• analytic
  • Such industrial scale assays as these are often done in well equipped laboratories and with automated organization of the procedure-from ordering an assay to pre-analytic sample processing (sample collection, necessary manipulations e.g. spinning for separation or other processes, aliquoting if necessary, storage, retrieval, pipetting/aspiration etc. (wikipedia.org)
  • An assay (analysis) is never an isolated process and must be combined with pre- and post-analytic procedures. (wikipedia.org)
  • Similarly, after the assay, the result may be documented, verified and transmitted/communicated in steps that are called post-analytic steps. (wikipedia.org)
  • i.e. not only analytic variations and errors intrinsic to the assay itself but also variations and errors involved in preanalytic and post analytic steps. (wikipedia.org)
  • Since the assay itself (the analytic step) gets much attention, steps that get less attention by the chain of users, i.e. the preanalytic and the post analytic steps, are often less stringently regulated and generally more prone to errors - e.g. preanalytic steps in medical laboratory assays may contribute to 32-75% of all lab errors. (wikipedia.org)
  • reactants
  • If the assay involves addition of exogenous reactants (the reagents), then their quantities are kept fixed (or in excess) so that the quantity (and quality) of the target is the only limiting factor for the reaction/assay process, and the difference in the assay outcome is used to deduce the unknown quality or quantity of the target in question. (wikipedia.org)
  • ligands
  • Affinity MS-based assays have been developed for screening chemical ligands towards different soluble protein targets, especially enzymes and kinases of therapeutic values. (rsc.org)
  • Some newer types are called "mix-and-measure" assays because they do not require separation of bound ligands. (wikipedia.org)
  • proteins
  • Each method has its strengths and weaknesses but they all struggle with intrinsically disordered proteins without any clearly defined tertiary structure as the essence of a thermal shift assay is measuring the temperature at which a protein goes from well-defined structure to disorder. (wikipedia.org)
  • functional
  • Radioligand binding and fibroblast proliferation assay demonstrated that the peptides were functional. (curehunter.com)
  • In contrast, (±)-UB-165 and (±)-anatoxin-a were similarly efficacious and similarly sensitive to α-conotoxin-MII in increasing intracellular Ca 2+ in SH-SY5Y cells, a functional assay for native α3-containing nAChR. (jneurosci.org)
  • For example, receptor functional assays, which measure GPCR downstream signaling effectors, 3 are inadequate for identifying allosteric or biased signaling modulators and often generate hits unsuitable for subsequent optimization. (rsc.org)
  • The assay usually aims to measure an intensive property of the analyte and express it in the relevant measurement unit (e.g. molarity, density, functional activity in enzyme international units, degree of some effect in comparison to a standard, etc. (wikipedia.org)
  • Thus
  • Thus, PIC behaves as a partial agonist in a human platelet aggregation assay. (biomedsearch.com)
  • Thus reading of an assay may be quite noisy and may involve greater difficulties in interpretation than an accurate chemical titration. (wikipedia.org)
  • test the quality of", from Anglo-French assaier, from assai (n.), from Old French essai "trial", and the noun assay thus means "trial, test of quality, test of character", mid-14th century, from Anglo-French assai and the meaning "analysis" is from the late 14th century. (wikipedia.org)
  • researchers
  • Through the development of RIA technology, researchers have been able to move beyond the use of radioactivity, and instead, use liquid- and solid-phase, competitive, and immunoradiometric assays. (wikipedia.org)
  • Radioligands are credited with making possible the study of biomolecular behaviour, a previously mysterious area of research that had evaded researchers. (wikipedia.org)
  • With this capacity radioligand techniques enabled researchers to identify receptor devices within cells. (wikipedia.org)
  • compound
  • Although binding assays are simple, they fail to provide information on whether or not the compound being tested affects the target's function. (wikipedia.org)
  • competitive
  • Those assays that are very highly commercially demanded have been well investigated in research and development sectors of professional industries, undergone generations of development and sophistication, and become copyrighted intellectual properties via highly competitive process patenting. (wikipedia.org)
  • drug
  • He has done extensive work using the rat model assay of drug discrimination in characterizing hallucinogenic drugs. (wikipedia.org)
  • cells
  • Any suggestions for ways to reduce background signal when doing these assays with plate-bound cells? (protocol-online.org)
  • On the other hand, older generation qualitative assays, especially bioassays, may be much more gross and less quantitative (e.g., counting death or dysfunction of an organism or cells in a population, or some descriptive change in some body part of a group of animals). (wikipedia.org)
  • level
  • Assays have become a routine part of modern medical, environmental, pharmaceutical, forensic and many other businesses at various scales from industrial to curbside or field level. (wikipedia.org)
  • value
  • For assay of currency coins, this literally meant analysis of the purity of the gold or silver or whatever precious component was used to represent the true value of the coin. (wikipedia.org)
  • done
  • The information communication (e.g. request to perform an assay and further information processing) or specimen handling (e.g. collection, transport and processing) that are done until the beginning of an assay are the preanalytic steps. (wikipedia.org)