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  • Genetic
  • The study design enabled us to comprehensively reconstruct the genetic regulatory network in these families, provide estimates of heritability, identify eQTL, evaluate missing heritability for the eQTL, and quantify the number of different alleles contributing to any given locus. (csuca.org)
  • Genetic variation at twentythree microsatellite loci in sixteen human populations por: Deka, Ranjan, et al. (csuca.org)
  • Due to their polygenic architectures, such traits are difficult to investigate with genetic mapping. (diva-portal.org)
  • The interaction effect among multiple genetic factors, i.e. epistasis, plays an important role in explaining susceptibility on common human diseases and phenotypic traits. (biomedcentral.com)
  • 1994
  • The most commonly used approach for the line means model is that of C hurchill and D oerge (1994) , in which trait observations are reassigned without replacement among the subjects. (genetics.org)
  • chromosome
  • After a genome-wide search for quantitative trait loci (QTL) influencing the aortic elastin, collagen, and cell protein contents in an F2 population derived from BN and LOU rats, we identified on chromosomes 2 and 14, 3 QTL specifically controlling elastin levels, and a further highly significant QTL on chromosome 17 linked to the level of cell proteins. (ahajournals.org)
  • Family with sequence similarity 193 member A is a protein that in humans is encoded by the FAM193A gene located on locus p16.3 of chromosome 4. (wikipedia.org)
  • A genetic locus conferring susceptibility was identified (juvenile audiogenic monogenic seizures1, jams1) on chromosome 10. (wikipedia.org)
  • Alleles that are closer together have lower rates of recombination than those that are located far apart.The distance between two alleles on a chromosome can be determined by calculating the percentage or recombination between two loci. (wikipedia.org)
  • phenotypic
  • By modeling the distribution of trait values across a tree, phylogenetic comparative methods also help to reconstruct the dynamics of phenotypic evolution. (genetics.org)
  • As such, they are best characterized in terms of sudden transitions to qualitatively distinct phenotypic states as opposed to quantitative extensions of previous states. (genetics.org)
  • This is called the Trait-Based approach and strictly uses phenotypic information only to select the individuals for a sample. (wikipedia.org)
  • susceptibility
  • In recent years, the availability of dense polymorphic marker linkage maps and robust statistical methods for estimating map positions and effects of QTL by linkage to these markers has generated an explosion of QTL maps for morphological, disease susceptibility, behavioral, and fitness-related traits in multiple species ( M ackay 2001 ). (genetics.org)
  • In this study, we have performed a genetic analysis in an F2 cohort of 161 rats derived from BN and LOU rat strains to detect genetic loci contributing to quantitative variations of aortic elastin, collagen, and cell protein contents and to test a possible relationship between these loci and those linked to susceptibility to aortic IEL ruptures. (ahajournals.org)
  • Mendelian
  • Castle's conclusion was based on the observation that novel traits that could be studied in the lab and that show Mendelian inheritance patterns reflect a large deviation from the wild type, and Castle believed that acquisition of such features is the basis of "discontinuous variation" that characterizes speciation. (wikipedia.org)
  • populations
  • With RI panels, as with other true-breeding populations such as panels of doubled haploid (DH) lines, marker genotypes need be measured only once and the trait value for a given genotype can be measured in replicated individuals. (genetics.org)
  • Bayesian
  • Moreover, the EBL proved to be less sensitive to tuning than the related Bayesian adaptive LASSO (BAL), which introduces locus-specific regularization parameters as well, but involves no mechanism for distinguishing between model sparsity and parameter shrinkage. (genetics.org)
  • Our method, the extended Bayesian LASSO (EBL), introduces locus-specific regularization parameters and utilizes a parameterization that clearly separates the overall model sparsity from the degree of shrinkage of individual regression parameters. (genetics.org)
  • protein
  • Ashokkumar K. and Ravikesavan R. 2008 Genetic studies of combining ability estimates for seed oil, seed protein and fibre quality traits in upland cotton ( G. hirsutum L. (springer.com)
  • The locus extends over about 8 kbp and contains the six coding exons that give rise to an open reading frame of 639 nucleotides encoding the GIPC3 protein of 312 amino acids. (wikipedia.org)
  • strains
  • joint analysis of these crosses can pinpoint the genetic backgrounds (strains) on which QTL arose, providing further insights into the genetic architecture of traits involved in food quality or disease. (genetics.org)
  • variance
  • For any given QTL model, the trait variance can be divided into three components: (1) the variance explained by the QTL in the model, (2) the variance explained by QTL or polygenes not in the model, and (3) nongenetic variance ( K napp and B ridges 1990 ). (genetics.org)
  • 2002
  • Cui H, Peng B, Xing Z, Xu G, Yu B, Zhang Q (2002) Molecular dissection of seedling-vigor and associated physiological traits in rice. (springer.com)
  • alleles
  • One way uses the frequency of marker alleles and compares them to individuals selected from the two tails of the trait distribution. (wikipedia.org)
  • novel
  • Ikeda T, Ohnishi S, Senda M, Miyoshi T, Ishimoto M, Kitamura K, Funatsuki H (2009) A novel major quantitative trait locus controlling seed development at low temperature in soybean ( Glycine max ). (springer.com)
  • framework
  • Still, it would be almost thirty years until the theoretical framework for evolution of complex traits would be widely formalized. (wikipedia.org)
  • content
  • Oil content in cottonseed is a major quality trait which when improved through breeding could enhance the competitiveness of cottonseed oil among other vegetable oils. (springer.com)
  • resistance
  • Quantitative trait loci (QTL) for wheat resistance to aluminum (Al) toxicity were analyzed using simple sequence repeats (SSRs) in a population of 192 F6 recombinant inbred lines (RILs) derived from a cross between an Al-resistant cultivar, Atlas 66 and an Al-sensitive cultivar, Chisholm. (ovid.com)
  • A leaf disc bioassay was used to study the components of quantitative resistance (latent period, uredinia number, and uredinia size) to 3 isolates of the leaf rust. (springer.com)
  • humans
  • Quantitative trait locus: Primates, chimp and gibbon, represented the closest group of orthologous proteins in relation to humans (E range = 0.0-0.0), these along with others were used make a multiple sequence alignment (MSA). (wikipedia.org)
  • 1996
  • A quasi-congenic QTL introgression strain carrying a low alcohol consumption gene from BALB/c has lower voluntary alcohol consumption than C57BL/6, with 96% of loci in common (Vadasz et al, 1996). (spotidoc.com)
  • Thus
  • Thus, a person carrying one or two copies of a high-risk variant is at increased risk of developing the associated disease or having the associated trait. (wikipedia.org)
  • species
  • This study exploits the recent production of a draft nuclear genome sequence for Arabidopsis lyrata to examine evolution of plant MIRNA and p4-siRNA loci between two congenic Brassicaceae species. (plantcell.org)
  • population
  • In the current study we have effectively identified loci for branched chain amino acid, serene, glycine, threonine and proline metabolism for seeds of a tomato Introgression Line mapping population. (ovid.com)
  • studies
  • Case-control studies use subjects who already have a disease, trait or other condition and determine if there are characteristics of these patients that differ from those who do not have the disease or trait. (wikipedia.org)
  • plant
  • In sexually reproducing organisms, much of the epigenetic modification within cells is reset during meiosis (e.g. marks at the FLC locus controlling plant vernalization), though some epigenetic responses have been shown to be conserved (e.g. transposon methylation in plants). (wikipedia.org)
  • Share
  • RAPD's are used also under the assumption that two samples share a same locus when a sample is produced. (wikipedia.org)