Chemicals and Drugs
QuinidineQuinineProcainamideAnti-Arrhythmia AgentsCytochrome P-450 CYP2D6DisopyramideFlecainideCinchona AlkaloidsDextromethorphanOxidoreductases, O-DemethylatingPropafenoneSparteineDebrisoquinLidocaine
GluconateSulfateMalariaDextromethorphanConcentrationsDigoxinQuinine or quinidineClass IA antiarrhythmicProcainamideIntravenousAntiarrhythmicsAntiarrhythmic drugPhenytoinCytochromeAntimalarialThrombocytopeniaTablets2023InhibitsIrregularToxicityConcomitantDrugsPreparationsDosageDosesFluoxetineMedicationsArrhythmiasConclusionsClinicallyCardiacPatientsTreatmentHeadacheIncreasesTreatPregnantPlasmaEffectsPrescription
Gluconate6
  • Eli Lilly has discontinued manufacture of parenteral quinidine gluconate in the US, and its future availability in many countries is uncertain. (wikipedia.org)
  • For adults, the dosage range for quinidine gluconate is from 648 to 2592 mg/day. (medicinenet.com)
  • Quinidine gluconate is indicated for severe or complicated malaria and is used in conjunction with doxycycline, tetracycline, or clindamycin. (medscape.com)
  • Quinidine gluconate can be administered IV and is the only parenterally available quinine derivative in the United States. (medscape.com)
  • The evaluation was requested by the local union to investigate work related skin rashes and respiratory symptoms among employees involved in producing quinidine-gluconate (7054253). (cdc.gov)
  • Background-- Quinidine gluconate, the only FDA-approved treatment for life-threatening malaria in the United States, has a problematic safety profile and is often unavailable in hospitals. (cdc.gov)
Sulfate5
  • Plasma samples, obtained at different time intervals after administration of single doses of quinidine sulfate to healthy human volunteers and to a dog, were analyzed by both procedures. (eurekamag.com)
  • The NDC code 68151-1991 is assigned by the FDA to the product Quinidine Sulfate which is product labeled by Carilion Materials Management. (ndclist.com)
  • Which are Quinidine Sulfate UNII Codes? (ndclist.com)
  • What is the NDC to RxNorm Crosswalk for Quinidine Sulfate? (ndclist.com)
  • Pill with imprint 5438 DAN DAN is White, Round and has been identified as Quinidine Sulfate 200 mg. (drugs.com)
Malaria11
  • Although intravenous quinidine is sometimes used to treat Plasmodium falciparum malaria, the future availability of this agent is uncertain. (wikipedia.org)
  • Quinidine also is used to treat malaria . (medicinenet.com)
  • The pharmacokinetics of quinine and quinidine in malaria. (tropmedres.ac)
  • When it is administered for treatment of P falciparum malaria, this drug must be used as part of combination therapy (eg, typically with quinine or quinidine). (medscape.com)
  • Clindamycin is part of combination therapy for drug-resistant malaria (eg, typically with quinine or quinidine). (medscape.com)
  • Quinine and quinidine: a comparison of EKG effects during the treatment of malaria. (ox.ac.uk)
  • We recorded electrocardiograms from 31 patients receiving quinine and 14 patients receiving quinidine for the treatment of Plasmodium falciparum malaria. (ox.ac.uk)
  • An antibiotic that can be used for the treatment of malaria in combination with a second drug, usually quinine or quinidine. (cdc.gov)
  • Quinidine is used to treat abnormal heart rhythms and malaria. (rxwiki.com)
  • Protocol eligibility required the presence of microscopically confirmed malaria, the need for intravenous treatment, and an impediment to quinidine. (cdc.gov)
  • The only FDA-approved treatment for severe malaria in the United States is quinidine, a stereoisomer of quinine that once saw routine hospital use as a Author Manuscript cardiac anti-arrhythmic medication (11, 12). (cdc.gov)
Dextromethorphan2
  • Dextromethorphan and quinidine combination is used to treat a rare condition called pseudobulbar affect (PBA) or emotional incontinence. (mayoclinic.org)
  • The primary objective of this study was to evaluate the tolerability of capsules containing dextromethorphan (DM) and quinidine (Q) in patients with painful DPN. (nih.gov)
Concentrations4
  • At micromolar concentrations, quinidine inhibits Na+/K+-ATPase by binding to the same receptor sites as the digitalis glycosides such as ouabain. (wikipedia.org)
  • An improved spectrofluorometric method was compared with a recently published GLC procedure for the determination of plasma concentrations of quinidine [an antiarrhythmic agent]. (eurekamag.com)
  • The results suggested that the overall binding of quinidine is relatively insensitive to changes in any one serum protein provided the others are present in normal concentrations. (bvsalud.org)
  • Airborne quinidine concentrations ranged from 0.2 milligram per cubic meter (mg/m3) in the packaging area to 5.0mg/m3 in the manufacturing area. (cdc.gov)
Digoxin1
  • Blood levels of digoxin ( Lanoxin ) are raised by quinidine due to a reduction in removal or reduced distribution in the body of digoxin. (medicinenet.com)
Quinine or quinidine2
  • Side effects from quinine or quinidine. (cdc.gov)
  • by itself for prevention or in combination with either quinine or quinidine when used for treatment. (cdc.gov)
Class IA antiarrhythmic2
  • Quinidine is a class IA antiarrhythmic agent used to treat heart rhythm disturbances. (wikipedia.org)
  • Here we present the cryo-EM structure of full-length human Na 1.5 bound to quinidine, a class Ia antiarrhythmic drug, at 3.3 Å resolution. (princeton.edu)
Procainamide1
  • Procainamide and quinidine also have been listed here for completeness and because they are used by many neurologists to treat muscle stiffness and muscle spasm. (medscape.com)
Intravenous1
  • Even when quinidine can be obtained, its intravenous regimen is complex, and its dosing fraught with safety concerns. (cdc.gov)
Antiarrhythmics2
  • Many heart drugs like quinidine (antiarrhythmics) are very effective, but they can infrequently cause new serious (possibly fatal) irregular heartbeats. (healthwarehouse.com)
  • Quinidine belongs to a group of drugs called antiarrhythmics. (rxwiki.com)
Antiarrhythmic drug2
  • Quinidine is an antiarrhythmic drug used in the treatment of abnormal heart rhythms such as atrial fibrillation , atrial flutter , and ventricular arrhythmias such as paroxysmal ventricular tachycardia. (medicinenet.com)
  • With the exact mechanism not known, amiodarone ( Cordarone ), another type of antiarrhythmic drug, may decrease removal of quinidine by the kidneys or liver giving rise to elevated quinidine blood levels, which may result in life-threatening arrhythmias, including torsades de pointes. (medicinenet.com)
Phenytoin1
  • Removal of quinidine by the liver is accelerated by phenobarbital, phenytoin ( Dilantin ), and rifampin ( Rifamate ), requiring an increase in quinidine dose. (medicinenet.com)
Cytochrome3
  • Quinidine is also an inhibitor of the cytochrome P450 enzyme 2D6, and can lead to increased blood levels of lidocaine, beta blockers, opioids, and some antidepressants. (wikipedia.org)
  • The elimination half-life of oral quinidine is 6 to 8 hours, and it is eliminated by the cytochrome P450 system in the liver. (wikipedia.org)
  • Oxidation of quinidine by human liver cytochrome P-450. (aspetjournals.org)
Antimalarial2
  • Quinidine is an antiarrhythmic agent and antimalarial drug. (medicinenet.com)
  • Quinidine, the only FDA-approved IV antimalarial drug, will no longer be available starting April 1, 2019. (cdc.gov)
Thrombocytopenia4
  • Quinidine can cause thrombocytopenia, granulomatous hepatitis, myasthenia gravis, and torsades de pointes (dangerous heart rhythm), so is not used much today. (wikipedia.org)
  • Quinidine-induced thrombocytopenia (low platelet count) is mediated by the immune system, and may lead to thrombocytic purpura. (wikipedia.org)
  • Quinidine-Induced Immune Thrombocytopenia" by Mansoor N. Saleh, Nadhav Dhodaphar et al. (henryford.com)
  • We have identified six cases of quinidine-induced immune thrombocytopenia based on clinical evidence and in association with elevated amounts of platelet surface IgG. (henryford.com)
Tablets1
  • Do not crush or chew quinidine tablets. (rxwiki.com)
20232
  • 2023. https://peds.unboundmedicine.com/pedscentral/view/Davis-Drug-Guide/51653/0/QUINIDINE. (unboundmedicine.com)
  • 2023. https://www.drugguide.com/ddo/view/Davis-Drug-Guide/51653/all/QUINIDINE. (drugguide.com)
Inhibits1
  • Quinidine also inhibits the transport protein P-glycoprotein and so can cause some peripherally acting drugs such as loperamide to have central nervous system side effects, such as respiratory depression, if the two drugs are coadministered. (wikipedia.org)
Irregular2
  • Quinidine can greatly improve your ability to perform normal activities by decreasing the number of irregular heartbeats you have. (ndclist.com)
  • If you are taking regular-release quinidine for an irregular heartbeat, the manufacturer recommends that you take no more than 4 grams daily. (healthwarehouse.com)
Toxicity3
  • Quinidine intoxication can lead to a collection of symptoms collectively known as cinchonism, with tinnitus (ringing in the ears) being among the most characteristic and common symptoms of this toxicity syndrome. (wikipedia.org)
  • Increased quinidine levels can increase the risk of quinidine toxicity and cardiac arrhythmias. (medicinenet.com)
  • Cimetidine ( Tagamet ) increases quinidine levels by decreasing the elimination of quinidine giving rise to elevated quinidine serum levels that may lead to quinidine toxicity. (medicinenet.com)
Concomitant2
  • Azole antifungals such as ketoconazole ( Nizoral ), fluconazole ( Diflucan ), itraconazole ( Sporanox PulsePak), voriconazole ( VFEND ), posaconazole (Noxafil), and protease inhibitor /antiretroviral drugs such as indinavir ( Crixivan ), and saquinavir ( Invirase ) should not be used with quinidine since their concomitant use can increase quinidine levels by inhibiting removal of quinidine by the liver . (medicinenet.com)
  • In addition to having a substantial adverse event profile quinidine can react with many concomitant medications, requiring dosage adjustments and careful monitoring, typically in an Intensive Care Unit (ICU) setting (15-17). (cdc.gov)
Drugs2
  • Which drugs or supplements interact with quinidine? (medicinenet.com)
  • The anticholinergic effect of drugs such as tri- and tetracyclic antidepressants, antihistamines, quinidine, amantadine, antipsychotics (e.g. butyrophenones, phenothiazines), disopyramide and other anticholinergics (e.g. tiotropium, ipratropium, atropine-like compounds) may be intensified by Buscopan. (janusinfo.se)
Preparations1
Dosage1
Doses1
  • It is important, therefore, to decrease quinidine doses when it is given concomitantly with amiodarone . (medicinenet.com)
Fluoxetine2
  • In contrast, quinidine and fluoxetine, both of which are inhibitors of CYP2D6 activity, did not exhibit a preincubation-dependent increase in inhibitory potency. (aspetjournals.org)
  • These data are consistent with mechanism-based inhibition of CYP2D6 by paroxetine but not by quinidine or fluoxetine. (aspetjournals.org)
Medications3
  • The authors did not observe significant safety risks using the low quinidine dose, but urged caution and also pointed out that quinidine interacts with a large number of other medications in dangerous or unpredictable ways. (wikipedia.org)
  • Before and while you are using quinidine, your doctor may prescribe other medications (e.g., "blood thinners"/anticoagulants such as warfarin, beta blockers such as metoprolol) to shrink any blood clots in the heart and to slow your pulse. (ndclist.com)
  • Eating grapefruit or drinking grapefruit juice may increase the amount of certain medications in your bloodstream, including quinidine. (healthwarehouse.com)
Arrhythmias2
  • Quinidine is occasionally used as a class I antiarrhythmic agent to prevent ventricular arrhythmias, particularly in Brugada Syndrome, although its safety in this indication is uncertain. (wikipedia.org)
  • Phenothiazines such as thioridazine (Mellaril), an antipsychotic drug, and tricyclic antidepressants such as amitriptyline ( Elavil , Endep ) should not be used with quinidine since they can cause cardiac arrhythmias, and their use with quinidine increases the risk of cardiac arrhythmias. (medicinenet.com)
Conclusions2
  • Conclusions: High AFR is associated with failure of quinidine cardioversion and AF recurrence after successful TVEC. (lu.se)
  • Conclusions-- Artesunate was a safe and clinically beneficial alternative to quinidine. (cdc.gov)
Clinically1
  • As a noninvasive marker that can be retrieved from surface ECG, AFR can be clinically useful in predicting the probability of responding to quinidine treatment as well as maintaining SR after electrical cardioversion. (lu.se)
Cardiac2
  • The effect of quinidine on the ion channels is to prolong the cardiac action potential, thereby prolonging the QT interval on the surface ECG. (wikipedia.org)
  • The effects of cinchona bark (the botanical source from which quinidine is extracted) had been commented on long before the understanding of cardiac physiology arose. (wikipedia.org)
Patients5
  • Plasma samples from patients treated with quinidine were also analyzed by both procedures. (eurekamag.com)
  • QT prolongation was considerably greater in the quinidine-treated patients. (ox.ac.uk)
  • Binding of quinidine to plasma proteins in normal subjects and in patients with hyperlipoproteinemias. (bvsalud.org)
  • Evaluation of the degree of protein binding of quinidine in plasma from normal subjects and patients with types IV and IIa hyperlipoproteinemias supported the computer predictions. (bvsalud.org)
  • The quinidine binding in plasma of patients with hyperlipoproteinemias did not differ statistically from that in the normal subjects. (bvsalud.org)
Treatment2
  • Methods: Electrocardiograms (ECG) from horses with persistent AF admitted for cardioversion with either medical treatment (quinidine) or transvenous electrical cardioversion (TVEC) were included. (lu.se)
  • Results: Of the 195 horses included, 74 received quinidine treatment and 121 were treated with TVEC. (lu.se)
Headache1
  • Common side effects of quinidine include diarrhea, lightheadedness, and headache. (rxwiki.com)
Increases1
  • Quinidine increases the action of the blood thinner warfarin ( Coumadin , Jantoven ), due to synergistic effects and can lead to excessive blood thinning and bleeding. (medicinenet.com)
Treat2
  • Quinidine is also used to treat short QT syndrome. (wikipedia.org)
  • Quinidine is a prescription medication used to treat abnormal heart rhythms. (rxwiki.com)
Pregnant2
  • Is quinidine safe to take if I'm pregnant or breastfeeding? (medicinenet.com)
  • Safety and efficacy of quinidine has not been established in pregnant women. (medicinenet.com)
Plasma1
  • Quinidine in the plasma binds to various lipoproteins as well as to albumin . (bvsalud.org)
Effects1
Prescription1