Rats inbred bb. Medical search. Frequent questions

The use of experimental animal models is therefore indispensable, and indeed more insight in the mechanism by which viruses can modulate diabetogenesis has been provided by studies in rodent models for T1D such as the biobreeding (BB) rat, nonobese diabetic (NOD) mouse or specific transgenic mouse strains. (nih.gov)
Alam G, Miller DB, O'Callaghan JP, Lu L, Williams RW, Jones BC 2016 MPTP neurotoxicity is highly concordant between the sexes among BXD recombinant inbred mouse strains. (genenetwork.org)
Xue Y, Li J, Yan L, Lu L, Liao FF 2015 Genetic variability to diet-induced hippocampal dysfunction in BXD recombinant inbred (RI) mouse strains. (genenetwork.org)
There is mounting evidence suggesting that inbred mouse strains with different genetic backgrounds demonstrate variable susceptibility to a fibrotic injury. (biomedcentral.com)
Quantitative trait locus (QTL) analysis is a common genetic approach that has been used in the past two decades to identify loci involved in differences in fibrotic response between inbred strains of mice [ 9 ]. (biomedcentral.com)
In this approach, two inbred strains that differ in fibrotic response are crossed and the F1 offspring are either mated together (intercross) or to one of the parental strains (backcross). (biomedcentral.com)

Like the NOD mice, BB rats are used as an animal model for Type 1 diabetes. (wikipedia.org)
NOD mice Type 1 Diabetes Autoimmunity Mordes JP, Poussier P, Blankenhorn EP, Greiner DL: Rat models of type 1 diabetes: Genetics, environment and autoimmunity. (wikipedia.org)
These mice have black hair (aa BB CC DD). (nomura-siam.com)
Quantitative Trait Loci and Candidate Genes for Neutrophil Recruitment in Sterile Inflammation Mapped in AXB-BXA Recombinant Inbred Mice. (genenetwork.org)
Evaluation of heritable determinants of blood and brain serotonin homeostasis using recombinant inbred mice. (genenetwork.org)
Animal models (e.g., mice, rats, zebrafish and others) are sufficiently like humans in their anatomy, physiology or response to a pathogen that researchers can extrapolate the results of animal model studies to better understand human physiology and disease. (genome.gov)

Analysis of the lyp phenotype in the F344 DNA recombinant rats helped us define the critical lyp interval as a region of approximately 33 Kb between D4Rhw6 (76.83 Mb) and IIsnp3 (77.16 Mb) containing Gimap1 , Gimap5 , and Gimap3 (formerly known as Ian2 , Ian5 , and Ian4 , resp. (hindawi.com)
Mucosal Shipping associated with Recombinant Vesicular Stomatitis Computer virus Vectors Revealing Package Healthy proteins of Respiratory system Syncytial Computer virus Induces Protective Defenses within 100 % cotton Rats. (pkc-signal.com)

Biobreeding rat, also known as the BB or BBDP rat, is an inbred laboratory rat strain that spontaneously develops autoimmune Type 1 Diabetes. (wikipedia.org)
One in Worcester, Massachusetts, has been inbred and known as BBDP/Wor and another one in Ottawa, Canada, an outbred strain known as BBdp. (wikipedia.org)
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. (lookformedical.com)
A strain of Rattus norvegicus used as a normotensive control for the spontaneous hypertensive rats (SHR). (lookformedical.com)
Rats, Inbred WF are a strain of laboratory rats that are commonly used in medical research due to their consistent genetic makeup and susceptibility to various diseases. (lookformedical.com)
An inbred strain of rat that is used for general BIOMEDICAL RESEARCH purposes. (jefferson.edu)
A cinnamon-colored strain of Long-Evans rats which carries a mutation causing fulminant hepatitis and jaundice, with an associated gross accumulation of copper in the liver. (nih.gov)
The Lewis Inbred rat is the only strain capable of developing immunological polyarthritis in 100% of the animals. (docksci.com)

P, Cervenka L, Falck JR, Imig JD, Kompanowska-Jezierska E. Combined treatment with epoxyeicosatrienoic acid analog and 20-hydroxyeicosatetraenoic acid antagonist provides substantial hypotensive effect in spontaneously hypertensive rats. (uams.edu)
Epoxyeicosatrienoic acid analog EET-B attenuates post-myocardial infarction remodeling in spontaneously hypertensive rats. (uams.edu)

The positional cloning and subsequent identification of the Gimap5 gene on RNO4 were in part established through generation of the DR. lyp congenic rat line along with recombination events following our method of marker assisted breeding of DP with F344 rats [ 2 , 4 , 5 ]. (hindawi.com)
Rats, Inbred F344" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (jefferson.edu)
This graph shows the total number of publications written about "Rats, Inbred F344" by people in this website by year, and whether "Rats, Inbred F344" was a major or minor topic of these publications. (jefferson.edu)
Below are the most recent publications written about "Rats, Inbred F344" by people in Profiles. (jefferson.edu)

They were originally derived from a Canadian colony of outbred Wistar rats that spontaneously develop hyperglycemia and ketoacidosis, characteristic of clinical onset of T1D. (wikipedia.org)
Rats wistar. (lookformedical.com)

Gimap5 was identified as the lyp gene in the BBDP rat through a frameshift mutation and premature truncation of the Gimap5 protein [ 2 , 6 ] and can be rescued in a P1-derived artificial chromosome (PAC) transgenic rat [ 7 ]. (hindawi.com)

However, compared to traditional laboratory animals like rats, very little is known about its behavior, either in the wild or in a laboratory setting. (researchgate.net)

Lymphopenia ( lyp ) is a prerequisite for spontaneous type 1 diabetes (T1D) in the BioBreeding (BB) diabetes prone (DP) rat [ 1 ]. (hindawi.com)

Our aim was to clone and sequence the cDNA of the BB diabetes prone (DP) and diabetes resistant (DR) alleles of all seven Gimap genes in the congenic DR. lyp rat line with 2 Mb of BB DP DNA introgressed onto the DR genetic background. (hindawi.com)

Two T1D susceptibility genes have been identified in the BB rat. (wikipedia.org)
Positional cloning of lymphopenia ( lyp ) in the BB rat revealed a frameshift mutation in Gimap5 , a member of at least seven related GTPase Immune Associated Protein genes located on rat chromosome 4q24. (hindawi.com)
Gimap5 is a member of at least seven related GTPase Immune Associated Protein ( Gimap ) genes located within 150 Kilobases (Kb) on rat chromosome (RNO) 4 [ 2 , 3 ]. (hindawi.com)
Rats bearing mutant genes which are phenotypically expressed in the animals. (lookformedical.com)
We then factor in your dog's breed composition, information at certain genes that affect size, and their inbreeding coefficient to calculate genetic age. (embarkvet.com)

Lymphopenia and abnormal lymphocyte subsets in the "BB" rat: relationship to the diabetic syndrome. (wikipedia.org)

rats, where 2 Mb of DP DNA was introgressed onto the BB diabetes resistant (DR) genetic background, are lymphopenic and 100% develop spontaneous T1D by 84 days of age [ 4 ]. (hindawi.com)
Previously, we reported on progressive retinal degeneration in a spontaneous obese rat (WNIN/Ob) model. (molvis.org)

There was a twofold increase in renal cortical alpha 1 (III) mRNA expression coincident with the onset of tubulointerstitial myofibroblasts infiltration in rats with PAN nephrosis beginning on day 6, which increased to a fivefold difference by day 10. (nih.gov)
Progressive loss of photoreceptor cells was observed in WNIN/GR-Ob rats with an onset as early as 3 months. (molvis.org)

Rat models of type 1 diabetes: genetics, environment, and autoimmunity. (wikipedia.org)

However, none of these agents produced conification of the vaginal smear of ovariectomized adult rats. (ijp-online.com)
Male adult Lewis Inbred rats aged exactly 7 weeks with a weight of 2OOr20 g (Charles River, MA U.S.A.) were used. (docksci.com)

Leguminoceae) was studied for the hypoglycaemic activity normal and alloxanised albino rats. (ijp-online.com)
The effect of clonidine hydrochloride has been studied in unanaesthetized albino rats, cats, dogs, guineapigs, pigeons and albino rabbits. (ijp-online.com)

Recently, 8 additional loci on rat chromosomes 1,2,3,6 (2 loci), 12 and 14 have been shown to be linked to Type 1 Diabetes in the BB rat. (wikipedia.org)
Diabetes in BB rats can be prevented by a single injection of mycobacterial adjuvants such as complete Freund's adjuvant (FCA). (wikipedia.org)
Impaired post-thymic development of regulatory CD4+25+ T cells contributes to diabetes pathogenesis in BB rats. (wikipedia.org)
Sadelain MW, Qin HY, Sumoski W, Parfrey N, Singh B, Rabinovitch A. Prevention of diabetes in the BB rat by early immunotherapy using Freund's adjuvant. (wikipedia.org)
The BB rat is investigated to clarify monogenic type 1 diabetes due to a frameshift mutation in the Gimap5 gene, which is coding for an anti-apoptopic protein. (lu.se)
Low dose poly I:C prevents diabetes in the diabetes prone BB rat. (umassmed.edu)

The Gimap5 mutation results in severe T cell lymphopenia in the BB rat and is thought to contribute to T1D pathogenesis through impaired development and function and regulatory T cells. (wikipedia.org)

Preferential activation of microsomal diacylglycerol/protein kinase C signaling during glucose treatment (De Novo phospholipid synthesis) of rat adipocytes. (jci.org)
Glucose has been reported to increase the de novo synthesis of diacylglycerol (DAG) and translocate and activate protein kinase C (PKC) in rat adipocytes. (jci.org)
Glucose rapidly increased DAG content and PKC enzyme activity in microsomes, but not in plasma membranes or other membranes, during a 30-min treatment of rat adipocytes. (jci.org)
In this study, we investigated the additional effect of impaired glucose tolerance (IGT), an essential component of MetS, on retinal degeneration using the WNIN/GR-Ob rat model. (molvis.org)
WNIN/GR-Ob rats with added glucose intolerance developed retinal degeneration similar to the parent line WNIN/Ob. (molvis.org)

accepted 1 August 1989) Abstract-The anti-arthritic activity of four superoxide dismutases (SODS) has been compared by using the adjuvant-induced polyarthritis rat model. (docksci.com)

Levels of dopamine, norepinephrine & 5-hydroxytryptamine in different regions of rat brain & spinal cord following chronic administration of organophosphate pesticide dichlorvos. (cdc.gov)
It is a syndrome the activity of rat, bovine and human Cu-SODS and that of human Mn-SOD on a model of chronic inflammation. (docksci.com)
Chronic arthritis is induced in the rat by injection of Mycobacterium tuberculosis. (docksci.com)

The retinal morphology and ultrastructure of WNIN/GR-Ob and age-matched littermate lean rats were studied by microscopy and immunohistochemistry. (molvis.org)

Many of the clinical signs observed in the rat closely resemble those of human rheumatic diseases and the Fiessinger-Leroy-Reiter syndrome. (docksci.com)

The relative anti-inflammatory activities of different superoxide dismutases (SODs)§ have already been compared using the carrageenan [2] and Adriamycin@ [3] models in rats. (docksci.com)
even Na v 1.3, known to be upregulated in rat neuropathic pain models, was lower in the SNI mouse model. (biomedcentral.com)

Membranes prepared from rat cerebral cortex were solubilized in buffer containing 1% digitonin. (unboundmedicine.com)
AU - Luthin,G R, AU - Wolfe,B B, PY - 1985/7/1/pubmed PY - 1985/7/1/medline PY - 1985/7/1/entrez SP - 37 EP - 44 JF - The Journal of pharmacology and experimental therapeutics JO - J Pharmacol Exp Ther VL - 234 IS - 1 N2 - Membranes prepared from rat cerebral cortex were solubilized in buffer containing 1% digitonin. (unboundmedicine.com)

Immunohistochemical analysis showed decreased levels of rhodopsin and postsynaptic density protein-95 (PSD-95) proteins and increased levels of glial fibrillary acidic protein (GFAP), vascular endothelial growth factor (VEGF), and calretinin in WNIN/GR-Ob rats compared with the age-matched lean controls, further supporting cellular stress/damage and retinal degeneration. (molvis.org)
The severity of retinal degeneration was greater in WNIN/GR-Ob rats compared to WNIN/Ob, suggesting a possible role for IGT in this model. (molvis.org)

Adjuvant-induced arthritis in rat, described by Pearson in 1956[1], is a systemic disease which involves articular and visceral manifestations. (docksci.com)

BB rats are the most extensively studied rat model of T1D. (wikipedia.org)

altemance of illumination, light 06.00 a.m.06.00 p.m., darkness, 06.00 p.m.-06.00 a.m. (this alternance was chosen as the major synchronizer), standardized diet (Rat-Entretien U.A.R.) and tap water were available ad lib. (docksci.com)

1976. Dichlorvos -- a 2-year inhalation carcinogenesis study in rats. (cdc.gov)

We conclude that although rats and opossums share many similar characteristics, including ecological niche, their divergent evolutionary heritage results in vastly different behavioral capabilities. (researchgate.net)

Together, these data suggest that muscarinic receptor sites solubilized from rat brain retain their abilities to interact selectively with muscarinic receptor agonists and antagonists. (unboundmedicine.com)

The effect of oral pretreatment of some antimicrobial agents was studied on the uterotropic response of immature female rats to a single oral dose of ethinyl oestradiol. (ijp-online.com)
Phenoxymethylpenicillin, tetracycline, rifampicin, chloroquine and streptomycin did not produce any significant change either on the uterotropic response of ethinyl oestradiol or on the uterine weight of control rats. (ijp-online.com)

In addition, treatment with ampicillin, neomycin or metronidazole alone significantly increased the uterine wet weight of control rats. (ijp-online.com)

These data demonstrate the cellular source of alpha 1(III) production within the renal tubulointerstitium following injury, and suggest that PDGF-BB may be mediating this production. (nih.gov)

Acute adiponectin delivery is cardioprotective in the aged female rat heart. (jefferson.edu)

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It is suggested that the hypothermic effect is mediated through activation of central (-adrenoceptors and it exhibits, like noradrenaline, species dependence and is blocked by phenoxybenzamine in the rat and the cat. (ijp-online.com)

Organisms1

Chemicals and Drugs2

Strains6

Mice6

Recombinant2

Strain8

Hypertensive rats2

F3444

Wistar2

Transgenic1

Laboratory1

Biobreeding1

Congenic1

Genes5

Diabetic1

Spontaneous2

Onset2

Autoimmunity1

Adult2

Albino2

Diabetes6

Lymphopenia1

Glucose5

Abstract1

Chronic3

Immunohistochemistry1

Diseases1

Models2

Membranes2

Retinal2

Manifestations1

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Year1

Characteristics1

Brain1

Response2

Control1

Data1

Female1

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