (RNO) 4 [ 2 , 3 ]. (hindawi.com)
Gimap5 was identified as the lyp gene in the BBDP rat through a frameshift mutation and premature truncation of the Gimap5 protein [ 2 , 6 ] and can be rescued in a P1-derived artificial chromosome (PAC) transgenic rat [ 7 ]. (hindawi.com)

A) Reduced susceptibility to DMBA‐induced mammary tumors in SS.BN2 consomic rats ( n = 14) compared with SS ( n = 40), as reported by Adamovic et al. (comprehensivephysiology.com)

Examination of OLETF-derived non-insulin-dependent diabetes mellitus QTL by construction of a series of congenic rats. (mcw.edu)
Our aim was to clone and sequence the cDNA of the BB diabetes prone (DP) and diabetes resistant (DR) alleles of all seven Gimap genes in the congenic DR. lyp rat line with 2 Mb of BB DP DNA introgressed onto the DR genetic background. (hindawi.com)
The positional cloning and subsequent identification of the Gimap5 gene on RNO4 were in part established through generation of the DR. lyp congenic rat line along with recombination events following our method of marker assisted breeding of DP with F344 rats [ 2 , 4 , 5 ]. (hindawi.com)

To learn more about a possible functional role of alpha-amino-3-hydroxy-5-methyl-4-isoxasole-propionate (AMPA) receptors in retinal development, the spatial distribution and temporal regulation of all AMPA receptor subunit proteins was studied in rats. (nih.gov)
GluR1 was not found in the outer retina, indicating that horizontal and bipolar cell processes in the rat express AMPA receptors composed of subunits GluR2 to 4. (nih.gov)
The differences in spatial and temporal subunit expression suggest that different retinal cell types selectively express distinct types of AMPA receptors during development of the rat retina. (nih.gov)

After 14 days, repeated allergen inhalation challenges were performed in the sensitized rats for 2 weeks. (indexarticles.com)
9) Allergen inhalation in sensitized BN rats causes an increase in production of tumor necrosis factor (TNF)-[alpha] and nitric oxide (NO) by alveolar macrophage and airways epithelial cells, and it can be inhibited by dexamethasone. (indexarticles.com)
1982. Acute inhalation toxicity of ammonia in rats with variable exposure periods. (cdc.gov)

Age related changes of social memory/recognition in male Fischer 344 rats. (omeka.net)
Two different habituation-dishabituation test paradigms were used to evaluate differences in social memory/recognition among 3-, 15- and 22-month-old male Fischer 344 rats. (omeka.net)

ACI rats also developed mammary tumors with chronic exposure to 17β-estradiol or DES. (diethylstilbestrol.co.uk)

Forced swim test (FST) in adult male Wistar rats and tail suspension test (TST) in adult male Swiss albino mice were used to investigate antidepressant activity of vitamin D administered in single dose and multiple doses. (ijbcp.com)
Castagné V, Moser P, Roux S, Porsolt RD. Rodent models of depression: forced swim and tail suspension behavioral despair tests in rats and mice. (ijbcp.com)

In Wistar rats, it has been reported that 3-nitropropionic acid leads to neurodegeneration and that the intravenous administration in rats provides valuable insight of Huntington's disease model [ 3 ]. (biomedcentral.com)

Genetic analysis of susceptibility to endometrial adenocarcinoma in the BDII rat model. (mcw.edu)
In the present work we used spectral karyotyping (SKY) to identify cancer-related aberrations in a well-characterized experimental model for spontaneous endometrial carcinoma in the BDII rat tumor model. (biomedcentral.com)

To elucidate whether allergic bronchitis interferes with vitamin A metabolism, we measured the vitamin A levels in the serum, the lung, and the liver following repeated allergen challenge in a rat model and compared them to normal rats. (indexarticles.com)
In addition, mutant rats had lower serum MCP-1 and leptin levels, indicative of reduced inflammation. (bvsalud.org)

No immunosuppressed isogeneic (ISO) and allogeneic (ALO) rats mixture offered as control. (pkc-inhibitor.com)

Results: The study rats showed severe bronchoconstriction after allergen challenge compared to the naive rats, and ex vivo TNF-[alpha] and NO production was significantly higher in the sensitized rats. (indexarticles.com)

Positions of QTL regulated responses to estrogens in 5 tissues in rats featured image credit figure/F1 . (diethylstilbestrol.co.uk)
Rats will be given vanadium, as sodium orthvanadate or vanadyl sulfate, in a liquid diet and a number of insulin-sensitive activities of target tissues measured and compared to control animals. (diabetestalk.net)

Lymphopenia ( lyp ) is a prerequisite for spontaneous type 1 diabetes (T1D) in the BioBreeding (BB) diabetes prone (DP) rat [ 1 ]. (hindawi.com)
rats, where 2 Mb of DP DNA was introgressed onto the BB diabetes resistant (DR) genetic background, are lymphopenic and 100% develop spontaneous T1D by 84 days of age [ 4 ]. (hindawi.com)

BAC clones are available from RIKEN BioResource Center by NBRP Rat Genome Information Upgrading Program ( Kyoto University , RIKEN Genomic Sciences Center, and Comparative Genomics Laboratory, National Institute of Genetics ) in Japan. (nig.ac.jp)

Rats, Inbred F344" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (jefferson.edu)

As the majority of the genes are conserved among mammals, the use of inbred animal model systems may serve as a tool for identification of underlying genes and pathways involved in tumorigenesis in humans. (biomedcentral.com)

Inside our prior experimental function we considered an optimistic aftereffect of low-dose tacrolimus immunosuppression over the inhibition of severe cell- and antibody-mediated rejection of cold-stored arterial grafts in rats [13,14]. (pkc-inhibitor.com)
Shown is the mean arterial pressure (MAP) in conscious SS ( n = 18), SS‐13 BN ( n = 15), and BN ( n = 16) rats exposed to a high‐salt (4.0% NaCl) diet for 4 weeks. (comprehensivephysiology.com)

The number bars represent chromosomes that were derived from SS (white) or BN (black). (comprehensivephysiology.com)

Neuropathic pain in aged rats: behavioral responses and astrocytic activation. (omeka.net)

At 7wk, HF-fed animals exhibited several immune alterations (blood leukocyte/neutrophil number, lymph node B-cell proportionality)-effects which were more pronounced in SD rats. (cdc.gov)
In BN rats, resolution of immune alterations was further compromised by HF diet, as many exposure-induced alterations in local/systemic immune markers were still evident in HF/WF animals at 24wk. (cdc.gov)

however, diet appeared to preferentially impact SD rats at this time point, as several inflammatory markers (lymph node cellularity, lung neutrophils) were further elevated in HF over Reg animals. (cdc.gov)
Collectively, HF diet appeared to have a greater impact on global immune status and exposure-induced lung injury in SD rats, but a more pronounced effect on inflammation resolution in BN rats. (cdc.gov)

5) The asthmatic rats have early airway responses and late airway response in high prevalence, (6) showing high levels of specific IgE on active immunization (6) and airway eosinophilia. (indexarticles.com)

In the current study, we examined the transcriptome of primary rat microglial cells following incubation with alcohol alone, or alcohol together with a robust inflammatory stimulus. (biomedcentral.com)
Microglial proliferation in the spinal cord of aged rats with a sciatic nerve injury. (omeka.net)

Rats were euthanized at 7, 12, and 24wk to evaluate local and systemic immune markers corresponding to the baseline, exposure, and recovery phases of the study, respectively. (cdc.gov)

MiRNA data were integrated with gene expression data from the same rats to investigate how differentially expressed miRNAs affect the expression of predicted target gene transcripts. (diabetestalk.net)

However, the vitamin A liver concentration in the study rats was significantly lower compared to the naive rats. (indexarticles.com)
Compared to wild-type BXH6 rats, BXH6-Tuft1 mutant rats exhibited lower body weight due to reduced visceral fat and ectopic fat accumulation in the liver and heart. (bvsalud.org)
The expression of 170 miRNAs was measured in liver and adipose tissue of GK and BN rats. (diabetestalk.net)

In view of all the aforementioned, the objective of the present work was to make a comparative analysis of the protective effects derivable from riboflavin (B 2 ) and pyridoxine (B 6 ) on 5-HIAA and dopamine levels, as well as on selected markers of oxidative stress in rats' brain regions after an induction of Huntington's disease (HD). (biomedcentral.com)

Effect of aging on the substance P receptor, NK-1, in the spinal cord of rats with peripheral nerve injury. (omeka.net)

Objective: To examine whether repeated allergen challenges could increase vitamin A consumption in a rat model. (indexarticles.com)

These studies were designed to investigate how the aging process alters the spinal antinociceptive efficacy of mu (mu), delta (delta) and epsilon (epsilon) opioid receptor agonists administered intrathecally (i.t.) in rats. (omeka.net)

With transmission disequilibrium test analysis, significant association was detected in three chromosomal regions (on RNO1, RNO11, and RNO17) in the SPRD crosses and in the short arm of RNO20 in the BN crosses. (mcw.edu)

The various other population had taken on the looks of flattened clones termed flattened rat ESCs (f-rESCs). (researchhunt.com)

MiR-125a also showed over-expression in the GK vs. BN analysis within adipose tissue (FC = 1.97, P = 0.078, P adjusted = 0.99), as did the previously reported miR-29a (FC = 1.51, P = 0.05, P adjusted = 0.99). (diabetestalk.net)

Acute adiponectin delivery is cardioprotective in the aged female rat heart. (jefferson.edu)

In contrast, ACI rats have a persistent proliferative response to DES in mammary epithelium without a compensatory increase in apoptosis and was associated with extensive hyperplasia. (diethylstilbestrol.co.uk)

Design: Allergic bronchitis was induced in 12 animals, and 12 rats remained naive. (indexarticles.com)

If inbred animal models are used, then both the genetic constitution and environmental influences can be carefully controlled. (mcw.edu)

Organisms3

Diseases1

Chemicals and Drugs7

Psychiatry and Psychology1

Strains17

Brown Norway5

Recombinant2

F344 and BN2

Strain11

Hypertensive rats2

Chromosome10

Consomic rats1

Congenic3

Receptors3

Inhalation3

Fischer2

Mammary tumors1

Mice2

Wistar1

BDII2

Serum2

Isogeneic1

Vivo1

Tissues2

Spontaneous2

Genome1

MeSH1

Mammals1

Arterial2

Chromosomes1

Behavioral1

Alterations2

Lung2

Responses1

Microglial2

Exposure1

Gene1

Liver3

Induction1

Peripheral1

Model1

Investigate1

Regions1

Clones1

Analysis1

Acute1

Response1

Animals1

Animal models1