• glucose
  • Generation of ATP Examples of Glucose Metabolic Fates Major Glucose Utilization Pathways in Cells of Higher Plants and Animals Catabolism via Pyruvate Pyruvate O OCH3 Lehninger 2000 Fig 15.1 Voet, Voet & Pratt 2013 Fig 15.16 C C O FERMENTATION Definition: A general term for the anaerobic degradation of glucose or other organic nutrients to obtain energy conserved in the form of ATP. (slidegur.com)
  • Generate ATP Triose stage Berg, Tymoczko & Stryer, 2002 Fig. 16.3 Stage 1 of Glycolysis Detail Berg, Tymoczko & Stryer, 2002 Fig. 16.X Conversion of Glucose by Hexokinase carbon numbering Hexokinase present in all cells of all organisms Kinases are enzymes that catalyze the transfer of a phosphoryl group from ATP to an acceptor Reaction Purposes: mechanism Glycolysis Step 1 G= -16.7 kJ/mol 1. (slidegur.com)
  • IMPORTANT - Two major cellular needs regulate the rate of glucose conversion into pyruvate: 1) The production of ATP. (slidegur.com)
  • structural
  • For example, the E. coli Pyruvate Kinase (UniProt:P0AD61, PDB: 1E0T) consists of three structural domains â one blue discontinuous domain which matches the FunFam 6921 in CATH superfamily 3.20.20.60, the second yellow continuous domain matches FunFam 2014 in the CATH superfamily 2.40.33.10 and the third green continuous domain matches FunFam 2481 in the CATH superfamily 3.40.1380.20. (cathdb.info)
  • human
  • Specific mutants were developed to evaluate the roles of several residues in [Alpha]8 helix of the regulatory (R) domain of human pyruvate dehydrogenase kinase 2 (PDHK2) in the linkage between the Regulatory (R) and catalytic (Cat) domain (Q144A), dichloroacetate (DCA)/pyruvate inhibition (R154C, R158A, I157F) and stimulation by reductive acetylation (L160A, R154C/L160A). (k-state.edu)
  • increase
  • 5. In conclusion, these results suggest that monokines increase pyruvate flux through hepatic PDH in vivo in rats fed ad libitum primarily by mechanisms other than covalent modification of PDH. (biochemj.org)